Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Assay: | 99.00 to 100.00 % sum of isomers
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Food Chemicals Codex Listed: | No |
Specific Gravity: | 1.13300 to 1.15300 @ 25.00 °C.
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Pounds per Gallon - (est).: | 9.428 to 9.594
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Refractive Index: | 1.57000 to 1.59000 @ 20.00 °C.
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Boiling Point: | 85.00 to 87.00 °C. @ 10.00 mm Hg
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Boiling Point: | 213.00 to 214.00 °C. @ 760.00 mm Hg
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Vapor Pressure: | 0.163000 mmHg @ 25.00 °C. (est) |
Flash Point: | 210.00 °F. TCC ( 98.89 °C. )
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logP (o/w): | 1.810 |
Soluble in: |
| alcohol | | water, 2379 mg/L @ 25 °C (est) |
Insoluble in: |
| water |
Organoleptic Properties:
Cosmetic Information:
Suppliers:
Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | Xi - Irritant |
R 36/37/38 - Irritating to eyes, respiratory system, and skin. S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 - Wear suitable gloves and eye/face protection.
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
Not determined
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | flavor and fragrance agents |
RIFM Fragrance Material Safety Assessment: Search |
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
Recommendation for 2-methyl-3-(methyl thio) pyrazine usage levels up to: | | 0.0200 % in the fragrance concentrate.
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Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.68 (μg/capita/day) |
Threshold of Concern: | 90 (μg/person/day) |
Structure Class: | III |
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
publication number: 4 |
Click here to view publication 4 |
| average usual ppm | average maximum ppm |
baked goods: | - | 4.00000 |
beverages(nonalcoholic): | - | - |
beverages(alcoholic): | - | - |
breakfast cereal: | - | - |
cheese: | - | - |
chewing gum: | - | - |
condiments / relishes: | - | - |
confectionery froastings: | - | - |
egg products: | - | - |
fats / oils: | - | - |
fish products: | - | - |
frozen dairy: | - | 2.00000 |
fruit ices: | - | 2.00000 |
gelatins / puddings: | - | 2.00000 |
granulated sugar: | - | - |
gravies: | - | - |
hard candy: | - | 2.00000 |
imitation dairy: | - | - |
instant coffee / tea: | - | - |
jams / jellies: | - | - |
meat products: | - | - |
milk products: | - | - |
nut products: | - | - |
other grains: | - | - |
poultry: | - | - |
processed fruits: | - | - |
processed vegetables: | - | - |
reconstituted vegetables: | - | - |
seasonings / flavors: | - | - |
snack foods: | - | - |
soft candy: | - | - |
soups: | - | - |
sugar substitutes: | - | - |
sweet sauces: | - | - |
Safety References:
References:
Other Information:
Potential Blenders and core components note
