2-oxobutyric acid, 600-18-0

Articles:

PubMed:	[Screening and identification of an endophytic bacterium with 1-aminocyclopropane-1-carboxylate deaminase activity from Panax ginseng and its effect on host growth].
PubMed:	Gordonibacter urolithinfaciens sp. nov., a urolithin-producing bacterium isolated from the human gut.
PubMed:	Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design.
PubMed:	A QM/MM study on the reaction pathway leading to 2-aceto-2-hydroxybutyrate in the catalytic cycle of AHAS.
PubMed:	Molecular evolution of threonine dehydratase in bacteria.
PubMed:	A one-pot system for production of L-2-aminobutyric acid from L-threonine by L-threonine deaminase and a NADH-regeneration system based on L-leucine dehydrogenase and formate dehydrogenase.
PubMed:	Highly stereoselective biosynthesis of (R)-α-hydroxy carboxylic acids through rationally re-designed mutation of D-lactate dehydrogenase.
PubMed:	Conserved pyridoxal protein that regulates Ile and Val metabolism.
PubMed:	Effect of amino acids on the formation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in creatinine/phenylalanine and creatinine/phenylalanine/4-oxo-2-nonenal reaction mixtures.
PubMed:	C-terminal binding proteins are essential pro-survival factors that undergo caspase-dependent downregulation during neuronal apoptosis.
PubMed:	Enhancing (L)-isoleucine production by thrABC overexpression combined with alaT deletion in Corynebacterium glutamicum.
PubMed:	BRCA1 expression is epigenetically repressed in sporadic ovarian cancer cells by overexpression of C-terminal binding protein 2.
PubMed:	Determination of α-keto acids in pork meat and Iberian ham via tandem mass spectrometry.
PubMed:	Synergy as design principle for metabolic engineering of 1-propanol production in Escherichia coli.
PubMed:	Microbial Community-Level Physiological Profiles (CLPP) and herbicide mineralization potential in groundwater affected by agricultural land use.
PubMed:	Efficient bioconversion of l-threonine to 2-oxobutyrate using whole cells of Pseudomonas stutzeri SDM.
PubMed:	Isolation of Rhizobacteria from Jatropha curcas and characterization of produced ACC deaminase.
PubMed:	Variability of Escherichia coli O157 strain survival in manure-amended soil in relation to strain origin, virulence profile, and carbon nutrition profile.
PubMed:	Effects of gamma-ray-induced free radicals on the metal content and amino acid composition of human metallothionein-1.
PubMed:	Asymmetric formal [3+2] cycloaddition reaction of isocyanoesters to 2-oxobutenoate esters by a multifunctional chiral silver catalyst.
PubMed:	Kinetic resolution of 2-hydroxybutanoate racemic mixtures by NAD-independent L-lactate dehydrogenase.
PubMed:	Mechanistic studies of 1-aminocyclopropane-1-carboxylate deaminase: characterization of an unusual pyridoxal 5'-phosphate-dependent reaction.
PubMed:	Biosynthesis of chiral 3-hydroxyvalerate from single propionate-unrelated carbon sources in metabolically engineered E. coli.
PubMed:	Three-component assembly and divergent ring-expansion cascades of functionalized 2-iminooxetanes.
PubMed:	Therapeutic targeting of C-terminal binding protein in human cancer.
PubMed:	Cloning and characterisation of a cystathionine β/γ-lyase from two Oenococcus oeni oenological strains.
PubMed:	Exploring methionine γ-lyase structure-function relationship via microspectrophotometry and X-ray crystallography.
PubMed:	Expanding metabolism for total biosynthesis of the nonnatural amino acid L-homoalanine.
PubMed:	Characterization of ACC deaminase gene in Pseudomonas entomophila strain PS-PJH isolated from the rhizosphere soil.
PubMed:	Efficient production of 2-oxobutyrate from 2-hydroxybutyrate by using whole cells of Pseudomonas stutzeri strain SDM.
PubMed:	Site-directed mutagenesis on human cystathionine-gamma-lyase reveals insights into the modulation of H2S production.
PubMed:	Transaminase-catalyzed asymmetric synthesis of L-2-aminobutyric acid from achiral reactants.
PubMed:	Acetohydroxyacid synthase, a novel target for improvement of L-lysine production by Corynebacterium glutamicum.
