Category: flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | colorless to yellow clear liquid (est) |
Assay: | 98.00 to 100.00 %
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Food Chemicals Codex Listed: | No |
Specific Gravity: | 1.19800 to 1.20200 @ 25.00 °C.
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Pounds per Gallon - (est).: | 9.969 to 10.002
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Refractive Index: | 1.53100 to 1.54100 @ 20.00 °C.
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Boiling Point: | 115.00 to 118.00 °C. @ 760.00 mm Hg
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Vapor Pressure: | 21.613001 mmHg @ 25.00 °C. (est) |
Flash Point: | 72.00 °F. TCC ( 22.22 °C. )
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logP (o/w): | 0.440 |
Soluble in: |
| alcohol | | water, 5.378e+004 mg/L @ 25 °C (est) |
Organoleptic Properties:
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Odor Type: fishy |
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| fishy nutty meaty |
Odor Description: at 0.10 % in propylene glycol. | pyridine nutty meaty |
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Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | Xn - Harmful. |
R 10 - Flammable. R 22 - Harmful if swallowed. R 37/38 - Irritating to respiratory system and skin. R 41 - Risk of serious damage to eyes. S 02 - Keep out of the reach of children. S 16 - Keep away from sources of ignition - No Smoking. S 20/21 - When using do not eat, drink or smoke. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 - Wear suitable gloves and eye/face protection.
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
oral-mouse LD50 983 mg/kg Drug and Chemical Toxicology. Vol. 3, Pg. 249, 1980.
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | flavoring agents |
Recommendation for thiazole usage levels up to: | | not for fragrance use.
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Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.012 (μg/capita/day) |
Maximised Survey-derived Daily Intakes (MSDI-USA): | 0.07 (μg/capita/day) |
Structure Class: | II |
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
publication number: 12 |
Click here to view publication 12 |
| average usual ppm | average maximum ppm |
baked goods: | - | - |
beverages(nonalcoholic): | - | - |
beverages(alcoholic): | - | - |
breakfast cereal: | - | - |
cheese: | - | - |
chewing gum: | - | 10.00000 |
condiments / relishes: | - | - |
confectionery froastings: | - | - |
egg products: | - | - |
fats / oils: | - | - |
fish products: | - | - |
frozen dairy: | - | - |
fruit ices: | - | - |
gelatins / puddings: | - | - |
granulated sugar: | - | - |
gravies: | - | - |
hard candy: | - | - |
imitation dairy: | - | 5.00000 |
instant coffee / tea: | - | - |
jams / jellies: | - | - |
meat products: | - | 5.00000 |
milk products: | - | - |
nut products: | - | 5.00000 |
other grains: | - | - |
poultry: | - | - |
processed fruits: | - | - |
processed vegetables: | - | - |
reconstituted vegetables: | - | 10.00000 |
seasonings / flavors: | - | 5.00000 |
snack foods: | - | - |
soft candy: | - | - |
soups: | - | - |
sugar substitutes: | - | - |
sweet sauces: | - | - |
Safety References:
European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
European Food Safety Authority (EFSA) reference(s): |
Flavouring Group Evaluation 76, (FGE.76)[1] - Consideration of sulphur-containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29, miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 76, Revision 1 (FGE.76Rev1): Consideration of sulphur-containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 and miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21Rev3 View page or View pdf |
EPI System: | View |
Chemical Carcinogenesis Research Information System: | Search |
AIDS Citations: | Search |
Cancer Citations: | Search |
Toxicology Citations: | Search |
EPA Substance Registry Services (TSCA): | 288-47-1 |
EPA ACToR: | Toxicology Data |
EPA Substance Registry Services (SRS): | Registry |
Laboratory Chemical Safety Summary : | 9256 |
National Institute of Allergy and Infectious Diseases: | Data |
WISER: | UN 1993 |
WGK Germany: | 3 |
| 1,3-thiazole |
Chemidplus: | 0000288471 |
EPA/NOAA CAMEO: | hazardous materials |
RTECS: | XJ1290000 for cas# 288-47-1 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
Articles:
PubMed: | Potential of aryl-urea-benzofuranylthiazoles hybrids as multitasking agents in Alzheimer's disease. |
PubMed: | Identification of the minimal cytolytic unit for streptolysin S and an expansion of the toxin family. |
PubMed: | Critical Intermediates Reveal New Biosynthetic Events in the Enigmatic Colibactin Pathway. |
PubMed: | Thyroid follicular lesions induced by thiazole-Zn feed treatment for one year in Sprague-Dawley rats. |
PubMed: | Activating and Inhibitory Functions of WNT/β-Catenin in the Induction of Cytochromes P450 by Nuclear Receptors in HepaRG Cells. |
PubMed: | New heterocyclic hybrids of pyrazole and its bioisosteres: design, synthesis and biological evaluation as dual acting antimalarial-antileishmanial agents. |
PubMed: | Isolation, identification, and formation conditions of a novel Maillard yellowish pigment, pyrrolothiazolate. |
PubMed: | 3D-QSAR, molecular docking and molecular dynamics studies of a series of RORγt inhibitors. |
PubMed: | Divisions of labor in the thiamin biosynthetic pathway among organs of maize. |
PubMed: | Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers. |
