Articles:
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2,4,6-trimethyldihydro-4H-1,3,5-dithiazine
Notes:
Occurs in a variety of foods and flavours and in food pyrolysis products [DFC] Flavourant with chicken aroma. Volatile component of roasted shrimp [DFC]
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Alfrebro LLC/ Archer Daniels Midland Company Let's get reacquainted Building great taste with aroma chemicals, extracts, and distillates The Alfrebro brand was established in the early 1900s by Alex Fries & Brothers, a Cincinnati Flavor Company. In 1980, the brand was re-launched as an aroma chemical manufacturer. Since its inception, Alfrebro’s primary focus has been to provide quality natural and high value synthetic chemicals. Email: Sarah Forbis Email: Sales Voice: 513-539-3021 Fax: 513-539-7372 US Voice: 513-539-7373 Newsroom Product(s): Thialdine 0.1% in ETOH, Natural
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Axxence Aromatic GmbH We bring nature to your flavour Dedicated to provide the best possible quality and supply service of natural aroma ingredients. Axxence Aromatic is entirely dedicated to provide the best possible quality and supply service of natural aroma ingredients to the Flavour & Fragrance Industry worldwide. Email: Service Voice: +49.2822.68561.0 Fax: +49.2822.68561.39 Sustainability Products List: View Product(s): 401800 THIALDINE Natural
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Beijing Lys Chemicals Co, LTD. From Grams to Tons Fine chemical high-tech company which contains R&D, production, and sales. BEIJING LYS CHEMICALS CO, LTD, established in 2004, is a fine chemical high-tech company which contains R&D, production, and sales. We mainly engaged in export and technology development of flavor and fragrance materials and pharmaceutical intermediates. We have nearly 500 kinds of products, from grams to tons, exported to USA, Europe, South Asia and etc. And we custom manufacture new products according to customers’ needs, and serve good quality products and service. Our goal is to become a fine chemical enterprise which could provide special products and services. Email: Mr. Jia Email: Mr. Guo Voice: 86-10-68418738 Fax: 86-10-68418739 Mr. Guo 86-10-68483445 Mr. Guo 86-10-68418739 News Product(s): 10287 Dihydro-2,4,6-trimethyl-1,3,5-(2H)dithiazine
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BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 638-17-5 DIHYDRO-2,4,6-TRIMETHYL-1,3,5(4H)DITHIAZINE
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Endeavour Specialty Chemicals Ltd Expertise in high impact aroma chemicals Endeavour Speciality Chemicals offers high-impact aroma chemicals, at small to medium scale. Speciality Chemical has more than 25 years experience of manufacturing high-impact aroma chemicals. With our core expertise in sulfur and heterocyclic chemistries, Endeavours products have applications in a range of industry sectors including flavours and fragrances, pharmaceutical research and material sciences. Endeavour also offer custom synthesis and contract manufacturing services at their UK manufacturing site. Email: Info Email: Sales Voice: +44 (0)1327 310 079 Fax: +44 (0)1327 310 701 Twitter Linkedin News Speciality Chemical Product Groups Product(s): TZ0050 5,6-Dihydro-2,4,6-trimethyl-4h-1,3,5-dithiazine
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Excellentia International Ingredients by Nature Exceptional quality and excellence in meeting our customers requirements. Excellentia International was founded in 2010 through the merger of Excellentia Flavors LLC and Polarome International. Collectively, these companies account for more than one hundred years of industry experience, and are recognized for exceptional quality and excellence in meeting our customers’ requirements. Email: Info Email: Sales Email: Regulatory Voice: 732.749.9840 Our Services Product(s): Thialdine Natural
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FCI SAS Inspired by Nature At FCI customer service is not a department it’s an attitude. Our team is composed of motivated professionals with great experience in the flavours and fragrances market. Our company has been serving this industry for more than 40 years and is ISO 9001 certified since 2009 . Whatever your question on flavour and fragrance ingredients: commercial, technical or regulatory – we will answer it very quickly. Email: Info Email: Philippe Faucher US Email: USA Sales Email: Germany Sales Email: Italy Sales Email: Japan Sales Voice: +33 (0)1 34 25 58 10 Fax: + 33 1 34 25 58 18 About Us Product(s): 18038 THIALDINE
