Category: flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | pale yellow to dark red solid (est) |
Assay: | 95.00 to 100.00 %
|
Food Chemicals Codex Listed: | No |
Specific Gravity: | 1.11000 to 1.12500 @ 20.00 °C.
|
Pounds per Gallon - (est).: | 9.247 to 9.372
|
Refractive Index: | 1.61200 to 1.62400 @ 20.00 °C.
|
Melting Point: | 132.00 °C. @ 760.00 mm Hg
|
Boiling Point: | 245.00 to 247.00 °C. @ 760.00 mm Hg
|
Vapor Pressure: | 0.049000 mmHg @ 25.00 °C. (est) |
Vapor Density: | 4.9 ( Air = 1 ) |
Flash Point: | 197.00 °F. TCC ( 91.67 °C. )
|
logP (o/w): | 1.610 |
Soluble in: |
| alcohol | | water, 3391 mg/L @ 25 °C (est) |
Insoluble in: |
| water |
Organoleptic Properties:
|
Odor Type: coffee |
|
| toasted coffee roasted coffee nutty fruity |
Odor Description: at 0.10 % in dipropylene glycol. | toasted coffee nutty fruity |
|
|
Flavor Type: burnt |
|
| phenolic burnt coffee roasted coffee nutty |
Taste Description:
| phenolic burnt coffee nutty |
|
Odor and/or flavor descriptions from others (if found). |
|
R C Treatt & Co Ltd |
2-Methylquinoxaline NI, Kosher |
Odor Description: | Toasted, roasted, burnt, nutty notes |
Taste Description: | burnt, roasted hazelnut-like Used in coffee and roast nut flavours. Normal use levels in finished consumer product: 0.1-10 ppm. Council of Europe limits: Foods (10 ppm); Beverages (10 ppm).C137 |
|
|
Cosmetic Information:
Suppliers:
Beijing Lys Chemicals |
2-Methyl quinoxaline
|
BOC Sciences |
For experimental / research use only. |
2-Methylquinoxaline 95%
|
Charkit Chemical |
METHYLQUINOXALINE, 2- M2450
|
DeLong Chemicals America |
2-Methyl quinoxaline, Kosher
|
Diffusions Aromatiques |
2-METHYLQUINOXALINE
|
Endeavour Specialty Chemicals |
2-Methylquinoxaline 98% F&F
|
Speciality Chemical Product Groups |
Ernesto Ventós |
2-METHYLQUINOXALINE
Odor: COFFEE, NUTTY, ROAST, TOASTED |
Matrix Scientific |
For experimental / research use only. |
2-Methylquinoxaline, 98%
|
Penta International |
2-METHYL QUINOXALINE
|
R C Treatt & Co Ltd |
2-Methylquinoxaline (1% in DPG)
|
R C Treatt & Co Ltd |
2-Methylquinoxaline
NI, Kosher Odor: Toasted, roasted, burnt, nutty notes Flavor: burnt, roasted hazelnut-like Used in coffee and roast nut flavours. Normal use levels in finished consumer product: 0.1-10 ppm. Council of Europe limits: Foods (10 ppm); Beverages (10 ppm).C137 |
Robinson Brothers |
2-Methylquinoxaline F&F
|
https://www.robinsonbrothers.uk/chemistry-competences |
Sigma-Aldrich |
2-Methylquinoxaline, ≥97%
|
Certified Food Grade Products |
Synerzine |
2-Methyl Quinoxaline
|
Taytonn ASCC |
2-Methylquinoxaline
Odor: Coffee, Nutty, Roast, Toasted |
TCI AMERICA |
For experimental / research use only. |
2-Methylquinoxaline >98.0%(GC)
|
WholeChem |
2-Methyl quinoxaline
|
Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | Xi - Irritant |
R 36/37/38 - Irritating to eyes, respiratory system, and skin. S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 - Wear suitable gloves and eye/face protection.
|
|
Hazards identification |
|
Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
|
Pictogram | |
|
Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
Not determined
|
Dermal Toxicity: |
Not determined
|
Inhalation Toxicity: |
Not determined
|
Safety in Use Information:
Category: | flavoring agents |
Recommendation for 2-methyl quinoxaline usage levels up to: | | not for fragrance use.
