Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Assay: | 95.00 to 100.00 %
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Food Chemicals Codex Listed: | No |
Boiling Point: | 115.00 °C. @ 102.00 mm Hg
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Boiling Point: | 368.00 to 370.00 °C. @ 760.00 mm Hg (est)
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Flash Point: | 326.00 °F. TCC ( 163.40 °C. ) (est)
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logP (o/w): | 6.257 (est) |
Soluble in: |
| alcohol | | water, 0.7481 mg/L @ 25 °C (est) |
Insoluble in: |
| water |
Organoleptic Properties:
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Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Alfa Biotechnology |
For experimental / research use only. |
Falcarinol 70%
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BOC Sciences |
For experimental / research use only. |
Falcarinol > 95%
Odor: characteristic Use: (R)-(-)-Falcarinol is a covalent cannabinoid (CB1) receptor antagonist that induces pro-allergic effects on skin, and is most commonly found in the extracts of carrots. |
Safety Information:
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
Not determined
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | natural substances and extractives |
Recommendation for falcarinol usage levels up to: | | not for fragrance use.
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Recommendation for falcarinol flavor usage levels up to: |
| not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
(3R,9Z)- | heptadeca-1,9-dien-4,6-diyn-3-ol | 1,9- | heptadecadiene-4,6-diyn-3-ol | 1,9- | heptadecadiene-4,6-diyn-3-ol, (3R,9Z)- | | panaxynol |
Articles:
PubMed: | Automated analytical standard production with supercritical fluid chromatography for the quantification of bioactive C17-polyacetylenes: A case study on food processing waste. |
PubMed: | Polyacetylene levels in carrot juice, effect of pH and thermal processing. |
PubMed: | Dietary polyacetylenes of the falcarinol type are inhibitors of breast cancer resistance protein (BCRP/ABCG2). |
PubMed: | Systemic allergic dermatitis caused by Apiaceae root vegetables. |
PubMed: | Absolute configuration of falcarinol (9Z-heptadeca-1,9-diene-4,6-diyn-3-ol) from Pastinaca sativa. |
PubMed: | Variability of the root essential oils of Seseli rigidum Waldst. & Kit. (Apiaceae) from different populations in Serbia. |
PubMed: | Biosynthesis of panaxynol and panaxydol in Panax ginseng. |
PubMed: | Quantitative Raman spectroscopy for the analysis of carrot bioactives. |
PubMed: | Chemical composition and antimicrobial activity of essential oil of different parts of Seseli rigidum. |
PubMed: | Variation in the volatile constituents of different plant parts of Ligusticopsis wallichiana from western Himalaya, India. |
PubMed: | Chemical composition and in vitro antimicrobial activity of the essential oil of the flowers of Tridax procumbens. |
PubMed: | Antitrypanosomal properties of Panax ginseng C. A. Meyer: new possibilities for a remarkable traditional drug. |
PubMed: | Effects of bioactive compounds from carrots (Daucus carota L.), polyacetylenes, beta-carotene and lutein on human lymphoid leukaemia cells. |
PubMed: | Anti-mycobacterial diynes from the Canadian medicinal plant Aralia nudicaulis. |
PubMed: | Polyacetylenes in fresh and stored carrots (Daucus carota): relations to root morphology and sugar content. |
PubMed: | [Simultaneous determination of panaxynol and panaxydol in fibrous root of Panax ginseng by HPLC]. |
PubMed: | The influence of the fungal pathogen Mycocentrospora acerina on the proteome and polyacetylenes and 6-methoxymellein in organic and conventionally cultivated carrots (Daucus carota) during post harvest storage. |
PubMed: | Quantification of polyacetylenes in apiaceous plants by high-performance liquid chromatography coupled with diode array detection. |
PubMed: | Spectroscopic studies on bioactive polyacetylenes and other plant components in wild carrot root. |
PubMed: | Characterisation of polyacetylenes isolated from carrot (Daucus carota) extracts by negative ion tandem mass spectrometry. |
PubMed: | Induction of apoptosis in human promyelocytic leukemia HL60 cells by panaxynol and panaxydol. |
PubMed: | Anticomplement activity of polyacetylenes from leaves of Dendropanax morbifera Leveille. |
PubMed: | Effect of ultrasound and blanching pretreatments on polyacetylene and carotenoid content of hot air and freeze dried carrot discs. |
PubMed: | Aliphatic C(17)-polyacetylenes of the falcarinol type as potential health promoting compounds in food plants of the Apiaceae family. |
