Category: stabilizing agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | white powder (est) |
Assay: | 99.00 to 100.00 %
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Food Chemicals Codex Listed: | No |
Melting Point: | 158.00 to 161.00 °C. @ 760.00 mm Hg
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Boiling Point: | 211.00 °C. @ 20.00 mm Hg
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Boiling Point: | 336.00 to 337.00 °C. @ 760.00 mm Hg
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Vapor Pressure: | 1.000000 mmHg @ 114.00 °C. |
Vapor Density: | 4.8 ( Air = 1 ) |
Flash Point: | > 212.00 °F. TCC ( > 100.00 °C. )
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logP (o/w): | 2.260 |
Soluble in: |
| alcohol | | water, 3808 mg/L @ 25 °C (est) | | water, 2240 mg/L @ 25 °C (exp) |
Organoleptic Properties:
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Odor Type: nutty |
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| phenolic nutty |
Odor Description: at 100.00 %. | faint phenolic nutty |
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Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Alfa Biotechnology |
For experimental / research use only. |
Salicylic acid 98%
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American International Chemical, LLC. |
Salicylic Acid from Wintergreen
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Aurochemicals |
SALICYLIC ACID, Natural
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BOC Sciences |
For experimental / research use only. |
Salicylic Acid >98%
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Charkit Chemical |
SALICYLIC ACID PHARMA/USP
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Charkit Chemical |
SALICYLIC ACID TECH GRADE
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Charkit Chemical |
SALICYLIC ACID USP
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ECSA Chemicals |
SALICYLIC ACID RPH- FU, KG 1
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ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY |
ECSA Chemicals |
SALICYLIC ACID
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EMD Millipore |
For experimental / research use only. |
Salicylic Acid
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Glentham Life Sciences |
Salicylic acid, 99%
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Glentham Life Sciences |
Salicylic acid, BP, Ph. Eur grade
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Global Essence |
Salicylic Acid Natural
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Graham Chemical |
Salicylic Acid
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Lipo Chemicals |
Lipo® CD-SA
Odor: characteristic Use: Lipo® CD-SA is an aqueous solution of cyclodextrin-encapsulated salicylic acid. Salicylic acid is a topical keratolytic agent. This compound is used in many personal care products to enhance exfoliation of the surface stratum corneum and in acne treatment products. |
Penta International |
SALICYLIC ACID FOOD GRADE
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Penta International |
SALICYLIC ACID NATURAL
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Penta International |
SALICYLIC ACID USP CRYSTAL
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Penta International |
SALICYLIC ACID USP POWDER
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Santa Cruz Biotechnology |
For experimental / research use only. |
Salicylic Acid ≥99%
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Sigma-Aldrich |
Salicylic acid, ≥99%, FG
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Certified Food Grade Products |
Silver Fern Chemical |
Salicylic Acid
Odor: characteristic Use: Salicylic Acid is widely used in the cosmetics, personal care, and pharmaceutical industries. It is also used in the manufacture of aspirin and salicylates, resins, as a food preservative, and a fungicide. |
TCI AMERICA |
For experimental / research use only. |
2-Hydroxybenzoic Acid >99.5%(T)
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Ungerer & Company |
Salicylic Acid Natural
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Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | Xn - Harmful. |
R 22 - Harmful if swallowed. R 36/38 - Irritating to skin and eyes. R 41 - Risk of serious damage to eyes. S 02 - Keep out of the reach of children. S 20/21 - When using do not eat, drink or smoke. S 22 - Do not breath dust. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 - Wear suitable gloves and eye/face protection.
