Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | yellow crystals (est) |
Assay: | 95.00 to 100.00 %
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Food Chemicals Codex Listed: | No |
Melting Point: | 147.00 to 148.00 °C. @ 760.00 mm Hg
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Boiling Point: | 448.00 to 449.00 °C. @ 760.00 mm Hg (est)
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Flash Point: | 437.00 °F. TCC ( 225.10 °C. ) (est)
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logP (o/w): | 1.407 (est) |
Soluble in: |
| alcohol | | water, 315.3 mg/L @ 25 °C (est) |
Insoluble in: |
| water |
Organoleptic Properties:
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Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
Preferred SDS: View |
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
Not determined
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | natural substances and extractives |
Recommendation for isopimpinellin usage levels up to: | | not for fragrance use.
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Recommendation for isopimpinellin flavor usage levels up to: |
| not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
4,9- | dimethoxy-7H-furo(3,2-g) (1)benzopyran-7-one | 4,9- | dimethoxy-7H-furo[3,2-g][1]benzopyran-7-one | 4,9- | dimethoxy-7H-furo[3,2-g]chromen-7-one | 4,9- | dimethoxy-furo[3,2-g]chromen-7-one | 5,8- | dimethoxyfurano-2,3,6,7-coumarin | 5,9- | dimethoxyfurano[3,2-g]chromen-2-one | 4,9- | dimethoxyfuro[3,2-g]chromen-7-one | 4,9- | dimethoxypsoralen | 5,8- | dimethoxypsoralen | 5,8- | dimethoxypsoralene | 7H- | furo(3,2-g)(1)benzopyran-7-one, 4,9-dimethoxy- (8CI)(9CI) | 7H- | furo[3,2-g][1]benzopyran-7-one, 4,9-dimethoxy- |
Articles:
PubMed: | [Chemical constituents of Angelica nitida roots]. |
PubMed: | Furocoumarins and coumarins photoinactivate Colletotrichum acutatum and Aspergillus nidulans fungi under solar radiation. |
PubMed: | Optimal extraction and fingerprint analysis of Cnidii fructus by accelerated solvent extraction and high performance liquid chromatographic analysis with photodiode array and mass spectrometry detections. |
PubMed: | The Canadian medicinal plant Heracleum maximum contains antimycobacterial diynes and furanocoumarins. |
PubMed: | 5-Geranyloxy-7-methoxycoumarin inhibits colon cancer (SW480) cells growth by inducing apoptosis. |
PubMed: | Coumarins from the Herb Cnidium monnieri and Chemically Modified Derivatives as Antifoulants against Balanus albicostatus and Bugula neritina Larvae. |
PubMed: | Essential oil composition and larvicidal activity of Toddalia asiatica roots against the mosquito Aedes albopictus (Diptera: Culicidae). |
PubMed: | Chemical composition of hexane extract of Citrus aurantifolia and anti-Mycobacterium tuberculosis activity of some of its constituents. |
PubMed: | Separation and purification of furanocoumarins from Toddalia asiatica (L.) Lam. using microwave-assisted extraction coupled with high-speed counter-current chromatography. |
PubMed: | Pressurized liquid extraction of coumarins from fruits of Heracleum leskowii with application of solvents with different polarity under increasing temperature. |
PubMed: | Simultaneous determination of pimpinellin, isopimpinellin and phellopterin in rat plasma by a validated UPLC-MS/MS and its application to a pharmacokinetic study after administration of Toddalia asiatica extract. |
PubMed: | Furanocoumarins in celeriac from different farming systems: a 3-year study. |
PubMed: | Larvicidal activity of Cnidium monnieri fruit coumarins and structurally related compounds against insecticide-susceptible and insecticide-resistant Culex pipiens pallens and Aedes aegypti. |
PubMed: | Biological activities of Indian celery, Seseli diffusum (Roxb. ex Sm.) Sant. & Wagh. |
PubMed: | Microbial transformation of Isopimpinellin by Glomerella cingulata. |
PubMed: | Effects of furanocoumarins from apiaceous vegetables on the catalytic activity of recombinant human cytochrome P-450 1A2. |
PubMed: | Furanocoumarins from Dorsteniafoetida. |
PubMed: | Vasorelaxation by extracts of Casimiroa spp. in rat resistance vessels and pharmacological study of cellular mechanisms. |
PubMed: | Antifibrotic activity of coumarins from Cnidium monnieri fruits in HSC-T6 hepatic stellate cells. |
