6-shogaol, 555-66-8

Articles:

PubMed:	Cytotoxic activity against small cell lung cancer cell line and chromatographic fingerprinting of six isolated compounds from the ethanolic extract of Benjakul.
PubMed:	Anti-inflammatory activity of grains of paradise (Aframomum melegueta Schum) extract.
PubMed:	Modulation of cytochrome P450 metabolism and transport across intestinal epithelial barrier by ginger biophenolics.
PubMed:	Ginger compound [6]-shogaol and its cysteine-conjugated metabolite (M2) activate Nrf2 in colon epithelial cells in vitro and in vivo.
PubMed:	Anthelmintic constituents from ginger (Zingiber officinale) against Hymenolepis nana.
PubMed:	[6]-Shogaol inhibits α-MSH-induced melanogenesis through the acceleration of ERK and PI3K/Akt-mediated MITF degradation.
PubMed:	Influence of side chain structure changes on antioxidant potency of the [6]-gingerol related compounds.
PubMed:	6-Shogaol exerts anti-proliferative and pro-apoptotic effects through the modulation of STAT3 and MAPKs signaling pathways.
PubMed:	6-shogaol, a major compound in ginger, induces aryl hydrocarbon receptor-mediated transcriptional activity and gene expression.
PubMed:	6-Shogaol, an active constituent of ginger, attenuates neuroinflammation and cognitive deficits in animal models of dementia.
PubMed:	Cysteine-conjugated metabolites of ginger components, shogaols, induce apoptosis through oxidative stress-mediated p53 pathway in human colon cancer cells.
PubMed:	Synthesis and quorum sensing inhibitory activity of key phenolic compounds of ginger and their derivatives.
PubMed:	Ginger and its pungent constituents non-competitively inhibit serotonin currents on visceral afferent neurons.
PubMed:	6-Shogaol from dried ginger inhibits growth of prostate cancer cells both in vitro and in vivo through inhibition of STAT3 and NF-κB signaling.
PubMed:	Variations in the contents of gingerols and chromatographic fingerprints of ginger root extracts prepared by different preparation methods.
PubMed:	Role of 6-shogaol in tert -butyl hydroperoxide-induced apoptosis of HepG2 cells.
PubMed:	Reply to Comments on the article "[6]-Shogaol induced calcium signal in rat insulinoma cells".
PubMed:	Comments on the article "[6]-Shogaol induced calcium signal in rat insulinoma cells".
PubMed:	Multitargeted effects of hangeshashinto for treatment of chemotherapy-induced oral mucositis on inducible prostaglandin E2 production in human oral keratinocytes.
PubMed:	Induction of lung cancer cell apoptosis through a p53 pathway by [6]-shogaol and its cysteine-conjugated metabolite M2.
PubMed:	Enterohepatic recirculation of bioactive ginger phytochemicals is associated with enhanced tumor growth-inhibitory activity of ginger extract.
PubMed:	Antitumor activity of gemcitabine can be potentiated in pancreatic cancer through modulation of TLR4/NF-κB signaling by 6-shogaol.
PubMed:	[6]-shogaol induces Ca²⁺ signals by activating the TRPV1 channels in the rat insulinoma INS-1E cells.
PubMed:	Inhibition of human low-density lipoprotein oxidation in vitro by ginger extracts.
PubMed:	Preventive Effect of TU-100 on a Type-2 Model of Colitis in Mice: Possible Involvement of Enhancing Adrenomedullin in Intestinal Epithelial Cells.
PubMed:	[6]-shogaol inhibits growth and induces apoptosis of non-small cell lung cancer cells by directly regulating Akt1/2.
PubMed:	6-Shogaol induces apoptosis in human leukemia cells through a process involving caspase-mediated cleavage of eIF2α.
PubMed:	6-Shogaol inhibits chondrocytes' innate immune responses and cathepsin-K activity.
PubMed:	Active components of ginger potentiate β-agonist-induced relaxation of airway smooth muscle by modulating cytoskeletal regulatory proteins.
