Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | white powder (est) |
Assay: | 95.00 to 100.00 %
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Food Chemicals Codex Listed: | No |
Melting Point: | 63.00 °C. @ 760.00 mm Hg
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Boiling Point: | 286.00 °C. @ 760.00 mm Hg
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Vapor Pressure: | 0.002000 mmHg @ 25.00 °C. (est) |
Flash Point: | 248.00 °F. TCC ( 120.20 °C. ) (est)
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logP (o/w): | 2.231 (est) |
Soluble in: |
| alcohol | | water, very slightly | | water, 1495 mg/L @ 25 °C (est) |
Insoluble in: |
| water |
Organoleptic Properties:
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Odor Type: vanilla |
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Odor Strength: | medium |
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Substantivity: | 232 hour(s) at 100.00 % |
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| warm spicy vanilla guaiacol phenolic carnation |
Odor Description: at 100.00 %. | warm spicy vanilla guaiacol phenolic carnation |
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Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | Xi - Irritant |
R 36/38 - Irritating to skin and eyes. S 02 - Keep out of the reach of children. S 22 - Do not breath dust. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36 - Wear suitable protective clothing.
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
intravenous-mouse LD50 180 mg/kg U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#06782
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | flavor and fragrance agents |
RIFM Fragrance Material Safety Assessment: Search |
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
Recommendation for methyl vanillate usage levels up to: | | 2.0000 % in the fragrance concentrate.
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Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.011 (μg/capita/day) |
Modified Theoretical Added Maximum Daily Intake (mTAMDI): | 3900 (μg/person/day) |
Threshold of Concern: | 1800 (μg/person/day) |
Structure Class: | I |
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Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i). |
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm. |
| average usage mg/kg | maximum usage mg/kg |
Dairy products, excluding products of category 02.0 (01.0): | 7.00000 | 35.00000 |
Fats and oils, and fat emulsions (type water-in-oil) (02.0): | 5.00000 | 25.00000 |
Edible ices, including sherbet and sorbet (03.0): | 10.00000 | 50.00000 |
Processed fruit (04.1): | 7.00000 | 35.00000 |
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): | - | - |
Confectionery (05.0): | 10.00000 | 50.00000 |
Chewing gum (05.0): | - | - |
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): | 5.00000 | 25.00000 |
Bakery wares (07.0): | 10.00000 | 50.00000 |
Meat and meat products, including poultry and game (08.0): | 2.00000 | 10.00000 |
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): | 2.00000 | 10.00000 |
Eggs and egg products (10.0): | - | - |
Sweeteners, including honey (11.0): | - | - |
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): | 5.00000 | 25.00000 |
Foodstuffs intended for particular nutritional uses (13.0): | 10.00000 | 50.00000 |
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): | 5.00000 | 25.00000 |
