kadsurenone
6(2H)-benzofuranone, 2-(3,4-dimethoxyphenyl)-3,3a-dihydro-3a-methoxy-3-methyl-5-(2-propen-1-yl)-, (2S,3R,3aS)-
 
Notes:
platelet-activating factor receptor antagonist from chinese herbal plant, haifenteng.
Synonyms   Articles   Notes   Search
CAS Number: 95851-37-9Picture of molecule3D/inchi
Nikkaji Web: J39.403C
MDL: MFCD00869351
XlogP3-AA: 3.20 (est)
Molecular Weight: 356.41828000
Formula: C21 H24 O5
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
Synonyms   Articles   Notes   Search   Top
Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 491.10 °C. @ 760.00 mm Hg (est)
Flash Point: 418.00 °F. TCC ( 214.20 °C. ) (est)
logP (o/w): 2.870 (est)
Soluble in:
 water, 39.51 mg/L @ 25 °C (est)
Synonyms   Articles   Notes   Search   Top
Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
None found
Synonyms   Articles   Notes   Search   Top
Suppliers:
 None found
Synonyms   Articles   Notes   Search   Top
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Synonyms   Articles   Notes   Search   Top
Safety in Use Information:
Category: natural substances and extractives
Recommendation for kadsurenone usage levels up to:
 not for fragrance use.
 
Recommendation for kadsurenone flavor usage levels up to:
 not for flavor use.
Synonyms   Articles   Notes   Search   Top
Safety References:
EPI System: View
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 122159
National Institute of Allergy and Infectious Diseases: Data
 (2S,3R,3aS)-2-(3,4-dimethoxyphenyl)-3a-methoxy-3-methyl-5-prop-2-enyl-2,3-dihydro-1-benzofuran-6-one
Chemidplus: 0095851379
Synonyms   Articles   Notes   Search   Top
References:
 (2S,3R,3aS)-2-(3,4-dimethoxyphenyl)-3a-methoxy-3-methyl-5-prop-2-enyl-2,3-dihydro-1-benzofuran-6-one
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 122159
Pubchem (sid): 135077970
Synonyms   Articles   Notes   Search   Top
Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C10638
HMDB (The Human Metabolome Database): Search
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
EFSA Update of results on the monitoring of furan levels in food: Read Report
EFSA Previous report: Results on the monitoring of furan levels in food: Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food: Read Report
Synonyms   Articles   Notes   Search   Top
Potential Blenders and core components note
 
