Category: antioxidants
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | yellow powder (est) |
Assay: | 92.00 to 100.00 %
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Food Chemicals Codex Listed: | No |
Boiling Point: | 499.00 to 503.00 °C. @ 760.00 mm Hg
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Flash Point: | 525.00 °F. TCC ( 273.89 °C. )
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logP (o/w): | 5.405 (est) |
Shelf Life: | 6.00 month(s) or longer if stored properly. |
Storage: | refrigerate in tightly sealed containers. |
Soluble in: |
| alcohol | | water, 2.727 mg/L @ 25 °C (est) |
Organoleptic Properties:
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Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Alfa Biotechnology |
For experimental / research use only. |
Carnosic acid 98%
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BOC Sciences |
For experimental / research use only. |
Carnosic Acid >98%
Odor: characteristic Use: Carnosic acid is a natural diterpenoid compound isolated from the herb of Rosmarinus officinalis L. Carnosic acid has protection against carcinogens in animals' studies and shows the activities of antimicrobial and antioxidant.
antimicrobial, antioxidant |
Coompo |
For experimental / research use only. |
Carnosic Acid from Plants ≥98%
Odor: characteristic Use: Carnosic acid has medicinal properties, is a potent antioxidant and protects skin cells against UV-A radiation (photoprotection). Studies in animals have also found a protection against carcinogens. They found that cells treated with carnosic acid triggered antioxidant enzyme production in the cells, which in turn lowered levels of reactive oxygen and nitrogen species (cell-damaging free radicals and peroxides).
carnosic acid substantially inhibited pancreatic lipase activity with IC50 values of 12 g/mL (36 M). Carnosic acid significantly inhibited triglyceride elevation in olive oil-loaded mice at doses of 5-20 mg/kg (p.o.). Furthermore, carnosic acid (20 mg/kg/day, p.o.) reduced the gain of body weight and the accumulation of epididymal fat weight in high fat diet-fed mice after 14 days. |
ExtraSynthese |
For experimental / research use only. |
Carnosic Acid (HPLC) ≥90%
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Foreverest Resources |
Carnosic Acid 10∼90%
Odor: characteristic Use: Carnosic acid (Salvin), is a natural benzenediol abietane diterpene found in rosemary and common sage. It used as an efficient and stable (high temperature durable) green food additive with non-toxic oil-soluble antioxidants. It can be added into oil and fatty food, pharmaceutical, chemical, cosmetics and feed, etc. |
Jiangyin Healthway |
Carnosic Acid
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New functional food ingredients |
Jiangyin Healthway |
Deoxypicrosalvinic acid ( Carnosic acid)
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Layn Natural ingredients |
Rosemary Extract Carnosic Acid / Rosmarinic Acid / Ursolic Acid
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Santa Cruz Biotechnology |
For experimental / research use only. |
Carnosic Acid ≥95%
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Sigma-Aldrich: Sigma |
For experimental / research use only. |
Carnosic acid from Rosmarinus officinalis ≥91%, powder
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Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | None - None found. |
S 02 - Keep out of the reach of children. S 22 - Do not breath dust. S 24/25 - Avoid contact with skin and eyes.
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
Not determined
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | antioxidants |
Recommendation for carnosic acid usage levels up to: | | not for fragrance use.