PubMed: | Simultaneous and sensitive determination of xanthotoxin, psoralen, isoimpinellin and bergapten in rat plasma by liquid chromatography-electrospray ionization mass spectrometry. |
PubMed: | Application of the concept of relative photomutagenic potencies to selected furocoumarins in V79 cells. |
PubMed: | Botanical origin of Indian celery seed (fruit). |
PubMed: | Comparison of citrus coumarins on carcinogen-detoxifying enzymes in Nrf2 knockout mice. |
PubMed: | Osthol and isopimpinellin from Fructus cnidii for the control of Dactylogyrus intermedius in Carassius auratus. |
PubMed: | Effects of naturally occurring coumarins on hepatic drug-metabolizing enzymes in mice. |
PubMed: | In vitro antiplasmodial activity of extract and constituents from Esenbeckia febrifuga, a plant traditionally used to treat malaria in the Brazilian Amazon. |
PubMed: | Identification of Ruta graveolens L. metabolites accumulated in the presence of abiotic elicitors. |
PubMed: | [Simultaneous determination of 5 active components in Fructus Cnidii by HPLC]. |
PubMed: | [Studies on the chemical constituents of the aerial parts of Seseli mairei]. |
PubMed: | [Studies on chemical constituents from fruits of Paliurus ramosissimus]. |
PubMed: | [Inhibitory effects of 11 coumarin compounds against growth of human bladder carcinoma cell line E-J in vitro]. |
PubMed: | Simultaneous determination of urinary metabolites of methoxypsoralens in human and Umbelliferae medicines by high-performance liquid chromatography. |
PubMed: | [Studies on chemical constituents in roots of Heracleum rapula]. |
PubMed: | Cytochrome P450-mediated metabolism of xanthotoxin by Papilio multicaudatus. |
PubMed: | Naturally occurring coumarins inhibit 7,12-dimethylbenz[a]anthracene DNA adduct formation in mouse mammary gland. |
PubMed: | Accumulation of biologically active furanocoumarins in agitated cultures of Ruta graveolens L. and Ruta graveolens ssp. divaricata (Tenore) Gams. |
PubMed: | Melanogenesis stimulation in murine b16 melanoma cells by umberiferae plant extracts and their coumarin constituents. |
PubMed: | Coumarins are competitive inhibitors of cytochrome P450 1B1, with equal potency for allelic variants. |
PubMed: | Accumulation of biologically active furanocoumarins in Ruta graveolens ssp. divaricata (Tenore) Gams in vitro culture. |
PubMed: | Natural furocoumarins as inducers and inhibitors of cytochrome P450 1A1 in rat hepatocytes. |
PubMed: | Preparative isolation and purification of coumarins from Cnidium monnieri (L.) Cusson by high-speed counter-current chromatography. |
PubMed: | [Quantification of isopimpinellin in root of Toddalia asiatica by HPLC]. |
PubMed: | Insecticidal effect of phthalides and furanocoumarins from Angelica acutiloba against Drosophila melanogaster. |
PubMed: | Computer-assisted, high-performance liquid chromatography with mass spectrometric detection for the analysis of coumarins in Peucedanum palustre and Angelica archangelica. |
PubMed: | [Studies on the coumarins in the root of Zanthoxylum dimorphophyllum]. |
PubMed: | The furanocoumarins in the roots of Heracleum sibiricum L. |
PubMed: | Cytotoxic activity of coumarins from the fruits of Cnidium monnieri on leukemia cell lines. |
PubMed: | LC determination of impurities in methoxsalen drug substance: isolation and identification of isopimpinellin as a major impurity by atmospheric pressure chemical ionization LC/MS and NMR. |
PubMed: | Constituents of Peucedanum zenkeri seeds and their antimicrobial effects. |
PubMed: | Naturally occurring coumarins inhibit human cytochromes P450 and block benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene DNA adduct formation in MCF-7 cells. |
PubMed: | A new dicoumarinyl ether and two rare furocoumarins from Ruta montana. |
PubMed: | HPLC-NMR/HPLC-MS analysis of the bark extract of Stauranthus perforatus. |
PubMed: | [Isolation and identification of active constituent of Toddalia asiatica in cardiovascular system]. |
PubMed: | Constituents of the fruits and leaves of Euodia daniellii. |
PubMed: | Oral administration of the citrus coumarin, isopimpinellin, blocks DNA adduct formation and skin tumor initiation by 7,12-dimethylbenz[a]anthracene in SENCAR mice. |
PubMed: | Amino acids in SRS1 and SRS6 are critical for furanocoumarin metabolism by CYP6B1v1, a cytochrome P450 monooxygenase. |
PubMed: | Effects of storage conditions on furocoumarin levels in intact, chopped, or homogenized parsnips. |
