Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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JECFA Food Flavoring: | 952 5,6,7,8-tetrahydroquinoxaline |
DG SANTE Food Flavourings: | 14.015 5,6,7,8-tetrahydroquinoxaline |
FEMA Number: | 3321 5,6,7,8-tetrahydroquinoxaline |
FDA: | No longer provide for the use of these seven synthetic flavoring substances |
FDA Mainterm (SATF): | 34413-35-9 ; 5,6,7,8-TETRAHYDROQUINOXALINE |
Physical Properties:
Appearance: | colorless to amber clear solid (est) |
Assay: | 98.00 to 100.00 %
|
Food Chemicals Codex Listed: | No |
Specific Gravity: | 1.07700 to 1.08700 @ 25.00 °C.
|
Pounds per Gallon - (est).: | 8.962 to 9.045
|
Refractive Index: | 1.53800 to 1.54800 @ 20.00 °C.
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Melting Point: | 29.00 to 30.00 °C. @ 760.00 mm Hg
|
Boiling Point: | 108.00 to 111.00 °C. @ 760.00 mm Hg
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Boiling Point: | 85.00 °C. @ 3.00 mm Hg
|
Vapor Pressure: | 0.055000 mmHg @ 25.00 °C. (est) |
Vapor Density: | 4.6 ( Air = 1 ) |
Flash Point: | 195.00 °F. TCC ( 90.56 °C. )
|
logP (o/w): | 1.158 (est) |
Shelf Life: | 12.00 month(s) or longer if stored properly. |
Storage: | refrigerate in tightly sealed containers. |
Soluble in: |
| alcohol | | water, slightly | | water, 2091 mg/L @ 25 °C (est) |
Organoleptic Properties:
|
Odor Type: nutty |
|
| musty nutty roasted beany cereal corn chip cheesy |
Odor Description: at 0.10 % in dipropylene glycol. | musty nut roasted bean cereal corn chip cheese |
|
| musty nutty roasted beany cereal |
Odor Description:
| Musty, nutty, roasted, beany, cereal cracker-like, with corn nuances Mosciano, Gerard P&F 19, No. 2, 55, (1994) |
|
|
Flavor Type: nutty |
|
| nutty musty corn taco popcorn |
Taste Description: at 10.00 ppm. | Nutty, musty, corn taco and popcorn-like Mosciano, Gerard P&F 19, No. 2, 55, (1994) |
|
Odor and/or flavor descriptions from others (if found). |
|
R C Treatt & Co Ltd |
5,6,7,8-Tetrahydroquinoxaline Halal, Kosher |
Odor Description: | Fatty/cheesy |
Taste Description: | nutty, roasted, cereal |
|
OQEMA |
5,6,7,8-Tetrahydro Quinoxaline |
Odor Description: | Fatty/cheesy |
Taste Description: | nutty, roasted, cereal |
|
|
Cosmetic Information:
Suppliers:
Advanced Biotech |
5,6,7,8 TETRAHYDROQUINOXALINE
|
Ambles Nature et Chimie |
5.6.7.8-TETRAHYDROQUINOXALINE
|
Anhui Haibei |
5,6,7,8-Tetrahydroquinoxaline
Odor: Musty nut roasted bean cereal cracker corn cheese |
Anhui Suzhou Jinli Aromatic Chemicals |
5,6,7,8-Tetrahydro quinoxaline
Odor: baked hazel nut, baked peanut |
Beijing Lys Chemicals |
5,6,7,8-Tetrahydroquinoxaline
|
BOC Sciences |
For experimental / research use only. |
5.6.7.8-Tetrahydroquinoxaline
|
