Category: flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | colorless clear liquid (est) |
Assay: | 95.00 to 100.00 %
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Food Chemicals Codex Listed: | No |
Specific Gravity: | 0.87400 to 0.88000 @ 25.00 °C.
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Pounds per Gallon - (est).: | 7.273 to 7.322
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Refractive Index: | 1.46800 to 1.47400 @ 20.00 °C.
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Boiling Point: | 92.00 to 93.00 °C. @ 760.00 mm Hg
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Vapor Pressure: | 68.372002 mmHg @ 25.00 °C. (est) |
Flash Point: | 64.00 °F. TCC ( 17.78 °C. )
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logP (o/w): | 1.530 (est) |
Soluble in: |
| alcohol | | water, 3910 mg/L @ 25 °C (est) |
Insoluble in: |
| water |
Similar Items: note |
allyl methyl disulfide |
allyl methyl trisulfide |
Organoleptic Properties:
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Odor Type: sulfurous |
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| alliaceous garlic onion |
Odor Description: at 0.10 % in propylene glycol. | alliaceous garlic onion |
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Flavor Type: garlic |
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| sulfurous alliaceous onion savory |
Taste Description:
| sulfurous alliaceous onion savory |
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Odor and/or flavor descriptions from others (if found). |
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R C Treatt & Co Ltd |
Allylmethyl sulphide Halal, Kosher |
Taste Description: | garlic The only component of natural garlic oil that is not FEMA. Used is in alliaceous flavours (onion, garlic, leek); and in savoury, soup, meat and seafood flavours. |
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Taytonn ASCC |
Allyl Methyl Sulphide |
Odor Description: | Alliaceous, Garlic, Onion |
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Cosmetic Information:
Suppliers:
Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | Xi - Irritant |
R 11 - Highly flammable. R 36/37/38 - Irritating to eyes, respiratory system, and skin. S 03/07 - Keep container tightly closed in cool place. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 33 - Take precautionary measures against static discharge. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
Not determined
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | flavoring agents |
IFRA Purity Specification: | < 0.1% free allyl alcohol |
Recommendation for allyl methyl sulfide usage levels up to: | | not for fragrance use.
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Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.99 (μg/capita/day) |
Modified Theoretical Added Maximum Daily Intake (mTAMDI): | 78 (μg/person/day) |
Threshold of Concern: | 540 (μg/person/day) |
Structure Class: | II |
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Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i). |
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm. |
| average usage mg/kg | maximum usage mg/kg |
Dairy products, excluding products of category 02.0 (01.0): | 0.20000 | 1.00000 |
Fats and oils, and fat emulsions (type water-in-oil) (02.0): | 0.10000 | 0.50000 |
Edible ices, including sherbet and sorbet (03.0): | 0.20000 | 1.00000 |
Processed fruit (04.1): | 0.20000 | 1.00000 |
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): | - | - |
Confectionery (05.0): | 0.20000 | 1.00000 |
Chewing gum (05.0): | - | - |
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): | 0.10000 | 0.50000 |
Bakery wares (07.0): | 0.20000 | 1.00000 |
Meat and meat products, including poultry and game (08.0): | 0.10000 | 0.20000 |
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): | 0.10000 | 0.20000 |
Eggs and egg products (10.0): | - | - |
Sweeteners, including honey (11.0): | - | - |
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): | 0.10000 | 0.50000 |
Foodstuffs intended for particular nutritional uses (13.0): | 0.20000 | 1.00000 |
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): | 0.10000 | 0.30000 |