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
oral-rat LD50 891 mg/kg BEHAVIORAL: MUSCLE WEAKNESS
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 21-3/1971
oral-mouse LD50 480 mg/kg "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 148, 1959.
oral-rabbit LD50 1300 mg/kg Drugs in Japan Vol. 6, Pg. 291, 1982.
intraperitoneal-rat LD50 157 mg/kg BEHAVIORAL: TREMOR
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 57(7-8), Pg. 31, 1992.
oral-mouse LD50 908 mg/kg (Sado, 1973)
gavage-rat LD50 1050 mg/kg (Hasegawa et al., 1989)
oral-cat LD50 400 mg/kg "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 148, 1959.
intraperitoneal-mouse LD50 300 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Gendai no Rinsho. Vol. 3, Pg. 675, 1969.
intravenous-mouse LD50 184 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Yakugaku Zasshi. Journal of Pharmacy. Vol. 91, Pg. 550, 1971.
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Dermal Toxicity: |
skin-rabbit LD50 > 10000 mg/kg BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 21-3/1971
skin-rat LD50 > 2000 mg/kg LIVER: OTHER CHANGES
SKIN AND APPENDAGES (SKIN): HAIR: OTHER Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 15(Suppl
subcutaneous-mouse LD50 520 mg/kg BEHAVIORAL: MUSCLE WEAKNESS
CARDIAC: CHANGE IN RATE Archives Internationales de Pharmacodynamie et de Therapie. Vol. 38, Pg. 9, 1930.
subcutaneous-rabbit LDLo 6000 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1392, 1935.
skin-man TDLo 57 mg/kg SENSE ORGANS AND SPECIAL SENSES: TINNITUS: EAR JAMA, Journal of the American Medical Association. Vol. 244, Pg. 660, 1980.
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Inhalation Toxicity: |
inhalation-rat LC50 > 900 mg/m3/1H BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 21-3/1971
inhalation-mammal (species unspecified) LC50 > 300 mg/m3 Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 57(7-8), Pg. 31, 1992.
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Safety in Use Information:
Category: | stabilizing agents |
Recommendation for ortho-salicylic acid usage levels up to: | | not for fragrance use.
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Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.024 (μg/capita/day) |
Maximised Survey-derived Daily Intakes (MSDI-USA): | 0.03 (μg/capita/day) |
Structure Class: | I |
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
publication number: 20 |
Click here to view publication 20 |
| average usual ppm | average maximum ppm |
baked goods: | - | - |
beverages(nonalcoholic): | 5.00000 | 50.00000 |
beverages(alcoholic): | 10.00000 | 100.00000 |
breakfast cereal: | - | - |
cheese: | - | - |
chewing gum: | - | - |
condiments / relishes: | - | - |
confectionery froastings: | - | - |
egg products: | - | - |
fats / oils: | - | - |
fish products: | - | - |
frozen dairy: | 10.00000 | 100.00000 |
fruit ices: | 10.00000 | 100.00000 |
gelatins / puddings: | - | - |
granulated sugar: | - | - |
gravies: | - | - |
hard candy: | - | - |
imitation dairy: | - | - |
instant coffee / tea: | - | - |
jams / jellies: | 10.00000 | 100.00000 |
meat products: | - | - |
milk products: | 5.00000 | 50.00000 |
nut products: | - | - |
other grains: | - | - |
poultry: | - | - |
processed fruits: | - | - |
processed vegetables: | - | - |
reconstituted vegetables: | - | - |
seasonings / flavors: | - | - |
snack foods: | - | - |
soft candy: | - | - |
soups: | - | - |
sugar substitutes: | - | - |
sweet sauces: | - | - |
Safety References:
Flavor & Extract Manufacturers Association (FEMA) reference(s): |
The FEMA GRAS assessment of hydroxyl- and alkoxy-substituted benzyl derivatives used as flavor ingredients. View pdf |
European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
European Food Safety Authority (EFSA) reference(s): |
