Category: flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | yellow to green crystals (est) |
Assay: | 98.00 to 100.00 %
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Food Chemicals Codex Listed: | No |
Melting Point: | 55.00 to 60.00 °C. @ 760.00 mm Hg
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Boiling Point: | 325.00 to 326.00 °C. @ 760.00 mm Hg
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Vapor Pressure: | 0.000442 mmHg @ 25.00 °C. (est) |
Flash Point: | > 212.00 °F. TCC ( > 100.00 °C. )
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logP (o/w): | 4.012 (est) |
Soluble in: |
| alcohol | | water, 12.9 mg/L @ 25 °C (est) |
Insoluble in: |
| water |
Organoleptic Properties:
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Odor Type: rubbery |
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| rubbery earthy mushroom |
Odor Description: at 0.10 % in propylene glycol. | rubbery earthy mushroom |
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Flavor Type: earthy |
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| earthy meaty roasted |
Taste Description:
| earthy meaty |
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Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | Xn - Harmful. |
R 22 - Harmful if swallowed. R 36/37/38 - Irritating to eyes, respiratory system, and skin. R 41 - Risk of serious damage to eyes. S 02 - Keep out of the reach of children. S 20/21 - When using do not eat, drink or smoke. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 - Wear suitable gloves and eye/face protection.
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
gavage-mouse LD50 [sex: M,F] 400 mg/kg (Moran et al., 1980)
oral-mouse LD50 400 mg/kg Drug and Chemical Toxicology. Vol. 3, Pg. 249, 1980.
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | flavoring agents |
Recommendation for 2-thienyl disulfide usage levels up to: | | not for fragrance use.
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Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.061 (μg/capita/day) |
Maximised Survey-derived Daily Intakes (MSDI-USA): | 0.07 (μg/capita/day) |
Structure Class: | III |
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
publication number: 5 |
Click here to view publication 5 |
| average usual ppm | average maximum ppm |
baked goods: | - | 0.15000 |
beverages(nonalcoholic): | - | - |
beverages(alcoholic): | - | - |
breakfast cereal: | - | 0.15000 |
cheese: | - | - |
chewing gum: | - | - |
condiments / relishes: | - | 0.15000 |
confectionery froastings: | - | - |
egg products: | - | - |
fats / oils: | - | - |
fish products: | - | - |
frozen dairy: | - | - |
fruit ices: | - | - |
gelatins / puddings: | - | - |
granulated sugar: | - | - |
gravies: | - | 0.15000 |
hard candy: | - | - |
imitation dairy: | - | - |
instant coffee / tea: | - | - |
jams / jellies: | - | - |
meat products: | - | 0.15000 |
milk products: | - | - |
nut products: | - | - |
other grains: | - | - |
poultry: | - | - |
processed fruits: | - | - |
processed vegetables: | - | - |
reconstituted vegetables: | - | - |
seasonings / flavors: | - | - |
snack foods: | - | - |
soft candy: | - | - |
soups: | - | 0.15000 |
sugar substitutes: | - | - |
sweet sauces: | - | - |
Safety References:
European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
European Food Safety Authority (EFSA) reference(s): |