PubMed:	A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-κB and Nrf2-Keap1 signaling pathways.
PubMed:	6-Shogaol, an active compound of ginger, protects dopaminergic neurons in Parkinson's disease models via anti-neuroinflammation.
PubMed:	Cysteine-conjugated metabolite of ginger component [6]-shogaol serves as a carrier of [6]-shogaol in cancer cells and in mice.
PubMed:	6-Shogaol inhibits breast and colon cancer cell proliferation through activation of peroxisomal proliferator activated receptor γ (PPARγ).
PubMed:	[6]-Shogaol inhibits the production of proinflammatory cytokines via regulation of NF-κB and phosphorylation of JNK in HMC-1 cells.
PubMed:	Glutathione conjugation attenuates biological activities of 6-dehydroshogaol from ginger.
PubMed:	Population pharmacokinetic analysis of daikenchuto, a traditional Japanese medicine (Kampo) in Japanese and US health volunteers.
PubMed:	6-Shogaol Protects against Oxidized LDL-Induced Endothelial Injruries by Inhibiting Oxidized LDL-Evoked LOX-1 Signaling.
PubMed:	Ginger and its pungent constituents non-competitively inhibit activation of human recombinant and native 5-HT3 receptors of enteric neurons.
PubMed:	Highly efficient sample preparation and quantification of constituents from traditional Chinese herbal medicines using matrix solid-phase dispersion extraction and UPLC-MS/MS.
PubMed:	Role of the Toll Like receptor (TLR) radical cycle in chronic inflammation: possible treatments targeting the TLR4 pathway.
PubMed:	A new phenanthrene derivative and two diarylheptanoids from the roots of Brassica rapa ssp. campestris inhibit the growth of cancer cell lines and LDL-oxidation.
PubMed:	Invadopodia-associated proteins blockade as a novel mechanism for 6-shogaol and pterostilbene to reduce breast cancer cell motility and invasion.
PubMed:	[6]-shogaol attenuates neuronal apoptosis in hydrogen peroxide-treated astrocytes through the up-regulation of neurotrophic factors.
PubMed:	Metabolites of ginger component [6]-shogaol remain bioactive in cancer cells and have low toxicity in normal cells: chemical synthesis and biological evaluation.
PubMed:	Metabolism of ginger component [6]-shogaol in liver microsomes from mouse, rat, dog, monkey, and human.
PubMed:	Characterization of thiol-conjugated metabolites of ginger components shogaols in mouse and human urine and modulation of the glutathione levels in cancer cells by [6]-shogaol.
PubMed:	Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men.
PubMed:	Epithelial transient receptor potential ankyrin 1 (TRPA1)-dependent adrenomedullin upregulates blood flow in rat small intestine.
PubMed:	The Cytotoxicity Mechanism of 6-Shogaol-Treated HeLa Human Cervical Cancer Cells Revealed by Label-Free Shotgun Proteomics and Bioinformatics Analysis.
PubMed:	Simultaneous determination of gingerols and shogaol using capillary liquid chromatography and its application in discrimination of three ginger varieties from Indonesia.
PubMed:	[Effect of Zingiber offiicinale and Aconitum cainichaeli before and after compatibility on contents of four gingerols].
PubMed:	[6]-Shogaol inhibits melanogenesis in B16 mouse melanoma cells through activation of the ERK pathway.
PubMed:	Effects of ginger and its constituents on airway smooth muscle relaxation and calcium regulation.
PubMed:	Identification of phase II metabolites of thiol-conjugated [6]-shogaol in mouse urine using high-performance liquid chromatography tandem mass spectrometry.
PubMed:	In vitro antioxidant and anti-inflammatory activities of 1-dehydro-[6]-gingerdione, 6-shogaol, 6-dehydroshogaol and hexahydrocurcumin.
PubMed:	Anti-platelet aggregation and vasorelaxing effects of the constituents of the rhizomes of Zingiber officinale.
PubMed:	6-Shogaol induces apoptosis in human hepatocellular carcinoma cells and exhibits anti-tumor activity in vivo through endoplasmic reticulum stress.
