Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | white solid (est) |
Assay: | 97.00 to 100.00 %
|
Food Chemicals Codex Listed: | No |
Melting Point: | 128.00 to 132.00 °C. @ 760.00 mm Hg
|
Boiling Point: | 369.00 to 371.00 °C. @ 760.00 mm Hg
|
Vapor Pressure: | 0.000005 mmHg @ 25.00 °C. (est) |
Flash Point: | 332.00 °F. TCC ( 166.67 °C. )
|
logP (o/w): | 6.405 (est) |
Soluble in: |
| alcohol | | water, 0.03402 mg/L @ 25 °C (est) |
Insoluble in: |
| water |
Organoleptic Properties:
|
Odor and/or flavor descriptions from others (if found). |
|
|
Cosmetic Information:
Suppliers:
BOC Sciences |
For experimental / research use only. |
Totarol >98%
Odor: characteristic Use: Totarol is a naturally produced diterpenoid isolated from the barks of Podocarpus totara. Recent studies show that (+)-totarol has unique antimicrobial and therapeutic properties.
anti-bacteria |
Charkit Chemical |
TOTAROL K7 LIQUID
|
Charkit Chemical |
TOTAROL
|
Santa Cruz Biotechnology |
For experimental / research use only. |
(4bS)-trans-8,8-Trimethyl-4b,5,6,7,8,8a,9,10-octahydro-1-isopropylphenanthren-2-ol
|
Sigma-Aldrich: Aldrich |
For experimental / research use only. |
4bS-trans-8,8-Trimethyl-4b,5,6,7,8,8a,9,10-octahydro-1-isopropyl-phenanthren-2-ol 98%
|
Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | Xi - Irritant |
R 36/37/38 - Irritating to eyes, respiratory system, and skin. S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36 - Wear suitable protective clothing.
|
|
Hazards identification |
|
Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
|
Pictogram | |
|
Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
Not determined
|
Dermal Toxicity: |
Not determined
|
Inhalation Toxicity: |
Not determined
|
Safety in Use Information:
Category: | natural substances and extractives |
Recommendation for totarol usage levels up to: | | not for fragrance use.
|
|
Recommendation for totarol flavor usage levels up to: |
| not for flavor use.
|
Safety References:
References:
| (4bS,8aS)-4b,8,8-trimethyl-1-propan-2-yl-5,6,7,8a,9,10-hexahydrophenanthren-2-ol |
NIST Chemistry WebBook: | Search Inchi |
Pubchem (cid): | 92783 |
Pubchem (sid): | 135049775 |
Pherobase: | View |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
4b,5,6,7,8,8a,9,10- | octahydro-4b,8,8-trimethyl-1-(1-methyl ethyl)-2-phenanthrenol | 4b,5,6,7,8,8a,9,10- | octahydro-4b,8,8-trimethyl-1-(1-methylethyl)-2-phenanthrenol | 2- | phenanthrenol, 4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-1-(1-methylethyl)-, (4bS-trans)- | 2- | phenanthrenol, 4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-1-(1-methylethyl)-, (4bS,8aS)- | 14-iso | propyl podocarpa-8,11,13-trien-13-ol | (4bS,8aS)-4b,8,8- | trimethyl-1-(propan-2-yl)-4b,5,6,7,8,8a,9,10-octahydrophenanthren-2-ol | (4bS,8aS)-4b,8,8- | trimethyl-1-propan-2-yl-5,6,7,8a,9,10-hexahydrophenanthren-2-ol | 4bS-trans-8,8- | trimethyl-4b,5,6,7,8,8a,9,10-octahydro-1-isopropyl-phenanthren-2-ol | (4bS)-trans-8,8- | trimethyl-4b,5,6,7,8,8a,9,10-octahydro-1-isopropylphenanthren-2-ol |
Articles:
PubMed: | Totarol prevents neuronal injury in vitro and ameliorates brain ischemic stroke: Potential roles of Akt activation and HO-1 induction. |
PubMed: | The synergy of berberine chloride and totarol against Staphylococcus aureus grown in planktonic and biofilm cultures. |
PubMed: | Inhibitory effect of totarol on exotoxin proteins hemolysin and enterotoxins secreted by Staphylococcus aureus. |
PubMed: | Phenolic diterpenoid derivatives as anti-influenza a virus agents. |
PubMed: | A comprehensive proteomic analysis of totarol induced alterations in Bacillus subtilis by multipronged quantitative proteomics. |
PubMed: | (4bS,8aS)-1-Isopropyl-4b,8,8-trimethyl-4b,5,6,7,8,8a,9,10-octa-hydro-phenan-thren-2-yl benzoate. |
PubMed: | Preparative mass-spectrometry profiling of bioactive metabolites in Saudi-Arabian propolis fractionated by high-speed countercurrent chromatography and off-line atmospheric pressure chemical ionization mass-spectrometry injection. |
PubMed: | (4bS,8aS)-1-Isopropyl-4b,8,8-trimethyl-4b,5,6,7,8,8a,9,10-octa-hydro-phenan-thren-2-yl acetate. |
PubMed: | More insight into the chemical composition of Greek propolis; differences and similarities with Turkish propolis. |
PubMed: | Inhibitors of bacterial tubulin target bacterial membranes in vivo. |
PubMed: | Extraction of essential oil from Cupressus sempervirens: comparison of global yields, chemical composition and antioxidant activity obtained by hydrodistillation and supercritical extraction. |
PubMed: | The Synthesis and Antimicrobial Activity of Heterocyclic Derivatives of Totarol. |