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): | 10.00000 | 50.00000 |
Ready-to-eat savouries (15.0): | 20.00000 | 100.00000 |
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): | 5.00000 | 25.00000 |
Safety References:
European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
European Food Safety Authority (EFSA) reference(s): |
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 20 (FGE.20): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical group 23 View page or View pdf |
Flavouring Group Evaluation 52 (FGE.52): Consideration of hydroxy- and alkoxy-substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
Flavouring Group Evaluation 54 (FGE.54)[1] - Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20 (2005) - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf |
Flavouring Group Evaluation 20, Revision 1 (FGE.20Rev1): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters from chemical group 23 View page or View pdf |
Flavouring Group Evaluation 54, Revision 1 (FGE.54Rev1): Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20Rev1 (2009) View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 20, Revision 2 (FGE.20Rev2): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 20, Revision 4 (FGE.20Rev4): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf |
EPI System: | View |
AIDS Citations: | Search |
Cancer Citations: | Search |
Toxicology Citations: | Search |
EPA Substance Registry Services (TSCA): | 3943-74-6 |
EPA ACToR: | Toxicology Data |
EPA Substance Registry Services (SRS): | Registry |
Laboratory Chemical Safety Summary : | 19844 |
National Institute of Allergy and Infectious Diseases: | Data |
WGK Germany: | 3 |
| methyl 4-hydroxy-3-methoxybenzoate |
Chemidplus: | 0003943746 |
RTECS: | DH2430000 for cas# 3943-74-6 |
References:
Other Information:
Potential Blenders and core components note
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For Odor |
No odor group found for these |
| bird of paradise fragrance | FR |
anisic |
para- | acetanisole | FL/FR |
ortho- | anisaldehyde | FL/FR |
para- | anisaldehyde | FL/FR |
| methyl para-anisate | FL/FR |
balsamic |
| benzoin | FL/FR |
sumatra | benzoin absolute | FL/FR |
siam | benzoin absolute | FL/FR |
| benzoin absolute replacer | FL/FR |
sumatra | benzoin gum | FL/FR |
siam | benzoin resin | FL/FR |
sumatra | benzoin resin | FL/FR |
| benzoin resin replacer | FR |
sumatra | benzoin resinoid | FL/FR |
siam | benzoin resinoid | FL/FR |
1- | benzoyl acetone | FL/FR |
| ethyl cinnamate | FL/FR |
| peru balsam absolute | FL/FR |
| peru balsam oil | FL/FR |
| peru balsam resinoid | FL/FR |
berry |
| raspberry ketone methyl ether | FL/FR |
caramellic |
| levulinic acid | FL/FR |
chocolate |
| chocolate specialty | FR |
| vanillyl ethyl ether | FL/FR |
coconut |
alpha- | angelica lactone | FL/FR |
coumarinic |
| coumane | FL/FR |
creamy |
| geranyl ethyl acetal | FR |
para- | vanillic acid | FL/FR |
para- | vanillyl alcohol | FL/FR |
| veratraldehyde | FL/FR |
floral |
| acetophenone | FL/FR |
| anisyl propanal / methyl anthranilate schiff's base | FR |
| coffee flower absolute | FR |
para- | cresyl laurate | FL/FR |
| heliotropin | FL/FR |
para- | methyl acetophenone | FL/FR |
fruity |
para- | anisyl propionate | FL/FR |
| ethyl methyl-para-tolyl glycidate | FL/FR |
| guaiacyl propionate | FL/FR |
| tolualdehydes (mixed o,m,p) | FL/FR |
| vanilla carboxylate | FL/FR |
green |
| butyl lactate | FL/FR |
minty |
| menthoxypropane diol | FL/FR |