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Recommendation for carnosic acid flavor usage levels up to: |
| not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s): |
Use of rosemary extracts as a food additive - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf |
EPI System: | View |
AIDS Citations: | Search |
Cancer Citations: | Search |
Toxicology Citations: | Search |
EPA ACToR: | Toxicology Data |
EPA Substance Registry Services (SRS): | Registry |
Laboratory Chemical Safety Summary : | 65126 |
National Institute of Allergy and Infectious Diseases: | Data |
WGK Germany: | 3 |
| (4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-4a-carboxylic acid |
Chemidplus: | 0003650097 |
References:
| (4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-4a-carboxylic acid |
NIST Chemistry WebBook: | Search Inchi |
Pubchem (cid): | 65126 |
Pubchem (sid): | 135022653 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
(4aR,10aS)-5,6- | dihydroxy-1,1-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-4a-carboxylic acid | (4aR,10aS)-5,6- | dihydroxy-7-isopropyl-1,1-dimethyl-2,3,4,9,10,10a-hexahydrophenanthrene-4a-carboxylic acid | | salvin |
Articles:
PubMed: | Carnosic acid attenuates obesity-induced glucose tolerance and hepatic fat accumulation by modulating genes of lipid metabolism in C57BL/6J-ob/ob mice. |
J-Stage: | Antiangiogenic Effect of Carnosic Acid and Carnosol, Neuroprotective Compounds in Rosemary Leaves |
PubMed: | Competitive reduction of perferrylmyoglobin radicals by protein thiols and plant phenols. |
PubMed: | Carnosic acid inhibits TLR4-MyD88 signaling pathway in LPS-stimulated 3T3-L1 adipocytes. |
PubMed: | Carnosic acid induces apoptosis associated with mitochondrial dysfunction and Akt inactivation in HepG2 cells. |
PubMed: | Carnosic acid suppresses colon tumor formation in association with antiadipogenic activity. |
PubMed: | Comprehensive foodomics study on the mechanisms operating at various molecular levels in cancer cells in response to individual rosemary polyphenols. |
PubMed: | Improving the sensory and oxidative stability of cooked and chill-stored lamb using dietary rosemary diterpenes. |
PubMed: | Stability of α-tocotrienol and α-tocopherol in salami-type sausages and curing brine depending on nitrite and pH. |
PubMed: | Carnosic acid inhibits the epithelial-mesenchymal transition in B16F10 melanoma cells: a possible mechanism for the inhibition of cell migration. |
PubMed: | Expression of microRNA-15b and the glycosyltransferase GCNT3 correlates with antitumor efficacy of Rosemary diterpenes in colon and pancreatic cancer. |
PubMed: | A rosemary extract rich in carnosic acid selectively modulates caecum microbiota and inhibits β-glucosidase activity, altering fiber and short chain fatty acids fecal excretion in lean and obese female rats. |
PubMed: | The mechanisms of carnosic acid attenuates tumor necrosis factor-α-mediated inflammation and insulin resistance in 3T3-L1 adipocytes. |
PubMed: | Rosemary (Rosmarinus officinalis) extract modulates CHOP/GADD153 to promote androgen receptor degradation and decreases xenograft tumor growth. |
PubMed: | A rosemary extract enriched in carnosic acid improves circulating adipocytokines and modulates key metabolic sensors in lean Zucker rats: Critical and contrasting differences in the obese genotype. |
PubMed: | Relevance of the carnosic acid/carnosol ratio for the level of rosemary diterpene transfer and for improving lamb meat antioxidant status. |
PubMed: | Shelf life of meat from lambs given essential oil-free rosemary extract containing carnosic acid plus carnosol at 200 or 400 mg kg⁻¹. |
PubMed: | Dietary carnosic acid suppresses hepatic steatosis formation via regulation of hepatic fatty acid metabolism in high-fat diet-fed mice. |
PubMed: | Anticholinesterase activity of phenolic acids and their derivatives. |
PubMed: | Relationship between the solubility, dosage and antioxidant capacity of carnosic acid in raw and cooked ground buffalo meat patties and chicken patties. |
PubMed: | Antioxidant activity of carnosic acid and rosmarinic acid in raw and cooked ground chicken patties. |
PubMed: | Bioavailability of the major bioactive diterpenoids in a rosemary extract: metabolic profile in the intestine, liver, plasma, and brain of Zucker rats. |
PubMed: | Antiadipogenic effect of carnosic acid, a natural compound present in Rosmarinus officinalis, is exerted through the C/EBPs and PPARγ pathways at the onset of the differentiation program. |
PubMed: | Rosmarinus officinalis extract suppresses Propionibacterium acnes-induced inflammatory responses. |
PubMed: | Effect of dietary carnosic acid on the fatty acid profile and flavour stability of meat from fattening lambs. |
PubMed: | Isolation of carnosic acid from rosemary extracts using semi-preparative supercritical fluid chromatography. |
