Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Food Chemicals Codex Listed: | No |
Boiling Point: | 367.00 to 368.00 °C. @ 760.00 mm Hg
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Vapor Pressure: | 0.000013 mmHg @ 25.00 °C. (est) |
Flash Point: | 309.00 °F. TCC ( 153.89 °C. )
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logP (o/w): | 1.775 (est) |
Soluble in: |
| alcohol | | water, 103.8 mg/L @ 25 °C (est) |
Insoluble in: |
| water |
Organoleptic Properties:
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Odor Type: herbal |
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Odor Strength: | medium |
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| herbal celery |
Odor Description: at 1.00 % in propylene glycol. | herbal celery |
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Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
BOC Sciences |
For experimental / research use only. |
Senkyunolide A >98%
Odor: characteristic Use: Senkyunolide A is a useful standard compound for the quality evaluation and chemical differentiation between Rhizoma chuanxiong and Angelica sinensis. |
Safety Information:
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
Not determined
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | natural substances and extractives |
Recommendation for sedanenolide usage levels up to: | | not for fragrance use.
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Recommendation for sedanenolide flavor usage levels up to: |
| not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
(-)-3- | butyl-4,5-dihydro-1(3H)-isobenzofuranone | 3- | butyl-4,5-dihydro-3H-2-benzofuran-1-one | 3-N- | butyl-4,5-dihydrophthalide | 3-N- | butyl-4,5-dihydrophthalide (S)-isomer | | senkyunolide | | senkyunolide A |
Articles:
PubMed: | Development of an analytical method coupling cell membrane chromatography with gas chromatography-mass spectrometry via microextraction by packed sorbent and its application in the screening of volatile active compounds in natural products. |
J-Stage: | Asymmetric Synthesis and Sensory Evaluation of Sedanenolide |
PubMed: | Evaluation of the influence of sulfur fumigation on the pharmacokinetics of four active ingredients in Si Wu Tang. |
PubMed: | [Quantitative determination of 5 active ingredients in different harvest periods of Ligusticum chuanxiong by HPLC]. |
PubMed: | Comparative analysis of main aromatic acids and phthalides in Angelicae Sinensis Radix, Chuanxiong Rhizoma, and Fo-Shou-San by a validated UHPLC-TQ-MS/MS. |
PubMed: | Multi-component analysis in sun-dried and sulfur-fumigated Angelicae Sinensis Radix by single marker quantitation and chemometric discrimination. |
PubMed: | Analysis of the Correlation between Commodity Grade and Quality of Angelica sinensis by Determination of Active Compounds Using Ultraperformance Liquid Chromatography Coupled with Chemometrics. |
PubMed: | Optimization of high-pressure ultrasonic-assisted simultaneous extraction of six major constituents from Ligusticum chuanxiong rhizome using response surface methodology. |
PubMed: | [Optimization of supercritical fluid extraction of bioactive components in Ligusticum chuanxiong by orthogonal array design]. |
PubMed: | Chemistry, technology, and nutraceutical functions of celery (Apium graveolens L.): an overview. |
PubMed: | [Study on the constituents of essential oil of Shunaoxin dropping pills by GC-MS]. |
PubMed: | [Chemical change of chuanxiong raw materials during storage]. |
PubMed: | Chemical changes of Angelicae Sinensis Radix and Chuanxiong Rhizoma by wine treatment: chemical profiling and marker selection by gas chromatography coupled with triple quadrupole mass spectrometry. |
PubMed: | Utilization of gene expression signature for quality control of traditional Chinese medicine formula Si-Wu-Tang. |
PubMed: | Online isolation and purification of four phthalide compounds from Chuanxiong rhizoma using high-speed counter-current chromatography coupled with semi-preparative liquid chromatography. |
PubMed: | [Analysis of chemical constituents of chuanxiong rhizoma absorbed into rat brain tissues by UPLC-Q-TOF-MS]. |
PubMed: | Chemical and biological assessment of angelica roots from different cultivated regions in a chinese herbal decoction danggui buxue tang. |
PubMed: | Isolation of the volatile fraction from Apium graveolens L. (Apiaceae) by supercritical carbon dioxide extraction and hydrodistillation: chemical composition and antifungal activity. |
PubMed: | Chemometric classification of morphologically similar Umbelliferae medicinal herbs by DART-TOF-MS fingerprint. |