Flavouring Group Evaluation 21: Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29. Miscellaneous substances from chemical group 30. (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
Flavouring Group Evaluation 76, (FGE.76)[1] - Consideration of sulphur-containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29, miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf |
Flavouring Group Evaluation 21, Revision 1 (FGE.21Rev1): Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 Miscellaneous substances from chemical group 30 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 96 (FGE.96): Consideration of 88 flavouring substances considered by EFSA for which EU production volumes / anticipated production volumes have been submitted on request by DG SANCO. Addendum to FGE. 51, 52, 53, 54, 56, 58, 61, 62, 63, 64, 68, 69, 70, 71, 73, 76, 77, 79, 80, 83, 84, 85 and 87. View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 76, Revision 1 (FGE.76Rev1): Consideration of sulphur-containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 and miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21Rev3 View page or View pdf |
EPI System: | View |
EPA Substance Registry Services (TSCA): | 6911-51-9 |
EPA ACToR: | Toxicology Data |
EPA Substance Registry Services (SRS): | Registry |
Laboratory Chemical Safety Summary : | 23347 |
National Institute of Allergy and Infectious Diseases: | Data |
WGK Germany: | 3 |
| 2-thiophen-2-yldisulfanylthiophene |
Chemidplus: | 0006911519 |
RTECS: | JO1987000 for cas# 6911-51-9 |
References:
Other Information:
Potential Blenders and core components note
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For Odor |
No odor group found for these |
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(E)-1,5- | octadien-3-ol | |
alliaceous |
| dipropyl disulfide | FL/FR |
balsamic |
(E)- | benzyl tiglate | FL/FR |
dextro- | borneol | FL/FR |
| bornyl formate | FL/FR |
iso | bornyl formate | FL/FR |
T- | cadinol | FL/FR |
dextro- | fenchone | FL/FR |
citrus |
(E+Z)-4,8- | dimethyl-3,7-nonadien-2-yl acetate | FL/FR |
coconut |
delta- | heptalactone | FL/FR |
| bean pyrazine | FL/FR |
| benzyl tiglate | FL/FR |
| dibenzyl ether | FL/FR |
2- | ethyl fenchol | FL/FR |
2- | ethyl hexyl acetate | FL/FR |
2- | ethyl-3-methoxypyrazine | FL/FR |
(-)-alpha- | fenchol | FL/FR |
| heptanal cyclic acetal with glycerol | FL/FR |
| heptanal glyceryl acetal | FL/FR |
(Z)- | linalool oxide (furanoid) | FL/FR |
| methyl 3-hexenoate | FL/FR |
| methyl undecylenate | FL/FR |
1- | nonen-3-ol | FL/FR |
| nutty pyrazine | FL/FR |
3- | octanol | FL/FR |
2- | octanone | FL/FR |
(Z)-4- | octen-1-ol | FL/FR |
3- | octen-2-one | FL/FR |
1- | octen-3-ol | FL/FR |
1- | octen-3-one | FL/FR |
| spathulenol | |
fatty |
3- | decen-2-one | FL/FR |
(E)-2- | decenal | FL/FR |
| methyl 10-undecenoate | FL/FR |
| methyl 2-hexenoate | FL/FR |
floral |
| dihydro-alpha-ionone | FL/FR |
| lilac pentanol | FL/FR |
| linalool oxide | FL/FR |
2- | methyl-4-phenyl butanal | FL/FR |
| octyl acetate | FL/FR |
| phenyl acetaldehyde 2,3-butylene glycol acetal | FL/FR |
2- | phenyl propionaldehyde dimethyl acetal | FL/FR |
2- | phenyl propyl acetate | FL/FR |
fruity |
| amyl formate | FL/FR |
| butyl propionate | FL/FR |
3- | mercaptohexyl acetate | FL/FR |
2- | methyl butyl isovalerate | FL/FR |
2- | nonanone | FL/FR |
2- | pentyl furan | FL/FR |