| vanillin menthoxypropane diol acetal | FL/FR |
musk |
omega- | pentadecalactone | FL/FR |
naphthyl |
2,4- | dimethyl benzaldehyde | FL/FR |
nutty |
| nutty cyclohexenone | FL/FR |
| resorcinol | FR |
2,3,5,6- | tetramethyl pyrazine | FL/FR |
phenolic |
| ethyl vanillate | FL/FR |
ortho- | guaiacol | FL/FR |
powdery |
para- | anisyl acetate | FL/FR |
smoky |
alpha- | ethoxy-ortho-cresol | FL/FR |
spicy |
para- | anisyl formate | FL/FR |
| clove leaf absolute | FR |
| clove leaf resinoid | FR |
| dianthus ethone | FR |
4- | ethyl guaiacol | FL/FR |
| ethyl isoeugenol | FL/FR |
(E)-iso | eugenol | FR |
3-(2- | furyl) acrolein | FL/FR |
(E)-para- | methoxycinnamaldehyde | FL/FR |
para- | methoxycinnamaldehyde | FL/FR |
4- | methyl guaiacol | FL/FR |
cis- | oak lactone | |
| spicy acetoacetate | FL/FR |
| zingerone | FL/FR |
sweet |
| tonka bean absolute replacer | FR |
| vanilla bean absolute (vanilla spp.) | FL/FR |
| vanilla oleoresin bali | FL/FR |
| vanilla resinoid | FL/FR |
| vanilla tahitensis fruit extract | FL/FR |
tonka |
| coumarin | FR |
| mint lactone | FL/FR |
| octahydrocoumarin | FL/FR |
tropical |
| curcuma amada roxb. rhizome oil CO2 extract | FL/FR |
vanilla |
| acetovanillone | FL/FR |
| crème brulee fragrance | FR |
ortho- | dimethyl hydroquinone | FL/FR |
| ethyl vanillin | FL/FR |
| ethyl vanillin acetate | FR |
| ethyl vanillin diethyl acetal | FR |
| ethyl vanillin hexylene glycol acetal | FR |
| ethyl vanillin isobutyrate | FL/FR |
| ethyl vanillin propylene glycol acetal | FL/FR |
| heliotropyl alcohol | FL/FR |
| propenyl guaethol | FL/FR |
iso | propyl vanillin | |
| vanilla | FR |
| vanilla aromatica fruit extract | FL/FR |
| vanilla bean absolute (vanilla planifolia) | FL/FR |
| vanilla bean absolute CO2 extract (vanilla planifolia) | FL/FR |
| vanilla bean fragrance | FR |
| vanilla bean oil (vanilla planifolia) | FR |
| vanilla bean oil (vanilla tahitensis) | FL/FR |
| vanilla bean oil CO2 extract | FL/FR |
| vanilla bean tincture | FR |
| vanilla cresol | FR |
| vanilla extract | FL/FR |
country | vanilla fragrance | FR |
french | vanilla fragrance | FR |
| vanilla fragrance | FR |
| vanilla oleoresin bourbon | FL/FR |
| vanilla planifolia fruit extract | FL/FR |
| vanilla planifolia fruit infusion | FR |
| vanilla planifolia fruit water | FL/FR |
| vanilla specialty | FR |
| vanilla tahitensis fruit absolute | FR |
| vanilla tahitensis fruit absolute CO2 extract | FL/FR |
| vanilla tahitensis fruit oil CO2 extract | FR |
| vanillin | FL/FR |
| vanillin 2,3-butylene glycol acetal | FL/FR |
| vanillin hexylene glycol acetal | FR |
| vanillin propylene glycol acetal | FL/FR |
| vanillyl acetate | FL/FR |
| vanillyl butyl ether | FL/FR |
| vanillyl isobutyrate | FL/FR |
| vanillylidene acetone | FL/FR |
woody |
| guaiacwood oil | FL/FR |
| guaiacyl acetate | FL/FR |
4- | hydroxybenzaldehyde | FL/FR |
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For Flavor |
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No flavor group found for these |
para- | anisyl propionate | FL/FR |
| benzoin | FL/FR |
1- | benzoyl acetone | FL/FR |
| coumane | FL/FR |
ortho- | dimethyl hydroquinone | FL/FR |
alpha- | ethoxy-ortho-cresol | FL/FR |
3-(2- | furyl) acrolein | FL/FR |
| glucoethyl vanillin | FL |
| glucovanillin | FL |
| guaiacyl propionate | FL/FR |
| heliotropyl alcohol | FL/FR |
| menthoxypropane diol | FL/FR |
(E)-para- | methoxycinnamaldehyde | FL/FR |
4- | methoxysalicylaldehyde | FL |