PubMed: | Effects of harvesting date and storage on the amounts of polyacetylenes in carrots, Daucus carota. |
PubMed: | [Inhibition of panaxynol on experimental delayed type hypersensitivity]. |
PubMed: | Comparison of polyacetylene content in organically and conventionally grown carrots using a fast ultrasonic liquid extraction method. |
PubMed: | Influence of Sous Vide and water immersion processing on polyacetylene content and instrumental color of parsnip (Pastinaca sativa) disks. |
PubMed: | Dermatitis from common ivy (Hedera helix L. subsp. helix) in Europe: past, present, and future. |
PubMed: | A new prenylated flavanonol from Seseli annuum roots showing protective effect on human lymphocytes DNA. |
PubMed: | Falcarinol is a covalent cannabinoid CB1 receptor antagonist and induces pro-allergic effects in skin. |
PubMed: | Structure determination of bisacetylenic oxylipins in carrots (Daucus carota L.) and enantioselective synthesis of falcarindiol. |
PubMed: | Panaxynol protects cortical neurons from ischemia-like injury by up-regulation of HIF-1alpha expression and inhibition of apoptotic cascade. |
PubMed: | Differential effects of falcarinol and related aliphatic C(17)-polyacetylenes on intestinal cell proliferation. |
PubMed: | Comparative research of chemical constituents, antifungal and antitumor properties of ether extracts of Panax ginseng and its endophytic fungus. |
PubMed: | Biotransformation of menthol and geraniol by hairy root cultures of Anethum graveolens: effect on growth and volatile components. |
PubMed: | Menthol and geraniol biotransformation and glycosylation capacity of Levisticum officinale hairy roots. |
PubMed: | Biomass and content of ginsenosides and polyacetylenes in American ginseng roots can be increased without affecting the profile of bioactive compounds. |
PubMed: | Reinvestigation of the bitter compounds in carrots (Daucus carota L.) by using a molecular sensory science approach. |
PubMed: | The polyacetylenes falcarinol and falcarindiol affect stress responses in myotube cultures in a biphasic manner. |
PubMed: | Purple carrot (Daucus carota L.) polyacetylenes decrease lipopolysaccharide-induced expression of inflammatory proteins in macrophage and endothelial cells. |
PubMed: | Antimycobacterial polyacetylenes from Levisticum officinale. |
PubMed: | Panaxydol and panaxynol protect cultured cortical neurons against Abeta25-35-induced toxicity. |
PubMed: | Nitrogen stress induction on Levisticum officinale hairy roots grown in darkness and under photoperiod conditions: effect on growth and volatile components. |
PubMed: | Antiproliferative effect of panaxynol on RASMCs via inhibition of ERK1/2 and CREB. |
PubMed: | Quantification of two polyacetylenes in Radix Ginseng and roots of related Panax species using a gas chromatography-mass spectrometric method. |
PubMed: | Determination of polyacetylenes in carrot roots (Daucus carota L.) by high-performance liquid chromatography coupled with diode array detection. |
PubMed: | Biphasic effect of falcarinol on caco-2 cell proliferation, DNA damage, and apoptosis. |
PubMed: | Simultaneous determination of ginsenosides and polyacetylenes in American ginseng root (Panax quinquefolium L.) by high-performance liquid chromatography. |
PubMed: | Structural changes of polyacetylenes in American ginseng root can be observed in situ by using Raman spectroscopy. |
PubMed: | Protective effect of panaxydol and panaxynol on sodium nitroprusside-induced apoptosis in cortical neurons. |
PubMed: | Inhibitory effects of coumarin and acetylene constituents from the roots of Angelica furcijuga on D-galactosamine/lipopolysaccharide-induced liver injury in mice and on nitric oxide production in lipopolysaccharide-activated mouse peritoneal macrophages. |
PubMed: | Panaxynol induces neurite outgrowth in PC12D cells via cAMP- and MAP kinase-dependent mechanisms. |
PubMed: | In situ simultaneous analysis of polyacetylenes, carotenoids and polysaccharides in carrot roots. |
PubMed: | Up-regulation of M1 muscarinic receptors expressed in CHOm1 cells by panaxynol via cAMP pathway. |
PubMed: | Spatial tissue distribution of polyacetylenes in carrot root. |
PubMed: | Polyacetylenes from the Apiaceae vegetables carrot, celery, fennel, parsley, and parsnip and their cytotoxic activities. |
PubMed: | Inhibitory effects of feeding with carrots or (-)-falcarinol on development of azoxymethane-induced preneoplastic lesions in the rat colon. |
PubMed: | [Allergic contact dermatitis to common ivy (Hedera helix L.)]. |