PubMed:	Directed evolution of Methanococcus jannaschii citramalate synthase for biosynthesis of 1-propanol and 1-butanol by Escherichia coli.
PubMed:	Identification of a methioninase inhibitor, myrsinoic acid B, from Myrsine seguinii Lév., and its inhibitory activities.
PubMed:	Direct methods and residue type specific isotope labeling in NMR structure determination and model-driven sequential assignment.
PubMed:	Isothermal titration microcalorimetry reveals the cooperative and noncompetitive nature of inhibition of Sinorhizobium meliloti L5-30 dihydrodipicolinate synthase by (S)-lysine.
PubMed:	[Overproduction of noncanonical amino acids by Escherichia coli cells].
PubMed:	Elucidation of an alternate isoleucine biosynthesis pathway in Geobacter sulfurreducens.
PubMed:	Production of the apoptotic cellular mediator 4-Methylthio-2-oxobutyric acid by using an enzymatic stirred tank reactor with in situ product removal.
PubMed:	SanM catalyzes the formation of 4-pyridyl-2-oxo-4-hydroxyisovalerate in nikkomycin biosynthesis by interacting with SanN.
PubMed:	Perspectives of bacterial ACC deaminase in phytoremediation.
PubMed:	A novel strategy for enzymatic synthesis of 4-hydroxyisoleucine: identification of an enzyme possessing HMKP (4-hydroxy-3-methyl-2-keto-pentanoate) aldolase activity.
PubMed:	The crystal structure of Escherichia coli TdcF, a member of the highly conserved YjgF/YER057c/UK114 family.
PubMed:	Bacillus decisifrondis sp. nov., isolated from soil underlying decaying leaf foliage.
PubMed:	Enzymology and evolution of the pyruvate pathway to 2-oxobutyrate in Methanocaldococcus jannaschii.
PubMed:	Silencing threonine deaminase and JAR4 in Nicotiana attenuata impairs jasmonic acid-isoleucine-mediated defenses against Manduca sexta.
PubMed:	Evidence for distinct L-methionine catabolic pathways in the yeast Geotrichum candidum and the bacterium Brevibacterium linens.
PubMed:	Accumulation of homolanthionine and activation of a novel pathway for isoleucine biosynthesis in Corynebacterium glutamicum McbR deletion strains.
PubMed:	Functional analysis of all aminotransferase proteins inferred from the genome sequence of Corynebacterium glutamicum.
PubMed:	Crystallization and some properties of D-lactate dehydrogenase from Staphylococcus sp. LDH-1.
PubMed:	Involvement of a branched-chain aminotransferase in production of volatile sulfur compounds in Yarrowia lipolytica.
PubMed:	The mitochondrial branched-chain aminotransferase (AtBCAT-1) is capable to initiate degradation of leucine, isoleucine and valine in almost all tissues in Arabidopsis thaliana.
PubMed:	Structural analysis of Pseudomonas 1-aminocyclopropane-1-carboxylate deaminase complexes: insight into the mechanism of a unique pyridoxal-5'-phosphate dependent cyclopropane ring-opening reaction.
PubMed:	Transcarboxylase 5S structures: assembly and catalytic mechanism of a multienzyme complex subunit.
PubMed:	Assay method for antitumor L-methionine gamma-lyase: comprehensive kinetic analysis of the complex reaction with L-methionine.
PubMed:	Role of a conserved arginine in the mechanism of acetohydroxyacid synthase: catalysis of condensation with a specific ketoacid substrate.
PubMed:	Reduced transaminase B (IlvE) activity caused by the lack of yjgF is dependent on the status of threonine deaminase (IlvA) in Salmonella enterica serovar Typhimurium.
PubMed:	Effect of alpha-ketobutyrate on microvascular thickness in the diabetic rat kidney.
PubMed:	Catabolism of volatile sulfur compounds precursors by Brevibacterium linens and Geotrichum candidum, two microorganisms of the cheese ecosystem.
PubMed:	Detection of carboxylic acids and inhibition of hippuric acid formation in rats treated with 3-butene-1,2-diol, a major metabolite of 1,3-butadiene.
PubMed:	Dual influence of the carbon source and L-methionine on the synthesis of sulphur compounds in the cheese-ripening yeast Geotrichum candidum.
PubMed:	A sensitive and robust method for obtaining intermolecular NOEs between side chains in large protein complexes.