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For Odor |
No odor group found for these |
| sulfuryl octanoate | FL/FR |
| methional propylene glycol acetal | |
| sulfuryl butyrate | FL/FR |
| sulfuryl decanoate | FL/FR |
| sulfuryl hexanoate | FL/FR |
| sulfuryl isobutyrate | FL/FR |
| sulfuryl propionate | FL/FR |
| dimethyl trisulfide | FL/FR |
| methyl furfuryl disulfide | FL/FR |
animal |
5- | methyl-7(H)-cyclopenta[b]pyrazine | |
| rum ether | FL/FR |
buttery |
3,4- | hexane dione | FL/FR |
camphoreous |
| butyrophenone | FL/FR |
chocolate |
| chocolate pyrazine A | FL/FR |
| cocoa hexenal | FL/FR |
2,6- | dimethyl pyrazine | FL/FR |
2,5- | dimethyl pyrazine | FL/FR |
2- | methoxy-3-methyl pyrazine | FL/FR |
2,4,5- | trimethyl thiazole | FL/FR |
cocoa |
2-iso | butyl-3,5-(and 3,6)-dimethyl pyrazine | FL/FR |
coconut |
| coconut naphthalenone | FL/FR |
coffee |
| coffee difuran | FL/FR |
2- | methyl-3-,5 or 6-(furfuryl thio) pyrazine | FL/FR |
corn chip |
| popcorn pyrimidine | FL/FR |
| nutty pyrazine | FL/FR |
fatty |
5- | butyl oxazole | |
fermented |
| ethyl crotonate | FL/FR |
fruity |
| nonyl isovalerate | FL/FR |
| tropical thiazole | FL/FR |
| tropical trithiane | FL/FR |
green |
2- | heptyl furan | FL/FR |
(R)-1- | hexen-3-ol | |
(E,Z)-2,6- | nonadienal | FL/FR |
| meaty dithiane | FL/FR |
4- | methyl nonanoic acid | FL/FR |
(R)-4- | methyl octanoic acid | |
(S)-4- | methyl octanoic acid | |
| sulfurol | FL/FR |
| sulfuryl acetate | FL/FR |
moldy |
| strawberry furanone methyl ether | FL/FR |
| hazelnut pyrazine | FL/FR |
mutton |
(S)-4- | methyl nonanoic acid | |
nutty |
3- | acetyl pyridine | FL/FR |
2- | acetyl-3-ethyl pyrazine | FL/FR |
2- | acetyl-3-methyl pyrazine | FL/FR |
2- | acetyl-3,5-dimethyl pyrazine | FL/FR |
2- | acetyl-3,5(or 6)-dimethyl pyrazine | FL/FR |
3,6- | cocoa pyrazine | FL/FR |
3,5- | cocoa pyrazine | FL/FR |
2,3- | dimethyl pyrazine | FL/FR |
2,4- | dimethyl-5-ethyl thiazole | |
2- | ethyl pyrazine | FL/FR |
2- | ethyl-4-methyl thiazole | FL/FR |
| filbert heptenone | FL/FR |
| filbert pyrazine | FL/FR |
2- | methyl pyrazine | FL/FR |
5- | methyl quinoxaline | FL/FR |
2- | methyl-3-ethoxypyrazine | FL/FR |
2- | methyl-3-pentenoic acid | FL/FR |
| nutty quinoxaline | FL/FR |
2,3,5- | trimethyl pyrazine | FL/FR |
phenolic |
2,3- | dimethyl benzofuran | FL/FR |
ortho- | guaiacol | FL/FR |
4- | vinyl phenol | FL/FR |
popcorn |
2- | acetyl pyrazine | FL/FR |
2- | acetyl pyridine | FL/FR |
2- | acetyl thiazole | FL/FR |
roasted |
2- | acetyl-2-pyrroline | |
savory |
laevo- | methionyl glycine | |
smoky |
| bacon fragrance | FR |
| pyroligneous acids | FL/FR |
| benzothiazole | FL/FR |
| dodecyl mercaptan | |
| ethyl 2-mercaptopropionate | FL/FR |
| ethyl 3-mercaptopropionate | FL/FR |
| fish thiol | FL/FR |
| furfuryl thioacetate | FL/FR |
2- | mercaptopropionic acid | FL/FR |
4- | methyl 4-mercaptopentan-2-one 1% solution | FL/FR |
2-( | methyl thio) phenol | FL/FR |
1- | phenethyl mercaptan | FL/FR |