|
|
Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.12 (μg/capita/day) |
Modified Theoretical Added Maximum Daily Intake (mTAMDI): | 270 (μg/person/day) |
Threshold of Concern: | 90 (μg/person/day) |
Structure Class: | III |
|
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i). |
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm. |
| average usage mg/kg | maximum usage mg/kg |
Dairy products, excluding products of category 02.0 (01.0): | 0.40000 | 2.00000 |
Fats and oils, and fat emulsions (type water-in-oil) (02.0): | 0.10000 | 0.50000 |
Edible ices, including sherbet and sorbet (03.0): | 0.40000 | 2.00000 |
Processed fruit (04.1): | 0.40000 | 2.00000 |
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): | - | - |
Confectionery (05.0): | 1.00000 | 5.00000 |
Chewing gum (05.0): | - | - |
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): | 0.20000 | 1.00000 |
Bakery wares (07.0): | 1.00000 | 5.00000 |
Meat and meat products, including poultry and game (08.0): | 0.10000 | 0.40000 |
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): | 0.10000 | 0.40000 |
Eggs and egg products (10.0): | - | - |
Sweeteners, including honey (11.0): | - | - |
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): | 0.10000 | 0.50000 |
Foodstuffs intended for particular nutritional uses (13.0): | 0.20000 | 1.00000 |
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): | 0.20000 | 1.00000 |
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): | 1.00000 | 5.00000 |
Ready-to-eat savouries (15.0): | 1.00000 | 5.00000 |
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): | 0.20000 | 1.00000 |
Safety References:
European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
European Food Safety Authority (EFSA) reference(s): |
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) View page or View pdf |
Flavouring Group Evaluation 50 (FGE.50): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) [1] View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010) View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 17, Revision 3 (FGE.17Rev3): Pyrazine derivatives from chemical group 24 View page or View pdf |
EPI System: | View |
Chemical Carcinogenesis Research Information System: | Search |
AIDS Citations: | Search |
Cancer Citations: | Search |
Toxicology Citations: | Search |
EPA ACToR: | Toxicology Data |
EPA Substance Registry Services (SRS): | Registry |
Laboratory Chemical Safety Summary : | 23686 |
National Institute of Allergy and Infectious Diseases: | Data |
WGK Germany: | 3 |
| 2-methylquinoxaline |
Chemidplus: | 0007251618 |
RTECS: | VD3450000 for cas# 7251-61-8 |
References:
Other Information:
Potential Blenders and core components note
|
For Odor |
No odor group found for these |
| sulfuryl octanoate | FL/FR |
| sulfuryl butyrate | FL/FR |
| sulfuryl decanoate | FL/FR |
| sulfuryl hexanoate | FL/FR |
| sulfuryl isobutyrate | FL/FR |
| sulfuryl propionate | FL/FR |
| valeraldehyde dibutyl acetal | FL/FR |
| valeraldehyde propylene glycol acetal | FL/FR |
| methyl furfuryl disulfide | FL/FR |
balsamic |
2- | acetyl furan | FL/FR |
| propyl benzoate | FL/FR |
bready |
| coffee furanone | FL/FR |
buttery |
| acetyl propionyl | FL/FR |
3,4- | hexane dione | FL/FR |
camphoreous |
| bornyl isobutyrate | FL/FR |