PubMed: | Bullous phytophotodermatitis associated with high natural concentrations of furanocoumarins in limes. |
PubMed: | Simultaneous determination of furanocoumarins in infusions and decoctions from "CarapiĆ”" (dorstenia species) by high-performance liquid chromatography. |
PubMed: | Antipruritic effect of Cnidii Monnieri Fructus (fruits of Cnidium monnieri CUSSON). |
PubMed: | Role of cytochrome P450 1a1 and 1b1 in the metabolic activation of 7,12-dimethylbenz[a]anthracene and the effects of naturally occurring furanocoumarins on skin tumor initiation. |
PubMed: | Inhibition of itch-scratch response by fruits of Cnidium monnieri in mice. |
PubMed: | Vasorelaxing effect of coumarins from Cnidium monnieri on rabbit corpus cavernosum. |
PubMed: | Oral administration of naturally occurring coumarins leads to altered phase I and II enzyme activities and reduced DNA adduct formation by polycyclic aromatic hydrocarbons in various tissues of SENCAR mice. |
PubMed: | Coumarin compounds in Ammi majus L. callus cultures. |
PubMed: | Furanocoumarins in Pastinaca sativa L. in vitro culture. |
PubMed: | Cytotoxic components from the bark of Stauranthus perforatus from Monteverde, Costa Rica. |
PubMed: | Rapid determination of furanocoumarins in creams and pomades using SPE and GC. |
PubMed: | Isolation And Structure Elucidation Of 5,7-disubstituted Simple Coumarins In The Fruits Of Heracleum Mantegazzianum. |
PubMed: | Effect of naturally occurring coumarins on the formation of epidermal DNA adducts and skin tumors induced by benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene in SENCAR mice. |
PubMed: | Isolation and characterization of CYP6B4, a furanocoumarin-inducible cytochrome P450 from a polyphagous caterpillar (Lepidoptera:papilionidae). |
PubMed: | Inhibition of the mutagenicity of 2-nitrofluorene, 3-nitrofluoranthene and 1-nitropyrene by flavonoids, coumarins, quinones and other phenolic compounds. |
PubMed: | Isolation and identification of antimicrobial furocoumarins from parsley. |
PubMed: | Development of an immunoassay to measure the absorption of dietary furanocoumarins in humans. |
PubMed: | Isopimpinellin is not phototoxic in a chick skin assay. |
PubMed: | Analysis, isolation and insecticidal activity of linear furanocoumarins and other coumarin derivatives fromPeucedanum (Apiaceae: Apioideae). |
PubMed: | Inhibition and inactivation of murine hepatic ethoxy- and pentoxyresorufin O-dealkylase by naturally occurring coumarins. |
PubMed: | Phototoxic coumarins in limes. |
PubMed: | Differential inhibition of coumarin 7-hydroxylase activity in mouse and human liver microsomes. |
PubMed: | [Studies on the chemical constituents of Rutaceae++ plants. LXVI. The chemical constituents of Toddalia asiatica (L.) Lam. (T. aculeata Pers.). (1). Chemical constituents of the root bark]. |
PubMed: | Phototoxicity due to Cachrys libanotis. |
PubMed: | Host plant resistance and linear furanocoumarin content of Apium accessions. |
PubMed: | Impact of atmospheric pollution on linear furanocoumarin content in celery. |
PubMed: | Heracleum mantegazzianum growth phases and furocoumarin content. |
PubMed: | Artificial defloration and furanocoumarin induction inPastinaca sativa (Umbelliferae). |
PubMed: | Isopimpinellin is not phototoxic to viruses and cells. |
PubMed: | Oxypeucedanin, a Major Furocoumarin in Parsley, Petroselinum crispum. |
PubMed: | [Isopimpinellin--a furocoumarin from Heracleum sphondylium with chromosome damaging activity]. |
PubMed: | Biologically active principles of crude drugs. Anti-allergic principles in "Cnidii monnieri". |
PubMed: | Identification of psoralen, 8-methoxypsoralen, isopimpinellin, and 5,7-dimethoxycoumarin in Pelea anisata H. Mann. |
PubMed: | Furocoumarins of Heracleum laciniatum: isolation, phototoxicity, absorption and action spectra studies. |
PubMed: | The furocoumarin composition of Pituranthos triradiatus. |
PubMed: | HPLC analysis of linear furocoumarins (psoralens) in healthy celery (Apium graveolens). |
PubMed: | Differential response of cultured parsley cells to elicitors from two non-pathogenic strains of fungi. 1. Identification of induced products as coumarin derivatives. |
PubMed: | The biosynthesis of isopimpinellin. |
PubMed: | Isolation of isopimpinellin from the fruits of Ammi majus L. natural coumarins. IV. |
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