Category: fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | colorless to pale yellow clear liquid (est) |
Food Chemicals Codex Listed: | No |
Soluble in: |
| alcohol |
Insoluble in: |
| water |
Organoleptic Properties:
Odor Strength: | medium |
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Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
Not determined
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | fragrance agents |
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
contains the following IFRA (Annex) restricted components: (non-analysis max. level reference only) |
geraniol | Max. Found: <0.40 % and Reason: Sensitization |
Recommendation for croton cajucara benth. leaf oil brazil usage levels up to: | | 5.0000 % in the fragrance concentrate.
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Recommendation for croton cajucara benth. leaf oil brazil flavor usage levels up to: |
| not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| croton cajucara benth. leaf oil brazil |
Articles:
PubMed: | Effects of 7-Hydroxycalamenene Isolated from Croton cajucara Essential Oil on Growth, Lipid Content and Ultrastructural Aspects of Rhizopus oryzae. |
PubMed: | In vitro cytocidal effects of the essential oil from Croton cajucara (red sacaca) and its major constituent 7- hydroxycalamenene against Leishmania chagasi. |
PubMed: | Antioxidant and antimicrobial activities of 7-hydroxy-calamenene-rich essential oils from Croton cajucara Benth. |
PubMed: | Treatment with aqueous extract from Croton cajucara Benth reduces hepatic oxidative stress in streptozotocin-diabetic rats. |
PubMed: | Molecular phylogenetics and character evolution of the "sacaca" clade: novel relationships of Croton section Cleodora (Euphorbiaceae). |
PubMed: | Involvement of glutathione, sulfhydryl compounds, nitric oxide, vasoactive intestinal peptide, and heat-shock protein-70 in the gastroprotective mechanism of Croton cajucara Benth. (Euphorbiaceae) essential oil. |
PubMed: | Hepatics alterations and genotoxic effects of Croton cajucara Benth (SACACA) in diabetic rats. |
PubMed: | Croton cajucara crude extract and isolated terpenes: activity on Trypanosoma cruzi. |
PubMed: | Vitamin E ameliorates high dose trans-dehydrocrotonin-associated hepatic damage in mice. |
PubMed: | The antiulcer effect of Croton cajucara Benth in normoproteic and malnourished rats. |
PubMed: | Histologic evaluation of rats' liver after Croton cajucara Benth (sacaca) administration. |
PubMed: | Protective effect of DCTN (trans-dehydrocrotonin) against induction of micronuclei and apoptosis by different mutagenic agents in vitro. |
PubMed: | The gastroprotective effect of the essential oil of Croton cajucara is different in normal rats than in malnourished rats. |
PubMed: | Croton cajucara Benth. leaf extract scavenges the stable free radical DPPH and protects against oxidative stress induced by paraquat. |
PubMed: | Plant active components - a resource for antiparasitic agents? |
PubMed: | Cardiovascular effects of trans-dehydrocrotonin, a diterpene from Croton cajucara in rats. |
PubMed: | Antimicrobial activity of Croton cajucara Benth linalool-rich essential oil on artificial biofilms and planktonic microorganisms. |
PubMed: | Would Sacaca, Croton cajucara Benth (Euphorbiaceae) be an hepatotoxic plant like Germander, Teucrium chamaedrys L. (Labiatae)? |
PubMed: | Antiulcer activity and subacute toxicity of trans-dehydrocrotonin from Croton cajucara. |
PubMed: | Chronic treatment with bark infusion from Croton cajucara lowers plasma triglyceride levels in genetic hyperlipidemic mice. |
PubMed: | Dehydrocrotonin and its derivative, dimethylamide-crotonin induce apoptosis with lipid peroxidation and activation of caspases-2, -6 and -9 in human leukemic cells HL60. |
