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cis-4-hydroxy-6-dodecenoic acid lactone
Notes:
Used as a food additive [EAFUS]
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BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 18679-18-0 cis-4-Hydroxy-6-decenoic acid lactone
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Penta International Corporation Chemistry innovation At Penta, our products and services help businesses do business better. For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes. US Email: Technical Services US Email: Sales US Voice: (973) 740-2300 US Fax: (973) 740-1839 Product(s): 04-85750 GAMMA-DODECEN-6-LACTONE
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Soda Aromatic Co., Ltd. Depth of Experience We guarantees product safety and quality. Our international sales department is happy to design the most suitable flavor & fragrance for specific uses of processed food, cosmetics, and fragrance manufactures all over the world, specializing in Asia.Let us help you with your flavor & fragrance needs. Email: Info Email: Sales Voice: +81-3-5645-7347 Fax: +81-3-3664-5204 Product(s): 611224002 cis-6-Dodecen-4-olide
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Synerzine, Inc. Innovation. Customization. Aroma Ingredients. Synerzine is a leading supplier of flavor and fragrance ingredients. Synerzine expresses what we have grown to embody as an organization - the synergy and connection between raw ingredients, science, technology, and the final product. Our experienced team is passionate about bringing our customers high-quality innovative ingredients that they can trust. Building upon our 44 year history, the Synerzine team provides customers around the globe with convenient access to over 1200 high-quality aroma ingredients. We actively engage with customers to add a wide array of new products and services on a regular basis. Our aim is to delight every customer with our exceptional services, large product selection, customization and the highest quality and safety standards. We provide our customers with true value designed to help them bring their products to market faster. US Email: Customer Service US Email: Sales US Voice: (404) 524-6744 US Fax: (404) 577-1651 Inquiry Products List: View Product(s): W08211 cis-4-Hydroxy-6-dodecenoic Acid Lactone
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R C Treatt and Co Ltd Innovative ingredient solutions World-leading innovative ingredient solutions provider for the flavour, fragrance and FMCG industries. We offer innovative and trend-setting product concepts for our customers, collaborating with them to create true value for their products. Email: Enquiries US Email: Enquiries Voice: +44 (0) 1284 702500 Fax: +44 (0) 1284 703809 US Voice: +1 863 668 9500 US Fax: +1 863 668 3388 Twitter Linkedin Youtube News Product(s): cis-6-Dodecen-4-olide NI
Used in dairy flavours for bakery and milk products at up to 1-ppm, imitation dairy at 5ppm, and fruit sorbet at 1ppm. Stability: excellent.
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| CAS Number: | 18679-18-0 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 242-497-9 | |
| FDA UNII: | O8B631XC2S | |
| Nikkaji Web: | J127.244F | |
| MDL: | MFCD01631681 | |
| CoE Number: | 625 | |
| XlogP3-AA: | 3.60 (est) | |
| Molecular Weight: | 196.28980000 | |
| Formula: | C12 H20 O2 | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
| EFSA/JECFA Comments: | JECFA evaluated 1,4-dodec-6-enolactone (CASrn as in Register). Register CASrn refers to the (Z)-isomer. | |
Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| JECFA Food Flavoring: | 249 cis-4-hydroxy-6-dodecenoic acid lactone |
| DG SANTE Food Flavourings: | 10.009 dodec-6-eno-1,4-lactone |
| FEMA Number: | 3780 cis-4-hydroxy-6-dodecenoic acid lactone |
| FDA: | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF): | 18679-18-0 ; (Z)-4-HYDROXY-6-DODECENOIC ACID LACTONE |
Physical Properties:
| Appearance: | colorless to yellow clear liquid (est) |
| Assay: | 95.50 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 0.98800 @ 25.00 °C. |
| Boiling Point: | 159.00 °C. @ 10.00 mm Hg |
| Boiling Point: | 310.00 to 311.00 °C. @ 760.00 mm Hg |
| Vapor Pressure: | 0.001000 mmHg @ 25.00 °C. (est) |
| Flash Point: | > 212.00 °F. TCC ( > 100.00 °C. ) |
| logP (o/w): | 3.105 (est) |
| Soluble in: | |
| alcohol | |
| water, 64.91 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor Type: fatty | |
| sweet fatty waxy dairy creamy fruity | |
| Odor Description: at 10.00 % in dipropylene glycol. | sweet fatty waxy dairy creamy fruity |
| sweet fatty waxy dairy creamy lactonic fruity | |
| Odor Description: at 2.00 %. | Sweet, fatty, waxy, dairy and creamy with a lactonic, fruity nuance Mosciano, Gerard P&F 22, No. 6, 41, (1997) |
| Flavor Type: fatty | |
| fatty waxy creamy dairy lactonic fruity | |
| Taste Description: at 5.00 ppm. | Fatty, waxy, creamy and dairy-like with a lactonic fruitness Mosciano, Gerard P&F 22, No. 6, 41, (1997) |
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| Astral Extracts |
| Gamma-Dodecen-6-lactone |
| BOC Sciences |
| For experimental / research use only. |
| cis-4-Hydroxy-6-decenoic acid lactone |
| Penta International |
| GAMMA-DODECEN-6-LACTONE |
| R C Treatt & Co Ltd |