| caramel furanone solution | FL/FR |
| coffee dione | FL/FR |
| cyclotene | FL/FR |
| ethyl 2-hydroxy-2-methyl butyrate | FL/FR |
| fenugreek absolute | FL/FR |
| fenugreek oleoresin | FL/FR |
5- | methyl furfural | FL/FR |
iso | propenyl pyrazine | FL/FR |
chocolate |
| chocolate pyrazine A | FL/FR |
| cocoa hexenal | FL/FR |
2,5- | dimethyl pyrazine | FL/FR |
2,6- | dimethyl pyrazine | FL/FR |
2- | methoxypyrazine | FL/FR |
2,4,5- | trimethyl thiazole | FL/FR |
cocoa |
2- | methyl butyraldehyde | FL/FR |
coconut |
alpha- | angelica lactone | FL/FR |
gamma- | heptalactone | FL/FR |
coffee |
| cichorium intybus root extract | FL/FR |
| cichorium intybus root solid extract | FL/FR |
roasted | coffea arabica seed extract | FL/FR |
| coffea arabica seed extract | FL/FR |
| coffea arabica seed oil | FL/FR |
| coffee absolute | FL/FR |
arabica | coffee bean butter | FL/FR |
roasted arabica | coffee bean essence | FL/FR |
roasted | coffee bean extract | FL/FR |
roasted arabica | coffee bean oil | FL/FR |
roasted arabica | coffee bean oil CO2 extract | FL/FR |
| coffee bean oil extract | FL/FR |
| coffee difuran | FL/FR |
| coffee resinoid | FL/FR |
| furfuryl mercaptan | FL/FR |
1- | hydroxy-2-butanone | FL/FR |
2- | methyl-3-,5 or 6-(furfuryl thio) pyrazine | FL/FR |
| popcorn pyrimidine | FL/FR |
coumarinic |
| coumane | FL/FR |
2- | ethyl-3-methoxypyrazine | FL/FR |
| nutty pyrazine | FL/FR |
ethereal |
| acetal | FL/FR |
fatty |
| coconut absolute | FL/FR |
fermented |
| valeraldehyde | FL/FR |
floral |
(-)-alpha- | bisabolol | FL/FR |
para- | cresyl laurate | FL/FR |
ortho- | methyl acetophenone | FL/FR |
fruity |
| allyl 2-ethyl butyrate | FL/FR |
iso | amyl nonanoate | FL/FR |
| benzaldehyde | FL/FR |
| guaiacyl propionate | FL/FR |
| methyl valerate | FL/FR |
3- | methyl-2-butenal | FL/FR |
| tropical thiazole | FL/FR |
2- | heptyl furan | FL/FR |
(E,Z)-2,6- | nonadien-1-yl acetate | FL/FR |
| tiglaldehyde | FL/FR |
herbal |
| thymyl methyl ether | FL/FR |
| wormwood oil america | FL/FR |
| wormwood oil italy | FL/FR |
| wormwood oil poland | FL/FR |
medicinal |
2,6- | xylenol | FL/FR |
moldy |
| strawberry furanone methyl ether | FL/FR |
musty |
2- | acetyl pyrrole | FL/FR |
3- | acetyl-2,5-dimethyl furan | FL/FR |
| hazelnut pyrazine | FL/FR |
| menthofuran | FL/FR |
naphthyl |
ortho- | methyl anisole | FL/FR |
para- | methyl anisole | FL/FR |
nutty |
3- | acetyl pyridine | FL/FR |
2- | acetyl-3-ethyl pyrazine | FL/FR |
2- | acetyl-3-methyl pyrazine | FL/FR |
2- | acetyl-3,5-dimethyl pyrazine | FL/FR |
2- | acetyl-5-methyl furan | FL/FR |
3,6- | cocoa pyrazine | FL/FR |
3,5- | cocoa pyrazine | FL/FR |
2,3- | dimethyl pyrazine | FL/FR |
4,5- | dimethyl-2-ethyl-3-thiazoline | FL/FR |
2- | ethyl pyrazine | FL/FR |
2- | ethyl-4-methyl thiazole | FL/FR |
| filbert heptenone | FL/FR |
| filbert heptenone B | FL/FR |
| filbert pyrazine | FL/FR |
(+)-(E,S)- | filbertone | FL/FR |
(-)-(E,R)- | filbertone | FL/FR |
european | hazelnut absolute | FL/FR |
roasted | hazelnut infusions | FL/FR |
european | hazelnut oil CO2 extract | FL/FR |
2,6- | lutidine | FL/FR |
2- | methyl pyrazine | FL/FR |
5- | methyl quinoxaline | FL/FR |
2- | methyl thio-3,5 or 6-methyl pyrazine | FL/FR |
2- | methyl-3-(methyl thio) pyrazine | FL/FR |
2- | methyl-3-ethoxypyrazine | FL/FR |
