Category: flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | colorless to pale yellow clear liquid (est) |
Assay: | 95.00 to 100.00 % sum of isomers
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Additional Assay Information: | sum of 2,3- 2,5- and 2,6- isomers |
Food Chemicals Codex Listed: | No |
Specific Gravity: | 0.96700 to 0.98000 @ 25.00 °C.
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Pounds per Gallon - (est).: | 8.046 to 8.155
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Refractive Index: | 1.48700 to 1.49700 @ 20.00 °C.
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Boiling Point: | 80.00 °C. @ 50.00 mm Hg
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Boiling Point: | 170.00 to 171.00 °C. @ 760.00 mm Hg
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Vapor Pressure: | 1.975000 mmHg @ 25.00 °C. (est) |
Flash Point: | 145.00 °F. TCC ( 62.78 °C. )
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logP (o/w): | 1.197 (est) |
Soluble in: |
| alcohol | | water | | water, 4903 mg/L @ 25 °C (est) |
Organoleptic Properties:
Cosmetic Information:
Suppliers:
Safety Information:
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
Not determined
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | flavoring agents |
Recommendation for 2-ethyl-6-methyl pyrazine usage levels up to: | | not for fragrance use.
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Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.37 (μg/capita/day) |
Maximised Survey-derived Daily Intakes (MSDI-USA): | 0.40 (μg/capita/day) |
Structure Class: | II |
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
publication number: 19 |
Click here to view publication 19 |
| average usual ppm | average maximum ppm |
baked goods: | 3.00000 | 6.00000 |
beverages(nonalcoholic): | 1.00000 | 3.00000 |
beverages(alcoholic): | 0.10000 | 1.00000 |
breakfast cereal: | - | - |
cheese: | - | - |
chewing gum: | - | - |
condiments / relishes: | - | - |
confectionery froastings: | - | - |
egg products: | - | - |
fats / oils: | - | - |
fish products: | - | - |
frozen dairy: | 2.00000 | 3.00000 |
fruit ices: | - | - |
gelatins / puddings: | 1.00000 | 3.00000 |
granulated sugar: | - | - |
gravies: | - | - |
hard candy: | - | - |
imitation dairy: | - | - |
instant coffee / tea: | - | - |
jams / jellies: | - | - |
meat products: | 1.00000 | 5.00000 |
milk products: | - | - |
nut products: | - | - |
other grains: | - | - |
poultry: | - | - |
processed fruits: | - | - |
processed vegetables: | - | - |
reconstituted vegetables: | - | - |
seasonings / flavors: | - | - |
snack foods: | - | - |
soft candy: | 2.00000 | 5.00000 |
soups: | - | - |
sugar substitutes: | - | - |
sweet sauces: | - | - |
Safety References:
Flavor & Extract Manufacturers Association (FEMA) reference(s): |
The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients. View pdf |
European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
European Food Safety Authority (EFSA) reference(s): |
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) View page or View pdf |
Flavouring Group Evaluation 50 (FGE.50): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) [1] View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010) View page or View pdf |
EPI System: | View |
AIDS Citations: | Search |
Cancer Citations: | Search |
Toxicology Citations: | Search |
EPA ACToR: | Toxicology Data |
EPA Substance Registry Services (SRS): | Registry |
Laboratory Chemical Safety Summary : | 26332 |
National Institute of Allergy and Infectious Diseases: | Data |
WISER: | UN 1993 |
WGK Germany: | 3 |
