Category: food additive and cosmetic agents
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| FDA/DG SANTE Petitions, Reviews, Notices: |
GRN 248 | Sucrose fatty acid esters (i.e., sucrose monoesters of lauric acid, palmitic acid, and stearic acid) manufactured by reaction of sucrose with vinyl esters of lauric, palmitic, and stearic acids View - notice PDF |
Physical Properties:
Assay: | 95.00 to 100.00 %
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Food Chemicals Codex Listed: | No |
Boiling Point: | 721.00 to 722.00 °C. @ 760.00 mm Hg (est)
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Flash Point: | 455.00 °F. TCC ( 235.30 °C. ) (est)
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logP (o/w): | 2.692 (est) |
Soluble in: |
| water, 29.8 mg/L @ 25 °C (est) |
Organoleptic Properties:
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Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
Preferred SDS: View |
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
Not determined
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | food additive and cosmetic agents |
Recommendation for sucrose laurate usage levels up to: | | not for fragrance use.
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Recommendation for sucrose laurate flavor usage levels up to: |
| not for flavor use.
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Safety References:
EPI System: | View |
Cancer Citations: | Search |
Toxicology Citations: | Search |
EPA ACToR: | Toxicology Data |
EPA Substance Registry Services (SRS): | Registry |
Laboratory Chemical Safety Summary : | 5360776 |
National Institute of Allergy and Infectious Diseases: | Data |
WGK Germany: | 1 |
| [(2S,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] dodecanoate |
Chemidplus: | 0025339995 |
References:
| [(2S,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] dodecanoate |
NIST Chemistry WebBook: | Search Inchi |
Pubchem (cid): | 5360776 |
Pubchem (sid): | 134996515 |
Other Information:
Potential Blenders and core components note
Potential Uses:
| emulsifying agents | |
| surfactants | |
Occurrence (nature, food, other): note
Synonyms:
[(2S,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-3,4- | dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] dodecanoate | alpha-delta- | glucopyranoside beta-delta-fructofuranosyl monododecanoate | a-D- | glucopyranoside, b-D-fructofuranosyl, monododecanoate | mono- | sucrose laurate | | sucrose monolaurate |
Articles:
PubMed: | Characterization of enzymatically prepared sugar medium-chain fatty acid monoesters. |
PubMed: | Effects of propylene glycol alginate and sucrose esters on the physicochemical properties of modified starch-stabilized beverage emulsions. |
PubMed: | Development and evaluation of optimized sucrose ester stabilized oleanolic acid nanosuspensions prepared by wet ball milling with design of experiments. |
PubMed: | Efficient delivery and distribution in skin of chlorogenic acid and resveratrol induced by microemulsion using sucrose laurate. |
PubMed: | Evaluation of Shirasu Porous Glass (SPG) membrane emulsification for the preparation of colloidal lipid drug carrier dispersions. |
PubMed: | Elution strategies for reversed-phase high-performance liquid chromatography analysis of sucrose alkanoate regioisomers with charged aerosol detection. |
PubMed: | Type II Fp of human mitochondrial respiratory complex II and its role in adaptation to hypoxia and nutrition-deprived conditions. |
PubMed: | Application of quantitative (19) F nuclear magnetic resonance spectroscopy in tape-stripping experiments with natural microemulsions. |
PubMed: | Solubilization of simvastatin and phytosterols in a dilutable microemulsion system. |
PubMed: | Effects of selected polysorbate and sucrose ester emulsifiers on the physicochemical properties of astaxanthin nanodispersions. |
PubMed: | [Modelling of pecutaneous drug permeation and investigation of penetration enhancer effect]. |
PubMed: | Natural microemulsions: formulation design and skin interaction. |
PubMed: | Preparation of nanoemulsions and solid lipid nanoparticles by premix membrane emulsification. |
PubMed: | Enhancement potential of sucrose laurate (L-1695) on intestinal absorption of water-soluble high molecular weight compounds. |
PubMed: | Effect of lactose monolaurate on pathogenic and nonpathogenic bacteria. |
PubMed: | A combined approach of vesicle formulations and microneedle arrays for transcutaneous immunization against hepatitis B virus. |
PubMed: | Highly efficient synthesis of sucrose monolaurate by alkaline protease Protex 6L. |
PubMed: | The effect of sucrose esters on a culture model of the nasal barrier. |
PubMed: | Detergents stabilize the conformation of phosphodiesterase 6. |
PubMed: | In vitro-in vivo study of CoQ10-loaded lipid nanoparticles in comparison with nanocrystals. |
PubMed: | Characterization of cephalexin loaded nonionic microemulsions. |