2- | methyl-3-propyl pyrazine | FL/FR |
| nutty cyclohexenone | FL/FR |
| nutty quinoxaline | FL/FR |
| sesame absolute | FL/FR |
| sesame absolute CO2 extract | FL/FR |
| shoyu pyrazine | FL/FR |
2,3,5,6- | tetramethyl pyrazine | FL/FR |
2,4,5- | trimethyl oxazole | FL/FR |
2,3,5- | trimethyl pyrazine | FL/FR |
| vinyl sulfurol | FL/FR |
phenolic |
para-alpha- | dimethyl styrene | FL/FR |
popcorn |
2- | acetyl pyrazine | FL/FR |
2- | acetyl thiazole | FL/FR |
roasted |
2- | acetyl-2-pyrroline | |
| fenugreek resinoid | FL/FR |
| trigonella foenum-graecum seed oil CO2 extract | FL/FR |
spicy |
3-(2- | furyl) acrolein | FL/FR |
sulfurous |
| benzothiazole | FL/FR |
| furfuryl thioacetate | FL/FR |
S- | furfuryl thioformate | FL/FR |
2- | methyl 5-(methyl thio) furan | FL/FR |
O- | methyl S-1-methoxyhexan-3-yl carbonothioate | FL/FR |
3- | thiohexanol | FL/FR |
sweet |
2- | hydroxy-3,4,5-trimethyl-2-cyclopenten-1-one | FL/FR |
tonka |
| whiskey lactone | FL/FR |
1- | furfuryl pyrrole | FL/FR |
| tetrahydrofurfuryl alcohol | FL/FR |
woody |
| juniper berry oleoresin | FL/FR |
| sandalwood oil | FL/FR |
|
For Flavor |
|
No flavor group found for these |
| acetyl acetaldehyde dimethyl acetal | FL |
2- | acetyl-2-pyrroline | |
2- | acetyl-6-methyl pyrazine | FL |
(E)- | aconitic acid | FL |
(-)-alpha- | bisabolol | FL/FR |
| bornyl isobutyrate | FL/FR |
| butyramide | FL |
| chocolate pyrazine A | FL/FR |
| chocolate pyrazine B | FL |
| cocos nucifera water | FL |
| coumane | FL/FR |
| cyclohexyl methyl pyrazine | FL |
2,5- | diethyl thiazole | FL |
2,5- | diethyl-4-methyl thiazole | FL |
6,7- | dihydro-2,3-dimethyl-5H-cyclopentapyrazine | FL |
| dimethyl dihydrocyclopentapyrazine | FL |
2,5- | dimethyl thiazole | FL |
2,5- | dimethyl-3-thiofuroyl furan | FL |
| ethyl 2-hydroxy-2-methyl butyrate | FL/FR |
2- | ethyl-3-methoxypyrazine | FL/FR |
(Z+E)-5- | ethyl-4-methyl-2-(2-butyl) thiazoline | FL |
(Z+E)-5- | ethyl-4-methyl-2-(2-methyl propyl) thiazoline | FL |
2- | formyl pyrrole | FL |
3-(2- | furyl) acrolein | FL/FR |
| guaiacyl propionate | FL/FR |
(E,E)-2,4- | heptadien-1-ol | FL |
2- | hexyl-5 or 6-keto-1,4-dioxane | FL |
2- | hydroxy-3,4,5-trimethyl-2-cyclopenten-1-one | FL/FR |
3- | mercapto-3-methyl butyl formate | FL |
2- | methoxypyrazine | FL/FR |
| methyl 2-(methyl thio) acetate | FL |
2- | methyl-3-,5 or 6-(furfuryl thio) pyrazine | FL/FR |
2- | methyl-3-(methyl thio) pyrazine | FL/FR |
2- | methyl-3-ethoxypyrazine | FL/FR |
| peanut dithiazine | FL |
2- | propyl pyridine | FL |
| pyrazines mixture | FL |
| pyrrole | FL |
para- | salicylic acid | FL |
| sulfuryl butyrate | FL/FR |
| sulfuryl decanoate | FL/FR |
| sulfuryl hexanoate | FL/FR |
| sulfuryl isobutyrate | FL/FR |
| thiazole | FL |
| valeraldehyde propylene glycol acetal | FL/FR |
|
5- | acetyl-2,3-dihydro-1,4-thiazine | FL |
| sulfuryl formate | FL |
| sulfuryl octanoate | FL/FR |
| sulfuryl propionate | FL/FR |
| valeraldehyde dibutyl acetal | FL/FR |
absinthe |
| absinthe flavor | FL |
alliaceous |
| benzyl mercaptan | FL |
| dicyclohexyl disulfide | FL |
2- | methyl thioacetaldehyde | FL |
| tropical thiazole | FL/FR |
anisic |
ortho- | methyl acetophenone | FL/FR |
astringent |
2- | methyl pyridine | FL |
bready |
2- | propionyl thiazole | FL |
brown |
| fenugreek oleoresin | FL/FR |