None Found
 
Synonyms   Articles   Notes   Search   Top
Potential Uses:
None Found
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 found in nature
Synonyms   Articles   Notes   Search   Top
Synonyms:
5-allyl-2-(3,4-dimethoxy-phenyl)-3a-methoxy-3-methyl-3,3a-dihydro-2H-benzofuran-6-one
(2S,3R,3aS)-5-allyl-2-(3,4-dimethoxyphenyl)-3a-methoxy-3-methyl-3,3a-dihydro-1-benzofuran-6(2H)-one
6(2H)-benzofuranone, 2-(3,4-dimethoxyphenyl)-3,3a-dihydro-3a-methoxy-3-methyl-5-(2-propen-1-yl)-, (2S,3R,3aS)-
 denudatin B
(2S-(2alpha,3beta,3aalpha))-2-(3,4-dimethoxyphenyl)-3,3a-dihydro-3a-methoxy-3-methyl-5-(2-propenyl)-6(2H)-benzofuranone
(2S,3R,3aS)-2-(3,4-dimethoxyphenyl)-3a-methoxy-3-methyl-5-prop-2-enyl-2,3-dihydro-1-benzofuran-6-one
Synonyms   Articles   Notes   Search   Top
Articles:
PubMed: Development of an LC-MS/MS method for quantification of kadsurenone in rat plasma and its application to a pharmacokinetic study.
PubMed: Platelet-activating factor (PAF)-antagonists of natural origin.
PubMed: [Neolignans and lignan from Piper wallichii].
PubMed: Pharmacokinetics of kadsurenone and its interaction with cyclosporin A in rats using a combined HPLC and microdialysis system.
PubMed: [Advances in pharmacological study of Piper kadsura (Choisy) Ohwi].
PubMed: Ambident effect of a p-sulfinyl group for the introduction of two carbon substituents to phenol rings: a convergent synthesis of diverse benzofuran neolignans.
PubMed: Platelet-activating factor antagonists.
PubMed: The biological activity of acetylated sphingosylphosphorylcholine derivatives.
PubMed: [Recent progress in the study of anti-PAF (platelet activating factor) constituents of medicinal herbs].
PubMed: [Anti-platelet activating factor constituents, 2,5-diaryltetrahydrofuran type lignans, from Piper futokadsura Sied. et Zucc].
PubMed: Trimucytin: a collagen-like aggregating inducer isolated from Trimeresurus mucrosquamatus snake venom.
PubMed: Stimulation of human polymorphonuclear leukocytes by leukotriene B4 and platelet-activating factor: an ultrastructural and pharmacological study.
PubMed: [PAF antagonistic benzofuran neolignans from Piper kadsura].
PubMed: PAF antagonism in vitro and in vivo by aglafoline from Aglaia elliptifolia Merr.
PubMed: Stimulation of tumour necrosis factor release by cytotoxic analogues of platelet-activating factor.
PubMed: Antagonism of platelet-activating factor-induced increase in cytosolic free calcium concentration in human endothelial cells.
PubMed: Platelet-activating factor (PAF) receptor antagonists inhibit arachidonic acid induced platelet aggregation in rabbit whole blood.
PubMed: Comparison of the actions of some platelet-activating factor antagonists on platelets and aortic smooth muscles.
PubMed: Inhibition of immune complex-induced enteropathy by three different platelet-activating factor receptor antagonists.
PubMed: The rational search for natural neolignans.
PubMed: Pharmacologic characterization of the rabbit neutrophil receptor for platelet-activating factor.
PubMed: Vasorelaxing effect in rat thoracic aorta caused by denudatin B, isolated from the Chinese herb, magnolia fargesii.
PubMed: Lipophilicity force field profile: an expressive visualization of the lipophilicity molecular potential gradient.
PubMed: Distinct stimulatory effect of platelet-activating factor on prostaglandin I2 and thromboxane A2 biosynthesis by rat dental pulp.
PubMed: Inhibition of thrombin- and collagen-induced phosphoinositides breakdown in rabbit platelets by a PAF antagonist--denudatin B, an isomer of kadsurenone.
PubMed: Development of specific functionally active receptors for platelet-activating factor in HL-60 cells following granulocytic differentiation.
PubMed: Kadsurenone and other related lignans as antagonists of platelet-activating factor receptor.
PubMed: Further characterization of PAF receptor and novel antagonists.
PubMed: Acute microcirculatory effects of platelet-activating factor.
PubMed: Antagonism of platelet activating factor-induced chemiluminescence in guinea-pig peritoneal macrophages in differing states of activation.
PubMed: PAF-receptor. 1. 'Cache-oreilles' effect of selected high-potency platelet-activating factor (PAF) antagonists.
PubMed: Pharmacologic modulation of D-49 phospholipase A2-induced paw edema in the mouse.
PubMed: Preliminary studies on phospholipase A2-induced mouse paw edema as a model to evaluate antiinflammatory agents.
PubMed: Antagonism of Paf-induced oedema formation in rabbit skin: a comparison of different antagonists.
PubMed: Platelet activating factor is a potent colonic secretagogue with actions independent of specific PAF receptors.
PubMed: Platelet-activating factor-induced calcium mobilization in human platelets and neutrophils: effects of PAF-acether antagonists.
PubMed: [The isolation and identification of PAF inhibitors from Piper wallichii (Miq.) Hand-Mazz and P. hancei Maxim].
PubMed: Platelet-activating factor stimulates arachidonic acid metabolism in rat liver cells (C-9 cell line) by a receptor-mediated mechanism.
PubMed: Metabolism of kadsurenone and 9,10-dihydrokadsurenone in rhesus monkeys and rat liver microsomes.
PubMed: Enhanced human monocyte cytotoxicity by platelet-activating factor.