PubMed: | Head group effects on molecular packing in lamellar liquid crystals. |
PubMed: | Sugar ester J-1216 enhances percutaneous permeation of ionized lidocaine. |
PubMed: | [The applicability of sucrose laurate in hot-melt technology]. |
PubMed: | Hydrolysis of fish oil by hyperactivated Rhizomucor miehei lipase immobilized by multipoint anion exchange. |
PubMed: | Sucrose monolaurate synthesis with Protex 6L immobilized on electrospun TiO2 nanofiber. |
PubMed: | Physicochemical characterization of drug-loaded rigid and elastic vesicles. |
PubMed: | Applicability of sucrose laurate as surfactant in solid dispersions prepared by melt technology. |
PubMed: | Full enzymatic hydrolysis of commercial sucrose laurate by immobilized-stabilized derivatives of lipase from Thermomyces lanuginosa. |
PubMed: | Investigating the stability of the nonionic surfactants tocopheryl polyethylene glycol succinate and sucrose laurate by HPLC-MS, DAD, and CAD. |
PubMed: | Effects of non-ionic surfactants on cytochrome P450-mediated metabolism in vitro. |
PubMed: | Inactivation of Bacillus amyloliquefaciens spores by a combination of sucrose laurate and pressure-assisted thermal processing. |
PubMed: | Sucrose monolaurate improves the efficacy of sodium hypochlorite against Escherichia coli O157:H7 on spinach. |
PubMed: | Ibuprofen penetration enhance by sucrose ester examined by ATR-FTIR in vivo. |
PubMed: | Phospholipids-embedded fully dilutable liquid nanostructures. Part 2: The role of sodium diclofenac. |
PubMed: | Effects of non-ionic surfactants on in vitro triglyceride digestion and their susceptibility to digestion by pancreatic enzymes. |
PubMed: | Influence of stabilizer systems on the properties and phase behavior of supercooled smectic nanoparticles. |
PubMed: | Solubilization of poorly water-soluble drugs by mixed micelles based on hydrogenated phosphatidylcholine. |
PubMed: | Formulation and characterization of microemulsions based on mixed nonionic surfactants and peppermint oil. |
PubMed: | Mixed micelle formation with phosphatidylcholines: the influence of surfactants with different molecule structures. |
PubMed: | Emulsification mechanism and storage instabilities of hydrocarbon-in-water sub-micron emulsions stabilised with Tweens (20 and 80), Brij 96v and sucrose monoesters. |
PubMed: | Mathematical modeling of pH-surfactant-mediated solubilization of nimesulide. |
PubMed: | Inhibitory effects of sucrose fatty acid esters on survival of Yersinia enterocolitica on eggshell surface and use of blue lake as indicator of bacterial penetration into eggs. |
PubMed: | Lecithin based nanoemulsions: A comparative study of the influence of non-ionic surfactants and the cationic phytosphingosine on physicochemical behaviour and skin permeation. |
PubMed: | Screening of detergents for solubilization, purification and crystallization of membrane proteins: a case study on succinate:ubiquinone oxidoreductase from Escherichia coli. |
PubMed: | Preparation and characterization of diphtheria toxoid-loaded elastic vesicles for transcutaneous immunization. |
PubMed: | Analysis of survival rates and cellular fatty acid profiles of Listeria monocytogenes treated with supercritical carbon dioxide under the influence of cosolvents. |
PubMed: | Glucosylation of sucrose laurate with cyclodextrin glucanotransferase. |
PubMed: | Effect of high hydrostatic pressure on four genotypes of F-specific RNA bacteriophages. |
PubMed: | Determination of regioisomeric distribution in carbohydrate fatty acid monoesters by LC-ESI-MS. |
PubMed: | Cellular uptake of carotenoid-loaded oil-in-water emulsions in colon carcinoma cells in vitro. |
PubMed: | Purification of human beta2-adrenergic receptor expressed in methylotrophic yeast Pichia pastoris. |
PubMed: | Influence of sucrose esters on the in vivo percutaneous penetration of octyl methoxycinnamate formulated in nanocapsules, nanoemulsion, and emulsion. |
PubMed: | Effect of sucrose fatty acid esters on transdermal permeation of lidocaine and ketoprofen. |
PubMed: | PFGSE-NMR study of the self-diffusion of sucrose fatty acid monoesters in water. |
PubMed: | Impact of excipients on the absorption of P-glycoprotein substrates in vitro and in vivo. |
PubMed: | Direct evidence for expression of type II flavoprotein subunit in human complex II (succinate-ubiquinone reductase). |
PubMed: | Skin penetration and mechanisms of action in the delivery of the D2-agonist rotigotine from surfactant-based elastic vesicle formulations. |
PubMed: | Rationalization of membrane protein crystallization with polyethylene glycol using a simple depletion model. |
PubMed: | Keratolytic activity of microemulsions. |
PubMed: | Binding and functional properties of the extrinsic proteins in oxygen-evolving photosystem II particle from a green alga, Chlamydomonas reinhardtii having his-tagged CP47. |