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 20 (FGE.20): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical group 23 View page or View pdf |
Flavouring Group Evaluation 52 (FGE.52): Consideration of hydroxy- and alkoxy-substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
Flavouring Group Evaluation 54 (FGE.54)[1] - Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20 (2005) - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf |
Flavouring Group Evaluation 9, Revision 1: (FGE.09 Rev1)[1] - Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols from chemical groups 8 and 30, and an ester of a phenol carboxylic acid from chemical group 25 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf |
Flavouring Group Evaluation 20, Revision 1 (FGE.20Rev1): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters from chemical group 23 View page or View pdf |
Flavouring Group Evaluation 54, Revision 1 (FGE.54Rev1): Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20Rev1 (2009) View page or View pdf |
Scientific Report of EFSA on the risk assessment of salts of authorised acids, phenols or alcohols for use in food contact materials [1] View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 20, Revision 2 (FGE.20Rev2): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf |
Flavouring Group Evaluation 9, Revision 2 (FGE.09Rev2): Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols from chemical group 8 and 30, and an ester of a phenol derivative from chemical group 25 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf |
EPI System: | View |
ClinicalTrials.gov: | search |
Daily Med: | search |
NIOSH International Chemical Safety Cards: | search |
Chemical Carcinogenesis Research Information System: | Search |
AIDS Citations: | Search |
Cancer Citations: | Search |
Toxicology Citations: | Search |
EPA GENetic TOXicology: | Search |
EPA Substance Registry Services (TSCA): | 69-72-7 |
EPA ACToR: | Toxicology Data |
EPA Substance Registry Services (SRS): | Registry |
Laboratory Chemical Safety Summary : | 338 |
National Institute of Allergy and Infectious Diseases: | Data |
SCCNFP: | opinion |
WGK Germany: | 1 |
| 2-hydroxybenzoic acid |
Chemidplus: | 0000069727 |
EPA/NOAA CAMEO: | hazardous materials |
RTECS: | 69-72-7 |
References:
Other Information:
(IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
Videos: | The Periodic Table of Videos |
tgsc: | Atomic Weights use for this web site |
(IUPAC): | Periodic Table of the Elements |
FDA Substances Added to Food (formerly EAFUS): | View |
FDA Indirect Additives used in Food Contact Substances: | View |
CHEBI: | View |
CHEMBL: | View |
Golm Metabolome Database: | Search |
Metabolomics Database: | Search |
UM BBD: | Search |
KEGG (GenomeNet): | C00805 |
HMDB (The Human Metabolome Database): | HMDB01895 |
FooDB: | FDB000882 |
YMDB (Yeast Metabolome Database): | YMDB01322 |
Export Tariff Code: | 2918.29.0800 |
MedlinePlusSupp: | View |
VCF-Online: | VCF Volatile Compounds in Food |
ChemSpider: | View |
Wikipedia: | View |
Formulations/Preparations: salicylic acid formulations:
salicylic acid formulations:
preparation
dose (%)
product
manufacturer
fostex medicated cleansing bar
bristol-myers
salicylic acid cleansing bar
stiefel
cream
fostex medicated cleansing cream
bristol-myers
deep cleansing shower gel
glaxosmithkline
neutrogena clear pore treatment
neutrogena
propa ph peel-off acne mask
stri-dex clear gel maximum strength (with sd alcohol 9.3%)
blistex
hydrisalic (with sd alcohol 40b and propylene glycol)
pedinol
clear away gel (with alcohol 57.6% ww, ether 16.4% ww in flexible collodion)
schering-plough
compound w gel (with alcohol 57.6% and ether 16.42% in flexible collodion)
medtech
duoplant gel (with alcohol 67.5% in flexible collodion)
schering-plough
lotion
salac acne medication-cleanser (with benzyl alcohol)
bioglan
sebasorb (with attapulgite activated 10%)
summers
ointment
mg 217 sal-acid
triton
plaster
trans-ver-sal (with propylene glycol)