PubMed: | Antiulcerogenic effect and cytotoxic activity of semi-synthetic crotonin obtained from Croton cajucara Benth. |
PubMed: | Comparison of the gastroprotective effect of a diterpene lactone isolated from Croton cajucara with its synthetic derivatives. |
PubMed: | Influence of protein phosphatase inhibitors on HL60 cells death induction by dehydrocrotonin. |
PubMed: | Comparative cytotoxicity of dimethylamide-crotonin in the promyelocytic leukemia cell line (HL60) and human peripheral blood mononuclear cells. |
PubMed: | Antileishmanial activity of a linalool-rich essential oil from Croton cajucara. |
PubMed: | Sensitivity to beta-adrenoceptor agonists of adipocytes from rats treated with an aqueous extract of Croton cajucara Benth. |
PubMed: | Cytotoxic effect of the diterpene lactone dehydrocrotonin from Croton cajucara on human promyelocytic leukemia cells. |
PubMed: | Effect of essential oil obtained from Croton cajucara Benth. on gastric ulcer healing and protective factors of the gastric mucosa. |
PubMed: | Derivatives of dehydrocrotonin, a diterpene lactone isolated from Croton cajucara: cytotoxicity in rat cultured hepatocytes and in V79 cells. |
PubMed: | Natural trans-crotonin: the antiulcerogenic effect of another diterpene isolated from the bark of Croton cajucara Benth. |
PubMed: | Investigations on the antinociceptive activity of crude extracts from Croton cajucara leaves in mice. |
PubMed: | Blood glucose- and triglyceride-lowering effect of trans-dehydrocrotonin, a diterpene from Croton cajucara Benth., in rats. |
PubMed: | Antigenotoxicity of trans-dehydrocrotonin, a clerodane diterpene from Croton cajucara. |
PubMed: | Effect of trans-dehydrocrotonin, a 19-nor-clerodane diterpene from Croton cajucara on experimental hypertriglyceridaemia and hypercholesterolaemia induced by Triton WR 1339 (tyloxapol) in mice. |
PubMed: | The lipid-lowering effect of trans-dehydrocrotonin, a clerodane diterpene from Croton cajucara Benth. in mice fed on high-fat diet. |
PubMed: | Gastroprotective effect of aparisthman, a diterpene isolated from Aparisthmium cordatum, on experimental gastric ulcer models in rats and mice. |
PubMed: | Evaluation of the gastroprotective activity of cordatin, a diterpene isolated from Aparisthmium cordatum (Euphorbiaceae). |
PubMed: | Ethnopharmacology, phytochemistry and pharmacology: a successful combination in the study of Croton cajucara. |
PubMed: | Gastroprotective effect of essential oil from Croton cajucara Benth. (Euphorbiaceae). |
PubMed: | Anti-inflammatory and antinociceptive effects in rodents of the essential oil of Croton cajucara Benth. |
PubMed: | Anti-tumour activity of two 19-nor-clerodane diterpenes, trans-dehydrocrotonin and trans-crotonin, from Croton cajucara. |
PubMed: | Antioestrogenic effect of trans-dehydrocrotonin, a nor-clerodane diterpene from Croton cajucara Benth. in rats. |
PubMed: | Investigation of genotoxic activity of trans-dehydrocrotonin, a clerodane diterpene from Croton cajucara. |
PubMed: | Cytotoxicity of trans-dehydrocrotonin from Croton cajucara on V79 cells and rat hepatocytes. |
PubMed: | Antiulcerogenic mechanisms of dehydrocrotonin, a diterpene lactone obtained from Croton cajucara. |
PubMed: | Effects of an essential oil from the bark of Croton cajucara Benth. on experimental gastric ulcer models in rats and mice. |
PubMed: | Antiulcerogenic activity of trans-dehydrocrotonin from Croton cajucara. |
PubMed: | Hypoglycemic effect of trans-dehydrocrotonin, a nor-clerodane diterpene from Croton cajucara. |
PubMed: | Investigation of anti-inflammatory and antinociceptive activities of trans-dehydrocrotonin, a 19-nor-clerodane diterpene from Croton cajucara. Part 1. |
PubMed: | Cajucarinolide and isocajucarinolide: anti-inflammatory diterpenes from Croton cajucara. |
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