Charkit Chemical |
TETRAHYDROQUINOXALINE,5,6,7,8- FEMA 3321
|
De Monchy Aromatics |
5,6,7,8-Tetrahydroquinoxaline
|
DeLong Chemicals America |
5,6,7,8-Tetrahydroquinoxaline, Kosher
|
Endeavour Specialty Chemicals |
5,6,7,8-Tetrahydroquinoxaline
|
Speciality Chemical Product Groups |
FCI SAS |
TETRAHYDROQUINOXALINE
Odor: Roasted peanut |
Fleurchem |
5,6,7,8-tetrahydroquinoxaline
|
Frutarom |
5-6-7-8-TETRAHYDROQUINOXALINE
KOSHER Flavor: Bean, Musty, Nutty, Roasted |
CBD Offering |
IFF |
5-6-7-8-TETRAHYDROQUINOXALINE
KOSHER Flavor: Bean, Musty, Nutty, Roasted |
Indukern F&F |
TETRAHYDROQUINOXALINE
Odor: CHEESE, NUTTY, CEREAL |
Jiangyin Healthway |
5,6,7,8-Tetrahydroquinoxaline
|
New functional food ingredients |
Jinan Enlighten Chemical Technology(Wutong Aroma ) |
5,6,7,8-Tetrahydro quinoxaline, Kosherk
|
Lluch Essence |
5,6,7,8-TETRAHYDROQUINOXALINE
|
M&U International |
5,6,7,8-TETRAHYDROQUINOXALINE, Kosher
|
OQEMA |
5,6,7,8-Tetrahydro Quinoxaline
|
Penta International |
5,6,7,8-TETRAHYDROQUINOXALINE
|
R C Treatt & Co Ltd |
5,6,7,8-Tetrahydroquinoxaline
Halal, Kosher Odor: Fatty/cheesy Flavor: nutty, roasted, cereal |
Robinson Brothers |
5,6,7,8-Tetrahydroquinoxaline F&F
|
https://www.robinsonbrothers.uk/chemistry-competences |
Santa Cruz Biotechnology |
For experimental / research use only. |
5,6,7,8-Tetrahydroquinoxaline
|
Sigma-Aldrich |
5,6,7,8-Tetrahydroquinoxaline, ≥97%, FG
Odor: cheese |
Certified Food Grade Products |
Sunaux International |
5,6,7,8-Tetrahydroquinoxaline
|
Synerzine |
5,6,7,8-Tetrahydroquinoxaline
also named Cyclohexapyrazine |
Taytonn ASCC |
5,6,7,8-Tetrahydroquinoxaline
Odor: Bean, Musty, Nutty, Roast |
TCI AMERICA |
For experimental / research use only. |
5,6,7,8-Tetrahydroquinoxaline >98.0%(GC)(T)
|
Tengzhou Jitian Aroma Chemiclal |
5,6,7,8-Tetrahydroquinoxaline
|
Tengzhou Xiang Yuan Aroma Chemicals |
5.6.7.8-Tetrohydro quinoxaline
|
Tianjin Danjun International |
5,6,7,8-Tetrahydroquinoxaline
|
United International |
5,6,7,8-Tetrahydroquinoxaline
|
Vigon International |
Tetrahydroquinoxaline-5,6,7,8
|
WholeChem |
5.6.7.8-Tetrahydroquinoxaline
|
Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | Xi - Irritant |
R 36/37/38 - Irritating to eyes, respiratory system, and skin. S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 - Wear suitable gloves and eye/face protection.
|
|
Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
Not determined
|
Dermal Toxicity: |
Not determined
|
Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | flavor and fragrance agents |
RIFM Fragrance Material Safety Assessment: Search |
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
Recommendation for nutty quinoxaline usage levels up to: | | 0.1000 % in the fragrance concentrate.