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Lluch Essence S.L. A family company dedicated to sales and distribution Flexibility, availability, price and quality. Flexibility, availability, price and quality make LLUCH ESSENCE S.L. one of Europe’s references when it comes to essential oils and aroma chemicals, and it is now well known all around the world. Email: Info Voice: 34 93 379 38 49 Fax: 34 93 370 65 04 Linkedin Product(s): THIALDINE NATURAL
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Natural Advantage Manufacturer of natural flavor ingredients With over 25 years experience in the flavor and food ingredient industries. Technology Improving Taste Natural Advantage was formed over seventeen years ago to supply the growing demand for natural food and flavor ingredients. We employ a wide range of multi-disciplined scientists who are dedicated to high quality service, customer satisfaction and creating an outstanding value for our clients. Email: Info Email: Customer service Voice: 318-215-1456 Fax: 318-335-1579 Facebook Twitter Instagram Linkedin Who We Are Technology Riverside Aromatics LTD.is the exclusive distributor for Europe in UK for any non-US based inquiries Products List: View Product(s): NA4018-50-Tri Thialdine Nat, 50% in Triacetin NA4018-50-Trio Thialdine Nat, 50% in Triacetin Nat USOC
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Penta International Corporation Chemistry innovation At Penta, our products and services help businesses do business better. For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes. US Email: Technical Services US Email: Sales US Voice: (973) 740-2300 US Fax: (973) 740-1839 Product(s): 04-21300 DIHYDRO-2,4,6-TRIMETHYL-1,3,5(4H)DITHIAZINE 04-21305 DIHYDRO-2,4,6-TRIMETHYL-1,3,5(4H)DITHIAZINE NATURAL 04-21306 DIHYDRO-2,4,6-TRIMETHYL-1,3,5(4H)DITHIAZINE NAT 0.1% IN ETOH
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Robinson Brothers Limited Providing Excellence in Chemistry Award-winning UK chemical manufacturer of chemical intermediates and high-impact aroma chemicals. Based in the UK, Robinson Brothers is an award-winning chemical manufacturer of chemical intermediates and high-impact aroma chemicals. Robinson Brothers serve many industry sectors across the globe, include: flavour/fragrance, pharmaceutical, agrochemical and material sciences. Our team of Chemists are experts in custom synthesis, contract manufacture and process optimisation. Email: Info Email: Sales Voice: +44 (0)121 553 2451 Fax: +44 (0)121 500 5183 Twitter Linkedin News And Exhibitions Custom Synthesis Industries And Applications https://www.robinsonbrothers.uk/chemistry-competences Products List: View Product(s): TZ0050 5,6-Dihydro-2,4,6-trimethyl-4h-1,3,5-dithiazine
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Synerzine, Inc. Innovation. Customization. Aroma Ingredients. Synerzine is a leading supplier of flavor and fragrance ingredients. Synerzine expresses what we have grown to embody as an organization - the synergy and connection between raw ingredients, science, technology, and the final product. Our experienced team is passionate about bringing our customers high-quality innovative ingredients that they can trust. Building upon our 44 year history, the Synerzine team provides customers around the globe with convenient access to over 1200 high-quality aroma ingredients. We actively engage with customers to add a wide array of new products and services on a regular basis. Our aim is to delight every customer with our exceptional services, large product selection, customization and the highest quality and safety standards. We provide our customers with true value designed to help them bring their products to market faster. US Email: Customer Service US Email: Sales US Voice: (404) 524-6744 US Fax: (404) 577-1651 Inquiry Products List: View Product(s): W2017 Thialdine
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R C Treatt and Co Ltd Innovative ingredient solutions World-leading innovative ingredient solutions provider for the flavour, fragrance and FMCG industries. We offer innovative and trend-setting product concepts for our customers, collaborating with them to create true value for their products. Email: Enquiries US Email: Enquiries Voice: +44 (0) 1284 702500 Fax: +44 (0) 1284 703809 US Voice: +1 863 668 9500 US Fax: +1 863 668 3388 Twitter Linkedin Youtube News Product(s): 5,6-Dihydro-2,4,6-Trimethyl-4H-1,3,5-Dithiazine Halal, Kosher
Used flavours for oils and fats at 0.35-3.5ppm; in meat and dairy flavours for snack foods and sauces at 3-6ppm; and in soups and seasonings, at 4-8ppm.