| methyl para-anisate | FL/FR |
cis- | oak lactone | |
iso | propyl vanillin | |
| vanillin menthoxypropane diol acetal | FL/FR |
| vanillyl butyl ether | FL/FR |
| vanilmandelic acid | FL |
acidic |
| levulinic acid | FL/FR |
anisic |
para- | acetanisole | FL/FR |
ortho- | anisaldehyde | FL/FR |
balsamic |
| benzoin absolute replacer | FL/FR |
sumatra | benzoin gum | FL/FR |
sumatra | benzoin resin | FL/FR |
siam | benzoin resin | FL/FR |
sumatra | benzoin resinoid | FL/FR |
siam | benzoin resinoid | FL/FR |
| ethyl cinnamate | FL/FR |
| peru balsam | FL |
| peru balsam absolute | FL/FR |
| peru balsam oil | FL/FR |
| peru balsam resinoid | FL/FR |
| vanillylidene acetone | FL/FR |
berry |
| raspberry ketone methyl ether | FL/FR |
bready |
2- | propionyl thiazole | FL |
cherry |
| heliotropin | FL/FR |
para- | methoxycinnamaldehyde | FL/FR |
coconut |
6- | methyl coumarin | FL |
| octahydrocoumarin | FL/FR |
creamy |
alpha- | angelica lactone | FL/FR |
para- | anisaldehyde | FL/FR |
| divanillin | FL |
| ethyl vanillate | FL/FR |
4- | hydroxybenzaldehyde | FL/FR |
para- | methyl acetophenone | FL/FR |
| mint lactone | FL/FR |
para- | vanillic acid | FL/FR |
para- | vanillyl alcohol | FL/FR |
| veratraldehyde | FL/FR |
floral |
pseudo | ionone | FL |
fruity |
para- | anisyl acetate | FL/FR |
| ethyl methyl-para-tolyl glycidate | FL/FR |
| tolualdehydes (mixed o,m,p) | FL/FR |
| vanilla carboxylate | FL/FR |
green |
| butyl lactate | FL/FR |
meaty |
4- | allyl-2,6-dimethoxyphenol | FL |
ortho- | thioguaiacol | FL |
naphthyl |
2,4- | dimethyl benzaldehyde | FL/FR |
nutty |
| furfural acetone | FL |
| nutty cyclohexenone | FL/FR |
2,3,5,6- | tetramethyl pyrazine | FL/FR |
powdery |
| acetophenone | FL/FR |
| powdery ketone | FL |
rummy |
| vanillyl ethyl ether | FL/FR |
spicy |
para- | anisyl formate | FL/FR |
sumatra | benzoin absolute | FL/FR |
siam | benzoin absolute | FL/FR |
| ethyl isoeugenol | FL/FR |
4- | methyl guaiacol | FL/FR |
| spicy acetoacetate | FL/FR |
| zingerone | FL/FR |
sweet |
| vanilla bean absolute (vanilla spp.) | FL/FR |
| vanilla bean aromatica | FL |
| vanilla bean planifolia | FL |
| vanilla oleoresin bali | FL/FR |
| vanilla resinoid | FL/FR |
| vanilla tahitensis fruit extract | FL/FR |
tropical |
| curcuma amada roxb. rhizome oil CO2 extract | FL/FR |
vanilla |
| acetovanillone | FL/FR |
| ethyl vanillin | FL/FR |
| ethyl vanillin isobutyrate | FL/FR |
| ethyl vanillin propylene glycol acetal | FL/FR |
omega- | pentadecalactone | FL/FR |
| propenyl guaethol | FL/FR |
| vanilla aromatica fruit extract | FL/FR |
| vanilla bean absolute (vanilla planifolia) | FL/FR |
| vanilla bean absolute CO2 extract (vanilla planifolia) | FL/FR |
| vanilla bean oil (vanilla tahitensis) | FL/FR |
| vanilla bean oil CO2 extract | FL/FR |
| vanilla bean tahitensis | FL |
| vanilla extract | FL/FR |
| vanilla oleoresin bourbon | FL/FR |
| vanilla planifolia fruit extract | FL/FR |
| vanilla planifolia fruit water | FL/FR |
| vanilla tahitensis fruit absolute CO2 extract | FL/FR |
| vanillin | FL/FR |
| vanillin 2,3-butylene glycol acetal | FL/FR |
| vanillin propylene glycol acetal | FL/FR |
| vanillyl acetate | FL/FR |
| vanillyl isobutyrate | FL/FR |
waxy |
para- | cresyl laurate | FL/FR |
woody |
4- | ethyl guaiacol | FL/FR |
ortho- | guaiacol | FL/FR |
| guaiacwood oil | FL/FR |
| guaiacyl acetate | FL/FR |