|
|
Maximised Survey-derived Daily Intakes (MSDI-EU): | 8.00 (μg/capita/day) |
Maximised Survey-derived Daily Intakes (MSDI-USA): | ND (μg/capita/day) |
Structure Class: | III |
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
publication number: 5 |
Click here to view publication 5 |
| average usual ppm | average maximum ppm |
baked goods: | - | 5.00000 |
beverages(nonalcoholic): | - | 5.00000 |
beverages(alcoholic): | - | - |
breakfast cereal: | - | 2.00000 |
cheese: | - | - |
chewing gum: | - | - |
condiments / relishes: | - | 2.00000 |
confectionery froastings: | - | - |
egg products: | - | - |
fats / oils: | - | - |
fish products: | - | - |
frozen dairy: | - | - |
fruit ices: | - | - |
gelatins / puddings: | - | 2.00000 |
granulated sugar: | - | - |
gravies: | - | 2.00000 |
hard candy: | - | 5.00000 |
imitation dairy: | - | - |
instant coffee / tea: | - | - |
jams / jellies: | - | - |
meat products: | - | 2.00000 |
milk products: | - | 1.00000 |
nut products: | - | - |
other grains: | - | - |
poultry: | - | - |
processed fruits: | - | - |
processed vegetables: | - | - |
reconstituted vegetables: | - | - |
seasonings / flavors: | - | - |
snack foods: | - | - |
soft candy: | - | - |
soups: | - | 2.00000 |
sugar substitutes: | - | - |
sweet sauces: | - | - |
Safety References:
Flavor & Extract Manufacturers Association (FEMA) reference(s): |
The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients. View pdf |
European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
European Food Safety Authority (EFSA) reference(s): |
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) View page or View pdf |
Flavouring Group Evaluation 50 (FGE.50): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) [1] View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010) View page or View pdf |
Safety and efficacy of pyrazine derivatives including saturated ones belonging to chemical group 24 when used as flavourings for all animal species View page or View pdf |
EPI System: | View |
AIDS Citations: | Search |
Cancer Citations: | Search |
Toxicology Citations: | Search |
EPA Substance Registry Services (TSCA): | 34413-35-9 |
EPA ACToR: | Toxicology Data |
EPA Substance Registry Services (SRS): | Registry |
Laboratory Chemical Safety Summary : | 36822 |
National Institute of Allergy and Infectious Diseases: | Data |
WGK Germany: | 3 |
| 5,6,7,8-tetrahydroquinoxaline |
Chemidplus: | 0034413359 |
References:
Other Information:
Potential Blenders and core components note
|
For Odor |
No odor group found for these |
| sulfuryl octanoate | FL/FR |
|
| sulfuryl butyrate | FL/FR |
| sulfuryl decanoate | FL/FR |
| sulfuryl hexanoate | FL/FR |
| sulfuryl isobutyrate | FL/FR |
| sulfuryl propionate | FL/FR |
anisic |
para- | anisaldehyde | FL/FR |
balsamic |
2- | acetyl furan | FL/FR |
iso | butyl cinnamate | FL/FR |
| ethyl cinnamate | FL/FR |
| methyl cinnamate | FL/FR |
3- | phenyl propyl alcohol | FL/FR |
bready |
| coffee furanone | FL/FR |
| cyclotene | FL/FR |
| immortelle absolute | FL/FR |
| maltol | FL/FR |
iso | propenyl pyrazine | FL/FR |