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): | 0.20000 | 1.00000 |
Ready-to-eat savouries (15.0): | 0.40000 | 2.00000 |
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): | 0.10000 | 0.50000 |
Safety References:
European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
European Food Safety Authority (EFSA) reference(s): |
Flavouring Group Evaluation 8 (FGE.08)[1]: Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical group 20 View page or View pdf |
Flavouring Group Evaluation 74 (FGE.74)[1]: Consideration of Simple Aliphatic Sulphides and Thiols evaluated by JECFA (61st meeting) Structurally related to Aliphatic and Alicyclic Mono-, Di-, Tri-, and Polysulphides with or without Additional Oxygenated Functional Groups from Chemical Group 20 evaluated by EFSA in FGE.08 (2008) View page or View pdf |
Flavouring Group Evaluation 8, Revision 1 (FGE.08Rev1): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30 View page or View pdf |
Flavouring Group Evaluation 91 (FGE.91): Consideration of simple aliphatic and aromatic sulphides and thiols evaluated by JECFA (53rd and 68th meetings) structurally related to aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups evaluated by EFSA in FGE.08Rev1 (2009) View page or View pdf |
Flavouring Group Evaluation 08 Rev2 (FGE.08 Rev2): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 8, Revision 3 (FGE.08Rev3): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 08, Revision 4 (FGE.08Rev4): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 08, Revision 5 (FGE.08Rev5): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30 View page or View pdf |
EPI System: | View |
Chemical Carcinogenesis Research Information System: | Search |
AIDS Citations: | Search |
Cancer Citations: | Search |
Toxicology Citations: | Search |
EPA Substance Registry Services (TSCA): | 10152-76-8 |
EPA ACToR: | Toxicology Data |
EPA Substance Registry Services (SRS): | Registry |
Laboratory Chemical Safety Summary : | 66282 |
National Institute of Allergy and Infectious Diseases: | Data |
WISER: | UN 1993 |
WGK Germany: | 3 |
| 3-methylsulfanylprop-1-ene |
Chemidplus: | 0010152768 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| allyl methyl sulphide | | allylmethylsulfide | | methyl allyl sulfide | | methyl prop-2-en-1-yl sulfide | | methyl propenyl sulfide | 3-( | methyl thio)-1-propene | 3-( | methylsulfanyl)prop-1-ene | 3- | methylsulfanylprop-1-ene | 3- | methylthio-1-propene | 3-( | methylthio)-1-propene | | prop-1-ene, 3-(methylthio)- | 1- | propene, 3-(methylthio)- | 2- | propenyl methyl sulfide | | sulfide, allyl methyl |
Articles:
PubMed: | Garlic |
PubMed: | Allicin Bioavailability and Bioequivalence from Garlic Supplements and Garlic Foods |
PubMed: | Quantification of Allyl Methyl Sulfide, Allyl Methyl Sulfoxide, and Allyl Methyl Sulfone in Human Milk and Urine After Ingestion of Cooked and Roasted Garlic |
PubMed: | Biomarkers of food intake for Allium vegetables |
PubMed: | Metabolism and pharmacokinetics studies of allyl methyl disulfide in rats |
PubMed: | Measurement of diallyl disulfide and allyl methyl sulfide emanating from human skin surface and influence of ingestion of grilled garlic |
PubMed: | Quantification of Volatile Metabolites Derived From Garlic (Allium sativum) in Human Urine |
PubMed: | Quantification of selected volatile organic compounds in human urine by gas chromatography selective reagent ionization time of flight mass spectrometry (GC-SRI-TOF-MS) coupled with head-space soli |
PubMed: | Oxidation-Triggerable Liposome Incorporating Poly(Hydroxyethyl Acrylate-co-Allyl methyl sulfide) as an Anticancer Carrier of Doxorubicin |
PubMed: | Fatty Acid Composition and Applications of Eriobotrya japonica Seed Oil |
PubMed: | [Research on volatiles of rakkyo (Allium Chinense G. Don) and Chinese chive (Allium Tuberosum Rottl. ex Sprengel) based on headspace and the molecular recognition of SERS] |
PubMed: | Characterization of key aroma compounds in aged garlic extract |
PubMed: | Anticarcinogenic properties of garlic: a review |
PubMed: | Identification and Quantification of Volatile Ramson-Derived Metabolites in Humans |