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Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| benzoic acid, 4-hydroxy-3-methoxy-, methyl ester | 4- | hydroxy-3-methoxybenzoic acid methyl ester | | methyl 3-methoxy-4-hydroxybenzoate | | methyl 4-hydroxy-3-methoxybenzoate | | vanillic acid methyl ester | | vanillic acid, methyl ester |
Articles:
PubMed: | [Chemical constituents of Illicium burmanicum]. |
J-Stage: | Antioxidative Properties of Vanillic Acid Esters in Multiple Antioxidant Assays |
PubMed: | Laccase catalyzed synthesis of iodinated phenolic compounds with antifungal activity. |
PubMed: | Hovenia dulcis Thunb extract and its ingredient methyl vanillate activate Wnt/β-catenin pathway and increase bone mass in growing or ovariectomized mice. |
PubMed: | Polyphenolic profile as a useful tool to identify the wood used in wine aging. |
PubMed: | Antioxidative properties of vanillic acid esters in multiple antioxidant assays. |
PubMed: | Constituents with tyrosinase inhibitory activities from branches of Ficus erecta var. sieboldii King. |
PubMed: | Phenolic compounds in cherry ( Prunus avium ) heartwood with a view to their use in cooperage. |
PubMed: | Prediction of solubility of drugs and other compounds in organic solvents. |
PubMed: | Volatile compounds of red wines macerated with Spanish, American, and French oak chips. |
PubMed: | Novel caffeic acid ester derivative induces apoptosis by expressing FasL and downregulating NF-KappaB: Potentiation of cell death mediated by chemotherapeutic agents. |
PubMed: | Downregulation of inflammatory responses by novel caffeic acid ester derivative by inhibiting NF-kappa B. |
PubMed: | Oxidation of lignin using aqueous polyoxometalates in the presence of alcohols. |
PubMed: | Preparation of lipophilic alkyl (hydroxy)benzoates by solvent-free lipase-catalyzed esterification and transesterification. |
PubMed: | Linear sesquiterpene lactones from Anthemis auriculata and their antibacterial activity. |
PubMed: | Neuroprotective and free radical scavenging activities of phenolic compounds from Hovenia dulcis. |
PubMed: | Lignin-derived compounds as efficient laccase mediators for decolorization of different types of recalcitrant dyes. |
PubMed: | Molecular determinants of substrate specificity in the feruloyl esterase module of xylanase 10B from Clostridium thermocellum. |
PubMed: | Purification and characterization of PrbA, a new esterase from Enterobacter cloacae hydrolyzing the esters of 4-hydroxybenzoic acid (parabens). |
PubMed: | Isolation and characterization of a veratrol:corrinoid protein methyl transferase from Acetobacterium dehalogenans. |
PubMed: | Field Efficacy of Verticillium lecanii, Sex Pheromone, and Pheromone Analogs as Potential Management Agents for Soybean Cyst Nematode. |
PubMed: | Isoprenyl phenyl ethers from liverworts of the genus Trichocolea: cytotoxic activity, structural corrections, and synthesis. |
PubMed: | Application of a Sex Pheromone, Pheromone Analogs, and Verticillium lecanii for Management of Heterodera glycines. |
PubMed: | Aristolochic acids, aristolactam alkaloids and amides from Aristolochia kankauensis. |
PubMed: | Corrinoid-Dependent Methyl Transfer Reactions Are Involved in Methanol and 3,4-Dimethoxybenzoate Metabolism by Sporomusa ovata. |
PubMed: | Multichannel coulometric detection coupled with liquid chromatography for determination of phenolic esters in honey. |
PubMed: | The influence of heat on the aroma of cloudberries (rubus Chamaemorus l.). |
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