PubMed: | Identification of the absorbed components and metabolites in rat plasma after oral administration of Rhizoma Chuanxiong decoction by HPLC-ESI-MS/MS. |
PubMed: | [Studies on the chemical constituents of Ligusticum sinense]. |
PubMed: | Asymmetric synthesis and sensory evaluation of sedanenolide. |
PubMed: | A bio-activity guided in vitro pharmacokinetic method to improve the quality control of Chinese medicines, application to Si Wu Tang. |
PubMed: | Isolation and identification of anti-inflammatory constituents from Ligusticum chuanxiong and their underlying mechanisms of action on microglia. |
PubMed: | [Analysis of volatile oils of Ligusticum chuanxiong Hort. from different geographical origins by comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry]. |
PubMed: | Identification and comparative quantification of bio-active phthalides in essential oils from si-wu-tang, fo-shou-san, radix angelica and rhizoma chuanxiong. |
PubMed: | Simultaneous determination of phenolic acids and phthalide compounds by liquid chromatography for quality assessment of Rhizoma cnidii. |
PubMed: | Simultaneous quantification of active components in the herbs and products of Si-Wu-Tang by high performance liquid chromatography-mass spectrometry. |
PubMed: | Identification and determination of the major constituents in Traditional Chinese Medicinal formula Danggui-Shaoyao-San by HPLC-DAD-ESI-MS/MS. |
PubMed: | GC-MS fingerprints for discrimination of Ligusticum chuanxiong from Angelica. |
PubMed: | Study of the anti-proliferative effects and synergy of phthalides from Angelica sinensis on colon cancer cells. |
PubMed: | Flavor enhancement of chicken broth from boiled celery constituents. |
PubMed: | Characterization of interaction property of multicomponents in Chinese Herb with protein by microdialysis combined with HPLC. |
PubMed: | Comparative analysis of Ligusticum chuanxiong and related umbelliferous medicinal plants by high performance liquid chromatography-electrospray ionization mass spectrometry. |
PubMed: | Low oral bioavailability and pharmacokinetics of senkyunolide a, a major bioactive component in Rhizoma Chuanxiong, in the rat. |
PubMed: | Relaxation effects of ligustilide and senkyunolide A, two main constituents of Ligusticum chuanxiong, in rat isolated aorta. |
PubMed: | Post-harvest alteration of the main chemical ingredients in Ligusticum chuanxiong Hort. (Rhizoma Chuanxiong). |
PubMed: | Screening and analysis of the multiple absorbed bioactive components and metabolites of Dangguibuxue decoction by the metabolic fingerprinting technique and liquid chromatography/diode-array detection mass spectrometry. |
PubMed: | Potent odorants characterize the aroma quality of leaves and stalks in raw and boiled celery. |
PubMed: | Time-course accumulation of main bioactive components in the rhizome of Ligusticum chuanxiong. |
PubMed: | [Determination of lactone components in chuanxiong by reversed-phase high performance liquid chromatography]. |
PubMed: | Identification and comparative determination of senkyunolide A in traditional Chinese medicinal plants Ligusticum chuanxiong and Angelica sinensis by HPLC coupled with DAD and ESI-MS. |
PubMed: | Phthalide Lactones from Ligusticum chuanxiong inhibit lipopolysaccharide-induced TNF-alpha production and TNF-alpha-mediated NF-kappaB Activation. |
PubMed: | Development of high-performance liquid chromatographic fingerprints for distinguishing Chinese Angelica from related umbelliferae herbs. |
PubMed: | HPLC-coupled spectroscopic techniques (UV, MS, NMR) for the structure elucidation of phthalides in Ligusticum chuanxiong. |
PubMed: | [Study on fingerprint of rhizoma chuanxiong by HPLC-DAD-MS]. |
PubMed: | Phytochemical analysis of anti-atherogenic constituents of Xue-Fu-Zhu-Yu-Tang using HPLC-DAD-ESI-MS. |
PubMed: | Simultaneous analysis of seventeen chemical ingredients of Ligusticum chuanxiong by on-line high performance liquid chromatography-diode array detector-mass spectrometry. |
PubMed: | Separation and identification of the phthalic anhydride derivatives of Liqusticum Chuanxiong Hort by GC-MS, TLC, HPLC-DAD, and HPLC-MS. |
PubMed: | Phthalide-based host-plant resistance toSpodoptera exigua andTrichoplusia ni inApium graveolens. |
PubMed: | Chemical structure-activity of cnidium rhizome-derived phthalides for the competence inhibition of proliferation in primary cultures of mouse aorta smooth muscle cells. |
PubMed: | Antiproliferative effects of the traditional Chinese medicine shimotsu-to, its component cnidium rhizome and derived compounds on primary cultures of mouse aorta smooth muscle cells. |
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