| 2-ethyl-6-methylpyrazine |
Chemidplus: | 0013925036 |
References:
Other Information:
Potential Blenders and core components note
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For Odor |
chocolate |
chocolate |
| cocoa hexenal | FL/FR |
earthy |
2- | ethyl-3-methoxypyrazine | FL/FR |
| nutty pyrazine | FL/FR |
fruity |
| allyl 2-ethyl butyrate | FL/FR |
nutty |
2- | acetyl-3-ethyl pyrazine | FL/FR |
2- | acetyl-3-methyl pyrazine | FL/FR |
2- | acetyl-3,5-dimethyl pyrazine | FL/FR |
2- | acetyl-3,5(or 6)-dimethyl pyrazine | FL/FR |
3,6- | cocoa pyrazine | FL/FR |
| filbert heptenone | FL/FR |
| filbert heptenone B | FL/FR |
(+)-(E,S)- | filbertone | FL/FR |
(-)-(E,R)- | filbertone | FL/FR |
european | hazelnut absolute | FL/FR |
roasted | hazelnut infusions | FL/FR |
european | hazelnut oil CO2 extract | FL/FR |
2,4,5- | trimethyl oxazole | FL/FR |
tobacco |
3- | ethyl pyridine | FL/FR |
| methyl benzoxole | FL/FR |
vegetable |
| methional | FL/FR |
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For Flavor |
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No flavor group found for these |
2- | ethyl-3-methoxypyrazine | FL/FR |
| green pea pyrazine | FL |
2- | methoxy-3-propyl pyrazine | FL |
| methyl 2-(methyl thio) acetate | FL |
4-( | methyl thio) butanol | FL |
alliaceous |
3- | mercapto-2-pentanone | FL |
2- | methyl thioacetaldehyde | FL |
astringent |
2- | methyl pyridine | FL |
burnt |
2- | methyl quinoxaline | FL |
2,4,5- | trimethyl oxazole | FL/FR |
caramellic |
3- | ethyl pyridine | FL/FR |
chocolate |
| chocolate hazelnut flavor | FL |
cocoa |
| cocoa hexenal | FL/FR |
earthy |
(±)-2- | mercapto-5-methylheptan-4-one | FL |
ethereal |
| allyl 2-ethyl butyrate | FL/FR |
green |
2,5- | dimethyl-4-ethyl oxazole | FL |
3- | methyl pyridine | FL |
1-(5- | methyl-2-furyl) propan-1-one | FL |
| propylene glycol acetone ketal | FL |
milky |
dextro,laevo-3-( | methyl thio) butanone | FL |
nutty |
3- | acetyl-2,5-dimethyl thiophene | FL |
2- | acetyl-3-ethyl pyrazine | FL/FR |
2- | acetyl-3-methyl pyrazine | FL/FR |
2- | acetyl-3,5-dimethyl pyrazine | FL/FR |
2- | acetyl-3,5(or 6)-dimethyl pyrazine | FL/FR |
| almond hazelnut flavor | FL |
3,5(6)- | cocoa pyrazine | FL |
3,6- | cocoa pyrazine | FL/FR |
2,5- | diethyl pyrazine | FL |
2,5- | diethyl-3-methyl pyrazine | FL |
| filbert flavor | FL |
| filbert heptenone | FL/FR |
| filbert heptenone B | FL/FR |
(-)-(E,R)- | filbertone | FL/FR |
(+)-(E,S)- | filbertone | FL/FR |
european | hazelnut absolute | FL/FR |
toasted | hazelnut cream flavor | FL |
european | hazelnut distillates | FL |
| hazelnut flavor | FL |
roasted | hazelnut infusions | FL/FR |
european | hazelnut oil CO2 extract | FL/FR |
european | hazelnut oleoresin | FL |
| hazelnut paste | FL |
| methyl benzoxole | FL/FR |
| nutty pyrazine | FL/FR |
spicy |
| chocolate cinnamon hazelnut flavor | FL |
| cinnamon hazelnut cappuccino flavor | FL |
| cinnamon hazelnut cream flavor | FL |
| cinnamon hazelnut flavor | FL |
sulfurous |
| potato butanone | FL |
tomato |
| methional | FL/FR |
vanilla |
| vanilla hazelnut flavor | FL |
vegetable |
| potato butyraldehyde | FL |
winey |
5- | ethyl-2-methyl pyridine | FL |
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Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
2- | ethyl-6-methyl pyrazine natural | 2- | ethyl-6-methyl-1,4-diazine | 2- | ethyl-6-methylpyrazine | 2- | ethyl-6-methylpyrazine natural | 6- | methyl-2-ethyl pyrazine | 2- | methyl-6-ethyl pyrazine | 2- | methyl-6-ethylpyrazine | | pyrazine, 2-ethyl-6-methyl- |
Articles:
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