PubMed: Differential effect of platelet-activating factor (PAF) receptor antagonists on peptide and PAF-stimulated prostaglandin release in unilateral ureteral obstruction.
PubMed: Inhibitory effect of platelet-activating factor (PAF) on luteinizing hormone-releasing hormone and somatostatin release from rat median eminence in vitro correlated with the characterization of specific PAF receptor sites in rat hypothalamus.
PubMed: Effect of platelet activating factor on leukocyte-endothelial cell interactions.
PubMed: Comparison of the platelet aggregation induced by three thrombin-like enzymes of snake venoms and thrombin.
PubMed: Identification of platelet-activating factor receptors in P388D1 murine macrophages.
PubMed: Vasoconstrictor effects of platelet-activating factor in the hamster cheek pouch microcirculation: dose-related relations and pathways of action.
PubMed: Platelet-activating factor primes neutrophil responses to agonists: role in promoting neutrophil-mediated endothelial damage.
PubMed: Effect of platelet-activating factor on microvascular permselectivity: dose-response relations and pathways of action in the hamster cheek pouch microcirculation.
PubMed: Platelet activating factor receptor blockade enhances recovery after multifocal brain ischemia.
PubMed: Effect of platelet activating factor antagonists on cultured rat mesangial cells.
PubMed: Involvement of platelet-activating factor (PAF) in cerebral post-ischemic phase in Mongolian gerbils.
PubMed: Specific receptor sites for platelet activating factor on rat liver plasma membranes.
PubMed: Evaluation of PAF antagonists using human neutrophils in a microtiter plate assay.
PubMed: Pharmacologic modulation of PAF-induced mortality in mice.
PubMed: Pharmacological actions of WEB 2086, a new specific antagonist of platelet activating factor.
PubMed: Pharmacologic antagonism of platelet activating factor and peptide leukotrienes inhibits guinea pig anaphylaxis.
PubMed: Structure-activity relationships of kadsurenone analogues.
PubMed: Species difference in the specific receptors of platelet activating factor.
PubMed: Specific binding of [3H]dihydrokadsurenone to rabbit platelet membranes and its inhibition by the receptor agonists and antagonists of platelet-activating factor.
PubMed: The inflammatory response of rabbit skin to topical arachidonic acid and its pharmacological modulation.
PubMed: Characterization of platelet activating factor (PAF)-acether-induced contractions of guinea-pig lung strips by selected inhibitors of arachidonic acid metabolism and by PAF-acether antagonists.
PubMed: Crystal and molecular structure of BN 52021, a PAF-acether antagonist. Comparison with the conformation of Kadsurenone and related compounds.
PubMed: Relative roles of leukotrienes and platelet activating factor in experimentally-induced gastric ulceration.
PubMed: Comparative effects of drugs on leukotrienes-, PAF-acether- and histamine- induced contractions of guinea-pig lung parenchymal strips.
PubMed: [Neolignans from Piper hancei Maxim].
PubMed: Specific inhibition of PAF-acether-induced platelet activation by BN 52021 and comparison with the PAF-acether inhibitors kadsurenone and CV 3988.
PubMed: Kadsurenone distinguishes between different platelet activating factor receptor subtypes on macrophages and polymorphonuclear leucocytes.
PubMed: Ionic and GTP regulation of binding of platelet-activating factor to receptors and platelet-activating factor-induced activation of GTPase in rabbit platelet membranes.
PubMed: Release of platelet activating factor and its involvement in the first phase of carrageenin-induced rat foot edema.
PubMed: Changes in cytosolic free calcium induced by platelet-activating factor in rabbit platelets: specific inhibition by BN 52021 and structurally related compounds.
PubMed: Cardiovascular alterations in the rabbit infused with platelet activating factor (PAF): effect of kadsurenone, a PAF-receptor antagonist.
PubMed: Inhibition of the platelet activating factor mediated component of guinea pig anaphylaxis by receptor antagonists.
PubMed: trans-2,5-Bis-(3,4,5-trimethoxyphenyl)tetrahydrofuran. An orally active specific and competitive receptor antagonist of platelet activating factor.
PubMed: [Antagonists of platelet activating factor].
PubMed: Characterization of cutaneous vascular permeability induced by platelet-activating factor in guinea pigs and rats and its inhibition by a platelet-activating factor receptor antagonist.
PubMed: Specific binding sites for platelet activating factor in human lung tissues.
PubMed: Platelet activating factor (PAF) involvement in endotoxin-induced hypotension in rats. Studies with PAF-receptor antagonist kadsurenone.
PubMed: Characterization of a platelet-activating factor receptor antagonist isolated from haifenteng (Piper futokadsura): specific inhibition of in vitro and in vivo platelet-activating factor-induced effects.
PubMed: The isolation and characterization of kadsurenone from haifenteng (Piper futokadsura) as an orally active specific receptor antagonist of platelet-activating factor.
Synonyms   Articles   Notes   Search   Top
Please share your Comments.
Email Address:
 
 
 
 
Top of Page Home
Copyright © 1980-2020 Perflavory ™ Disclaimer Privacy Policy