1- | hydroxy-2-butanone | FL/FR |
5- | methyl furfural | FL/FR |
burnt |
| bacon dithiazine | FL |
| furfuryl alcohol | FL |
1-(2- | furfuryl thio) propanone | FL |
iso | propenyl pyrazine | FL/FR |
2,4,5- | trimethyl oxazole | FL/FR |
2,6- | xylenol | FL/FR |
buttery |
| butyroin | FL |
3,4- | hexane dione | FL/FR |
camphoreous |
ortho- | methyl anisole | FL/FR |
caramellic |
| caramel furanone | FL |
| caramel furanone solution | FL/FR |
| cyclotene | FL/FR |
| fenugreek absolute | FL/FR |
| fenugreek resinoid | FL/FR |
chocolate |
| mocha cream flavor | FL |
cocoa |
| chocolate enhancers | FL |
| cocoa hexenal | FL/FR |
coffee |
| cappuccino flavor | FL |
| chicory flavor | FL |
| chicory root distillates | FL |
| chicory root essence | FL |
roasted | chicory root oil | FL |
| chicory tincture | FL |
| cichorium intybus root extract | FL/FR |
| cichorium intybus root solid extract | FL/FR |
| coffea arabica seed extract | FL/FR |
roasted | coffea arabica seed extract | FL/FR |
| coffea arabica seed oil | FL/FR |
| coffea canephora seed extract | FL |
| coffee absolute | FL/FR |
arabica | coffee bean butter | FL/FR |
roasted | coffee bean concentrate | FL |
roasted arabica | coffee bean essence | FL/FR |
roasted | coffee bean essence | FL |
roasted robusta | coffee bean essence | FL |
roasted | coffee bean extract | FL/FR |
roasted robusta | coffee bean extract | FL |
dried roasted | coffee bean extract | FL |
roasted arabica | coffee bean oil CO2 extract | FL/FR |
| coffee bean oil extract | FL/FR |
| coffee creme brulee flavor | FL |
| coffee difuran | FL/FR |
| coffee dione | FL/FR |
| coffee distillates | FL |
espresso | coffee distillates | FL |
| coffee enhancers | FL |
espresso | coffee essence | FL |
espresso | coffee extract | FL |
irish | coffee flavor | FL |
dark roast | coffee flavor | FL |
| coffee flavor | FL |
espresso | coffee flavor | FL |
| coffee liqueur flavor | FL |
| coffee pyrazine | FL |
| coffee resinoid | FL/FR |
| coffee royale flavor | FL |
| difurfuryl ether | FL |
| diisoamyl thiomalate | FL |
2,4- | dimethyl thiazole | FL |
2- | ethyl-4-methyl thiazole | FL/FR |
| furfuryl mercaptan | FL/FR |
| methyl furfuryl disulfide | FL/FR |
| methyl furfuryl mercaptopropionate | FL |
| methyl furfuryl thiol | FL |
2- | methyl-5-vinyl pyrazine | FL |
2-iso | propyl pyrazine | FL |
2- | thiophene thiol | FL |
corn chip |
2- | acetyl thiazole | FL/FR |
2- | acetyl-2-thiazoline | FL |
| popcorn pyrimidine | FL/FR |
creamy |
alpha- | angelica lactone | FL/FR |
dairy |
| creme brulle coffee flavor | FL |
earthy |
| difurfuryl sulfide | FL |
(±)-2- | mercapto-5-methylheptan-4-one | FL |
2- | methyl-3-propyl pyrazine | FL/FR |
ethereal |
| allyl 2-ethyl butyrate | FL/FR |
fatty |
| coconut absolute | FL/FR |
(E,E)-2,4- | decadienal | FL |
2- | heptyl furan | FL/FR |
(E,E)-2,4- | nonadienal | FL |
fishy |
4,5- | dimethyl thiazole | FL |
fruity |
| benzaldehyde | FL/FR |
| furfuryl isobutyrate | FL |
| furfuryl isovalerate | FL |
| furfuryl propionate | FL |
2,4- | hexadien-1-ol | FL |
| methyl valerate | FL/FR |
3- | methyl-2-butenal | FL/FR |
| propyl benzoate | FL/FR |
| tiglaldehyde | FL/FR |
fusel |
2- | methyl butyraldehyde | FL/FR |
garlic |
| garlic oleoresin | FL |
green |
| dihydroxyacetophenone (mixed isomers) | FL |