PubMed: | Anti-Campylobacter activities and resistance mechanisms of natural phenolic compounds in Campylobacter. |
PubMed: | Carnosic acid attenuates lipopolysaccharide-induced liver injury in rats via fortifying cellular antioxidant defense system. |
PubMed: | Phenolic antioxidant scavenging of myosin radicals generated by hypervalent myoglobin. |
PubMed: | Phytochemical profile of Rosmarinus officinalis and Salvia officinalis extracts and correlation to their antioxidant and anti-proliferative activity. |
PubMed: | Effects of optimized mixtures containing phenolic compounds on the oxidative stability of sausages. |
PubMed: | Effect of Rosemarinus officinalis L. on MMP-9, MCP-1 levels, and cell migration in RAW 264.7 and smooth muscle cells. |
PubMed: | Acute and 30-day oral toxicity studies of administered carnosic acid. |
PubMed: | Relevance of carnosic acid, carnosol, and rosmarinic acid concentrations in the in vitro antioxidant and antimicrobial activities of Rosmarinus officinalis (L.) methanolic extracts. |
PubMed: | Degradation study of carnosic acid, carnosol, rosmarinic acid, and rosemary extract (Rosmarinus officinalis L.) assessed using HPLC. |
PubMed: | Inhibition of gastric lipase as a mechanism for body weight and plasma lipids reduction in Zucker rats fed a rosemary extract rich in carnosic acid. |
PubMed: | Concentration of antioxidant polyphenols from Thymus capitatus extracts by membrane process technology. |
PubMed: | Meat texture and antioxidant status are improved when carnosic acid is included in the diet of fattening lambs. |
PubMed: | Optimization of ultrasound assisted extraction of antioxidant compounds from marjoram (Origanum majorana L.) using response surface methodology. |
PubMed: | Carnosic acid dietary supplementation at 0.12% rates slows down meat discoloration in gluteus medius of fattening lambs. |
PubMed: | Effects of heat and ultraviolet radiation on the oxidative stability of pine nut oil supplemented with carnosic acid. |
PubMed: | Rosemary and cancer prevention: preclinical perspectives. |
PubMed: | Carnosic acid attenuates renal injury in an experimental model of rat cisplatin-induced nephrotoxicity. |
PubMed: | Oxidative stability of fish oil supplemented with carnosic acid compared with synthetic antioxidants during long-term storage. |
PubMed: | Structure and function of the oxidation products of polyphenols and identification of potent lipoxygenase inhibitors from Fe-catalyzed oxidation of resveratrol. |
PubMed: | Carnosic acid-rich rosemary (Rosmarinus officinalis L.) leaf extract limits weight gain and improves cholesterol levels and glycaemia in mice on a high-fat diet. |
PubMed: | Storage method, drying processes and extraction procedures strongly affect the phenolic fraction of rosemary leaves: an HPLC/DAD/MS study. |
PubMed: | The canine sand maze: an appetitive spatial memory paradigm sensitive to age-related change in dogs. |
PubMed: | Chemical stabilization of oils rich in long-chain polyunsaturated fatty acids during storage. |
PubMed: | Anti-inflammatory effects of supercritical carbon dioxide extract and its isolated carnosic acid from Rosmarinus officinalis leaves. |
PubMed: | Carnosic acid prevents obesity and hepatic steatosis in ob/ob mice. |
PubMed: | Rosmanol potently induces apoptosis through both the mitochondrial apoptotic pathway and death receptor pathway in human colon adenocarcinoma COLO 205 cells. |
PubMed: | Importance of extract standardization and in vitro/ex vivo assay selection for the evaluation of antioxidant activity of botanicals: a case study on three Rosmarinus officinalis L. extracts. |
PubMed: | Introduction of distillate rosemary leaves into the diet of the Murciano-Granadina goat: transfer of polyphenolic compounds to goats' milk and the plasma of suckling goat kids. |
PubMed: | Inhibition of heterocyclic amine formation in beef patties by ethanolic extracts of rosemary. |
PubMed: | Flavonoids and phenolic compounds from Rosmarinus officinalis. |
PubMed: | Investigation of antioxidant and rosmarinic acid variation in the sage collection of the genebank in Gatersleben. |
PubMed: | Testing and enhancing the in vitro bioaccessibility and bioavailability of Rosmarinus officinalis extracts with a high level of antioxidant abietanes. |
PubMed: | Bactericidal activity of glutaraldehyde-like compounds from olive products. |
PubMed: | Relationship between the antioxidant capacity and effect of rosemary (Rosmarinus officinalis L.) polyphenols on membrane phospholipid order. |
PubMed: | Variations in essential oil, phenolic compounds, and antioxidant activity of tunisian cultivated Salvia officinalis L. |
PubMed: | In vitro antimicrobial and antioxidant activity of commercial rosemary extract formulations. |
