Category: flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Assay: | 95.00 to 100.00 %
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Food Chemicals Codex Listed: | No |
Boiling Point: | 406.00 to 408.00 °C. @ 760.00 mm Hg (est)
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Flash Point: | 365.00 °F. TCC ( 184.70 °C. ) (est)
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logP (o/w): | 6.318 (est) |
Soluble in: |
| water, 1.745 mg/L @ 25 °C (est) |
Organoleptic Properties:
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Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
Not determined
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | flavoring agents |
Recommendation for falcarindiol usage levels up to: | | not for fragrance use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| falcalindiol | (3S,8S,9Z)- | heptadeca-1,9-dien-4,6-diyne-3,8-diol | | heptadeca-1,9-diene-4,6-diyne-3,8-diol | 1,9- | heptadecadiene-4,6-diyne-3,8-diol, (3S,8S,9Z)- |
Articles:
PubMed: | Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review. |
PubMed: | Determination of six polyynes in Oplopanax horridus and Oplopanax elatus using polyethylene glycol modified reversed migration microemulsion electrokinetic chromatography. |
PubMed: | Automated analytical standard production with supercritical fluid chromatography for the quantification of bioactive C17-polyacetylenes: A case study on food processing waste. |
PubMed: | Anticancer activities of polyynes from the root bark of Oplopanax horridus and their acetylated derivatives. |
PubMed: | Polyacetylenes from Radix et Rhizoma Notopterygii incisi with an inhibitory effect on nitric oxide production in vitro. |
PubMed: | Polyacetylene levels in carrot juice, effect of pH and thermal processing. |
PubMed: | Dietary polyacetylenes of the falcarinol type are inhibitors of breast cancer resistance protein (BCRP/ABCG2). |
PubMed: | Inhibition of glycogen synthase kinase-3β by falcarindiol isolated from Japanese Parsley (Oenanthe javanica). |
PubMed: | Identification of potential anticancer compounds from Oplopanax horridus. |
PubMed: | Quality of carrots as affected by pre- and postharvest factors and processing. |
PubMed: | Polyacetylenes from Notopterygium incisum--new selective partial agonists of peroxisome proliferator-activated receptor-gamma. |
PubMed: | The Canadian medicinal plant Heracleum maximum contains antimycobacterial diynes and furanocoumarins. |
PubMed: | Quantitative Raman spectroscopy for the analysis of carrot bioactives. |
PubMed: | Influence of field attack by carrot psyllid (Trioza apicalis Förster) on sensory quality, antioxidant capacity and content of terpenes, falcarindiol and 6-methoxymellein of carrots (Daucus carota L.). |
PubMed: | The antitumor natural compound falcarindiol promotes cancer cell death by inducing endoplasmic reticulum stress. |
PubMed: | Antimycobacterials from lovage root (Ligusticum officinale Koch). |
PubMed: | [Fingerprint analysis of Glehniae Radix by TLC]. |
PubMed: | Melanogenesis inhibitory bisabolane-type sesquiterpenoids from the roots of Angelica koreana. |
PubMed: | Falcarindiol allosterically modulates GABAergic currents in cultured rat hippocampal neurons. |
PubMed: | Effects of bioactive compounds from carrots (Daucus carota L.), polyacetylenes, beta-carotene and lutein on human lymphoid leukaemia cells. |
PubMed: | Polyacetylenes in fresh and stored carrots (Daucus carota): relations to root morphology and sugar content. |
PubMed: | The influence of the fungal pathogen Mycocentrospora acerina on the proteome and polyacetylenes and 6-methoxymellein in organic and conventionally cultivated carrots (Daucus carota) during post harvest storage. |
PubMed: | Components of rhizome extract of Cnidium officinale Makino and their in vitro biological effects. |
PubMed: | Quantification of polyacetylenes in apiaceous plants by high-performance liquid chromatography coupled with diode array detection. |
PubMed: | Spectroscopic studies on bioactive polyacetylenes and other plant components in wild carrot root. |
PubMed: | Characterisation of polyacetylenes isolated from carrot (Daucus carota) extracts by negative ion tandem mass spectrometry. |
PubMed: | Anticomplement activity of polyacetylenes from leaves of Dendropanax morbifera Leveille. |
PubMed: | Effect of ultrasound and blanching pretreatments on polyacetylene and carotenoid content of hot air and freeze dried carrot discs. |
PubMed: | Dietary diacetylene falcarindiol induces phase 2 drug-metabolizing enzymes and blocks carbon tetrachloride-induced hepatotoxicity in mice through suppression of lipid peroxidation. |
PubMed: | Medicinal plant extracts with efflux inhibitory activity against Gram-negative bacteria. |
PubMed: | Effects of harvesting date and storage on the amounts of polyacetylenes in carrots, Daucus carota. |