tobacco |
| methyl benzoxole | FL/FR |
tonka |
| whiskey lactone | FL/FR |
waxy |
| butyl laurate | FL/FR |
woody |
| cedrenyl acetate | FR |
4- | hydroxybenzaldehyde | FL/FR |
2- | methoxy-4-vinyl phenol | FL/FR |
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For Flavor |
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No flavor group found for these |
4- | acetyl-2-methyl pyrimidine | FL |
2- | acetyl-2-pyrroline | |
2- | acetyl-5-methyl pyrazine | FL |
2- | acetyl-6-methyl pyrazine | FL |
(E)- | aconitic acid | FL |
| amyl mercaptan | FL |
1,2- | butane dithiol | FL |
5- | butyl oxazole | |
2-iso | butyl-3,5-(and 3,6)-dimethyl pyrazine | FL/FR |
2(4)-iso | butyl-4(2),6-dimethyl dihydro-4H-1,3,5-dithiazine | FL |
2-(2- | butyl)-4,5-dimethyl-3-thiazoline | FL |
| butyrophenone | FL/FR |
| chocolate pyrazine A | FL/FR |
| chocolate pyrazine B | FL |
| coconut naphthalenone | FL/FR |
2,5- | diethyl thiazole | FL |
6,7- | dihydro-2,3-dimethyl-5H-cyclopentapyrazine | FL |
| dihydro-2,4,6-trimethyl-1,3,5(4H)-dithiazine | FL |
| dimethyl dihydrocyclopentapyrazine | FL |
| dimethyl tetrasulfide | FL |
2,5- | dimethyl thiazole | FL |
4,5- | dimethyl-2-ethyl thiazole | FL |
2,6- | dimethyl-3-((2-methyl-3-furyl)thio)-4-heptanone | FL |
bis(2,5- | dimethyl-3-furyl) disulfide | FL |
(Z+E)-2,5- | dimethyl-3-tetrahydrofuran thiol | FL |
(Z+E)-2,5- | dimethyl-3-thioacetoxytetrahydrofuran | FL |
2,5- | dimethyl-3-thiofuroyl furan | FL |
2,4- | dimethyl-5-ethyl thiazole | |
S- | ethyl 2-acetyl aminoethane thioate | FL |
| ethyl 3-mercaptopropionate | FL/FR |
| ethyl dimethyl pyrazine | FL |
2- | ethyl-3-methyl thiopyrazine | FL |
(Z+E)-5- | ethyl-4-methyl-2-(2-butyl) thiazoline | FL |
(Z+E)-5- | ethyl-4-methyl-2-(2-methyl propyl) thiazoline | FL |
2,4- | heptadien-1-ol | FL |
(E,E)-2,4- | heptadien-1-ol | FL |
(R)-1- | hexen-3-ol | |
2- | hexyl thiophene | FL |
1-(3- | hydroxy-5-methyl-2-thienyl) ethanone | FL |
3- | mercapto-3-methyl butyl formate | FL |
4- | mercapto-3-methyl-2-butanol | FL |
| methional propylene glycol acetal | |
laevo- | methionyl glycine | |
| methyl 2-(methyl thio) acetate | FL |
4- | methyl 4-mercaptopentan-2-one 1% solution | FL/FR |
| methyl dihydrofuran thiol | FL |
(S)-4- | methyl nonanoic acid | |
(R)-4- | methyl octanoic acid | |
(S)-4- | methyl octanoic acid | |
2- | methyl thiazolidine | FL |
2- | methyl-1-butane thiol | FL |
4- | methyl-2-(methyl thiomethyl)-2-hexenal | FL |
2- | methyl-2-thiazoline | FL |
2- | methyl-3-,5 or 6-(furfuryl thio) pyrazine | FL/FR |
2- | methyl-3-ethoxypyrazine | FL/FR |
3-((2- | methyl-3-furyl)thio)-4-heptanone | FL |
4-((2- | methyl-3-furyl)thio)-5-nonanone | FL |
2- | methyl-3-pentenoic acid | FL/FR |
5- | methyl-7(H)-cyclopenta[b]pyrazine | |
1,9- | nonane dithiol | FL |
| nonyl isovalerate | FL/FR |
| peanut dithiazine | FL |
1- | phenethyl mercaptan | FL/FR |
2- | propionyl pyrrole | FL |
iso | propyl disulfide | FL |
2-iso | propyl-3-(methyl thio) pyrazine | FL |