PubMed:	6-shogaol-rich extract from ginger up-regulates the antioxidant defense systems in cells and mice.
PubMed:	Molecular mechanism inhibiting human hepatocarcinoma cell invasion by 6-shogaol and 6-gingerol.
PubMed:	Optimization of Extraction Conditions for the 6-Shogaol-rich Extract from Ginger (Zingiber officinale Roscoe).
PubMed:	Zingiber officinale (ginger) as an anti-emetic in cancer chemotherapy: a review.
PubMed:	Anti-Candida and radical scavenging activities of essential oils and oleoresins of Zingiber officinale Roscoe and essential oils of other plants belonging to the family Zingiberaceae.
PubMed:	6-Shogaol, a ginger product, modulates neuroinflammation: a new approach to neuroprotection.
PubMed:	Effects of [6]-shogaol on cholinergic signaling in HT22 cells following neuronal damage induced by hydrogen peroxide.
PubMed:	Phenylpropanoid ester from Zingiber officinale and their inhibitory effects on the production of nitric oxide.
PubMed:	[Phenolic and amide constituents from Lycianthes marlipoensis].
PubMed:	Cytotoxic, cytoprotective and antioxidant effects of isolated phenolic compounds from fresh ginger.
PubMed:	Metabolism of [6]-shogaol in mice and in cancer cells.
PubMed:	Protection by [6]-shogaol against lipopolysaccharide-induced toxicity in murine astrocytes is related to production of brain-derived neurotrophic factor.
PubMed:	Anti-inflammatory effects of [6]-shogaol: potential roles of HDAC inhibition and HSP70 induction.
PubMed:	Pharmacokinetics of daikenchuto, a traditional Japanese medicine (kampo) after single oral administration to healthy Japanese volunteers.
PubMed:	Antiinflammatory effects of ginger and some of its components in human bronchial epithelial (BEAS-2B) cells.
PubMed:	Examination of the pharmacokinetics of active ingredients of ginger in humans.
PubMed:	Shogaols at proapoptotic concentrations induce G(2)/M arrest and aberrant mitotic cell death associated with tubulin aggregation.
PubMed:	Chemopreventive effects of dietary phytochemicals against cancer invasion and metastasis: phenolic acids, monophenol, polyphenol, and their derivatives.
PubMed:	Ginger suppresses phthalate ester-induced airway remodeling.
PubMed:	Protective Effects of Ginger against Aspirin-Induced Gastric Ulcers in Rats.
PubMed:	Effects of ginger constituents on the gastrointestinal tract: role of cholinergic M3 and serotonergic 5-HT3 and 5-HT4 receptors.
PubMed:	Preparation of the monomers of gingerols and 6-shogaol by flash high speed counter-current chromatography.
PubMed:	Quantitation of 6-, 8- and 10-Gingerols and 6-Shogaol in Human Plasma by High-Performance Liquid Chromatography with Electrochemical Detection.
PubMed:	6-Shogaol, an active constituent of ginger, inhibits breast cancer cell invasion by reducing matrix metalloproteinase-9 expression via blockade of nuclear factor-κB activation.
PubMed:	Profiling of the compounds absorbed in human plasma and urine after oral administration of a traditional Japanese (kampo) medicine, daikenchuto.
PubMed:	Effect of [6]-shogaol on cytosolic Ca2+ levels and proliferation in human oral cancer cells (OC2).
PubMed:	Zingiber officinale (ginger) compounds have tetracycline-resistance modifying effects against clinical extensively drug-resistant Acinetobacter baumannii.
PubMed:	Larvicidal constituents of Zingiber officinale (ginger) against Anisakis simplex.
PubMed:	Anti-invasion effects of 6-shogaol and 6-gingerol, two active components in ginger, on human hepatocarcinoma cells.
PubMed:	[Chemical constituents of rhizomes of Zingiber officinale].