| styralyl butyrate | FL/FR |
| tropical thiazole | FL/FR |
| tropical trithiane | FL/FR |
fungal |
| hydroxymethyl hexyl ethyl ketone | FL/FR |
green |
iso | amyl formate | FL/FR |
| cortex pyridine | FL/FR |
| cumin acetaldehyde | FL/FR |
iso | cyclocitral (IFF) | FL/FR |
| earthy acetal | FL/FR |
| fern absolute | |
(E)-3- | hexen-1-ol | FL/FR |
(Z)-3- | hexen-1-yl tiglate | FL/FR |
(Z)- | leaf acetal | FL/FR |
(Z)-1,5- | octadien-3-ol | |
| phenyl acetaldehyde dimethyl acetal | FL/FR |
1- | phenyl-2-pentanol | FL/FR |
2- | propenyl-para-cymene | FR |
iso | propyl quinoline | FR |
4-iso | propyl quinoline | FL/FR |
3,5,5- | trimethyl hexanol | FL/FR |
6- | hydroxydihydrotheaspirane (mixture of isomers) | FL/FR |
2- | methyl-3-buten-2-ol | FL/FR |
alpha- | pinene | FL/FR |
musty |
| menthofuran | FL/FR |
naphthyl |
ortho- | methyl anisole | FL/FR |
nutty |
2- | acetyl-3-ethyl pyrazine | FL/FR |
| filbert pyrazine | FL/FR |
2- | methyl thio-3,5 or 6-methyl pyrazine | FL/FR |
2- | methyl-3-ethoxypyrazine | FL/FR |
2,3,5- | trimethyl pyrazine | FL/FR |
spicy |
alpha- | caryophyllene alcohol | FL/FR |
beta- | caryophyllene alcohol | FL/FR |
| caryophyllene alcohol | FL/FR |
2- | octanol | FL/FR |
vegetable |
| methional | FL/FR |
waxy |
1- | dodecanol | FL/FR |
| octyl isobutyrate | FL/FR |
2- | tridecanone | FL/FR |
woody |
beta- | caryophyllene alcohol acetate | FL/FR |
| dihydro-beta-ionone | FL/FR |
| germacrene B | |
| pinacol | FR |
beta- | terpineol | FL/FR |
| verdoxan | FR |
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For Flavor |
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No flavor group found for these |
| bean pyrazine | FL/FR |
| benzyl disulfide | FL |
| benzyl tiglate | FL/FR |
dextro- | borneol | FL/FR |
| bornyl formate | FL/FR |
T- | cadinol | FL/FR |
| caryophyllene alcohol | FL/FR |
alpha- | caryophyllene alcohol | FL/FR |
beta- | caryophyllene alcohol | FL/FR |
beta- | caryophyllene alcohol acetate | FL/FR |
| dimethyl dihydrocyclopentapyrazine | FL |
(E+Z)-4,8- | dimethyl-3,7-nonadien-2-yl acetate | FL/FR |
| earthy acetal | FL/FR |
2- | ethyl hexyl acetate | FL/FR |
2- | ethyl-3-methoxypyrazine | FL/FR |
2- | ethyl-4,5-dimethyl oxazole | FL |
| fern absolute | |
| furfural diethyl acetal | FL |
| germacrene B | |
| green pea pyrazine | FL |
| heptanal cyclic acetal with glycerol | FL/FR |
| heptanal glyceryl acetal | FL/FR |
| hydroxymethyl hexyl ethyl ketone | FL/FR |
(Z)- | linalool oxide (furanoid) | FL/FR |
2- | methoxy-3-propyl pyrazine | FL |
| methyl 2-hexenoate | FL/FR |
tris( | methyl thio) methane | FL |
2- | methyl-3-buten-2-ol | FL/FR |
2- | methyl-3-ethoxypyrazine | FL/FR |
2- | methyl-4-phenyl butanal | FL/FR |
1,5- | octadien-3-ol | FL |
(E)-1,5- | octadien-3-ol | |
(Z)-1,5- | octadien-3-ol | |
1,5- | octadien-3-one | FL |
(Z)-4- | octen-1-ol | FL/FR |
| phenyl acetaldehyde 2,3-butylene glycol acetal | FL/FR |
2- | phenyl propyl acetate | FL/FR |
4-iso | propyl quinoline | FL/FR |
| pyrazine | FL |
| spathulenol | |
beta- | terpineol | FL/FR |
alliaceous |
| dipropyl disulfide | FL/FR |
3- | mercapto-2-pentanone | FL |
| tropical thiazole | FL/FR |
astringent |
2,3- | dimethyl quinoxaline | FL |
balsamic |
(E)- | benzyl tiglate | FL/FR |
berry |
| dihydro-alpha-ionone | FL/FR |
bready |
| mango furanone | FL |
camphoreous |
(-)-alpha- | fenchol | FL/FR |