clear away
schering-plough
clear away plantar system
schering-plough
compound w one step pads
medtech
freezone pads
medtech
mediplast
beiersdorf
sal-acid
pedinol
pledgets (saturated with solution)
oxy balance daily cleansing pads (with sd alcohol 40b 40% and propylene glycol)
glaxosmithkline
stri-dex regular strength pads (with sd alcohol 28%)
blistex
stri-dex sensitive skin pads (with sd alcohol 28% and aloe)
blistex
noxzema 2-in-1 pads extra strength
procter & gamble
oxy balance maximum daily cleansing pads (with sd alcohol 40b 50% and propylene glycol)
glaxosmithkline
stayclear deep cleaning pads
boots
stri-dex pads maximum strength (with sd alcohol 40 44%)
blistex
stri-dex super scrub pads (with sd alcohol 54%)
blistex
shampoo
ionil plus (with sd alcohol 40 12%)
healthpoint
dhs sal shampoo
person & covey
neutrogena tsal maximum strength
neutrogena
solution
propa ph cleanser (with sd alcohol 40 25% and aloe)
propa ph normalsensitive astringent cleanser
sebucare lotion (with alcohol 61%)
bristol-myers squibb
multi-action astringent (with alcohol 38.8%)
glaxosmithkline
noxzema 2-in-1 astringent
procter & gamble
propa ph foaming face wash
propa ph maximum strength astringent cleanser
stayclear zone-controlled clearstick
boots
gordofilm (in flexible collodian)
gordon
clear away liquid (with 17% sd alcohol 32, ether 52% in flexible collodion)
schering-plough
compound w solution (with alcohol 21.2% and ether 63.5% in flexible collodion)
medtech
duofilm (with alcohol sd 32 17% and ether 52% in flexible collodion)
schering-plough
occlusal-hp (with isopropyl alcohol 63% in a polyacrylic vehicle)
bioglan
off-ezy wart remover (with alcohol 21% and ether 65% in flexible collodion)
salactic film (with isopropyl alcohol 2.7% in a flexible collodion)
pedinol
sal-plant gel (with isopropyl alcohol 2.5% in flexible collodion)
pedinol
wart-off (with alcohol 26.35% in flexible collodion)
pfizer
freezone (with alcohol 20.5% and ether 65.5% in flexible collodion)
medtech
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Potential Blenders and core components note
Potential Uses:
| antidandruff agents | |
| bacteriostatic | |
| castoreum | FR |
| fungicide | |
| hair conditioning | |
| keratolytics | |
| preservatives | |
| skin conditioning | |
Occurrence (nature, food, other): note
Synonyms:
| acidum salicylicum | | amiperfect | | amipreserve | | benzoic acid, 2-hydroxy- | | benzoic acid, o-hydroxy- | 2- | carboxyphenol | o- | carboxyphenol | ortho- | carboxyphenol | | compound W | | domerine | | duofilm | | duoplant | | fostex | | freezone | 2- | hydroxy-benzoic acid | 2- | hydroxybenzene carboxylic acid | 2- | hydroxybenzenecarboxylic acid | 2- | hydroxybenzoic acid | o- | hydroxybenzoic acid | ortho- | hydroxybenzoic acid | | phenol-2-carboxylic acid | | retarder W | 2- | salicylic acid | o- | salicylic acid | | salicylic acid crystalline/powder | | salicylic acid natural | | salicylic acid USP crystal | | salicylic acid USP powder | | saligel | | salonil | | sebucare | | verrugon |
Articles:
PubMed: | Effects of salicylic acid and putrescine on storability, quality attributes and antioxidant activity of plum cv. 'Santa Rosa'. |
J-Stage: | Cellulase Applied to the Leaves of Sweet Pepper (Capsicum annuum L. var. grossum) Upregulates the Production of Salicylic and Azelaic Acids |
PubMed: | Effects of postharvest salicylic acid dipping on Alternaria rot and disease resistance of jujube fruit during storage. |
PubMed: | After-ripening induced transcriptional changes of hormonal genes in wheat seeds: the cases of brassinosteroids, ethylene, cytokinin and salicylic acid. |
PubMed: | Evaluation of the pharmacological properties of salicylic acid-derivative organoselenium: 2-hydroxy-5-selenocyanatobenzoic acid as an anti-inflammatory and antinociceptive compound. |
PubMed: | Toxicology of isoproturon to the food crop wheat as affected by salicylic acid. |