| sulfuryl butyrate | FL/FR |
| sulfuryl decanoate | FL/FR |
| sulfuryl hexanoate | FL/FR |
| sulfuryl isobutyrate | FL/FR |
| thiazole | FL |
3- | thienyl mercaptan | FL |
| thioacetic acid | FL |
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3,5- | diisopropyl-1,2,4-trithiolane | FL |
3,5- | dimethyl-1,2,4-trithiolane | FL |
3,7- | dimethyl-2,6-octadien-1-yl cyclopropyl carboxamide | FL |
2,4- | dimethyl-3-oxazoline | FL |
4- | mercapto-2-pentanone 1% in acetoin | FL |
2- | methyl-1-methyl thio-2-butene | FL |
| pyrrolidino-(1,2E)-4H-2,4-dimethyl-1,3,5-dithiazine | FL |
| sulfuryl formate | FL |
| sulfuryl octanoate | FL/FR |
| sulfuryl propionate | FL/FR |
1-(2- | thienyl) butanone | FL |
alliaceous |
| allyl disulfide | FL |
| allyl mercaptan | FL |
1,3- | butane dithiol | FL |
| cyclopentyl mercaptan | FL |
| dimethyl trisulfide | FL/FR |
3- | mercapto-2-pentanone | FL |
3- | tetrahydrothiophenone | FL |
| tropical thiazole | FL/FR |
bready |
2- | propionyl thiazole | FL |
burnt |
| bacon dithiazine | FL |
1,6- | hexane dithiol | FL |
2- | methyl quinoxaline | FL |
| rum ether | FL/FR |
buttery |
3,4- | hexane dione | FL/FR |
chemical |
2,3- | dimethyl benzofuran | FL/FR |
2,5- | dimethyl furan | FL |
cocoa |
| cocoa hexenal | FL/FR |
coffee |
| coffee difuran | FL/FR |
2- | ethyl-4-methyl thiazole | FL/FR |
| methyl furfuryl disulfide | FL/FR |
corn |
2- | acetyl pyridine | FL/FR |
2- | acetyl thiazole | FL/FR |
| popcorn pyrimidine | FL/FR |
creamy |
4- | hydroxybenzaldehyde | FL/FR |
earthy |
| difurfuryl sulfide | FL |
1,8- | octane dithiol | FL |
eggy |
iso | propyl mercaptan | FL |
fatty |
2- | heptyl furan | FL/FR |
4- | methyl nonanoic acid | FL/FR |
2- | pentyl thiophene | FL |
fishy |
4,5- | dimethyl thiazole | FL |
fruity |
2,4- | hexadien-1-ol | FL |
| tropical trithiane | FL/FR |
green |
4- | methyl thiazole | FL |
(E,Z)-2,6- | nonadienal | FL/FR |
4- | penten-1-yl acetate | FL |
meaty |
4- | allyl-2,6-dimethoxyphenol | FL |
| benzothiazole | FL/FR |
2,6- | dimethyl pyrazine | FL/FR |
2,6- | dimethyl thiophenol | FL |
2,5- | dimethyl-3-furan thiol | FL |
| dodecyl mercaptan | |
1,1- | ethane dithiol 1% in ethanol 94.5% / ethyl acetate 4% | FL |
| furfuryl 2-methyl-3-furyl disulfide | FL |
| meaty dithiane | FL/FR |
3- | mercapto-2-butanone | FL |
(R,S)-2- | mercapto-3-butanol | FL |
2- | mercaptomethyl pyrazine | FL |
2- | mercaptopropionic acid | FL/FR |
2- | methyl 3-(methyl thio) furan | FL |
2-( | methyl thio) phenol | FL/FR |
| methyl thiofuryl butanal | FL |
12- | methyl tridecanal | FL |
bis(2- | methyl-3-furyl) disulfide | FL |
S-(2- | methyl-3-furyl) ethane thioate | FL |
2- | methyl-3-tetrahydrofuran thiol | FL |
2- | methyl-3-thioacetoxytetrahydrofuran | FL |
| phenyl mercaptan | FL |
| propyl 2-mercaptopropionate | FL |
| pyrazinyl ethane thiol | FL |
2- | pyridinyl methane thiol | FL |
| sulfurol | FL/FR |
| sulfuryl acetate | FL/FR |
| thialdine | FL |
ortho- | thiocresol | FL |
ortho- | thioguaiacol | FL |