PubMed: | Hydrophobic constituents and their potential anticancer activities from Devil's Club (Oplopanax horridus Miq.). |
PubMed: | [O-methylnotopterol, a new natural product from the roots and rhizomes of Notopterygium incisum]. |
PubMed: | Quantitative analysis of six polyynes and one polyene in Oplopanax horridus and Oplopanax elatus by pressurized liquid extraction and on-line SPE-HPLC. |
PubMed: | Comparison of polyacetylene content in organically and conventionally grown carrots using a fast ultrasonic liquid extraction method. |
PubMed: | [Fast determination of active components in Angelica dahurica extract using capillary electrochromatography with methacrylate ester-based monolithic columns]. |
PubMed: | Influence of Sous Vide and water immersion processing on polyacetylene content and instrumental color of parsnip (Pastinaca sativa) disks. |
PubMed: | Oploxynes A and B, polyacetylenes from the stems of Oplopanax elatus. |
PubMed: | Isolation and identification of two new polyynes from a North American ethnic medicinal plant--Oplopanax horridus (Smith) Miq. |
PubMed: | A new prenylated flavanonol from Seseli annuum roots showing protective effect on human lymphocytes DNA. |
PubMed: | Sesquiterpenes from Oplopanax horridus. |
PubMed: | The herbal medicine compound falcarindiol from Notopterygii Rhizoma suppresses dendritic cell maturation. |
PubMed: | Activation of the Nrf2/ARE pathway via S-alkylation of cysteine 151 in the chemopreventive agent-sensor Keap1 protein by falcarindiol, a conjugated diacetylene compound. |
PubMed: | New antibacterial and cytotoxic activities of falcarindiol isolated in Crithmum maritimum L. leaf extract. |
PubMed: | Structure determination of bisacetylenic oxylipins in carrots (Daucus carota L.) and enantioselective synthesis of falcarindiol. |
PubMed: | Differential effects of falcarinol and related aliphatic C(17)-polyacetylenes on intestinal cell proliferation. |
PubMed: | [Study on chemical constituents from Cicuta virosa var. latisecta]. |
PubMed: | Induction of antioxidant and phase 2 drug-metabolizing enzymes by falcarindiol isolated from Notopterygium incisum extract, which activates the Nrf2/ARE pathway, leads to cytoprotection against oxidative and electrophilic stress. |
PubMed: | Polyacetylenes from sardinian Oenanthe fistulosa: a molecular clue to risus sardonicus. |
PubMed: | [Studies on chemical constituents of Peucedanum delavayi]. |
PubMed: | Indoleacetic acid falcarindiol ester induces granulocytic differentiation of the human leukemia cell line HL-60. |
PubMed: | Reinvestigation of the bitter compounds in carrots (Daucus carota L.) by using a molecular sensory science approach. |
PubMed: | The polyacetylenes falcarinol and falcarindiol affect stress responses in myotube cultures in a biphasic manner. |
PubMed: | Anti-TB polyynes from the roots of Angelica sinensis. |
PubMed: | Purple carrot (Daucus carota L.) polyacetylenes decrease lipopolysaccharide-induced expression of inflammatory proteins in macrophage and endothelial cells. |
PubMed: | Antimycobacterial polyacetylenes from Levisticum officinale. |
PubMed: | Novel coumarin glycoside and phenethyl vanillate from Notopterygium forbesii and their binding affinities for opioid and dopamine receptors. |
PubMed: | [Studies on chemical constituents of rhizomes of Ligusticum chuanxiong]. |
PubMed: | Hederyne A, a new antimicrobial polyacetylene from galls of Hedera rhombea Bean. |
PubMed: | Cytotoxic constituents from angelicae sinensis radix. |
PubMed: | Lignans and coumarins from the roots of Anthriscus sylvestris and their increase of caspase-3 activity in HL-60 cells. |
PubMed: | The polyacetylene falcarindiol with COX-1 activity isolated from Aegopodium podagraria L. |
PubMed: | [Studies on the chemical constituents of the aerial parts of Seseli mairei]. |
PubMed: | Growth inhibitory indole acetic acid polyacetylenic ester from Japanese ivy (Hedera rhombea Bean). |
PubMed: | Determination of polyacetylenes in carrot roots (Daucus carota L.) by high-performance liquid chromatography coupled with diode array detection. |
PubMed: | Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis. |
PubMed: | Antibacterial activity of components from Lomatium californicum. |
PubMed: | The antimycobacterial constituents of dill (Anethum graveolens). |
PubMed: | In vitro GABA-transaminase inhibitory compounds from the root of Angelica dahurica. |
PubMed: | Inhibitory effects of coumarin and acetylene constituents from the roots of Angelica furcijuga on D-galactosamine/lipopolysaccharide-induced liver injury in mice and on nitric oxide production in lipopolysaccharide-activated mouse peritoneal macrophages. |
PubMed: | LC-DAD-APCI-MS-based screening and analysis of the absorption and metabolite components in plasma from a rabbit administered an oral solution of danggui. |