| cis-6-Dodecen-4-olide
NI Odor: milk fat Flavor: fresh cream and butter; rich fatty Used in dairy flavours for bakery and milk products at up to 1-ppm, imitation dairy at 5ppm, and fruit sorbet at 1ppm. Stability: excellent. |
| Soda Aromatic |
| cis-6-Dodecen-4-olide |
| Synerzine |
| cis-4-Hydroxy-6-dodecenoic Acid Lactone |
Safety Information:
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
oral-rat LD50 [sex: M,F] > 5000 mg/kg (Watanabe & Morimoto, 1990a) | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | flavor and fragrance agents | ||
| RIFM Fragrance Material Safety Assessment: Search | |||
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice | |||
| Recommendation for (Z)-dairy lactone usage levels up to: | |||
| 1.0000 % in the fragrance concentrate. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.012 (μg/capita/day) | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 16 | |||
| Click here to view publication 16 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | 3.00000 | 10.00000 | |
| beverages(nonalcoholic): | - | - | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | - | - | |
| condiments / relishes: | - | - | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | - | - | |
| fruit ices: | 0.20000 | 1.00000 | |
| gelatins / puddings: | - | - | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | - | - | |
| imitation dairy: | 1.00000 | 5.00000 | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | - | - | |
| milk products: | 2.00000 | 10.00000 | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | - | - | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
Safety References:
| Flavor & Extract Manufacturers Association (FEMA) reference(s): | |
| The FEMA GRAS assessment of lactones used as flavor ingredients. View pdf | |
| European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): | |
| Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to - Flavouring Group Evaluation 10: Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - (Commission Regulation (EC) No 1565/2000 of 18 July 2000) View page or View pdf | |
| Flavouring Group Evaluation 10, Revision 1 (FGE10 Rev1)[1] - Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) View page or View pdf | |
| Flavouring Group Evaluation 64 (FGE.64): Consideration of aliphatic acyclic diols, triols, and related substances evaluated by JECFA (57th meeting) structurally related to aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 evaluated by EFSA in FGE.10Rev1 (EFSA, 2008ab) View page or View pdf | |
| Scientific Opinion on Flavouring Group Evaluation 92 (FGE.92): Consideration of aliphatic acyclic diols, triols, and related substances evaluated by JECFA (68th meeting) structurally related to aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones evaluated by EFSA in FGE.10Rev1 (2009) View page or View pdf | |
| Scientific Opinion on Flavouring Group Evaluation 10, Revision 2 (FGE.10Rev2): Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 View page or View pdf | |
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 5352428 |
| National Institute of Allergy and Infectious Diseases: | Data |
| 5-[(Z)-oct-2-enyl]oxolan-2-one | |
| Chemidplus: | 0018679180 |
References:
| 5-[(Z)-oct-2-enyl]oxolan-2-one | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 5352428 |
| Pubchem (sid): | 135021308 |
| Flavornet: | 18679-18-0 |
| Pherobase: | View |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| KEGG (GenomeNet): | C03107 |
| HMDB (The Human Metabolome Database): | HMDB32331 |
| FooDB: | FDB009601 |
| Export Tariff Code: | 2932.29.6000 |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| EFSA Update of results on the monitoring of furan levels in food: | Read Report |
| EFSA Previous report: Results on the monitoring of furan levels in food: | Read Report |
| EFSA Report of the CONTAM Panel on provisional findings on furan in food: | Read Report |
Potential Blenders and core components note
Potential Uses:
| butter | FL | |
| cream | FR | |
| dairy | FL | |
| fruit | FR | |
| fungus | FR | |
| milk | FL | |
| sorbet | ||
| tropical | FL |
Occurrence (nature, food, other): note
| butter Search PMC Picture | |
| cheese swiss cheese Search PMC Picture | |
| dairy products Search PMC Picture | |
| lamb Search PMC Picture | |
| mushroom Search PMC Picture | |
| peach fruit Search Trop Picture | |
| sheep Search PMC Picture |
Synonyms:
| (Z)- | dihydro-5-(2-octenyl) furan-2(3H)-one |
| cis- | dihydro-5-(2-octenyl) furan-2(3H)-one |
| dihydro-5-(2-octenyl)-2(3H)-furanone, (Z)- | |
| (Z)- | dihydro-5-(2-octenyl)furan-2(3H)-one |
| dodec-6-eno-1,4-lactone | |
| 1,4- | dodec-6-enolactone, cis- |
| (Z)-6- | dodecen-4-olide |
| cis-6- | dodecen-4-olide |
| 6- | dodecen-4-olide, cis- |
| gamma- | dodecen-6-lactone |
| (Z)-6- | dodecen-gamma-lactone |
| cis-6- | dodecen-gamma-lactone |
| 2(3H)- | furanone, dihydro-5-(2-octenyl)-, (Z)- |
| 2(3H)- | furanone, dihydro-5-[(2Z)-2-octen-1-yl]- |
| (Z)-4- | hydroxy-6-dodecenoic acid lactone |
| cis-4- | hydroxy-6-dodecenoic acid lactone |
| 4- | hydroxy-6-dodecenoic acid lactone, cis- |
| cis-4- | hydroxydodec-6-enoic acid lactone |
| 5-[(2Z)- | oct-2-en-1-yl]dihydrofuran-2(3H)-one |
| 5-((Z)- | oct-2-enyl) oxolan-2-one |
| 5-[(Z)- | oct-2-enyl]oxolan-2-one |