Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | colorless to pale yellow clear liquid (est) |
Assay: | 96.00 to 100.00 %
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Food Chemicals Codex Listed: | No |
Specific Gravity: | 0.96200 @ 25.00 °C.
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Refractive Index: | 1.51400 @ 20.00 °C.
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Melting Point: | 18.00 °C. @ 760.00 mm Hg
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Boiling Point: | 254.00 to 256.00 °C. @ 764.00 mm Hg
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Vapor Pressure: | 0.010000 mmHg @ 25.00 °C. (est) |
Vapor Density: | 5.6 ( Air = 1 ) |
Flash Point: | 235.00 °F. TCC ( 112.78 °C. )
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logP (o/w): | 3.790 |
Soluble in: |
| alcohol | | water, 123.8 mg/L @ 25 °C (est) |
Insoluble in: |
| water |
Organoleptic Properties:
Odor Strength: | low |
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Odor Description: at 100.00 %. | mild phenolic |
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Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | Xn - Harmful. |
R 22 - Harmful if swallowed. R 36/37/38 - Irritating to eyes, respiratory system, and skin. S 02 - Keep out of the reach of children. S 20/21 - When using do not eat, drink or smoke. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
intravenous-dog LD50 30 mg/kg Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 38, Pg. 1117, 1996.
intravenous-man LDLo 386 mg/kg/14D- LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING Critical Care Medicine. Vol. 23, Pg. 1928, 1995.
unreported-man TDLo 2857 ug/kg/1D- BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
BEHAVIORAL: REGIDITY
BEHAVIORAL: IRRITABILITY Anaesthesia. Vol. 43, Pg. 170, 1988.
intraperitoneal-mouse LD50 170 mg/kg Journal of Medicinal and Pharmaceutical Chemistry. Vol. 2, Pg. 201, 1960.
intravenous-mouse LD50 50 mg/kg BEHAVIORAL: GENERAL ANESTHETIC
BEHAVIORAL: ANALGESIA
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Journal of Medicinal Chemistry. Vol. 23, Pg. 1350, 1980.
oral-mouse LD50 1100 mg/kg Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995.
intravenous-rabbit LDLo 20 mg/kg BEHAVIORAL: MUSCLE WEAKNESS
BEHAVIORAL: GENERAL ANESTHETIC
BEHAVIORAL: SLEEP Journal of Medicinal Chemistry. Vol. 23, Pg. 1350, 1980.
intravenous-rat LD50 42 mg/kg Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21, Pg. 11, 1993.
oral-rat LD50 500 mg/kg Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995.
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| ampofol | | aquafol | | aquavan | 2,6- | di-iso-propylphenol | 2,6- | di-isopropylphenol | 2,6- | di(propan-2-yl)phenol | 2,6- | diiso propyl phenol | | diisopropyl-2 6 phenol | 2,6- | diisopropyl-phenol | | diisopropylphenol | 2,6- | diisopropylphenol | | dipravan | | diprivan 10 | 2,6- | dipropan-2-ylphenol | | disoprivan | | disoprofol | | fresofol | | ivofol | 2,6-bis(1- | methylethyl)benzolol | 2,6-bis( | methylethyl)phenol | 2,6-bis(1- | methylethyl)phenol | | phenol, 2,6-bis(1-methylethyl)- | | phenol, 2,6-diisopropyl- | 2,6-bis( | propan-2-yl)phenol | | propofol | | propofolum | 2,6-bis(iso | propyl) phenol | 2,6-bis(iso | propyl)-phenol | 2,6-bis(iso | propyl)phenol | | rapinovet | | recofol |
Articles:
PubMed: | Propofol infusion associated metabolic acidosis in patients undergoing neurosurgical anesthesia: a retrospective study. |
PubMed: | Protective effect of acetyl-L-carnitine on propofol-induced toxicity in embryonic neural stem cells. |
PubMed: | Propofol administration is safe in adult eosinophilic esophagitis patients sensitized to egg, soy, or peanut. |
PubMed: | Drugs and the death penalty. |
PubMed: | Effects of propofol on expression of hippocampal neuronal nitric oxide synthase and carboxy-terminal PDZ ligand of neuronal nitric oxide synthase in stressed rats undergoing electroconvulsive shock. |
PubMed: | Entropy correlates with Richmond Agitation Sedation Scale in mechanically ventilated critically ill patients. |
PubMed: | Simultaneous determination of 11 related impurities in propofol by gas chromatography/tandem mass spectrometry coupled with pulsed splitless injection technique. |