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Qingdao Free Trade Zone United International Co Ltd Quality Products A partner in your supply chain solution. Qingdao Free Trade Zone United International Trade Co., Ltd.was founded in 1996, specializing in the production and import and export of food additives,flavor raw materials and pharmaceutical and chemical raw materials. The company has experienced R&D and business personnel,product quality, low price, efficient service and fast insight and grasp the latest market information. Email: Info Email: Sales Voice: +86-532-83893699 Fax: +86-532-83893695 Product(s): 7057 Thialdine
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WholeChem, LLC Connecting Innovators To the Building Blocks Of the Universe Custom manufacturer and distributor of specialty ingredients. We make global local. SQF-Certified Supplier We owe our success to our integrity, our dedication to the industry, and our commitment to our clients. We invite your inquiries regarding our current product list and any other products you may be having trouble sourcing. Email: Info Email: Orders Voice: +1 (262) 995.8668 Certification Our Services Products List: View Product(s): Dihydro-2,4,6-trimethyl-1,3,5-(2H)dithiazine
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| CAS Number: | 638-17-5 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 211-323-3 | |
| FDA UNII: | ZKG651IE9G | |
| Nikkaji Web: | J6.921C | |
| XlogP3-AA: | 2.50 (est) | |
| Molecular Weight: | 163.30661000 | |
| Formula: | C6 H13 N S2 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
| Also(can) Contains: | 2,4,6-trimethyl dihydro-1,3,5-dithiazine | |
| EFSA/JECFA Comments: | JECFA evaluated 2,4,6-trimethyldihydro-4H-1,3,5-dithiazine (CASrn as in Register). (R)- or (S)- enantiomer not specified by CASrn in Register. Mixture of diastereoisomers, each of them racemic (EFFA, 2013b). | |
Category: flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| JECFA Food Flavoring: | 1049 2,4,6-trimethyldihydro-4H-1,3,5-dithiazine |
| DG SANTE Food Flavourings: | 15.109 2,4,6-trimethyldihydro-4H-1,3,5-dithiazine |
| FEMA Number: | 4018 2,4,6-trimethyldihydro-4H-1,3,5-dithiazine |
| FDA: | No longer provide for the use of these seven synthetic flavoring substances |
Physical Properties:
| Appearance: | pale brownish yellow crystals (est) |
| Assay: | 99.00 to 100.00 % sum of isomers |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 46.00 to 48.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 260.00 to 261.00 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure: | 0.012000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 232.00 °F. TCC ( 111.11 °C. ) |
| logP (o/w): | 0.523 (est) |
| Soluble in: | |
| alcohol | |
| water, 7000 mg/L @ 20 °C (exp) | |
| Insoluble in: | |
| water | |
Organoleptic Properties:
| Odor Type: meaty | |
| sulfurous nutty hazelnut corn meaty earthy clam | |
| Odor Description: at 0.10 % in propylene glycol. | sulfurous nutty hazelnut corn meaty earthy clam Luebke, William tgsc, (2017) |
| Flavor Type: meaty | |
| sulfurous onion green onion radish garlic onion cooked onion earthy brothy | |
| Taste Description: | sulfurous green onion radish garlic cooked onion earthy brothy Luebke, William tgsc, (2017) |
| Odor and/or flavor descriptions from others (if found). | |
| Kingchem Laboratories | |
| THIALDINE | |
| Odor Description: | Heated meat, roasted beef-like |
| FCI SAS | |
| THIALDINE | |
| Odor Description: | Very rich and powerful earthy sulfurous |
| Taste Description: | meaty roasted |
Cosmetic Information:
| None found |
Suppliers:
Safety Information:
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intraperitoneal-mouse LD50 265 mg/kg Radiation Research. Vol. 7, Pg. 22, 1957. | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | flavoring agents | ||