PubMed:	Reaction of 1-amino-2-methylenecyclopropane-1-carboxylate with 1-aminocyclopropane-1-carboxylate deaminase: analysis and mechanistic implications.
PubMed:	Amino acid catabolism and generation of volatiles by lactic acid bacteria.
PubMed:	Substrate recognition by 2-oxoacid:ferredoxin oxidoreductase from Sulfolobus sp. strain 7.
PubMed:	Synthesis of labeled 1-amino-2-methylenecyclopropane-1-carboxylic acid, an inactivator of 1-aminocyclopropane-1-carboxylate deaminase.
PubMed:	Sulfur compound production by Geotrichum candidum from L-methionine: importance of the transamination step.
PubMed:	Contribution of enzymic alpha, gamma-elimination reaction in detoxification pathway of selenomethionine in mouse liver.
PubMed:	The large scale synthesis of "unnatural" amino acids.
PubMed:	Conversion of Escherichia coli pyruvate oxidase to an 'alpha-ketobutyrate oxidase'.
PubMed:	Biochemical and molecular characterization of taurine:pyruvate aminotransferase from the anaerobe Bilophila wadsworthia.
PubMed:	L-Vinylglycine is an alternative substrate as well as a mechanism-based inhibitor of 1-aminocyclopropane-1-carboxylate synthase.
PubMed:	Metabolic and K(ATP) channel-independent actions of keto acid initiators of insulin secretion.
PubMed:	Engineering of a novel biochemical pathway for the biosynthesis of L-2-aminobutyric acid in Escherichia coli K12.
PubMed:	Artefactual pyruvate and 2-oxobutyrate produced by trimethylsilylation of methylmalonic and ethylmalonic acids in the presence of oxygen.
PubMed:	Metabolic engineering of Arabidopsis and Brassica for poly(3-hydroxybutyrate-co-3-hydroxyvalerate) copolymer production.
PubMed:	Description of Cellulophaga baltica gen. nov., sp. nov. and Cellulophaga fucicola gen. nov., sp. nov. and reclassification of [Cytophaga] lytica to Cellulophaga lytica gen. nov., comb. nov.
PubMed:	Use of 13C nuclear magnetic resonance and gas chromatography to examine methionine catabolism by lactococci.
PubMed:	Substrate selectivity and biochemical properties of 4-hydroxy-2-keto-pentanoic acid aldolase from Escherichia coli.
PubMed:	Pyruvate protects neurons against hydrogen peroxide-induced toxicity.
PubMed:	Active site plasticity in D-amino acid oxidase: a crystallographic analysis.
PubMed:	Oocyte and zygote ketoaldehyde utilisation.
PubMed:	High resolution 1H NMR investigations of the reactivities of alpha-keto acid anions with hydrogen peroxide.
PubMed:	Production of heteropolymeric polyhydroxyalkanoate in Escherichia coli from a single carbon source.
PubMed:	Determination of short-chain aliphatic, oxo- and hydroxy-acids in drinking water at low microgram per liter concentrations.
PubMed:	Metabolic effects of inhibitors of two enzymes of the branched-chain amino acid pathway in Salmonella typhimurium.
PubMed:	The effect of three alpha-keto acids on 3-mercaptopyruvate sulfurtransferase activity.
PubMed:	In vivo threonine oxidation rate is dependent on threonine dietary supply in growing pigs fed low to adequate levels.
PubMed:	A spectrophotometric determination of alpha-dicarbonyl compounds and its application to the enzymatic formation of alpha-ketobutyrate.
PubMed:	Channeling behavior and activity models for Escherichia coli K-12 acetohydroxy acid synthases at physiological substrate levels.
PubMed:	Threonine dehydratases of Corynebacterium glutamicum with altered allosteric control: their generation and biochemical and structural analysis.
PubMed:	Methionine transamination--metabolic function and subcellular compartmentation.
PubMed:	Threonine 246 at the active site of the L-lactate dehydrogenase of Bacillus stearothermophilus is important for catalysis but not for substrate binding.
PubMed:	The oxygenase reaction of acetolactate synthase.
PubMed:	Cofactor identification of threonine-serine dehydratase from sheep liver.
PubMed:	Acetohydroxy acid synthase and threonine deaminase activities, and the biosynthesis of isoleucine-leucine-valine in Streptococcus bovis.
PubMed:	Alpha-keto acids are novel siderophores in the genera Proteus, Providencia, and Morganella and are produced by amino acid deaminases.
