Category: flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | amber clear liquid (est) |
Assay: | 99.00 to 100.00 %
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Food Chemicals Codex Listed: | No |
Specific Gravity: | 1.14000 to 1.15200 @ 25.00 °C.
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Pounds per Gallon - (est).: | 9.486 to 9.586
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Refractive Index: | 1.54800 to 1.56800 @ 20.00 °C.
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Boiling Point: | 110.00 to 111.00 °C. @ 1.00 mm Hg
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Vapor Pressure: | 0.001000 mmHg @ 25.00 °C. (est) |
Flash Point: | > 212.00 °F. TCC ( > 100.00 °C. )
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logP (o/w): | 4.573 (est) |
Soluble in: |
| alcohol | | water, 0.7564 mg/L @ 25 °C (est) |
Insoluble in: |
| water |
Organoleptic Properties:
Odor Description: at 0.10 % in propylene glycol. | meaty |
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Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Beijing Lys Chemicals |
bis(2,5-dimethyl-3-furyl)disulfide
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BOC Sciences |
For experimental / research use only. |
3,3'-Dithiobis[2,5-dimethylfuran]
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Carbosynth |
For experimental / research use only. |
3,3'-Dithiobis(2,5-dimethylfUran)
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DeLong Chemicals America |
Bis(2,5-dimethyl-3-furyl)disulfide, Kosher
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Penta International |
bis(2,5-DIMETHYL-3-FURYL)DISULFIDE NATURAL 5% IN ETHYL ALCOHOL
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Penta International |
bis(2,5-DIMETHYL-3-FURYL)DISULFIDE
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Tengzhou Jitian Aroma Chemiclal |
bis(2,5-Dimethyl-3-furyl)disulfide
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Tianjin Danjun International |
3,3'-dithiobis[2,5-dimethylfuran]
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WholeChem |
Bis(2,5-dimethyl-3-furyl)disulfide
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Chemical Sources Association |
Need This Item for Flavor/Food?: You can contact the CSA |
Safety Information:
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
Not determined
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | flavoring agents |
Recommendation for bis(2,5-dimethyl-3-furyl) disulfide usage levels up to: | | not for fragrance use.
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Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.012 (μg/capita/day) |
Maximised Survey-derived Daily Intakes (MSDI-USA): | 0.70 (μg/capita/day) |
NOEL (No Observed Effect Level): | 0.45 (mg/kg bw per day) |
Structure Class: | III |
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
publication number: 10 |
Click here to view publication 10 |
| average usual ppm | average maximum ppm |
baked goods: | - | 0.10000 |
beverages(nonalcoholic): | - | - |
beverages(alcoholic): | - | - |
breakfast cereal: | - | - |
cheese: | - | - |
chewing gum: | - | - |
condiments / relishes: | - | - |
confectionery froastings: | - | - |
egg products: | - | - |
fats / oils: | - | - |
fish products: | - | - |
frozen dairy: | - | - |
fruit ices: | - | - |
gelatins / puddings: | - | - |
granulated sugar: | - | - |
gravies: | - | 0.10000 |
hard candy: | - | - |
imitation dairy: | - | - |
instant coffee / tea: | - | - |
jams / jellies: | - | - |
meat products: | - | 0.10000 |
milk products: | - | - |
nut products: | - | - |
other grains: | - | - |
poultry: | - | - |
processed fruits: | - | - |
processed vegetables: | - | - |
reconstituted vegetables: | - | - |
seasonings / flavors: | - | - |
snack foods: | - | - |
soft candy: | - | - |
soups: | - | 0.10000 |
sugar substitutes: | - | - |
sweet sauces: | - | - |
Safety References:
European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
European Food Safety Authority (EFSA) reference(s): |
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 13 (FGE.13); Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14 (Commission Regulation (EC) No 1565/2000 of 18 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 13Rev1: Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14 View page or View pdf |