| strawberry furanone | FL/FR |
cereal |
| bran absolute | FR |
chocolate |
iso | amyl phenyl acetate | FL/FR |
2,5- | dimethyl pyrazine | FL/FR |
coconut |
gamma- | nonalactone (aldehyde C-18 (so-called)) | FL/FR |
gamma- | octalactone | FL/FR |
coffee |
| cichorium intybus root solid extract | FL/FR |
| popcorn pyrimidine | FL/FR |
earthy |
| nutty pyrazine | FL/FR |
floral |
| bois de rose oil brazil | FL/FR |
| ethyl phenyl acetate | FL/FR |
green |
2- | heptyl furan | FL/FR |
hay |
| beeswax absolute | FL/FR |
honey |
| phenyl acetic acid | FL/FR |
medicinal |
| quinoline | CS |
musty |
2- | acetyl pyrrole | FL/FR |
3- | acetyl-2,5-dimethyl furan | FL/FR |
| hazelnut pyrazine | FL/FR |
| menthofuran | FL/FR |
2- | acetyl-3-ethyl pyrazine | FL/FR |
2- | acetyl-3-methyl pyrazine | FL/FR |
2- | acetyl-3,5-dimethyl pyrazine | FL/FR |
2- | acetyl-3,5(or 6)-dimethyl pyrazine | FL/FR |
5- | acetyl-4-methyl thiazole | |
2- | acetyl-5-methyl furan | FL/FR |
roasted | chestnut fragrance | FR |
3,6- | cocoa pyrazine | FL/FR |
4,5- | dimethyl-2-ethyl-3-thiazoline | FL/FR |
2,4- | dimethyl-5-ethyl thiazole | |
2- | ethyl pyrazine | FL/FR |
| filbert heptenone | FL/FR |
| filbert heptenone B | FL/FR |
| filbert pyrazine | FL/FR |
2,6- | lutidine | FL/FR |
| methoxymethyl pyrazine | FL/FR |
5- | methyl quinoxaline | FL/FR |
| nutty cyclohexenone | FL/FR |
| sesame absolute | FL/FR |
2,3,5,6- | tetramethyl pyrazine | FL/FR |
2,3,5- | trimethyl pyrazine | FL/FR |
| vinyl sulfurol | FL/FR |
popcorn |
2- | acetyl pyrazine | FL/FR |
2- | acetyl thiazole | FL/FR |
powdery |
para- | anisyl alcohol | FL/FR |
roasted |
2- | acetyl-2-pyrroline | |
spicy |
| cassia bark oil china | FL/FR |
| clove bud oil | FL/FR |
alpha- | methyl cinnamaldehyde | FL/FR |
sulfurous |
| dimethyl sulfide | FL/FR |
| furfuryl thioacetate | FL/FR |
tonka |
| tonka bean absolute | FR |
vanilla |
| ethyl vanillin | FL/FR |
| vanilla bean absolute (vanilla planifolia) | FL/FR |
| vanillyl acetate | FL/FR |
woody |
4- | hydroxybenzaldehyde | FL/FR |
|
For Flavor |
|
No flavor group found for these |
| acetyl acetaldehyde dimethyl acetal | FL |
2- | acetyl-2-pyrroline | |
5- | acetyl-4-methyl thiazole | |
(E)- | aconitic acid | FL |
| cyclohexyl methyl pyrazine | FL |
2,5- | diethyl thiazole | FL |
6,7- | dihydro-2,3-dimethyl-5H-cyclopentapyrazine | FL |
| dimethyl dihydrocyclopentapyrazine | FL |
6,7- | dimethyl dihydrocyclopentapyrazine | FL |
2,5- | dimethyl pyrazine and 2,6-dimethyl pyrazine mixture | FL |
2,5- | dimethyl thiazole | FL |
2,4- | dimethyl-5-ethyl thiazole | |
| methyl 2-(methyl thio) acetate | FL |
| pyrazines mixture | FL |
| sulfuryl butyrate | FL/FR |
| sulfuryl decanoate | FL/FR |
| sulfuryl hexanoate | FL/FR |
| sulfuryl isobutyrate | FL/FR |
|
5- | acetyl-2,3-dihydro-1,4-thiazine | FL |
| sulfuryl formate | FL |
| sulfuryl octanoate | FL/FR |
| sulfuryl propionate | FL/FR |
ammoniacal |
2- | methyl piperidine | FL |
balsamic |
iso | butyl cinnamate | FL/FR |
| ethyl cinnamate | FL/FR |
bready |
2- | propionyl thiazole | FL |
brown |