PubMed: | In situ simultaneous analysis of polyacetylenes, carotenoids and polysaccharides in carrot roots. |
PubMed: | Spatial tissue distribution of polyacetylenes in carrot root. |
PubMed: | Polyacetylenes from the Apiaceae vegetables carrot, celery, fennel, parsley, and parsnip and their cytotoxic activities. |
PubMed: | Inhibitory constituents against cyclooxygenases from Aralia cordata Thunb. |
PubMed: | Falcarindiol impairs the expression of inducible nitric oxide synthase by abrogating the activation of IKK and JAK in rat primary astrocytes. |
PubMed: | Cytotoxic constituents of roots of Chaerophyllum hirsutum. |
PubMed: | Quantitative studies and sensory analyses on the influence of cultivar, spatial tissue distribution, and industrial processing on the bitter off-taste of carrots (Daucus carota l.) and carrot products. |
PubMed: | New constituents of Artemisia monosperma. |
PubMed: | The anti-staphylococcal activity of Angelica dahurica (Bai Zhi). |
PubMed: | Falcarindiol inhibits nitric oxide-mediated neuronal death in lipopolysaccharide-treated organotypic hippocampal cultures. |
PubMed: | Lignans, phenylpropanoids and polyacetylenes from Chaerophyllum aureum L. (Apiaceae). |
PubMed: | Structural and sensory characterization of compounds contributing to the bitter off-taste of carrots (Daucus carota L.) and carrot puree. |
PubMed: | Four guaianolides from Sinodielsia yunnanensis. |
PubMed: | Olefin cross-metathesis as a tool in natural product degradation. The stereochemistry of (+)-falcarindiol. |
PubMed: | Chemosystematic investigations of irregular diterpenes in Anisotome and related New Zealand Apiaceae. |
PubMed: | Inducible nitric oxide synthase inhibitors from Saposhnikovia divaricata and Panax quinquefolium. |
PubMed: | Synthesis and cytotoxic activity of a series of diacetylenic compounds related to falcarindiol. |
PubMed: | Medicinal foodstuffs. XX. Vasorelaxant active constituents from the roots of Angelica furcijuga Kitagawa: structures of hyuganins A, B, C, and D. |
PubMed: | Cytotoxic constituents from the roots of Anthriscus sylvestris. |
PubMed: | Stereoselective total synthesis of (3R,8S)-falcarindiol, a common polyacetylenic compound from umbellifers |
PubMed: | Antiproliferative constituents from umbelliferae plants. V. A new furanocoumarin and falcarindiol furanocoumarin ethers from the root of Angelica japonica. |
PubMed: | Hepatoprotective and nitric oxide production inhibitory activities of coumarin and polyacetylene constituents from the roots of Angelica furcijuga. |
PubMed: | Novel antiproliferative falcarindiol furanocoumarin ethers from the root of Angelica japonica. |
PubMed: | Inhibitory effects of Angelica pubescens f. biserrata on 5-lipoxygenase and cyclooxygenase. |
PubMed: | Antiproliferative constituents in umbelliferae plants. IV. Constituents in the fruits of Anthriscus sylvestris Hoffm. |
PubMed: | Antiproliferative constituents in umbelliferae plants. III. Constituents in the root and the ground part of Anthriscus sylvestris Hoffm. |
PubMed: | Antiproliferative constituents in Umbelliferae plants II. Screening for polyacetylenes in some Umbelliferae plants, and isolation of panaxynol and falcarindiol from the root of Heracleum moellendorffii. |
PubMed: | [Polyacetylene compounds from Panax notoginsenoside]. |
PubMed: | 5-Lipoxygenase and cyclooxygenase inhibitory active constituents from Qianghuo (Notopterygium incisum). |
PubMed: | Effects of cicutoxin and related polyacetylenes from Cicuta virosa on neuronal action potentials: a comparative study on the mechanism of the convulsive action. |
PubMed: | [Chemical constituents of Aralia fargesii Franch]. |
PubMed: | Cytotoxic falcarinol oxylipins from Dendropanax arboreus. |
PubMed: | Potent allelochemical falcalindiol from Glehnia littoralis F. Schm. |
PubMed: | Polyacetylenes from water hemlock, Cicuta virosa. |
PubMed: | Screening of polyacetylenic alcohols in crude drugs using the ELISA for panaxytriol. |
PubMed: | Panaxynol, a polyacetylene compound isolated from oriental medicines, inhibits mammalian lipoxygenases. |
PubMed: | Bioactive metabolites from Sicilian marine fennel, Crithmum maritimum. |
PubMed: | Isolation, identification, and bioassay of chemicals affecting nonpreference carrot-root resistance to carrot-fly larva. |
PubMed: | Isolation of the antifungal compounds falcarindiol and sarisan from Heteromorpha trifoliata. |
PubMed: | Elicitation of diacetylenic compounds in suspension cultured cells of eggplant. |
PubMed: | Allergic contact dermatitis from falcarinol isolated from Schefflera arboricola. |
PubMed: | Antibiotic compounds from New Zealand plants. I. Falcarindiol, an anti-dermatophyte agent from Schefflera digitata. |
PubMed: | Anti-nociceptive substances from the roots of Angelica acutiloba. |
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