metallic |
2,5- | dihydroxy-1,4-dithiane | FL |
moldy |
| strawberry furanone methyl ether | FL/FR |
musty |
2,5- | dimethyl pyrazine | FL/FR |
2- | ethoxythiazole | FL |
| hazelnut pyrazine | FL/FR |
2,3,5- | trimethyl pyrazine | FL/FR |
nutty |
3- | acetyl pyridine | FL/FR |
3- | acetyl-2,5-dimethyl thiophene | FL |
2- | acetyl-3-ethyl pyrazine | FL/FR |
2- | acetyl-3-methyl pyrazine | FL/FR |
2- | acetyl-3,5-dimethyl pyrazine | FL/FR |
2- | acetyl-3,5(or 6)-dimethyl pyrazine | FL/FR |
2- | acetyl-4-methyl thiazole | FL |
3,6- | cocoa pyrazine | FL/FR |
3,5- | cocoa pyrazine | FL/FR |
3,5- | diethyl-2-methyl pyrazine | FL |
2,5- | diethyl-3-methyl pyrazine | FL |
2,3- | dimethyl pyrazine | FL/FR |
2- | ethyl pyrazine | FL/FR |
| filbert heptenone | FL/FR |
| filbert pyrazine | FL/FR |
european | hazelnut oleoresin | FL |
2- | methoxy-3-methyl pyrazine | FL/FR |
| methyl benzoxole | FL/FR |
2- | methyl pyrazine | FL/FR |
5- | methyl quinoxaline | FL/FR |
| nutty pyrazine | FL/FR |
| nutty quinoxaline | FL/FR |
| nutty thiazole | FL |
2,4,5- | trimethyl thiazole | FL/FR |
onion |
| ethyl 2-mercaptopropionate | FL/FR |
| furfuryl isopropyl sulfide | FL |
phenolic |
2- | ethyl benzene thiol | FL |
4- | vinyl phenol | FL/FR |
popcorn |
2- | propionyl-2-thiazoline | FL |
radish |
3-( | methyl thio) propyl mercaptoacetate | FL |
roasted |
2- | acetyl pyrazine | FL/FR |
| furfuryl thioacetate | FL/FR |
| hexyl mercaptan | FL |
rummy |
| ethyl crotonate | FL/FR |
smoky |
2- | methoxy-4-vinyl phenol | FL/FR |
| prosopis juliflora wood extract | FL |
| pyroligneous acids | FL/FR |
sulfurous |
2,3- | butane dithiol | FL |
| ethyl methyl sulfide | FL |
S- | ethyl thioacetate | FL |
| fish thiol | FL/FR |
| methyl 2-methyl-3-furyl disulfide | FL |
3- | methyl-2-butane thiol | FL |
2- | naphthyl mercaptan | FL |
| roasted butanol | FL |
vegetable |
| tyramine | FL |
wasabi |
2-( | methyl thio) ethyl acetate | FL |
waxy |
| butyl laurate | FL/FR |
woody |
ortho- | guaiacol | FL/FR |
| whiskey lactone | FL/FR |
yeasty |
| faex extracts | FL |
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Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
2- | methyl 3-methyl thio pyrazine | 2- | methyl mercapto-3-methyl pyrazine | 2- | methyl thio-3-methyl pyrazine | 2-( | methyl thio)-3-methyl pyrazine | 3- | methyl-2-methyl thiopyrazine | 3- | methyl-2-methylthiopyrazine | 2- | methyl-3-(methyl thio) pyrazine | 2- | methyl-3-(methylmercapto)pyrazine | 2- | methyl-3-(methylsulfanyl)pyrazine | 2- | methyl-3-(methylthio)pyrazine | 2- | methyl-3-methyl mercaptopyrazine | 2- | methyl-3-methyl sulfanyl pyrazine | 2- | methyl-3-methylsulfanylpyrazine | 2- | methyl-3-methylthiopyrazine | 2- | methylmercapto-3-methylpyrazine | 2- | methylthio-3-methyl pyrazine | 2- | methylthio-3-methylpyrazine | 2-( | methylthio)-3-methylpyrazine | | pyrazine, 2-methyl-3-(methylthio)- | | pyrazine, methyl(methylthio)- |
Articles:
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