Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Assay: | 95.00 to 100.00 %
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Food Chemicals Codex Listed: | No |
Boiling Point: | 214.00 to 216.00 °C. @ 760.00 mm Hg
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Vapor Pressure: | 0.032000 mmHg @ 25.00 °C. (est) |
Flash Point: | 200.00 °F. TCC ( 93.33 °C. )
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logP (o/w): | 3.216 (est) |
Soluble in: |
| alcohol | | water, 434.5 mg/L @ 25 °C (est) |
Insoluble in: |
| water |
Organoleptic Properties:
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Odor Type: mentholic |
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| mentholic cooling minty |
Odor Description: at 10.00 % in dipropylene glycol. | mentholic cooling minty |
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Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
oral-mouse LD50 4000 mg/kg Quarterly Journal of Pharmacy & Pharmacology. Vol. 5, Pg. 233, 1932.
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Safety References:
EPI System: | View |
AIDS Citations: | Search |
Cancer Citations: | Search |
Toxicology Citations: | Search |
EPA Substance Registry Services (TSCA): | 491-01-0 |
EPA ACToR: | Toxicology Data |
EPA Substance Registry Services (SRS): | Registry |
Laboratory Chemical Safety Summary : | 19243 |
National Institute of Allergy and Infectious Diseases: | Data |
| 5-methyl-2-(propan-2-yl)cyclohexanol |
Chemidplus: | 0003623516 |
| (2R,5R)-5-methyl-2-propan-2-ylcyclohexan-1-ol |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| cyclohexanol, 5-methyl-2-(1-methylethyl)-, (2R,5R)- | (±)-neo | menthol | D,L-neo | menthol | trans-1,3-cis-1,4-(±)- | menthol | (2R,5R)-5- | methyl-2-propan-2-ylcyclohexan-1-ol |
Articles:
PubMed: | [On the assay of DL-menthol for contamination by DL-neomenthol. 2. Report on the menthol monography in a new German pharmacopoeia]. |
PubMed: | Acaricidal activity of constituents derived from peppermint oil against Tyrophagus putrescentiae. |
PubMed: | Genetic variability, character association, and path analysis for economic traits in menthofuran rich half-sib seed progeny of Mentha piperita L. |
PubMed: | Identification of genetic markers linked to anthracnose resistance in sorghum using association analysis. |
PubMed: | Immunocytochemical localization of short-chain family reductases involved in menthol biosynthesis in peppermint. |
PubMed: | The Arabidopsis short-chain dehydrogenase/reductase 3, an abscisic acid deficient 2 homolog, is involved in plant defense responses but not in ABA biosynthesis. |
PubMed: | Stereoselective effects of monoterpenes on the microviscosity and curvature of model membranes assessed by DPH steady-state fluorescence anisotropy and light scattering analysis. |
PubMed: | Chemical diversity of Ziziphora clinopodioides: composition of the essential oil of Z. clinopodioides from Tajikistan. |
PubMed: | Peppermint oil decreases the production of virulence-associated exoproteins by Staphylococcus aureus. |
PubMed: | Intraspecific variability of the essential oil of Ziziphora clinopodioides ssp. rigida from Iran. |
PubMed: | Chirality recognition in menthol and neomenthol: preference for homoconfigurational aggregation. |
PubMed: | Molecular cloning and characterization of a broad substrate terpenoid oxidoreductase from Artemisia annua. |
PubMed: | Evolution of morphine biosynthesis in opium poppy. |
PubMed: | Headspace solid-phase microextraction-gas chromatography-mass spectrometry determination of the characteristic flavourings menthone, isomenthone, neomenthol and menthol in serum samples with and without enzymatic cleavage to validate post-offence alcohol drinking claims. |
PubMed: | Terpene conjugates of diaminedichloridoplatinum(II) complexes: antiproliferative effects in HL-60 leukemia, 518A2 melanoma, and HT-29 colon cancer cells. |
PubMed: | A role for a menthone reductase in resistance against microbial pathogens in plants. |
PubMed: | Sedative effect of monoterpene alcohols in mice: a preliminary screening. |
PubMed: | Volatile terpenoids of endophyte-free and infected peppermint (Mentha piperita L.): chemical partitioning of a symbiosis. |
PubMed: | Biotransformation of (-)-menthone by human liver microsomes. |
PubMed: | Monoterpene metabolism. Cloning, expression, and characterization of menthone reductases from peppermint. |
PubMed: | Effect of Mentha x piperita essential oil and monoterpenes on cucumber root membrane potential. |
PubMed: | Effect of melting point of chiral terpenes on human stratum corneum uptake. |
PubMed: | Monoterpene composition of essential oil from peppermint (Mentha x piperita L.) with regard to leaf position using solid-phase microextraction and gas chromatography/mass spectrometry analysis. |
PubMed: | Influence of drug lipophilicity on terpenes as transdermal penetration enhancers. |
PubMed: | Effect of l-menthol on laryngeal receptors. |
PubMed: | The effects of menthol isomers on nasal sensation of airflow. |
PubMed: | Biotransformation by divison-arrested and immobilized plant cells: bioconversion of monoterpenes by gamma-irradiated suspended and entrapped cells of mentha and Nicotiana. |
PubMed: | Metabolism of Monoterpenes : Evidence for the Function of Monoterpene Catabolism in Peppermint (Mentha piperita) Rhizomes. |
PubMed: | Metabolism of Monoterpenes : Early Steps in the Metabolism of d-Neomenthyl-beta-d-Glucoside in Peppermint (Mentha piperita) Rhizomes. |
PubMed: | Biotransformation by plant cells immobilized in cross-linked polyacrylamide-hydrazide. |
PubMed: | Metabolism of Monoterpenes: Conversion of l-Menthone to l-Menthol and d-Neomenthol by Stereospecific Dehydrogenases from Peppermint (Mentha piperita) Leaves. |
PubMed: | Demonstration of the Intercellular Compartmentation of l-Menthone Metabolism in Peppermint (Mentha piperita) Leaves. |
PubMed: | Biotransformation of monoterpenes by mentha cell lines: conversion of menthone to neomenthol. |
PubMed: | Metabolism of Monoterpenes : EVIDENCE FOR COMPARTMENTATION OF l-MENTHONE METABOLISM IN PEPPERMINT (MENTHA PIPERITA) LEAVES. |
PubMed: | Metabolism of Monoterpenes: Demonstration of (+)-Neomenthyl-beta-d-Glucoside as a Major Metabolite of (-)-Menthone in Peppermint (Mentha Piperita). |
PubMed: | [On the assay of DL-menthol for contamination by DL-neomenthol. 2. Report on the menthol monography in a new German pharmacopoeia]. |
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