PubMed: | Lignans, phenylpropanoids and polyacetylenes from Chaerophyllum aureum L. (Apiaceae). |
PubMed: | Structural and sensory characterization of compounds contributing to the bitter off-taste of carrots (Daucus carota L.) and carrot puree. |
PubMed: | Chemoenzymatic asymmetric total syntheses of antitumor agents (3R,9R,10R)- and (3S,9R,10R)-Panaxytriol and (R)- and (S)-Falcarinol from Panax ginseng using an enantioconvergent enzyme-triggered cascade reaction. |
PubMed: | A tumor cell growth inhibitor from Saposhnikovae divaricata. |
PubMed: | Occupational allergic contact dermatitis from falcarinol. |
PubMed: | [GC-MS analysis of essential oils from the roots of Saposhnikovia divaricata (Turcz.) Schischk, Libanotis laticalycina Shan et Sheh, Seseli yunnanense Franch. and Peucedanum dielsianum Fedde ex Wolff]. |
PubMed: | Gymnasterkoreaynes A-F, cytotoxic polyacetylenes from Gymnaster koraiensis. |
PubMed: | Chemosystematic investigations of irregular diterpenes in Anisotome and related New Zealand Apiaceae. |
PubMed: | Chemical composition and cytotoxic and antimicrobial activity of Calycotome villosa (Poiret) link leaves. |
PubMed: | Medicinal foodstuffs. XX. Vasorelaxant active constituents from the roots of Angelica furcijuga Kitagawa: structures of hyuganins A, B, C, and D. |
PubMed: | Effects of a lipoxygenase inhibitor, panaxynol, on vascular contraction induced by angiotensin II. |
PubMed: | The allergens of Dendropanax trifidus Makino and Fatsia japonica Decne. et Planch. and evaluation of cross-reactions with other plants of the Araliaceae family. |
PubMed: | Effect of petroleum ether extract of Panax ginseng roots on proliferation and cell cycle progression of human renal cell carcinoma cells. |
PubMed: | Hepatoprotective and nitric oxide production inhibitory activities of coumarin and polyacetylene constituents from the roots of Angelica furcijuga. |
PubMed: | Allergic contact dermatitis from common ivy confirmed with stored allergens. |
PubMed: | Inhibition of 15-hydroxyprostaglandin dehydrogenase activity in rabbit gastric antral mucosa by panaxynol isolated from oriental medicines. |
PubMed: | Antiproliferative constituents in Umbelliferae plants II. Screening for polyacetylenes in some Umbelliferae plants, and isolation of panaxynol and falcarindiol from the root of Heracleum moellendorffii. |
PubMed: | The major allergen of Dendropanax trifidus Makino. |
PubMed: | Effects of cicutoxin and related polyacetylenes from Cicuta virosa on neuronal action potentials: a comparative study on the mechanism of the convulsive action. |
PubMed: | Cytotoxic falcarinol oxylipins from Dendropanax arboreus. |
PubMed: | Effect of non-saponin fraction from Panax ginseng on cGMP and thromboxane A2 in human platelet aggregation. |
PubMed: | Panaxynol, a polyacetylene compound isolated from oriental medicines, inhibits mammalian lipoxygenases. |
PubMed: | Bioactive metabolites from Sicilian marine fennel, Crithmum maritimum. |
PubMed: | The first specific antibody against cytotoxic polyacetylenic alcohol, panaxynol. |
PubMed: | Cytotoxic activity of polyacetylene compounds in Panax ginseng C. A. Meyer. |
PubMed: | Isolation, identification, and bioassay of chemicals affecting nonpreference carrot-root resistance to carrot-fly larva. |
PubMed: | Antiplatelet actions of panaxynol and ginsenosides isolated from ginseng. |
PubMed: | Human maximization test of falcarinol, the principal contact allergen of English ivy and Algerian ivy (Hedera helix, H. canariensis). |
PubMed: | [Chemical studies on crude drug processing. V. On the constituents of ginseng radix rubra (2): Comparison of the constituents of white ginseng and red ginseng prepared from the same Panax ginseng root]. |
PubMed: | Allergic and irritant contact dermatitis from falcarinol and didehydrofalcarinol in common ivy (Hedera helix L.). |
PubMed: | Allergic contact dermatitis from falcarinol isolated from Schefflera arboricola. |
PubMed: | In vitro effect of Panax ginseng on phytohaemagglutinin-induced lymphocyte transformation. |
PubMed: | [Chemical studies of crude drugs (1). Constituents of Ginseng radix rubra]. |
PubMed: | [Studies on anti-inflammatory agents. IV. Anti-inflammatory constituents from roots of Panax ginseng C.A. Meyer (author's transl)]. |
PubMed: | High-pressure liquid chromatographic separation of the naturally occurring toxicants myristicin, related aromatic ethers and falcarinol. |
PubMed: | Analysis of myristicin and falcarinol in carrots by high-pressure liquid chromatography. |
PubMed: | Anti-nociceptive substances from the roots of Angelica acutiloba. |
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