Articles:
| None found yet. Try the PubMed Search. |
2-acetyloxypropyl(trimethyl)azanium;chloride
Notes:
a quaternary ammonium parasympathomimetic agent with the muscarinic actions of acetylcholine. it is hydrolyzed by acetylcholinesterase at a considerably slower rate than acetylcholine and is more resistant to hydrolysis by nonspecific cholinesterases so that its actions are more prolonged. it is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (from martindale, the extra pharmacopoeia, 30th ed, p1116)
| CAS Number: | 62-51-1 |  3D/inchi
|
| Other(deleted CASRN): | 2410-07-3 | |
| ECHA EINECS - REACH Pre-Reg: | 200-537-2 | |
| FDA UNII: | 0W5ETF9M2K | |
| Nikkaji Web: | J98.376D | |
| Beilstein Number: | 4162373 | |
| MDL: | MFCD00011817 | |
| Molecular Weight: | 195.68886000 | |
| Formula: | C8 H18 Cl N O2 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 172.00 °C. @ 760.00 mm Hg |
| Flash Point: | 32.00 °F. TCC ( 0.00 °C. ) (est) |
| logP (o/w): | -3.957 (est) |
| Soluble in: | |
| water, 1e+006 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Methacholine chloride ≥98%
Odor: characteristic Use: Methacholine chloride, a synthetic choline ester, is pharmaceutical agent acting as a b2-adrenergic agonist used in the treatment of pulmonary and respiratory diseases including asthma.
Used in the treatment of pulmonary and respiratory diseases including asthma. |
| Penta International |
| ACETYL-B-METHYLCHOLINE CHLORIDE REGULAR GRADE |
| Penta International |
| METHACHOLINE CHLORIDE USP GRADE |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Acetyl-β-methylcholine chloride >98% |
| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| Acetyl-β-methylcholine chloride ≥98% (TLC), powder |
| TCI AMERICA |
| For experimental / research use only. |
| Methacholine Chloride >98.0%(T) |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intravenous-guinea pig LDLo 3750 ug/kg VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION Archives Internationales de Pharmacodynamie et de Therapie. Vol. 106, Pg. 245, 1956. intraperitoneal-mouse LD50 160 mg/kg Toxicology and Applied Pharmacology. Vol. 28, Pg. 227, 1974. intravenous-mouse LD50 15 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 58, Pg. 337, 1936. oral-mouse LD50 740 mg/kg Pharmacology and Toxicology. English translation of FATOAO. Vol. 22, Pg. 210, 1959. intravenous-rat LD50 20 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 58, Pg. 337, 1936. oral-rat LD50 750 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 58, Pg. 337, 1936. | |
| Dermal Toxicity: | |
|
subcutaneous-mouse LD50 90 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 58, Pg. 337, 1936. subcutaneous-rat LD50 75 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 58, Pg. 337, 1936. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis | ||
| Recommendation for acetyl-beta-methyl choline chloride usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for acetyl-beta-methyl choline chloride flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| ClinicalTrials.gov: | search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 62-51-1 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 6114 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| 2-acetyloxypropyl(trimethyl)azanium;chloride | |
| Chemidplus: | 0000062511 |
| RTECS: | BR5250000 for cas# 62-51-1 |
References:
| 2-acetyloxypropyl(trimethyl)azanium;chloride | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 62-51-1 |
| Pubchem (cid): | 6114 |
| Pubchem (sid): | 134971371 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | D04970 |
| HMDB (The Human Metabolome Database): | Search |
| Export Tariff Code: | 2923.90.0000 |
| ChemSpider: | View |
| Wikipedia: | View |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| 2- | acetoxy-N,N,N-trimethyl-1-propanaminium chloride |
| 2- | acetoxy-N,N,N-trimethylpropan-1-aminium chloride |
| (2- | acetoxypropyl)trimethylammonium chloride |
| acetyl-b-methylcholine chloride | |
| (±)- | acetyl-b-methylcholine chloride |
| o- | acetyl-b-methylcholine chloride |
| 2- | acetyloxy-N,N,N-trimethylpropan-1-aminium chloride |
| 2-( | acetyloxy)-N,N,N-trimethyl-1-propanaminium chloride |
| 2-( | acetyloxy)-N,N,N-trimethylpropan-1-aminium chloride |
| 2- | acetyloxypropyl(trimethyl)azanium;chloride |
| amechol | |
| chloride, methacholine | |
| (2- | hydroxypropyl)trimethylammonium chloride acetate |
| mecholine | |
| mecholyl | |
| methacholine chloride | |
| methacholinium chloride | |
| methacoline chloride | |
| 1- | methyl-2-(trimethylamino)ethyl acetate, chloride |
| b- | methylacetylcholine chloride |
| 1- | propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, chloride |
| 1- | propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, chloride (1:1) |
| provocholine | |
| provokit | |
| trimethyl-b-acetoxypropylammonium chloride |