PubMed:	6-Shogaol is more effective than 6-gingerol and curcumin in inhibiting 12-O-tetradecanoylphorbol 13-acetate-induced tumor promotion in mice.
PubMed:	Pharmacokinetics of [6]-shogaol, a pungent ingredient of Zingiber officinale Roscoe (Part I).
PubMed:	Anti-inflammatory properties of red ginger (Zingiber officinale var. Rubra) extract and suppression of nitric oxide production by its constituents.
PubMed:	Six-shogaol inhibits production of tumour necrosis factor alpha, interleukin-1 beta and nitric oxide from lipopolysaccharide-stimulated RAW 264.7 macrophages.
PubMed:	Larvicidal activities of ginger (Zingiber officinale) against Angiostrongylus cantonensis.
PubMed:	Increased growth inhibitory effects on human cancer cells and anti-inflammatory potency of shogaols from Zingiber officinale relative to gingerols.
PubMed:	Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol.
PubMed:	6-Shogaol inhibits monosodium urate crystal-induced inflammation--an in vivo and in vitro study.
PubMed:	Identification and quantification of gingerols and related compounds in ginger dietary supplements using high-performance liquid chromatography-tandem mass spectrometry.
PubMed:	6-Shogaol, an active constituent of dietary ginger, induces autophagy by inhibiting the AKT/mTOR pathway in human non-small cell lung cancer A549 cells.
PubMed:	Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels.
PubMed:	TBK1-targeted suppression of TRIF-dependent signaling pathway of Toll-like receptors by 6-shogaol, an active component of ginger.
PubMed:	Inhibition of homodimerization of toll-like receptor 4 by 6-shogaol.
PubMed:	[Analysis of volatile and non-volatile compositions in ginger oleoresin by gas chromatography-mass spectrometry].
PubMed:	Simultaneous determination of 6-gingerol, 8-gingerol, 10-gingerol and 6-shogaol in rat plasma by liquid chromatography-mass spectrometry: Application to pharmacokinetics.
PubMed:	Modulation of macrophage functions by compounds isolated from Zingiber officinale.
PubMed:	Specific reaction of alpha,beta-unsaturated carbonyl compounds such as 6-shogaol with sulfhydryl groups in tubulin leading to microtubule damage.
PubMed:	Goshuyuto, a traditional Japanese medicine for migraine, inhibits platelet aggregation in guinea-pig whole blood.
PubMed:	Analysis of anti-platelet aggregation components of Rhizoma Zingiberis using chicken thrombocyte extract and high performance liquid chromatography.
PubMed:	Pharmacokinetics of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol and conjugate metabolites in healthy human subjects.
PubMed:	6-Shogaol suppressed lipopolysaccharide-induced up-expression of iNOS and COX-2 in murine macrophages.
PubMed:	[RP-HPLC fingerprint evaluating different ginger juice as processing material].
PubMed:	6-Shogaol and 6-gingerol, the pungent of ginger, inhibit TNF-alpha mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes.
PubMed:	Changes in the contents of oleoresin and pungent bioactive principles of Jamaican ginger (Zingiber officinale Roscoe.) during maturation.
PubMed:	Cytotoxic components from the dried rhizomes of Zingiber officinale Roscoe.
PubMed:	6-Shogaol induces apoptosis in human colorectal carcinoma cells via ROS production, caspase activation, and GADD 153 expression.
PubMed:	Ginger inhibits cell growth and modulates angiogenic factors in ovarian cancer cells.
PubMed:	Liquid chromatographic determination of 6-, 8-, 10-gingerol, and 6-shogaol in ginger (Zingiber officinale) as the raw herb and dried aqueous extract.
PubMed:	Stability of [6]-gingerol and [6]-shogaol in simulated gastric and intestinal fluids.
PubMed:	Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms.
PubMed:	High-performance liquid chromatographic analysis of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol in ginger-containing dietary supplements, spices, teas, and beverages.
PubMed:	6-shogaol (alkanone from ginger) induces apoptotic cell death of human hepatoma p53 mutant Mahlavu subline via an oxidative stress-mediated caspase-dependent mechanism.