| Recommendation for thialdine usage levels up to: | |||
| not for fragrance use. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 1.10 (μg/capita/day) | ||
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 3.30 (μg/capita/day) | ||
| Structure Class: | II | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 20 | |||
| Click here to view publication 20 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | 8.00000 | 16.00000 | |
| beverages(nonalcoholic): | 3.00000 | 6.00000 | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | 0.07000 | 0.35000 | |
| cheese: | - | - | |
| chewing gum: | 10.00000 | 20.00000 | |
| condiments / relishes: | 3.00000 | 6.00000 | |
| confectionery froastings: | - | - | |
| egg products: | 4.00000 | 8.00000 | |
| fats / oils: | 0.35000 | 3.50000 | |
| fish products: | 0.35000 | 3.50000 | |
| frozen dairy: | 4.00000 | 8.00000 | |
| fruit ices: | 3.00000 | 6.00000 | |
| gelatins / puddings: | 3.00000 | 6.00000 | |
| granulated sugar: | - | - | |
| gravies: | 4.00000 | 8.00000 | |
| hard candy: | 5.00000 | 10.00000 | |
| imitation dairy: | 3.00000 | 6.00000 | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | 3.00000 | 6.00000 | |
| milk products: | 3.00000 | 6.00000 | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | 0.20000 | 2.00000 | |
| processed fruits: | - | - | |
| processed vegetables: | 0.20000 | 2.00000 | |
| reconstituted vegetables: | 0.20000 | 2.00000 | |
| seasonings / flavors: | 200.00000 | 500.00000 | |
| snack foods: | 3.00000 | 6.00000 | |
| soft candy: | 4.00000 | 8.00000 | |
| soups: | 4.00000 | 8.00000 | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
Safety References:
| European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): | |
| Flavouring Group Evaluation 21, Revision 1 (FGE.21Rev1): Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 Miscellaneous substances from chemical group 30 View page or View pdf | |
| Scientific Opinion on Flavouring Group Evaluation 76, Revision 1 (FGE.76Rev1): Consideration of sulphur-containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 and miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21Rev3 View page or View pdf | |
| EPI System: | View |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 12518 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| (4R,6S)-2,4,6-trimethyl-1,3,5-dithiazinane | |
| Chemidplus: | 0000638175 |
| RTECS: | JO6430000 for cas# 638-17-5 |
References:
| (4R,6S)-2,4,6-trimethyl-1,3,5-dithiazinane | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 12518 |
| Pubchem (sid): | 134978715 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| HMDB (The Human Metabolome Database): | HMDB31187 |
| FooDB: | FDB020393 |
| Export Tariff Code: | 2934.10.0090 |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
Potential Blenders and core components note
Potential Uses:
| meat | FL |
Occurrence (nature, food, other): note
| beef Search PMC Picture | |
| chicken fried chicken Search PMC Picture | |
| clam Search PMC Picture | |
| peanut butter Search PMC Picture | |
| shrimp cooked shrimp Search PMC Picture | |
| squid Search Picture |
Synonyms:
| (R,S)- | dihydro-2,4,6-trimethyl-1,3,5-(4H)dithiazine |
| (R,S)- | dihydro-2,4,6-trimethyl-1,3,5(4H)dithiazine |
| (2-alpha,4-alpha,6-alpha)- | dihydro-2,4,6-trimethyl-4H-1,3,5-dithiazine |
| 4H-1,3,5- | dithiazine, (R,S)-dihydro-2,4,6-trimethyl- |
| (R,S)-1,3,5- | dithiazine, perhydro-2,4,6-trimethyl |
| (R,S)-2,4,6- | trimethyl dihydro-1,3,5(4H)-dithiazine |
| (4R,6S)-2,4,6- | trimethyl-1,3,5-dithiazinane |
| (R,S)-2,4,6- | trimethyl-5H-1,3,5-dithiazine |
| 2,4,6- | trimethyldihydro-4H-1,3,5-dithiazine |