3,4- | dimethoxystyrene | FL |
2,5- | dimethyl thiophene | FL |
2,5- | dimethyl-4-ethyl oxazole | FL |
3- | methyl pyridine | FL |
4- | methyl thiazole | FL |
1-(5- | methyl-2-furyl) propan-1-one | FL |
2- | methyl-5-isopropyl pyrazine | FL |
(E,Z)-2,6- | nonadien-1-yl acetate | FL/FR |
2- | vinyl pyrazine | FL |
herbal |
| wormwood oil america | FL/FR |
| wormwood oil italy | FL/FR |
| wormwood oil poland | FL/FR |
lactonic |
gamma- | heptalactone | FL/FR |
meaty |
| benzothiazole | FL/FR |
2,6- | dimethyl pyrazine | FL/FR |
3- | mercapto-2-butanone | FL |
2- | methyl 3-(methyl thio) furan | FL |
molasses |
| molasses blackstrap | FL |
moldy |
| strawberry furanone methyl ether | FL/FR |
mustard |
| furfuryl methyl ether | FL |
musty |
2,5- | dimethyl pyrazine | FL/FR |
2- | ethoxythiazole | FL |
| hazelnut pyrazine | FL/FR |
| menthofuran | FL/FR |
2- | methyl 5-(methyl thio) furan | FL/FR |
| propionaldehyde | FL |
| shoyu pyrazine | FL/FR |
| thymyl methyl ether | FL/FR |
2,3,5- | trimethyl pyrazine | FL/FR |
naphthyl |
para- | methyl anisole | FL/FR |
nutty |
| acetal | FL/FR |
2- | acetyl furan | FL/FR |
3- | acetyl pyridine | FL/FR |
2- | acetyl pyrrole | FL/FR |
3- | acetyl-2,5-dimethyl furan | FL/FR |
3- | acetyl-2,5-dimethyl thiophene | FL |
2- | acetyl-3-ethyl pyrazine | FL/FR |
2- | acetyl-3-methyl pyrazine | FL/FR |
2- | acetyl-3,5-dimethyl pyrazine | FL/FR |
2- | acetyl-5-methyl furan | FL/FR |
| aconitic acid | FL |
| almond hazelnut flavor | FL |
| arachis hypogaea fruit extract | FL |
2- | butyl-2-butenal | FL |
roasted | chestnut flavor | FL |
3,5(6)- | cocoa pyrazine | FL |
3,6- | cocoa pyrazine | FL/FR |
3,5- | cocoa pyrazine | FL/FR |
| coffee furanone | FL/FR |
2,5- | diethyl pyrazine | FL |
3,5- | diethyl-2-methyl pyrazine | FL |
2,5- | diethyl-3-methyl pyrazine | FL |
2,3- | dimethyl pyrazine | FL/FR |
4,5- | dimethyl-2-ethyl-3-thiazoline | FL/FR |
2,4- | dimethyl-5-vinyl thiazole | FL |
2- | ethyl pyrazine | FL/FR |
1- | ethyl-2-acetyl pyrrole | FL |
2- | ethyl-6-methyl pyrazine | FL |
| filbert heptenone | FL/FR |
| filbert heptenone B | FL/FR |
| filbert pyrazine | FL/FR |
(+)-(E,S)- | filbertone | FL/FR |
(-)-(E,R)- | filbertone | FL/FR |
european | hazelnut absolute | FL/FR |
european | hazelnut distillates | FL |
| hazelnut flavor | FL |
roasted | hazelnut infusions | FL/FR |
european | hazelnut oil CO2 extract | FL/FR |
european | hazelnut oleoresin | FL |
| hazelnut paste | FL |
2,6- | lutidine | FL/FR |
2- | methyl pyrazine | FL/FR |
5- | methyl quinoxaline | FL/FR |
2- | methyl thio-3,5 or 6-methyl pyrazine | FL/FR |
| nutty cyclohexenone | FL/FR |
| nutty pyrazine | FL/FR |
| nutty quinoxaline | FL/FR |
| nutty thiazole | FL |
| peanut oxazole | FL |
| sesame absolute | FL/FR |
| sesame absolute CO2 extract | FL/FR |
| sesame distillates | FL |
| tetrahydrofurfuryl alcohol | FL/FR |
2,3,5,6- | tetramethyl pyrazine | FL/FR |
2,4,5- | trimethyl thiazole | FL/FR |
| vinyl sulfurol | FL/FR |
onion |
| furfuryl isopropyl sulfide | FL |
popcorn |
2- | propionyl-2-thiazoline | FL |
roasted |
2- | acetyl pyrazine | FL/FR |
roasted arabica | coffee bean oil | FL/FR |
| ethyl 3-(furfuryl thio) propionate | FL |
| furfuryl thioacetate | FL/FR |
| hexyl mercaptan | FL |
O- | methyl S-1-methoxyhexan-3-yl carbonothioate | FL/FR |