PubMed: | Composition and antipathogenic activities of the twig essential oil of Chamaecyparis formosensis from Taiwan. |
PubMed: | Synthesis, biological evaluation and mechanistic studies of totarol amino alcohol derivatives as potential antimalarial agents. |
PubMed: | Biota: sediment partitioning of aluminium smelter related PAHs and pulp mill related diterpenes by intertidal clams at Kitimat, British Columbia. |
PubMed: | Composition, antioxidant and antimicrobial activities of the seed essential oil of Calocedrus formosana from Taiwan. |
PubMed: | Molecular basis of the anti-inflammatory property exhibited by cyclo-pentano phenanthrenol isolated from Lippia nodiflora. |
PubMed: | Synthesis of antimicrobial natural products targeting FtsZ: (+)-totarol and related totarane diterpenes. |
PubMed: | Antimycobacterial terpenoids from Juniperus communis L. (Cuppressaceae). |
PubMed: | Antiparasitic, nematicidal and antifouling constituents from Juniperus berries. |
PubMed: | Antibacterial novel phenolic diterpenes from Podocarpus macrophyllus D. Don. |
PubMed: | Assessment of some diterpenoids in commercial distilled gin. |
PubMed: | Antifibrotic activity of diterpenes from Biota orientalis leaves on hepatic stellate cells. |
PubMed: | Synthesis of totarane diterpenes: totarol, maytenoquinone, 6-deoxymaytenoquinone and 8,11,13-totaratriene-12,13-diol. |
PubMed: | The antifungal compound totarol of Thujopsis dolabrata var. hondai seeds selects for fungi on seedling root surfaces. |
PubMed: | Occurrence and estrogenicity of phenolics in paper-recycling process water: pollutants originating from thermal paper in waste paper. |
PubMed: | The phenolic diterpene totarol inhibits multidrug efflux pump activity in Staphylococcus aureus. |
PubMed: | Totarol inhibits bacterial cytokinesis by perturbing the assembly dynamics of FtsZ. |
PubMed: | Gastroprotective and cytotoxic effect of semisynthetic ferruginol derivatives. |
PubMed: | Cytotoxic diterpenoids from Podocarpus madagascariensis from the Madagascar rainforest. |
PubMed: | Antimycobacterial constituents from Juniperus procera, Ferula communis and Plumbago zeylanica and their in vitro synergistic activity with isonicotinic acid hydrazide. |
PubMed: | Novel domino reactions for diterpene synthesis. |
PubMed: | Antineoplastic agents. 529. Isolation and structure of nootkastatins 1 and 2 from the Alaskan yellow cedar Chamaecyparis nootkatensis. |
PubMed: | Synthesis of totarol amino alcohol derivatives and their antiplasmodial activity and cytotoxicity. |
PubMed: | Development of a method to quantify in vitro the synergistic activity of "natural" antimicrobials. |
PubMed: | The propolis of stingless bees: terpenes from the tibia of three Frieseomelitta species. |
PubMed: | A MAS-NMR study of the location of (+)-totarol, a diterpenoid bioactive molecule, in phospholipid model membranes. |
PubMed: | Aromatase inhibitory activities of standishinal and the diterpenoids from the bark of Thuja standishii. |
PubMed: | A cyclic peroxide of clerodenoic acid from the Taiwanese liverwort Schistochila acuminata. |
PubMed: | (+)-Totarol from Chamaecyparis nootkatensis and activity against Mycobacterium tuberculosis. |
PubMed: | Anti-tumor promoting diterpenes from the stem bark of Thuja standishii (Cupressaceae). |
PubMed: | Effects of (+)-totarol, a diterpenoid antibacterial agent, on phospholipid model membranes. |
PubMed: | A fluorescence study of the interaction and location of (+)-totarol, a diterpenoid bioactive molecule, in model membranes. |
PubMed: | Totarol, totaradiol and ferruginol: three diterpenes from Thuja plicata (Cupressaceae). |
PubMed: | The synthesis and antibacterial activity of totarol derivatives. Part 3: Modification of ring-B. |
PubMed: | The synthesis and antibacterial activity of totarol derivatives. Part 2: Modifications at C-12 and O-13. |
PubMed: | The synthesis and antibacterial activity of totarol derivatives. Part 1: modifications of ring-C and pro-drugs. |
PubMed: | Potentiation of methicillin activity against methicillin-resistant Staphylococcus aureus by diterpenes. |
PubMed: | Antioxidative action of diterpenoids from Podocarpus nagi. |
PubMed: | Inhibition of lipid peroxidation by diterpenoid from Podocarpus nagi. |
PubMed: | Antibacterial activity of anacardic acid and totarol, alone and in combination with methicillin, against methicillin-resistant Staphylococcus aureus. |
PubMed: | Mode of antibacterial action of totarol, a diterpene from Podocarpus nagi. |
PubMed: | Isolation and characterization of platelet-activating factor receptor binding antagonists from Biota orientalis. |
PubMed: | Antibacterial activity of totarol and its potentiation. |
|