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N1-(2-methoxy-4-methylbenzyl)-N2-2(2-(5-methylpyridin-2-yl)ethyl)oxalamide
Notes:
Used as a food additive [EAFUS]
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Chemical sources Association Inc Exchange of knowledge Need This Item for Flavor? You can contact the Chemical Sources Association. Events Links Product(s):
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| CAS Number: | 745047-94-3 |  3D/inchi
|
| FDA UNII: | 50H0N03SQU | |
| XlogP3-AA: | 2.40 (est) | |
| Molecular Weight: | 341.41091000 | |
| Formula: | C19 H23 N3 O3 | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
| EFSA/JECFA Comments: | (Flavour Industry, 2008). [FL-no: 16.099, 16.100 and 16.101] should be named by the same nomenclature principles. | |
Category: flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| JECFA Food Flavoring: | 1769 N1-(2-methoxy-4-methylbenzyl)-N2-2(2-(5-methylpyridin-2-yl)ethyl)oxalamide |
| DG SANTE Food Flavourings: | 16.100 N1-(2-methoxy-4-methylbenzyl)-N2-2(2-(5-methylpyridin-2-yl)ethyl)oxalamide |
| FEMA Number: | 4234 N1-(2-methoxy-4-methylbenzyl)-N2-2(2-(5-methylpyridin-2-yl)ethyl)oxalamide |
| FDA: | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF): | 745047-94-3 ; N1-(2-METHOXY-4-METHYLBENZYL)-N2-(2-(5-METHYLPYRIDIN-2-YL)ETHYL)OXALAMIDE |
Physical Properties:
| Appearance: | white to pale beige powder (est) |
| Assay: | 99.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 132.00 to 133.00 °C. @ 760.00 mm Hg |
| Flash Point: | 32.00 °F. TCC ( 0.00 °C. ) (est) |
| logP (o/w): | 2.691 (est) |
| Soluble in: | |
| alcohol, slightly | |
| water, 1298 mg/L @ 25 °C (est) | |
| Insoluble in: | |
| water | |
Organoleptic Properties:
| Odor Strength: | high , recommend smelling in a 0.10 % solution or less |
| Flavor Type: savory | |
| savory meaty | |
| Taste Description: | savory meaty |
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| Axsyn |
| For experimental / research use only. |
| Ethanediamide,N1-[(2-methoxy-4-methylphenyl)methyl]-N2-[2-(5-methyl-2-pyridinyl)ethyl]- |
| Parchem |
| N1-(2-methoxy-4-methyl benzyl)-N2-2(2-(5-methyl pyridin-2-yl)ethyl) oxalamide |
| Chemical Sources Association |
| Need This Item for Flavor/Food?: You can contact the CSA |
Safety Information:
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| Not determined | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | flavoring agents | ||
| Recommendation for N1-(2-methoxy-4-methyl benzyl)-N2-2(2-(5-methyl pyridin-2-yl)ethyl) oxalamide usage levels up to: | |||
| not for fragrance use. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.012 (μg/capita/day) | ||
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 0.01 (μg/capita/day) | ||
| Modified Theoretical Added Maximum Daily Intake (mTAMDI): | ND (μg/person/day) | ||
| NOEL (No Observed Effect Level): | 100.00 (mg/kg bw per day) | ||
| Threshold of Concern: | 90 (μg/person/day) | ||
| Structure Class: | III | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 22 | |||
| Click here to view publication 22 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | 1.00000 | 2.00000 | |
| beverages(nonalcoholic): | - | - | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | - | - | |
| cheese: | 1.00000 | 3.00000 | |
| chewing gum: | - | - | |
| condiments / relishes: | 2.00000 | 4.00000 | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | 2.00000 | 4.00000 | |
| fish products: | 1.00000 | 3.00000 | |
| frozen dairy: | - | - | |
| fruit ices: | - | - | |
| gelatins / puddings: | - | - | |
| granulated sugar: | - | - | |
| gravies: | 2.00000 | 4.00000 | |
| hard candy: | - | - | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | 1.00000 | 3.00000 | |
| milk products: | - | - | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | 1.00000 | 3.00000 | |
| processed fruits: | - | - | |
| processed vegetables: | 1.00000 | 3.00000 | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | 5.00000 | 10.00000 | |
| snack foods: | 5.00000 | 10.00000 | |
| soft candy: | - | - | |
| soups: | 2.00000 | 4.00000 | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
Safety References:
| European Food Safety Athority(efsa): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): | |
| Scientific Opinion on Flavouring Group Evaluation 94: Consideration of aliphatic amines and amides evaluated in addendum to the JECFA group aliphatic and aromatic amines and amides by JECFA View page or View pdf | |
| Scientific Opinion on Flavouring Group Evaluation 94, Revision 2 (FGE.94Rev2): Consideration of aliphatic amines and amides evaluated in an addendum to the group of aliphatic and aromatic amines and amides evaluated by the JECFA (68th meeting) View page or View pdf | |
| EPI System: | View |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 11210019 |
| National Institute of Allergy and Infectious Diseases: | Data |
| N-[(2-methoxy-4-methylphenyl)methyl]-N'-[2-(5-methylpyridin-2-yl)ethyl]oxamide | |
| Chemidplus: | 0745047943 |
References:
| N-[(2-methoxy-4-methylphenyl)methyl]-N'-[2-(5-methylpyridin-2-yl)ethyl]oxamide | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 11210019 |
| Pubchem (sid): | 42289664 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| HMDB (The Human Metabolome Database): | HMDB32382 |
| FooDB: | FDB009801 |
| ChemSpider: | View |
Potential Blenders and core components note
Potential Uses:
| meat | FL | |
| savory | FL |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| ethanediamide,N1-[(2-methoxy-4-methylphenyl)methyl]-N2-[2-(5-methyl-2-pyridinyl)ethyl]- | |
| N-(2- | methoxy-4-methylbenzyl)-N'-[2-(5-methyl-2-pyridinyl)ethyl]ethanediamide |
| N1-(2- | methoxy-4-methylbenzyl)-N2-(2-(5-methyl(pyridin-2-yl))ethyl)oxalamide |
| N1-(2- | methoxy-4-methylbenzyl)-N2-2(2-(5-methylpyridin-2-yl)ethyl)oxalamide |
| N-[(2- | methoxy-4-methylphenyl)methyl]-N'-[2-(5-methyl-2-pyridinyl)ethyl]ethanediamide |
| N-[(2- | methoxy-4-methylphenyl)methyl]-N'-[2-(5-methylpyridin-2-yl)ethyl]oxamide |