PubMed:	A nonpungent component of steamed ginger--[10]-shogaol--increases adrenaline secretion via the activation of TRPV1.
PubMed:	6-Shogaol reduced chronic inflammatory response in the knees of rats treated with complete Freund's adjuvant.
PubMed:	6-Shogaol, a natural product, reduces cell death and restores motor function in rat spinal cord injury.
PubMed:	Species differences in the prokinetic effects of ginger.
PubMed:	Variation in concentration and labeling of ginger root dietary supplements.
PubMed:	The effect of extracts from ginger rhizome on inflammatory mediator production.
PubMed:	Mode of action of gingerols and shogaols on 5-HT3 receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum.
PubMed:	Cardiovascular effects of ginger aqueous extract and its phenolic constituents are mediated through multiple pathways.
PubMed:	5-HT3 receptor blocking activity of arylalkanes isolated from the rhizome of Zingiber officinale.
PubMed:	Commercially processed dry ginger (Zingiber officinale): composition and effects on LPS-stimulated PGE2 production.
PubMed:	Separation and isolation methods for analysis of the active principles of Sho-saiko-to (SST) oriental medicine.
PubMed:	Component of Zingiber officinale that improves the enhancement of small intestinal transport.
PubMed:	The herbal medicine Dai-kenchu-to and one of its active components [6]-shogaol increase intestinal blood flow in rats.
PubMed:	The stability of gingerol and shogaol in aqueous solutions.
PubMed:	Stomachic principles in ginger. III. An anti-ulcer principle, 6-gingesulfonic acid, and three monoacyldigalactosylglycerols, gingerglycolipids A, B, and C, from Zingiberis Rhizoma originating in Taiwan.
PubMed:	Capsaicin-like effect of (6)-shogaol on substance P-containing primary afferents of rats: a possible mechanism of its analgesic action.
PubMed:	[Stomachic principles in ginger. II. Pungent and anti-ulcer effects of low polar constituents isolated from ginger, the dried rhizoma of Zingiber officinale Roscoe cultivated in Taiwan. The absolute stereostructure of a new diarylheptanoid].
PubMed:	6-Gingesulfonic acid, a new anti-ulcer principle, and gingerglycolipids A, B, and C, three new monoacyldigalactosylglycerols, from zingiberis rhizoma originating in Taiwan.
PubMed:	[The study of Chinese herbal medicinal prescription with enzyme inhibitory activity. V. The study of hange-shashin-to, kanzo-shashin-to, shokyo-shashin-to with adenosine 3',5'-cyclic monophosphate phosphodiesterase].
PubMed:	[The effect of ginger on serotonin induced hypothermia and diarrhea].
PubMed:	Gastrointestinal motility enhancing effect of ginger and its active constituents.
PubMed:	Lethal efficacy of extract from Zingiber officinale (traditional Chinese medicine) or [6]-shogaol and [6]-gingerol in Anisakis larvae in vitro.
PubMed:	Reversed effects between crude and processed ginger extracts on PGF2 alpha-induced contraction in mouse mesenteric veins.
PubMed:	Chemical structural requirement in gingerol derivatives for potentiation of prostaglandin F2 alpha-induced contraction in isolated mesenteric veins of mice.
PubMed:	[Pharmacological studies on ginger. V. Pharmacological comparison between (6)-shogaol and capsaicin].
PubMed:	Pharmacological studies on ginger. II. Pressor action of (6)-shogaol in anesthetized rats, or hindquarters, tail and mesenteric vascular beds of rats.
PubMed:	[Pharmacological studies on ginger. IV. Effect of (6)-shogaol on the arachidonic cascade].
PubMed:	Pharmacological studies on ginger. III. Effect of the spinal destruction on (6)-shogaol-induced pressor response in rats.
PubMed:	Pharmacological studies on ginger. I. Pharmacological actions of pungent constitutents, (6)-gingerol and (6)-shogaol.
PubMed:	The active part of the [6]-gingerol molecule in mutagenesis.