PubMed: | Acitretin exhibits inhibitory effects towards UDP-glucuronosyltransferase (UGT)1A9-mediated 4-methylumbelliferone (4-MU) and propofol glucuronidation reaction. |
PubMed: | Anaesthetic considerations for endoscopic retrograde cholangio-pancreatography procedures. |
PubMed: | US Propofol Drug Shortages: A Review of the Problem and Stakeholder Analysis. |
PubMed: | Claw amphiphiles with a dendrimer core: nanoparticle stability and drug encapsulation are directly proportional to the number of digits. |
PubMed: | Assessment of oxidative stress and antioxidant property using electron spin resonance (ESR) spectroscopy. |
PubMed: | Evaluation of sigmoidal maturation and allometric models: prediction of propofol clearance in neonates and infants. |
PubMed: | Self-administration of propofol is mediated by dopamine D1 receptors in nucleus accumbens in rats. |
PubMed: | Effects of propofol on the activation of hippocampal CaMKIIα in depressed rats receiving electroconvulsive therapy. |
PubMed: | Propofol allergy: assessing for patient risks. |
PubMed: | [Fospropofol: A new prodrug of propofol]. |
PubMed: | Dexmedetomidine: a guide to its use for sedation in the US. |
PubMed: | Identification of UDP-glucuronosyltransferase isoforms involved in hepatic and intestinal glucuronidation of phytochemical carvacrol. |
PubMed: | When one drug affects 2 patients: a review of medication for the management of nonlabor-related pain, sedation, infection, and hypertension in the hospitalized pregnant patient. |
PubMed: | Safe injection practices for administration of propofol. |
PubMed: | Dependence potential of propofol: behavioral pharmacology in rodents. |
PubMed: | Potential hypersensitivity due to the food or food additive content of medicinal products in Spain. |
PubMed: | Pharmacokinetics of ketamine and propofol combination administered as ketofol via continuous infusion in cats. |
PubMed: | Propofol sedation for ERCP procedures: a dilemna? Observations from an anesthesia perspective. |
PubMed: | Differential involvement of GABAA and GABAB receptors in propofol self-administration in rats. |
PubMed: | Drug shortage. |
PubMed: | Procedural sedation practices in Australian Emergency Departments. |
PubMed: | Anaesthesia of three young grey seals (Halichoerus grypus) for fracture repair. |
PubMed: | Non-anaesthesiologists should not be allowed to administer propofol for procedural sedation: a Consensus Statement of 21 European National Societies of Anaesthesia. |
PubMed: | Anesthesia in the patient with multiple drug allergies: are all allergies the same? |
PubMed: | Allergic reactions to propofol in egg-allergic children. |
PubMed: | Computer-assisted personalized sedation. |
PubMed: | My patient is allergic to eggs, can i use propofol? A case report and review. |
PubMed: | Why are there so many drug shortages? |
PubMed: | Administration of propofol. |
PubMed: | The reality of drug shortages--the case of the injectable agent propofol. |
PubMed: | Identification of the human UDP-glucuronosyltransferases involved in the glucuronidation of combretastatin A-4. |
PubMed: | [Unexpected vomiting during anesthetic induction in a patient with a history of anterosternal esophageal reconstruction]. |
PubMed: | Off-label medication use in an academic hospital pediatric critical care unit. |
PubMed: | Schedule of controlled substances; placement of fospropofol into schedule IV. Final rule. |
PubMed: | Fospropofol: a new sedative-hypnotic agent for monitored anesthesia care. |
PubMed: | Fospropofol disodium, a water-soluble prodrug of the intravenous anesthetic propofol (2,6-diisopropylphenol). |
PubMed: | Effect of administration of propofol and xylazine hydrochloride on recovery of horses after four hours of anesthesia with desflurane. |
PubMed: | Anesthesia or sedation for gastroenterologic endoscopies. |
PubMed: | The effect of postoperative fasting on vomiting in children and their assessment of pain. |
PubMed: | Self-limited febrile syndromes temporally associated with the use of propofol for sedation in gastrointestinal endoscopic procedures. |
PubMed: | Fospropofol approved for monitored anesthesia care. |
PubMed: | Delirium at the end of life. |
PubMed: | Use of propofol in patients with food allergies. |
PubMed: | Questions unanswered: propofol use in the pediatric intensive care unit. |