PubMed: | The immature stages and natural history of Veladyris pardalis (Salvin, 1869) in Eastern Ecuador (Lepidoptera: Nymphalidae: Lthomiinae). |
PubMed: | Effect of marinades on the formation of heterocyclic amines in grilled beef steaks. |
PubMed: | Antioxidant effect rosemary (Rosmarinus officinalis L.) and oregano (Origanum vulgare L.) extracts on TBARS and colour of model raw pork batters. |
PubMed: | Synergistic antileukemic activity of carnosic acid-rich rosemary extract and the 19-nor Gemini vitamin D analogue in a mouse model of systemic acute myeloid leukemia. |
PubMed: | Polyphenolic transmission to Segureno lamb meat from ewes' diet supplemented with the distillate from rosemary (Rosmarinus officinalis) leaves. |
PubMed: | [Enhancement of differentiation induction of HL-60 cells by 1,25-dihydroxyvitamin D3 in combination with carnosic acid]. |
PubMed: | Direct determination of carnosic acid in a new active packaging based on natural extract of rosemary. |
PubMed: | Enhanced carnosic acid levels in two rosemary accessions exposed to cold stress conditions. |
PubMed: | Characterization of two unknown compounds in methanol extracts of rosemary oil. |
PubMed: | Low-density lipoprotein, collagen, and thrombin models reveal that Rosemarinus officinalis L. exhibits potent antiglycative effects. |
PubMed: | Potential of rosemary (Rosemarinus officinalis L.) diterpenes in preventing lipid hydroperoxide-mediated oxidative stress in Caco-2 cells. |
PubMed: | Carnosic acid from rosemary extracts: a potential chemoprotective agent against aflatoxin B1. An in vitro study. |
PubMed: | Rosemary (Rosmarinus officinalis) diterpenes affect lipid polymorphism and fluidity in phospholipid membranes. |
PubMed: | Isolation of functional ingredients from rosemary by preparative-supercritical fluid chromatography (Prep-SFC). |
PubMed: | Liquid chromatograpic-mass spectrometric analysis of phenolics and free radical scavenging activity of rosemary extract from different raw material. |
PubMed: | Radioprotective-antimutagenic effects of rosemary phenolics against chromosomal damage induced in human lymphocytes by gamma-rays. |
PubMed: | Antioxidant activity of a catechol derived from abietic acid. |
PubMed: | Cooperative antitumor effects of vitamin D3 derivatives and rosemary preparations in a mouse model of myeloid leukemia. |
PubMed: | Pressurized liquid extraction-capillary electrophoresis-mass spectrometry for the analysis of polar antioxidants in rosemary extracts. |
PubMed: | Phenolic and triterpenoid antioxidants from Origanum majorana L. herb and extracts obtained with different solvents. |
PubMed: | Relevance of carnosic acid concentrations to the selection of rosemary, Rosmarinus officinalis (L.), accessions for optimization of antioxidant yield. |
PubMed: | Potential for the use of ultrasound in the extraction of antioxidants from Rosmarinus officinalis for the food and pharmaceutical industry. |
PubMed: | Antioxidant activity of organic extracts from aqueous infusions of sage. |
PubMed: | Phenolic diterpenes, flavones, and rosmarinic acid distribution during the development of leaves, flowers, stems, and roots of Rosmarinus officinalis. Antioxidant activity. |
PubMed: | Rapid quantitative enrichment of carnosic acid from rosemary (Rosmarinus officinalis L.) by isoelectric focused adsorptive bubble chromatography. |
PubMed: | Subcritical water extraction of antioxidant compounds from rosemary plants. |
PubMed: | Recovery mechanism of the antioxidant activity from carnosic acid quinone, an oxidized sage and rosemary antioxidant. |
PubMed: | Antioxidant activity of chemical components from sage (Salvia officinalis L.) and thyme (Thymus vulgaris L.) measured by the oil stability index method. |
PubMed: | Apianane terpenoids from Salvia officinalis. |
PubMed: | Antioxidant mechanism of carnosic acid: structural identification of two oxidation products. |
PubMed: | Carnosic acid and promotion of monocytic differentiation of HL60-G cells initiated by other agents. |
PubMed: | Subcellular compartmentation of the diterpene carnosic acid and its derivatives in the leaves of rosemary. |
PubMed: | Activities of antioxidants are affected by colloidal properties of oil-in-water and water-in-oil emulsions and bulk oils. |
PubMed: | Development of in vitro models for cellular and molecular studies in toxicology and chemoprevention. |
PubMed: | An evaluation of the antioxidant and antiviral action of extracts of rosemary and Provençal herbs. |
PubMed: | Antioxidative constituents of Rosmarinus officinalis and Salvia officinalis. II. Isolation of carnosic acid and formation of other phenolic diterpenes. |
PubMed: | Protection by albumin against the pro-oxidant actions of phenolic dietary components. |
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