PubMed: | Allyl methyl sulfide, an organosulfur compound alleviates hyperglycemia mediated hepatic oxidative stress and inflammation in streptozotocin - induced experimental rats |
PubMed: | Analysis of Breath Specimens for Biomarkers of Plasmodium falciparum Infection |
PubMed: | Allyl methyl sulfide, a garlic active component mitigates hyperglycemia by restoration of circulatory antioxidant status and attenuating glycoprotein components in streptozotocin-induced experiment |
PubMed: | Effect of milk on the deodorization of malodorous breath after garlic ingestion |
PubMed: | Deodorization with ku-ding-cha containing a large amount of caffeoyl quinic acid derivatives |
PubMed: | Deodorization of Garlic Breath by Foods, and the Role of Polyphenol Oxidase and Phenolic Compounds |
PubMed: | Layered double hydroxide/poly(vinylpyrrolidone) coated solid phase microextraction Arrow for the determination of volatile organic compounds in water |
PubMed: | Quantification of volatile metabolites derived from garlic in human breast milk |
PubMed: | Deodorization of garlic breath volatiles by food and food components |
PubMed: | Do garlic-derived allyl sulfides scavenge peroxyl radicals? |
PubMed: | Primary screening and application of repellent plant volatiles to control tea leafhopper, Empoasca onukii Matsuda |
PubMed: | Mechanisms of the preventive properties of some garlic components in the carbon tetrachloride-promoted oxidative stress. Diallyl sulfide; diallyl disulfide; allyl mercaptan and allyl methyl sulfide |
PubMed: | Volatile sulphur compounds and pathways of L-methionine catabolism in Williopsis yeasts |
PubMed: | Kinetic characterizations of diallyl sulfide analogs for their novel role as CYP2E1 enzyme inhibitors |
PubMed: | Reactivity of allyl methyl sulphide, the in-vitro metabolite of garlic, with some amino acids and with phospholipid involved in viral infections |
PubMed: | Detection of Volatile Metabolites of Garlic in Human Breast Milk |
PubMed: | [Study of volatile organic compounds of fresh allium species using headspace combined with surface-enhanced Raman scattering] |
PubMed: | [Clinical and pathologic features of tonsil-associated skin-bone-joint-kidney diseases] |
PubMed: | Screening of organosulfur compounds as inhibitors of human CYP2A6 |
PubMed: | Garlic Influences Gene Expression In Vivo and In Vitro |
PubMed: | A Miniature Gas Sampling Interface with Open Microfluidic Channels: Characterization of Gas-to-Liquid Extraction Efficiency of Volatile Organic Compounds |
PubMed: | In vitro evaluation of structural analogs of diallyl sulfide as novel CYP2E1 inhibitors for their protective effect against xenobiotic-induced toxicity and HIV replication |
PubMed: | Allicin and allicin-derived garlic compounds increase breath acetone through allyl methyl sulfide: use in measuring allicin bioavailability |
PubMed: | Modulation of cytochrome P450 enzymes by organosulfur compounds from garlic |
PubMed: | Novel Sulfur Metabolites of Garlic Attenuate Cardiac Hypertrophy and Remodeling through Induction of Na(+)/K(+)-ATPase Expression |
PubMed: | Actinobacillus pleuropneumoniae is impaired by the garlic volatile allyl methyl sulfide (AMS) in vitro and in-feed garlic alleviates pleuropneumonia in a pig model |
PubMed: | Detection of Volatile Metabolites Derived from Garlic (Allium sativum) in Human Urine |
PubMed: | Allylmethylsulfide, a Sulfur Compound Derived from Garlic, Attenuates Isoproterenol-Induced Cardiac Hypertrophy in Rats |
PubMed: | In vivo metabolism of diallyl disulphide in the rat: identification of two new metabolites |
PubMed: | Allyl Methyl Sulfide Preserved Pressure Overload-Induced Heart Failure Via Modulation of Mitochondrial Function |
PubMed: | Product ion distributions for the reactions of NO(+) with some physiologically significant volatile organosulfur and organoselenium compounds obtained using a selective reagent ionization time-of-f |
PubMed: | Enhancement by organosulfur compounds from garlic and onions of diethylnitrosamine-induced glutathione S-transferase positive foci in the rat liver |
PubMed: | Remotely triggered scaffolds for controlled release of pharmaceuticals |
PubMed: | Asymmetric copper-catalyzed |
PubMed: | Effect of Fresh Garlic on Lipid Oxidation and Microbiological Changes of Pork Patties during Refrigerated Storage |