Consideration of sulfur-substituted furan derivatives used as flavouring agents evaluated by JECFA (59th meeting) structurally related to a subgroup of substances within the group of “Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14” evaluated by EFSA in FGE.13Rev1 (2009) View page or View pdf |
Flavouring Group Evaluation 67 (FGE.67): Consideration of 40 furan-substituted aliphatic hydrocarbons, alcohols, aldehydes, ketones, carboxylic acids and related esters, sulfides, disulfides and ethers evaluated by JECFA at the 65th meeting (JECFA, 2006b) and re-evaluated at the 69th meeting (JECFA, 2009c) View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 13, Revision 2 (FGE.13Rev2): Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 67, Revision 1 (FGE.67Rev.1): Consideration of 40 furan-substituted aliphatic hydrocarbons, alcohols, aldehydes, ketones, carboxylic acids and related esters, sulfides, disulfides and ethers evaluated by JECFA at the 65th meeting (JECFA, 2006b) and re-evaluated at the 69th meeting (JECFA, 2009c) View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 65, Revision 1 (FGE.65Rev1): Consideration of sulfur-substituted furan derivatives used as flavouring agents evaluated by JECFA (59th meeting) structurally related to a subgroup of substances within the group of ‘Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14’ evaluated by EFSA in FGE.13Rev2 (2011) View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 13 Revision 3 (FGE.13Rev3): furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14 View page or View pdf |
EPI System: | View |
AIDS Citations: | Search |
Cancer Citations: | Search |
Toxicology Citations: | Search |
EPA Substance Registry Services (TSCA): | 28588-73-0 |
EPA ACToR: | Toxicology Data |
EPA Substance Registry Services (SRS): | Registry |
Laboratory Chemical Safety Summary : | 642117 |
National Institute of Allergy and Infectious Diseases: | Data |
| 3-(2,5-dimethylfuran-3-yl)disulfanyl-2,5-dimethylfuran |
Chemidplus: | 0028588730 |
References:
Other Information:
Potential Blenders and core components note
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For Odor |
alliaceous |
| dimethyl trisulfide | FL/FR |
| rum ether | FL/FR |
2- | methyl-3-,5 or 6-(furfuryl thio) pyrazine | FL/FR |
earthy |
| nutty pyrazine | FL/FR |
fermented |
| ethyl crotonate | FL/FR |
fruity |
| tropical thiazole | FL/FR |
| tropical trithiane | FL/FR |
green |
2- | heptyl furan | FL/FR |
(E,Z)-2,6- | nonadienal | FL/FR |
| meaty dithiane | FL/FR |
4- | methyl nonanoic acid | FL/FR |
| sulfurol | FL/FR |
| sulfuryl acetate | FL/FR |
moldy |
| strawberry furanone methyl ether | FL/FR |
musty |
| hazelnut pyrazine | FL/FR |
2- | ethyl-4-methyl thiazole | FL/FR |
2- | methyl-3-(methyl thio) pyrazine | FL/FR |
phenolic |
2,3- | dimethyl benzofuran | FL/FR |
ortho- | guaiacol | FL/FR |
4- | vinyl phenol | FL/FR |
| pyroligneous acids | FL/FR |
| benzothiazole | FL/FR |
| ethyl 2-mercaptopropionate | FL/FR |
| ethyl 3-mercaptopropionate | FL/FR |
| fish thiol | FL/FR |
2- | mercaptopropionic acid | FL/FR |
4- | methyl 4-mercaptopentan-2-one 1% solution | FL/FR |
2-( | methyl thio) phenol | FL/FR |
1- | phenethyl mercaptan | FL/FR |
tobacco |
| methyl benzoxole | FL/FR |
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For Flavor |
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No flavor group found for these |
4- | acetyl-2-methyl pyrimidine | FL |
| amyl mercaptan | FL |
1,2- | butane dithiol | FL |
2-(2- | butyl)-4,5-dimethyl-3-thiazoline | FL |
2,5- | diethyl thiazole | FL |
| dihydro-2,4,6-trimethyl-1,3,5(4H)-dithiazine | FL |
| dimethyl tetrasulfide | FL |
2,6- | dimethyl-3-((2-methyl-3-furyl)thio)-4-heptanone | FL |
(Z+E)-2,5- | dimethyl-3-tetrahydrofuran thiol | FL |
(Z+E)-2,5- | dimethyl-3-thioacetoxytetrahydrofuran | FL |
2,5- | dimethyl-3-thiofuroyl furan | FL |
S- | ethyl 2-acetyl aminoethane thioate | FL |
| ethyl 3-mercaptopropionate | FL/FR |
2- | ethyl-3-methyl thiopyrazine | FL |
(Z+E)-5- | ethyl-4-methyl-2-(2-butyl) thiazoline | FL |
(Z+E)-5- | ethyl-4-methyl-2-(2-methyl propyl) thiazoline | FL |
2- | hexyl thiophene | FL |
1-(3- | hydroxy-5-methyl-2-thienyl) ethanone | FL |
4- | mercapto-3-methyl-2-butanol | FL |
4- | methyl 4-mercaptopentan-2-one 1% solution | FL/FR |
| methyl dihydrofuran thiol | FL |
2- | methyl thiazolidine | FL |
2- | methyl-1-butane thiol | FL |