PubMed: | Eugenol enhances the resistance of tomato against tomato yellow leaf curl virus. |
PubMed: | Reciprocal crosstalk between jasmonate and salicylate defence-signalling pathways modulates plant volatile emission and herbivore host-selection behaviour. |
PubMed: | Application of Tb(4)O(7) nanoparticles for lasalocid and salicylate determination in food analysis. |
PubMed: | A systemic response of geophytes is demonstrated by patterns of protein expression and the accumulation of signal molecules in Zantedeschia aethiopica. |
PubMed: | Biotic elicitors effectively increase the glucosinolates content in Brassicaceae sprouts. |
PubMed: | Opening of Iris flowers is regulated by endogenous auxins. |
PubMed: | The effects of host defence elicitors on betacyanin accumulation in Amaranthus mangostanus seedlings. |
PubMed: | Two centrosymmetric dinuclear phenanthroline-copper(II) complexes with 3,5-dichloro-2-hydroxybenzoic acid and 5-chloro-2-hydroxybenzoic acid. |
PubMed: | Influence of elicitation with H₂O₂ on phenolics content, antioxidant potential and nutritional quality of Lens culinaris sprouts. |
PubMed: | Novel interrelationship between salicylic acid, abscisic acid, and PIP2-specific phospholipase C in heat acclimation-induced thermotolerance in pea leaves. |
PubMed: | [Changes in H2O2 and salicylic acid contents as well as plasma membrane H+-ATPase activity and their relations in pea leaves during thermotolerance induction]. |
PubMed: | Phenolic Compounds from Halimodendron halodendron (Pall.) Voss and Their Antimicrobial and Antioxidant Activities. |
PubMed: | Hydrogen peroxide scavenging, antioxidant and anti-radical activity of some phenolic acids. |
PubMed: | Nematicidal activity of mint aqueous extracts against the root-knot nematode Meloidogyne incognita. |
PubMed: | Anti-inflammatory drugs selectively target sporangium development in Mucor. |
PubMed: | New CE-ESI-MS analytical method for the separation, identification and quantification of seven phenolic acids including three isomer compounds in virgin olive oil. |
PubMed: | Effect of chemical systemic acquired resistance elicitors on avenanthramide biosynthesis in oat (Avena sativa). |
PubMed: | Determination of the antioxidant capacity of active food packagings by in situ gas-phase hydroxyl radical generation and high-performance liquid chromatography-fluorescence detection. |
PubMed: | Effect of external stress on density and size of glandular trichomes in full-grown Artemisia annua, the source of anti-malarial artemisinin. |
PubMed: | Pleiotropic changes in Arabidopsis f5h and sct mutants revealed by large-scale gene expression and metabolite analysis. |
PubMed: | Aspirin inhibits secretagogue-stimulated and postprandial pancreatic exocrine secretion in conscious rats. |
PubMed: | Multi-substrate flavonol O-glucosyltransferases from strawberry (Fragaria x ananassa) achene and receptacle. |
PubMed: | Benzothiadiazole induces the accumulation of phenolics and improves resistance to powdery mildew in strawberries. |
PubMed: | Phenolic acid profiles in some small berries. |
PubMed: | Salicylate activity. 3. Structure relationship to systemic acquired resistance. |
PubMed: | Chemical marker for ALS-inhibitor herbicides: 2-aminobutyric acid proportional in sub-lethal applications. |
PubMed: | Development of a yeast bio-assay to screen anti-mitochondrial drugs. |
PubMed: | Inhibition of pancreatic lipase by phenolic acids--examination in vitro. |
PubMed: | Valine pathway is more crucial than phenyl propanoid pathway in regulating capsaicin biosynthesis in Capsicum frutescens mill. |
PubMed: | Metabolic profiling of root exudates of Arabidopsis thaliana. |
PubMed: | Adsorption and Chemical Modification of Phenols on a Silver Surface. |
PubMed: | Is there a role for dietary salicylates in health? |
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