| trigonella foenum-graecum seed oil CO2 extract | FL/FR |
solvent |
2- | ethyl furan | FL |
| methyl phenyl sulfide | FL |
spicy |
| chocolate cinnamon hazelnut flavor | FL |
| cinnamon hazelnut cappuccino flavor | FL |
| cinnamon hazelnut cream flavor | FL |
para-alpha- | dimethyl styrene | FL/FR |
sulfurous |
2,3- | butane dithiol | FL |
| butyl mercaptan | FL |
| ethyl methyl sulfide | FL |
O- | ethyl S-1-methoxyhexan-3-yl carbonothioate | FL |
S- | ethyl thioacetate | FL |
S- | furfuryl thioformate | FL/FR |
| furfuryl thiopropionate | FL |
3- | methyl-2-butane thiol | FL |
2- | thienyl mercaptan | FL |
3- | thiohexanol | FL/FR |
toasted |
| acetyl propionyl | FL/FR |
vanilla |
| vanilla hazelnut flavor | FL |
vegetable |
1- | furfuryl pyrrole | FL/FR |
waxy |
para- | cresyl laurate | FL/FR |
winey |
iso | amyl nonanoate | FL/FR |
5- | ethyl-2-methyl pyridine | FL |
| valeraldehyde | FL/FR |
woody |
| juniper berry oleoresin | FL/FR |
| sandalwood oil | FL/FR |
| whiskey lactone | FL/FR |
|
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| coffee oxaline | 2- | methyl chinoxaline | 2- | methylquinoxaline | | quinoxaline, 2-methyl- |
Articles:
US Patents: | 3,931,166 - Certain 2,5-dimethyl-3-thiopyrazines |
PubMed: | Antimicrobial activity of quinoxaline 1,4-dioxide with 2- and 3-substituted derivatives. |
PubMed: | Pyrrolo[1,2-a]quinoxalines: novel synthesis via annulation of 2-alkylquinoxalines. |
PubMed: | Investigation of the antidyskinetic site of action of metabotropic and ionotropic glutamate receptor antagonists. Intracerebral infusions in 6-hydroxydopamine-lesioned rats with levodopa-induced dyskinesia. |
PubMed: | mGluR1, but not mGluR5, activates feed-forward inhibition in the medial prefrontal cortex to impair decision making. |
PubMed: | Microinjections of urocortin1 into the nucleus ambiguus of the rat elicit bradycardia. |
PubMed: | 2-Methyl-3-(n-octylsulfan-yl)quinoxaline. |
PubMed: | 2-(3-Aryl-2-propenoyl)-3-methylquinoxaline-1,4-dioxides: a novel cluster of tumor-specific cytotoxins which reverse multidrug resistance. |
PubMed: | Cardiovascular responses to microinjections of urocortins into the NTS: role of inotropic glutamate receptors. |
PubMed: | Face-washing behavior induced by the group I metabotropic glutamate receptor agonist (S)-3,5-DHPG in mice is mediated by mGlu1 receptor. |
PubMed: | Involvement of AMPA/kainate, NMDA, and mGlu5 receptors in the nucleus accumbens core in cue-induced reinstatement of cocaine seeking in rats. |
PubMed: | Detection of dideoxyosone intermediates of glycation using a monoclonal antibody: characterization of major epitope structures. |
PubMed: | Retrograde endocannabinoid signaling in a postsynaptic neuron/synaptic bouton preparation from basolateral amygdala. |
PubMed: | On the microscopic theory of polar solvation dynamics. |
PubMed: | Preparation and quantification of methylglyoxal in human plasma using reverse-phase high-performance liquid chromatography. |
PubMed: | Thermodynamic properties of quinoxaline-1,4-dioxide derivatives: a combined experimental and computational study. |
PubMed: | Effects of static vs. tidal hydrology on pollutant transformation in wetland sediments. |