4- | methyl-2-(methyl thiomethyl)-2-hexenal | FL |
2- | methyl-2-thiazoline | FL |
2- | methyl-3-,5 or 6-(furfuryl thio) pyrazine | FL/FR |
2- | methyl-3-(methyl thio) pyrazine | FL/FR |
3-((2- | methyl-3-furyl)thio)-4-heptanone | FL |
4-((2- | methyl-3-furyl)thio)-5-nonanone | FL |
1,9- | nonane dithiol | FL |
1- | phenethyl mercaptan | FL/FR |
iso | propyl disulfide | FL |
| thiazole | FL |
3- | thienyl mercaptan | FL |
| thioacetic acid | FL |
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3,5- | diisopropyl-1,2,4-trithiolane | FL |
3,5- | dimethyl-1,2,4-trithiolane | FL |
3,7- | dimethyl-2,6-octadien-1-yl cyclopropyl carboxamide | FL |
2,4- | dimethyl-3-oxazoline | FL |
4- | mercapto-2-pentanone 1% in acetoin | FL |
2- | methyl-1-methyl thio-2-butene | FL |
| pyrrolidino-(1,2E)-4H-2,4-dimethyl-1,3,5-dithiazine | FL |
1-(2- | thienyl) butanone | FL |
alliaceous |
| allyl disulfide | FL |
1,3- | butane dithiol | FL |
| cyclopentyl mercaptan | FL |
| dimethyl trisulfide | FL/FR |
3- | mercapto-2-pentanone | FL |
| tropical thiazole | FL/FR |
burnt |
| bacon dithiazine | FL |
1,6- | hexane dithiol | FL |
| rum ether | FL/FR |
chemical |
2,3- | dimethyl benzofuran | FL/FR |
2,5- | dimethyl furan | FL |
coffee |
2- | ethyl-4-methyl thiazole | FL/FR |
earthy |
1,8- | octane dithiol | FL |
eggy |
iso | propyl mercaptan | FL |
fatty |
2- | heptyl furan | FL/FR |
4- | methyl nonanoic acid | FL/FR |
2- | pentyl thiophene | FL |
fruity |
| tropical trithiane | FL/FR |
green |
4- | methyl thiazole | FL |
(E,Z)-2,6- | nonadienal | FL/FR |
4- | penten-1-yl acetate | FL |
meaty |
4- | allyl-2,6-dimethoxyphenol | FL |
| benzothiazole | FL/FR |
2,6- | dimethyl thiophenol | FL |
2,5- | dimethyl-3-furan thiol | FL |
1,1- | ethane dithiol 1% in ethanol 94.5% / ethyl acetate 4% | FL |
| furfuryl 2-methyl-3-furyl disulfide | FL |
| meaty dithiane | FL/FR |
3- | mercapto-2-butanone | FL |
2- | mercaptomethyl pyrazine | FL |
2- | mercaptopropionic acid | FL/FR |
2- | methyl 3-(methyl thio) furan | FL |
2-( | methyl thio) phenol | FL/FR |
| methyl thiofuryl butanal | FL |
12- | methyl tridecanal | FL |
bis(2- | methyl-3-furyl) disulfide | FL |
S-(2- | methyl-3-furyl) ethane thioate | FL |
2- | methyl-3-tetrahydrofuran thiol | FL |
2- | methyl-3-thioacetoxytetrahydrofuran | FL |
| phenyl mercaptan | FL |
| propyl 2-mercaptopropionate | FL |
| pyrazinyl ethane thiol | FL |
2- | pyridinyl methane thiol | FL |
| sulfurol | FL/FR |
| sulfuryl acetate | FL/FR |
| thialdine | FL |
ortho- | thiocresol | FL |
ortho- | thioguaiacol | FL |
metallic |
2,5- | dihydroxy-1,4-dithiane | FL |
moldy |
| strawberry furanone methyl ether | FL/FR |
musty |
| hazelnut pyrazine | FL/FR |
nutty |
3- | acetyl-2,5-dimethyl thiophene | FL |
2- | acetyl-4-methyl thiazole | FL |
3,5- | diethyl-2-methyl pyrazine | FL |
2,5- | diethyl-3-methyl pyrazine | FL |
| methyl benzoxole | FL/FR |
| nutty pyrazine | FL/FR |
| nutty thiazole | FL |
onion |
| ethyl 2-mercaptopropionate | FL/FR |
| furfuryl isopropyl sulfide | FL |
phenolic |
2- | ethyl benzene thiol | FL |
4- | vinyl phenol | FL/FR |
popcorn |
2- | propionyl-2-thiazoline | FL |
radish |
3-( | methyl thio) propyl mercaptoacetate | FL |
rummy |
| ethyl crotonate | FL/FR |
smoky |
| prosopis juliflora wood extract | FL |
| pyroligneous acids | FL/FR |
sulfurous |
2,3- | butane dithiol | FL |
| ethyl methyl sulfide | FL |
S- | ethyl thioacetate | FL |
| fish thiol | FL/FR |
| methyl 2-methyl-3-furyl disulfide | FL |
3- | methyl-2-butane thiol | FL |
2- | naphthyl mercaptan | FL |
| roasted butanol | FL |
vegetable |
| tyramine | FL |
wasabi |
2-( | methyl thio) ethyl acetate | FL |
woody |
ortho- | guaiacol | FL/FR |
yeasty |
| faex extracts | FL |
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Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
3-((2,5- | dimethyl-3-furyl)disulfanyl)-2,5-dimethyl furan | bis(2,5- | dimethyl-3-furyl)disulfide | bis(2,5- | dimethyl-3-furyl)disulfide natural 5% in ethyl alcohol | 3-(2,5- | dimethylfuran-3-yl)disulfanyl-2,5-dimethylfuran | 3,3'- | disulfanediylbis(2,5-dimethylfuran) | 3,3,1- | dithiobis(2,5-dimethyl furan) | 3,3'- | dithiobis(2,5-dimethyl furan) | 3,3,1- | dithiobis(2,5-dimethylfuran) | 3,3'- | dithiobis(2,5-dimethylfuran) | 3,3'- | dithiobis[2,5-dimethylfuran] | | furan, 3,3'-dithiobis[2,5-dimethyl]- |
Articles:
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