6- | hydroxydihydrotheaspirane (mixture of isomers) | FL/FR |
ortho- | methyl anisole | FL/FR |
cheesy |
2- | nonanone | FL/FR |
coffee |
| difurfuryl ether | FL |
| methyl furfuryl mercaptopropionate | FL |
cooling |
dextro- | fenchone | FL/FR |
creamy |
| acetyl ethyl carbinol | FL |
3- | octen-2-one | FL/FR |
| octyl isobutyrate | FL/FR |
dairy |
2- | octanone | FL/FR |
earthy |
2- | ethyl fenchol | FL/FR |
(±)-2- | mercapto-5-methylheptan-4-one | FL |
1- | nonen-3-ol | FL/FR |
1,8- | octane dithiol | FL |
1- | octen-3-one | FL/FR |
fatty |
2- | tridecanone | FL/FR |
fruity |
| amyl formate | FL/FR |
| butyl propionate | FL/FR |
| dibenzyl ether | FL/FR |
| lilac pentanol | FL/FR |
| methyl 3-hexenoate | FL/FR |
2- | methyl butyl isovalerate | FL/FR |
2- | phenyl propionaldehyde dimethyl acetal | FL/FR |
1- | phenyl-2-pentanol | FL/FR |
| styralyl butyrate | FL/FR |
| tropical trithiane | FL/FR |
green |
iso | amyl formate | FL/FR |
| cortex pyridine | FL/FR |
| cumin acetaldehyde | FL/FR |
iso | cyclocitral (IFF) | FL/FR |
3- | decen-2-one | FL/FR |
(E)-3- | hexen-1-ol | FL/FR |
(Z)-3- | hexen-1-yl tiglate | FL/FR |
(Z)- | leaf acetal | FL/FR |
| linalool oxide | FL/FR |
2- | pentyl furan | FL/FR |
| phenyl acetaldehyde dimethyl acetal | FL/FR |
2- | propyl pyrazine | FL |
| propylene glycol acetone ketal | FL |
3,5,5- | trimethyl hexanol | FL/FR |
hay |
| lactadione | FL |
herbal |
| oregano oleoresin | FL |
lactonic |
delta- | heptalactone | FL/FR |
meaty |
roast | chicken flavor | FL |
2- | mercaptomethyl pyrazine | FL |
roasted | pork flavor | FL |
2- | pyridinyl methane thiol | FL |
ortho- | thiocresol | FL |
roast | turkey flavor | FL |
milky |
dextro,laevo-3-( | methyl thio) butanone | FL |
mushroom |
1- | octen-3-ol | FL/FR |
musty |
| menthofuran | FL/FR |
3- | octanol | FL/FR |
| propionaldehyde | FL |
2,3,5- | trimethyl pyrazine | FL/FR |
nutty |
2- | acetyl-1-methyl pyrrole | FL |
2- | acetyl-3-ethyl pyrazine | FL/FR |
| filbert pyrazine | FL/FR |
2- | methyl thio-3,5 or 6-methyl pyrazine | FL/FR |
| nutty pyrazine | FL/FR |
| nutty thiazole | FL |
phenolic |
| propyl 2-furoate | FL |
roasted |
3,5- | diisobutyl-1,2,4-trithiolane | FL |
soapy |
1- | dodecanol | FL/FR |
solvent |
2- | ethyl furan | FL |
spicy |
2- | octanol | FL/FR |
sulfurous |
| diphenyl disulfide | FL |
| potato butanone | FL |
| roasted butanol | FL |
tomato |
| methional | FL/FR |
tropical |
3- | mercaptohexyl acetate | FL/FR |
waxy |
(E)-2- | decenal | FL/FR |
| methyl 10-undecenoate | FL/FR |
| methyl undecylenate | FL/FR |
| octyl 2-furoate | FL |
| octyl acetate | FL/FR |
winey |
5- | ethyl-2-methyl pyridine | FL |
woody |
iso | bornyl formate | FL/FR |
| dihydro-beta-ionone | FL/FR |
alpha- | pinene | FL/FR |
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Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| di-2-thienyl disulfide | 2,2'- | disulfanediyldithiophene | | disulfide, 2-thienyl | 2,2'- | dithienyl disulfide | alpha,alpha'- | dithienyl disulfide | 2,2'- | dithiobis(thiophene) | 2,2- | dithiodithiophene | 2,2'- | dithiodithiophene | 2,2- | dithiothiophene | 2- | thienyl disulphide | 2,2'-bis( | thienyl) disulfide | 2- | thienyldisulfide | 2- | thiophen-2-yl disulfanyl thiophene | 2- | thiophen-2-yldisulfanylthiophene | | thiophene, 2,2'-dithiobis- | | thiophene, 2,2'-dithiodi- |
Articles:
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