PubMed: | Sucrose cocoate, a component of cosmetic preparations, enhances nasal and ocular peptide absorption. |
PubMed: | The in vivo and in vitro interactions of elastic and rigid vesicles with human skin. |
PubMed: | Transdermal delivery of pergolide from surfactant-based elastic and rigid vesicles: characterization and in vitro transport studies. |
PubMed: | Efficient transesterification of sucrose catalysed by the metalloprotease thermolysin in dimethylsulfoxide. |
PubMed: | Elasticity of vesicles assessed by electron spin resonance, electron microscopy and extrusion measurements. |
PubMed: | Production and purification of recombinant human alpha 2C2 adrenergic receptor using Saccharomyces cerevisiae. |
PubMed: | Bacterial spore inhibition and inactivation in foods by pressure, chemical preservatives, and mild heat. |
PubMed: | Elasticity of vesicles affects hairless mouse skin structure and permeability. |
PubMed: | Lipase-catalyzed regioselective acylation of sucrose in two-solvent mixtures. |
PubMed: | Feasibility of using food-grade additives to control the growth of Clostridium perfringens. |
PubMed: | Purification and characterization of a complex from placental syncytiotrophoblast microvillous membranes which inhibits the proliferation of human umbilical vein endothelial cells. |
PubMed: | Role of fluidity of membranes on the guanyl nucleotide-dependent binding of cholecystokinin-8S to rat brain cortical membranes. |
PubMed: | One-step purification of histidine-tagged cytochrome bo3 from Escherichia coli and demonstration that associated quinone is not required for the structural integrity of the oxidase. |
PubMed: | Separation and detection of closely related peptides by micellar electrokinetic chromatography coupled with electrospray ionization mass spectrometry using the partial filling technique. |
PubMed: | Distinct biochemical properties of the native members of the G12 G-protein subfamily. Characterization of G alpha 12 purified from rat brain. |
PubMed: | Formation of the functional complexes of m2 muscarinic acetylcholine receptors with GTP-binding regulatory proteins in solution. |
PubMed: | Inhibitory effects of sucrose monolaurate, alone and in combination with organic acids, on Listeria monocytogenes and Staphylococcus aureus. |
PubMed: | Sucrose laurate gels as a percutaneous delivery system for oestradiol in rabbits. |
PubMed: | Micellization and solubilization behavior of sucrose laurate, a new pharmaceutical excipient. |
PubMed: | Effect of sucrose monolaurate on acid production, levels of glycolytic intermediates, and enzyme activities of Streptococcus mutans NCTC 10449. |
PubMed: | Purification and characterization of phosphatidylcholine phospholipase D from pig lung. |
PubMed: | Solubilization of muscarinic receptor subtypes from baculovirus infected Sf9 insect cells. |
PubMed: | Fast atom bombardment mass spectrometry of sucrose monocaprate and sucrose monolaurate. |
PubMed: | Solubilization and characterization of atrial muscarinic acetylcholine receptors in sucrose monolaurate. |
PubMed: | Small subunits of Photosystem I reaction center complexes from Synechococcus elongatus. I. Is the psaF gene product required for oxidation of cytochrome c-553? |
PubMed: | Crystallization and preliminary X-ray crystallographic studies of bovine heart mitochondrial cytochrome bc1 complex. |
PubMed: | Structure-activity study of inhibition of amphotericin B (Fungizone) binding to sterols, toxicity to cells, and lethality to mice by esters of sucrose. |
PubMed: | A novel guanine nucleotide-binding protein coupled to the alpha 1-adrenergic receptor. II. Purification, characterization, and reconstitution. |
PubMed: | Concentration dependent dual effect of the monolauryl ester of sucrose on the antifungal activity and absorption spectra of amphotericin B (Fungizone). |
PubMed: | Characterization of 17-beta-estradiol-dependent and -independent somatostatin receptor subtypes in rat anterior pituitary. |
PubMed: | Micellar solubilization of timobesone acetate in aqueous and aqueous propylene glycol solutions of nonionic surfactants. |
PubMed: | Effect of stilbenedisulfonate binding on the state of association of the membrane-spanning domain of band 3 from bovine erythrocyte membrane. |
PubMed: | Effects of the detergent sucrose monolaurate on binding of amphotericin B to sterols and its toxicity for cells. |
PubMed: | The effects of fatty acids and their monoesters on the metabolic activity of dental plaque. |
PubMed: | Activation of phosphodiesterase in frog rod outer segment by an intermediate of rhodopsin photolysis I. |
PubMed: | Effect of phospholipid and detergent on the Schiff base of cephalopod rhodopsin and metarhodopsin. |
PubMed: | Studies on cephalopod rhodopsin. Fatty acid esters of sucrose as effective detergents. |
PubMed: | The stability of sucrose monolaurate: rate of formation of lauric acid. |
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