PubMed: | [Elective colon resection in Germany. A survey of the perioperative anesthesiological management]. |
PubMed: | Use of anesthetic agents in neonates and young children. |
PubMed: | Delirium at the end of life. |
PubMed: | Respiratory failure due to morbid obesity in a patient with Prader-Willi syndrome: an experience of long-term mechanical ventilation. |
PubMed: | Reports of death with use of propofol (Diprivan) for nonprocedural (long-term) sedation and literature review. |
PubMed: | Nurse-administered propofol sedation: a review of current evidence. |
PubMed: | Electroconvulsive therapy (ECT) in a six-year-old girl suffering from major depressive disorder with catatonic features. |
PubMed: | The propofol controversy. |
PubMed: | The propofol debate continues. |
PubMed: | Sedation and analgesia for gastrointestinal endoscopy during pregnancy. |
PubMed: | The major role of clinicians in the discovery of off-label drug therapies. |
PubMed: | Use of intravenous steroids at induction of anaesthesia for adult tonsillectomy to reduce post-operative nausea and vomiting and pain: a double-blind randomized controlled trial. |
PubMed: | Propofol 6% as sedative in children under 2 years of age following major craniofacial surgery. |
PubMed: | Droperidol and dolasetron alone or in combination for prevention of postoperative nausea and vomiting after vitrectomy. |
PubMed: | Safety of sodium phosphate tablets in patients receiving propofol-based sedation for colonoscopy. |
PubMed: | Efficacy and safety of endoscopic dilation of esophageal strictures in epidermolysis bullosa. |
PubMed: | Glucuronidation as a mechanism of intrinsic drug resistance in human colon cancer: reversal of resistance by food additives. |
PubMed: | The FDA warning against prolonged sedation with propofol in children remains warranted. |
PubMed: | Pediatric drug labeling: improving the safety and efficacy of pediatric therapies. |
PubMed: | [Caloric overload in critically ill patients treated with parenteral nutrition]. |
PubMed: | Differential role of leptin receptors at the hypothalamic paraventricular nucleus in tonic regulation of food intake and cardiovascular functions. |
PubMed: | Propofol syndrome in children. |
PubMed: | Possible anaphylaxis after propofol in a child with food allergy. |
PubMed: | Gastroenterologist-administered propofol versus meperidine and midazolam for advanced upper endoscopy: a prospective, randomized trial. |
PubMed: | Propofol does not modify the hemodynamic status of children with intracardiac shunts undergoing cardiac catheterization. |
PubMed: | Microchip vagal pacing reduces food intake and body mass. |
PubMed: | The effect of propofol administered intravenously on appetite stimulation in dogs. |
PubMed: | Enhanced intestinal motility influences absorption in anaesthetized rat. |
PubMed: | Propofol improves recovery from paraquat acute toxicity in vitro and in vivo. |
PubMed: | 'Diprivan': a change of formulation. |
PubMed: | Comparison of the intravenous reinforcing effects of propofol and methohexital in baboons. |
PubMed: | Propofol containing sulfite-potential for injury. |
PubMed: | Antioxidant effects of propofol in human hepatic microsomes: concentration effects and clinical relevance. |
PubMed: | "Preservatives" in propofol. |
PubMed: | Effect of enteral versus parenteral feeding on hepatic blood flow and steady state propofol pharmacokinetics in ICU patients. |
PubMed: | Muscimol-like discriminative stimulus effects of GABA agonists in rats. |
PubMed: | [Ban of the use of metomidate (Hypnodil) in swine. Background, consequences and alternatives]. |
PubMed: | Pharmacologic influence on nutrition support therapy: use of propofol in a patient receiving combined enteral and parenteral nutrition support. |
PubMed: | The publication of commercially supported supplements statement. |
PubMed: | How do anesthesiologists select patients when introducing a new drug into practice? |
PubMed: | The initial clinical experience of 1819 physicians in maintaining anesthesia with propofol: characteristics associated with prolonged time to awakening. |
PubMed: | Endogenous Candida endophthalmitis after intravenous anesthesia with propofol. |
PubMed: | A method for quantitative analysis of flavor-tainting alkylphenols and aromatic thiols in fish. |
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