PubMed:	A mechanism for valine-resistant growth of Escherichia coli K-12 supported by the valine-sensitive acetohydroxy acid synthase IV activity from ilvJ662.
PubMed:	Eurystatins A and B, new prolyl endopeptidase inhibitors. II. Physico-chemical properties and structure determination.
PubMed:	In vivo nephrotoxic action of an isomeric mixture of S-(1-phenyl-2-hydroxyethyl)glutathione and S-(2-phenyl-2-hydroxyethyl)glutathione in Fischer-344 rats.
PubMed:	Physiological implications of the substrate specificities of acetohydroxy acid synthases from varied organisms.
PubMed:	Leaky pantothenate and thiamin mutations of Salmonella typhimurium conferring suphometuron methyl sensitivity.
PubMed:	Pleiotropic effects of poxA regulatory mutations of Escherichia coli and Salmonella typhimurium, mutations conferring sulfometuron methyl and alpha-ketobutyrate hypersensitivity.
PubMed:	Effects of alpha-ketobutyrate and alpha-hydroxybutyrate on the enzymatic determination of acetoacetate and beta-hydroxybutyrate.
PubMed:	Physiological implications of the specificity of acetohydroxy acid synthase isozymes of enteric bacteria.
PubMed:	Involvement of ack-pta operon products in alpha-ketobutyrate metabolism by Salmonella typhimurium.
PubMed:	Toxic accumulation of alpha-ketobutyrate caused by inhibition of the branched-chain amino acid biosynthetic enzyme acetolactate synthase in Salmonella typhimurium.
PubMed:	A method for simultaneous determination of the two possible products of acetohydroxy acid synthase.
PubMed:	Methionine metabolism in isolated perfused livers from rats fed on zinc-deficient and restricted diets.
PubMed:	Effect of alpha-ketobutyrate on palmitic acid and pyruvate metabolism in isolated rat hepatocytes.
PubMed:	Effects of organic acids on the synthesis of citrulline by intact rat liver mitochondria.
PubMed:	The occurrence of 4-methylthio-2-hydroxybutyrate in human urine.
PubMed:	Sensitivity of a Salmonella typhimurium aspC mutant to sulfometuron methyl, a potent inhibitor of acetolactate synthase II.
PubMed:	High performance liquid chromatography determination of cystathionase activity in human and rabbit lenses.
PubMed:	p-Cresol formation by cell-free extracts of Clostridium difficile.
PubMed:	alpha-Ketobutyrate metabolism in perfused rat liver: regulation of alpha-ketobutyrate decarboxylation and effects of alpha-ketobutyrate on pyruvate dehydrogenase.
PubMed:	Directed biosynthesis of paulomycin A. The effect of L-methionine, L-threonine and alpha-ketobutyric acid.
PubMed:	Heat-shock treatment lethal for mammalian cells deprived of glucose and glutamine: protection by alpha-keto acids.
PubMed:	Biochemical oxygen activation as the basis for the physiological action of tetrachlorodecaoxide (TCDO).
PubMed:	Defect in alpha-ketobutyrate metabolism: a new inborn error.
PubMed:	[Kinetics of uptake of Pherajod by the rabbit eye].
PubMed:	Biochemical model reactions for cataract research.
PubMed:	[The uptake of potassium iodide and its effect as an antioxidant in isolated rabbit eyes].
PubMed:	In vivo study of LDH isoenzyme activities in heart, liver and testis cytosols of gossypol-treated rats.
PubMed:	Synthesis of the isoleucyl- and valyl-tRNA synthetases and the isoleucine-valine biosynthetic enzymes in a threonine deaminase regulatory mutant of Escherichia coli K-12.
PubMed:	Characterization of alpha-ketobutyrate metabolism in rat tissues: effects of dietary protein and fasting.
PubMed:	Transaminase inhibitors block glycolysis and G1 to S phase progression in chick embryo fibroblasts: reversal by alpha-keto acids.
PubMed:	Metabolic alterations mediated by 2-ketobutyrate in Escherichia coli K12.
PubMed:	Role of 2-ketobutyrate as an alarmone in E. coli K12: inhibition of adenylate cyclase activity mediated by the phosphoenolpyruvate: glycose phosphotransferase transport system.
PubMed:	Mycoplanecins, novel antimycobacterial antibiotics from Actinoplanes awajinensis subsp. mycoplanecinus subsp. nov. III. Structural determination of mycoplanecin A.