PubMed: | A non-invasive method for in vivo skin volatile compounds sampling |
PubMed: | Composition, stability, and bioavailability of garlic products used in a clinical trial |
PubMed: | Mammary cancer prevention by regular garlic and selenium-enriched garlic |
PubMed: | Determination of urine-derived odorous compounds in a source separation sanitation system |
PubMed: | Volatile sulfur compounds in human expiration after eating raw or heat-treated garlic |
PubMed: | Differentiation of mouth versus gut as site of origin of odoriferous breath gases after garlic ingestion |
PubMed: | Blood and breath profiles of volatile organic compounds in patients with end-stage renal disease |
PubMed: | Inhibition of heterocyclic aromatic amine formation in fried ground beef patties by garlic and selected garlic-related sulfur compounds |
PubMed: | Significant inhibition of garlic essential oilon benzo[a]pyrene formation in charcoal-grilled pork sausagesrelates to sulfide compounds |
PubMed: | "Masked" Lewis-acidity of an aluminum à-phosphinoamide complex |
PubMed: | In situ solvothermal growth of metal-organic framework-5 supported on porous copper foam for noninvasive sampling of plant volatile sulfides |
PubMed: | Naturally occurring diallyl disulfide inhibits the formation of carcinogenic heterocyclic aromatic amines in boiled pork juice |
PubMed: | Photoionization-Generated Dibromomethane Cation Chemical Ionization Source for Time-of-Flight Mass Spectrometry and Its Application on Sensitive Detection of Volatile Sulfur Compounds |
PubMed: | Diallylsulfide and allylmethylsulfide are uniquely effective among organosulfur compounds in inhibiting CYP2E1 protein in animal models |
PubMed: | The determination of metabolites of garlic preparations in breath and human plasma |
PubMed: | Comparative study of extraction techniques for determination of garlic flavor components by gas chromatography-mass spectrometry |
PubMed: | Modulation of cytokine secretion by garlic oil derivatives is associated with suppressed nitric oxide production in stimulated macrophages |
PubMed: | Metabolites of diallyl disulfide and diallyl sulfide in primary rat hepatocytes |
PubMed: | Determination of allicin, S-allylcysteine and volatile metabolites of garlic in breath, plasma or simulated gastric fluids |
PubMed: | Differential effects of organosulfur compounds from garlic oil on nitric oxide and prostaglandin E2 in stimulated macrophages |
PubMed: | Garlic components inhibit angiotensin II-induced cell-cycle progression and migration: Involvement of cell-cycle inhibitor p27(Kip1) and mitogen-activated protein kinase |
PubMed: | Post-fasting olfactory, transcriptional, and feeding responses in Drosophila |
PubMed: | Radioprotective activity of naturally occurring organosulfur compounds |
PubMed: | Effect of alkyl sulfides on diazomethane-induced methylation of DNA in vitro |
PubMed: | Volatile organic compounds of Schenella pityophilus |
PubMed: | Inhibition of cytochrome P4502E1 expression by organosulfur compounds allylsulfide, allylmercaptan and allylmethylsulfide in rats |
PubMed: | Low allicin release from garlic supplements: a major problem due to the sensitivities of alliinase activity |
PubMed: | Modulation of rat hepatic cytochrome P-450 activity by garlic organosulfur compounds |
PubMed: | Intake of New Zealand Blackcurrant Powder Affects Skin-Borne Volatile Organic Compounds in Middle-Aged and Older Adults |
PubMed: | Ajoene exerts potent effects in 3T3-L1 adipocytes by inhibiting adipogenesis and inducing apoptosis |
PubMed: | Allylmethylsulfide Down-Regulates X-Ray Irradiation-Induced Nuclear Factor-kappaB Signaling in C57/BL6 Mouse Kidney |
PubMed: | Enhanced expression of rat microsomal epoxide hydrolase gene by organosulfur compounds |
PubMed: | Fragmentation of allylmethylsulfide by chemical ionization: dependence on humidity and inhibiting role of water |
PubMed: | Design and synthesis of novel oxindoles as potential non-nucleosidic reverse transcriptase inhibitors against HIV |
PubMed: | A preliminary study on the action of genus Allium on thyroid 131iodide uptake in rats |
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