| beeswax absolute | FL/FR |
burnt |
iso | propenyl pyrazine | FL/FR |
buttery |
| diacetyl | FL |
caramellic |
| caramel furanone | FL |
| cyclotene | FL/FR |
| maltol | FL/FR |
| strawberry furanone | FL/FR |
coconut |
gamma- | nonalactone (aldehyde C-18 (so-called)) | FL/FR |
coffee |
| cichorium intybus root solid extract | FL/FR |
corn chip |
2- | acetyl thiazole | FL/FR |
2- | acetyl-2-thiazoline | FL |
| popcorn pyrimidine | FL/FR |
creamy |
para- | anisaldehyde | FL/FR |
4- | hydroxybenzaldehyde | FL/FR |
fatty |
2- | heptyl furan | FL/FR |
fishy |
4,5- | dimethyl thiazole | FL |
floral |
iso | amyl phenyl acetate | FL/FR |
| bois de rose oil brazil | FL/FR |
| phenyl acetic acid | FL/FR |
fruity |
para- | anisyl alcohol | FL/FR |
2- | ethyl-2,5-dihydro-4-methyl thiazole | FL |
green |
| immortelle absolute | FL/FR |
honey |
| ethyl phenyl acetate | FL/FR |
lactonic |
gamma- | octalactone | FL/FR |
malty |
| yeast thiazoline | FL |
musty |
2,5- | dimethyl pyrazine | FL/FR |
2- | ethoxythiazole | FL |
| hazelnut pyrazine | FL/FR |
| menthofuran | FL/FR |
2,3,5- | trimethyl pyrazine | FL/FR |
nutty |
2- | acetyl furan | FL/FR |
2- | acetyl pyrrole | FL/FR |
3- | acetyl-2,5-dimethyl furan | FL/FR |
3- | acetyl-2,5-dimethyl thiophene | FL |
2- | acetyl-3-ethyl pyrazine | FL/FR |
2- | acetyl-3-methyl pyrazine | FL/FR |
2- | acetyl-3,5-dimethyl pyrazine | FL/FR |
2- | acetyl-3,5(or 6)-dimethyl pyrazine | FL/FR |
2- | acetyl-5-methyl furan | FL/FR |
| arachis hypogaea fruit extract | FL |
3,6- | cocoa pyrazine | FL/FR |
| coffee furanone | FL/FR |
4,5- | dimethyl-2-ethyl-3-thiazoline | FL/FR |
2- | ethyl pyrazine | FL/FR |
1- | ethyl-2-acetyl pyrrole | FL |
| filbert heptenone | FL/FR |
| filbert heptenone B | FL/FR |
| filbert pyrazine | FL/FR |
2,6- | lutidine | FL/FR |
| methoxymethyl pyrazine | FL/FR |
5- | methyl quinoxaline | FL/FR |
| nutty cyclohexenone | FL/FR |
| nutty pyrazine | FL/FR |
| nutty thiazole | FL |
| peanut oxazole | FL |
| sesame absolute | FL/FR |
2,3,5,6- | tetramethyl pyrazine | FL/FR |
| vinyl sulfurol | FL/FR |
popcorn |
2- | propionyl-2-thiazoline | FL |
roasted |
2- | acetyl pyrazine | FL/FR |
3,5- | diisobutyl-1,2,4-trithiolane | FL |
| furfuryl thioacetate | FL/FR |
spicy |
| cassia bark oil china | FL/FR |
| clove bud oil | FL/FR |
alpha- | methyl cinnamaldehyde | FL/FR |
| methyl cinnamate | FL/FR |
3- | phenyl propyl alcohol | FL/FR |
sulfurous |
| dimethyl sulfide | FL/FR |
vanilla |
| ethyl vanillin | FL/FR |
| vanilla bean absolute (vanilla planifolia) | FL/FR |
| vanillyl acetate | FL/FR |
|
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| cyclohexapyrazine | | quinoxaline, 5,6,7,8-tetrahydro- | 5,6,7,8- | tetrahydro quinoxaline | | tetrahydro terrazine-014 (IFF) | | tetrahydroquinoxaline | 5,6,7,8- | tetrahydroquinoxaline | 5,6,7,8- | tetrahydroquinoxaline natural | 5,6,7,8- | tetrahydroquinoxaline natural 1% in ethyl alcohol | 5,6,7,8- | tetrahydroquinoxaline natural 5% in ethyl alcohol | | tetrahydroterrazine (IFF) |
Articles:
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