PubMed:	The structure of the abortive nicotinamide adenine dinucleotide-pyruvate-lactate dehydrogenase complex as determined by circular dichroism.
PubMed:	2-Ketobutyrate: a putative alarmone of Escherichia coli.
PubMed:	Metabolic basis for the isoleucine, pantothenate or methionine requirement of ilvG strains of Salmonella typhimurium.
PubMed:	Effect of pyruvate and its analogs on the thiamine pyrophosphate binding in the active center of muscle pyruvate dehydrogenase.
PubMed:	Acetohydroxy acid synthase isoenzymes of Escherichia coli K12 and Salmonella typhimurium.
PubMed:	Mechanistic studies on the pyridoxal phosphate enzyme 1-aminocyclopropane-1-carboxylate deaminase from Pseudomonas sp.
PubMed:	Conversion of alpha-ketobutyrate to alpha-amino-n-butyric acid by isolated rat liver cells: effect of ethanol.
PubMed:	A role for threonine deaminase in the regulation of alpha-acetolactate biosynthesis in Escherichia coli K12.
PubMed:	Properties of alpha-hydroxyacid dehydrogenase isozymes from Trypanosoma cruzi.
PubMed:	Decrease of intracellular cystine content in cystinotic fibroblasts by inhibitors of gamma-glutamyl transpeptidase.
PubMed:	[Estimation of serine- and threonine dehydratase activity of blood serum].
PubMed:	A sensitive determination of alpha-keto acids by gas-liquid chromatography and its application to the assay of L-glutamate dehydrogenase and aminotransferases.
PubMed:	Hydroxyamino acid utilization and alpha-ketobutyrate toxicity in Pseudomonas cepacia.
PubMed:	Substrate channeling: alpha-ketobutyrate inhibition of acetohydroxy acid synthase in Salmonella typhimurium.
PubMed:	Beta-hydroxy-alpha-ketobutyric acid in Drosophila melanogaster, with reference to biosynthesis of drosopterins.
PubMed:	Stereochemistry of the conversions of L-threonine and D-threonine into 2-oxobutanoate by the L-threonine and D-threonine dehydratases of Serratia marcescens.
PubMed:	Serine sensitivity of Escherichia coli K 12: partial characterization of a serine resistnat mutant that is extremely sensitive to 2-ketobutyrate.
PubMed:	[Oxidative deamination of beta-methylaspartic acid].
PubMed:	Inactivation of the pyruvate dehydrogenase component from pigeon breast muscle pyruvate dehydrogenase complex by alpha-ketobutyric acid.
PubMed:	Methionine degradation by Pseudomonas fluorescens UK1 and its methionine-utilizing mutant.
PubMed:	High-speed liquid chromatographic determination of phenylpyruvic acid.
PubMed:	Sheep liver serine-threonine dehydratase. I. Purification and evidence for covalently linked alpha-ketobutyrate as its cofactor.
PubMed:	The formation of 2-hydroxybutyric acid in experimental animals.
PubMed:	beta-Decarboxylation of L-aspartic acid: a metal chelate-catalyzed reaction.
PubMed:	Neuropharmacological comparison of cystathionine, cysteine, homoserine and alpha-ketobutyric acid in cats.
PubMed:	A comparative study of the ability of methionine or linolenic acid to act as precursors of ethylene in plant tissues.
PubMed:	Biosynthesis of ethylene. 4-methylmercapto-2-oxobutyric acid: an intermediate in the formation from methionine.
PubMed:	On the mechanism of sensitivity to leucine in the case of "leucine sensitive hypoglycemia". II. The hypoglycemic affect of alpha-ketobutyric acid in the case of "leucine sensitive hypoglycemia".
PubMed:	2-Oxobutyric acid: effects of its condensation products on lactate dehydrogenase activity.
PubMed:	Effect of alpha-ketobutyric acid on exytetracycline production in serine-containing medium.
PubMed:	Alpha-keto acids in vitamin-free casein hydrolyzates (acid).
PubMed:	Effects of certain thiamine analogs on the enzymatic decarboxylation of alpha-ketobutyric acid.
PubMed:	alpha-Ketobutyric acid as a product in the enzymatic cleavage of cystathionine.
PubMed:	Pyruvate oxidation in brain: Evidence derived from the metabolism of alpha-ketobutyric acid.