PubMed: | Alternative pathway for the formation of 4,5-dihydroxy-2,3-pentanedione, the proposed precursor of 4-hydroxy-5-methyl-3(2H)-furanone as well as autoinducer-2, and its detection as natural constituent of tomato fruit. |
PubMed: | Role of guanylyl cyclase and cytochrome P-450 on renal response to nitric oxide. |
PubMed: | 5-hydroxytryptamine3 (5-HT3) receptors mediate spinal 5-HT antinociception: an antisense approach. |
PubMed: | The metabotropic glutamate receptor agonist 1S,3R-ACPD stimulates and modulates NMDA receptor mediated excitotoxicity in organotypic hippocampal slice cultures. |
PubMed: | Synthesis and cytotoxicity of 2-methyl-4, 9-dihydro-1-substituted-1H-imidazo[4,5-g]quinoxaline-4,9-diones and 2,3-disubstituted-5,10-pyrazino[2,3-g]quinoxalinediones. |
PubMed: | Evidence of high levels of methylglyoxal in cultured Chinese hamster ovary cells. |
PubMed: | MK-801-induced hyperlocomotion: differential effects of M100907, SDZ PSD 958 and raclopride. |
PubMed: | 5-Hydroxytryptamine-facilitated release of substance P from rat spinal cord slices is mediated by nitric oxide and cyclic GMP. |
PubMed: | Pharmacological properties of quinoxaline derivatives as a new class of 5-HT3 receptor antagonists. |
PubMed: | Methylglyoxal assay in cells as 2-methylquinoxaline using 1,2-diaminobenzene as derivatizing reagent. |
PubMed: | Pharmacology of cloned human 5-HT1D receptor-mediated functional responses in stably transfected rat C6-glial cell lines: further evidence differentiating human 5-HT1D and 5-HT1B receptors. |
PubMed: | Serotonin enhances gastric acid response to TRH analogue in dorsal vagal complex through 5-HT2 receptors in rats. |
PubMed: | Differential affinity of dihydroimidazoquinoxalines and diimidazoquinazolines to the alpha 1 beta 2 gamma 2 and alpha 6 beta 2 gamma 2 subtypes of cloned GABAA receptors. |
PubMed: | Noradrenergic mediation of spinal antinociception by 5-hydroxytryptamine: characterization of receptor subtypes. |
PubMed: | The assay of methylglyoxal in biological systems by derivatization with 1,2-diamino-4,5-dimethoxybenzene. |
PubMed: | 5-hydroxytryptamine (5-HT)1A receptors and the tail-flick response. I. 8-hydroxy-2-(di-n-propylamino) tetralin HBr-induced spontaneous tail-flicks in the rat as an in vivo model of 5-HT1A receptor-mediated activity. |
PubMed: | Characterization of serotonin receptors in isolated rat intramyocardial coronary artery. |
PubMed: | Simple and sensitive determination of methylglyoxal in biological samples by gas chromatography with electron-capture detection. |
PubMed: | Determination of methylglyoxal as 2-methylquinoxaline by high-performance liquid chromatography and its application to biological samples. |
PubMed: | Cyclic voltammetry of phenazines and quinoxalines including mono- and di-N-oxides. Relation to structure and antimicrobial activity. |
PubMed: | [Ergotropic efficacy of 2,3-dimethylquinoxaline-1,4-dioxide and 2-methylquinoxaline-1,4-dioxide in growing broilers using hydrocolloid-rich rations as well as broiler fattening feed]. |
PubMed: | Studies on biologically active pteridines. III. The absolute configuration at the C-6 chiral center of tetrahydrobiopterin cofactor and related compounds. |
PubMed: | Antibacterial effects of iodinin, 2-methylquinoxaline di-n-oxide and 2,6-dimethoxybenzoquinone in vitro. |
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