PubMed: | Fate of thiabendazole through the treatment of a simulated agro-food industrial effluent by combined MBR/Fenton processes at μg/L scale. |
PubMed: | Use of peptide nucleic acids (PNAs) for genotyping by solution and surface methods. |
PubMed: | Synthesis and antimosquito properties of 2,6-substituted benzo[d]thiazole and 2,4-substituted benzo[d]thiazole analogues against Anopheles arabiensis. |
PubMed: | Volatiles and water- and fat-soluble precursors of Saanen goat and cross Suffolk lamb flavour. |
PubMed: | Effects of pubertal exposure to thiazole-Zn on thyroid function and development in female rats. |
PubMed: | FDA-approved drugs selected using virtual screening bind specifically to G-quadruplex DNA. |
PubMed: | Pharmacokinetic optimization of 4-substituted methoxybenzoyl-aryl-thiazole and 2-aryl-4-benzoyl-imidazole for improving oral bioavailability. |
PubMed: | [Thiamine and its derivatives in the regulation of cell metabolism]. |
PubMed: | Flavor release of the tomato flavor enhancer, 2-isobutylthiazole, from whey protein stabilized model dressings. |
PubMed: | Charged states of 1,3,5-triazine molecules as models for star-shaped molecular architecture: a DFT and spectroelectrochemical study. |
PubMed: | Chemistry of clothianidin and related compounds. |
PubMed: | Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities. |
PubMed: | DNA/ligand/ion-based ensemble for fluorescence turn on detection of cysteine and histidine with tunable dynamic range. |
PubMed: | [Mu3-cis-N-(2-aminoethyl)-N'-(2-carboxylatophenyl)oxamidato(3-)]bis(2,2'-diamino-4,4'-bi-1,3-thiazole)tetracopper(II) bis(2,4,6-trinitrophenolate). |
PubMed: | Use of viability staining in combination with flow cytometry for rapid viability assessment of Lactobacillus rhamnosus GG in complex protein matrices. |
PubMed: | Synthesis and biological activity evaluation of 1,2,3-thiadiazole derivatives as potential elicitors with highly systemic acquired resistance. |
PubMed: | Synthesis and insecticidal activity of N-substituted (1,3-thiazole)alkyl sulfoximine derivatives. |
PubMed: | Synthesis, herbicidal activities, and 3D-QSAR of 2-cyanoacrylates containing aromatic methylamine moieties. |
PubMed: | Reticulated platelets interfere with flow cytometric reticulocyte counts. |
PubMed: | Induction of tachyzoite egress from cells infected with the protozoan Neospora caninum by nitro- and bromo-thiazolides, a class of broad-spectrum anti-parasitic drugs. |
PubMed: | Aqua(2,2'-diamino-4,4'-bi-1,3-thiazole-kappa2N,N')(oxydiacetato-kappa3O,O',O'')cobalt(II) trihydrate. |
PubMed: | Instrumental and sensory characterization of heat-induced odorants in aseptically packaged soy milk. |
PubMed: | In vitro efficacy of nitro- and bromo-thiazolyl-salicylamide compounds (thiazolides) against Besnoitia besnoiti infection in Vero cells. |
PubMed: | Comparison of three lychee cultivar odor profiles using gas chromatography-olfactometry and gas chromatography-sulfur detection. |
PubMed: | Structure-activity relationships from in vitro efficacies of the thiazolide series against the intracellular apicomplexan protozoan Neospora caninum. |
PubMed: | Effect of UVC-induced damage to DNA on the intercalation of thiazole orange: a convenient reporter for DNA damage. |
PubMed: | Diaqua(2,2'-diamino-4,4'-bi-1,3-thiazole)oxosulfatovanadium(IV) tetrahydrate. |
PubMed: | Expression pattern of matrix metalloproteinases in alcohol- and thermally oxidized sunflower oil-induced toxicity: protective role of an aminothiazole derivative. |
PubMed: | Development of quality evaluation sensor for fish freshness control based on KI value. |
PubMed: | Absorption, tissue distribution, excretion, and metabolism of clothianidin in rats. |
PubMed: | Generation of group-specific antibodies against sulfonamides. |
PubMed: | Differential effects of tomato (Lycopersicon esculentum mill) matrix on the volatility of important aroma compounds. |
PubMed: | Development of a flow cytometric method to analyze subpopulations of bacteria in probiotic products and dairy starters. |
PubMed: | Flow cytometric assessment of viability of lactic acid bacteria. |
PubMed: | Approaches to wine aroma: release of aroma compounds from reactions between cysteine and carbonyl compounds in wine. |
PubMed: | Amino- and urea-substituted thiazoles inhibit photosynthetic electron transfer. |
PubMed: | Flow cytometric method for detecting thiazole orange-positive (reticulated) platelets in thrombocytopenic horses. |
PubMed: | Formation of toxic metabolites from thiabendazole and other thiazoles in mice. Identification of thioamides as ring cleavage products. |
PubMed: | Possible role of thioformamide as a proximate toxicant in the nephrotoxicity of thiabendazole and related thiazoles in glutathione-depleted mice: structure-toxicity and metabolic studies. |
PubMed: | Nephrotoxicity of thiazoles structurally related to thiabendazole in mice depleted of glutathione by treatment with buthionine sulfoximine. |
PubMed: | 2-(oxadiazolyl)- and 2-(thiazolyl)imidazo[1,2-a]pyrimidines as agonists and inverse agonists at benzodiazepine receptors. |
PubMed: | Quantitation of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide and 2-amino-4-(5-nitro-2-furyl)thiazole in rodent diet. |
PubMed: | The sensitizing potential of metalworking fluid biocides (phenolic and thiazole compounds) in the guinea-pig maximization test in relation to patch-test reactivity in eczema patients. |
PubMed: | The effect of histamine, H1 and H2 agonists, and H1 and H2 antagonists on postprandial pancreatic polypeptide release in dogs. |
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