isoamyl amine
isopentylamine
 
Notes:
Widespread in fungi and higher plants e.g. apple, banana, wine grape, swede, rhubarb, porcini (Boletus edulis). Protein degradn. product. Present in bread, apple, banana, white wine, cheeses, rye and ergot
  • Augustus Oils
    • Augustus Oils Ltd
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      Augustus Oils Ltd, in harmony with nature - to present it at its best...
      A wealth of experience, expertise and knowledge has allowed Augustus to bridge the gulf in expectation and trust between growers and users of natural ingredients. The Company works in partnership with customers on the one hand, and growers, farmers and distillers on the other. Both users and producers can then focus on exactly what they do best, while skilled Augustus technicians closely monitor and control the delivered product. This ensures users can have the confidence that they will receive the best raw materials suited to their requirements.
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      Product(s):
      Iso Amyl Amine
       
  • Penta International
    • Penta International Corporation
      Chemistry innovation
      At Penta, our products and services help businesses do business better.
      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
      US Email: Technical Services
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      US Voice: (973) 740-2300
      US Fax: (973) 740-1839
      Product(s):
      09-51400 ISOPENTYLAMINE
       
  • Sigma-Aldrich
  • Synerzine
    • Synerzine, Inc.
      Innovation. Customization. Aroma Ingredients.
      Synerzine is a leading supplier of flavor and fragrance ingredients.
      Synerzine expresses what we have grown to embody as an organization - the synergy and connection between raw ingredients, science, technology, and the final product. Our experienced team is passionate about bringing our customers high-quality innovative ingredients that they can trust.
      Building upon our 44 year history, the Synerzine team provides customers around the globe with convenient access to over 1200 high-quality aroma ingredients. We actively engage with customers to add a wide array of new products and services on a regular basis. Our aim is to delight every customer with our exceptional services, large product selection, customization and the highest quality and safety standards. We provide our customers with true value designed to help them bring their products to market faster.
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      Product(s):
      W01755 isoAmyl Amine
       
  • TCI AMERICA
    • TCI AMERICA
      Moving Your Chemistry Forward
      We continuously strive to advance our technology.
      With East & West Coast distribution centers, count on TCI to deliver products quickly and reliably. Over 30,000 Reagents available today in benchtop to bulk quantities. We also offer custom synthesis solutions. Sign up for a TCI account today for fast and free shipping!
      Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 70 years of synthesis experience and multi-purpose plants enable TCI to offer more than 30,000 products as well as custom synthesis.
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      Product(s):
      I0082 isoamylamine >98.0%(GC)(T)
       
  • R C Treatt & Co Ltd
    • R C Treatt and Co Ltd
      Innovative ingredient solutions
      World-leading innovative ingredient solutions provider for the flavour, fragrance and FMCG industries.
      We offer innovative and trend-setting product concepts for our customers, collaborating with them to create true value for their products.
      Email: Enquiries
      US Email: Enquiries
      Voice: +44 (0) 1284 702500
      Fax: +44 (0) 1284 703809
      US Voice: +1 863 668 9500
      US Fax: +1 863 668 3388
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      Product(s):
      Isopentylamine Kosher
       
Synonyms   Articles   Notes   Search
CAS Number: 107-85-7Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 203-526-0
FDA UNII: LPO0L33SHY
Nikkaji Web: J95.661I
Beilstein Number: 1209230
MDL: MFCD00008203
CoE Number: 512
XlogP3-AA: 1.00 (est)
Molecular Weight: 87.16561000
Formula: C5 H13 N
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
JECFA Food Flavoring: 1587  isopentylamine
DG SANTE Food Flavourings: 11.001  3-methylbutylamine
FEMA Number: 3219 isopentylamine
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):107-85-7 ; ISOPENTYLAMINE
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Physical Properties:
Appearance: colorless to pale yellow clear liquid (est)
Assay: 98.00 to 100.00 % 
Food Chemicals Codex Listed: No
Specific Gravity: 0.74700 to 0.75300 @  25.00 °C.
Pounds per Gallon - (est).: 6.216 to  6.266
Refractive Index: 1.40500 to 1.41100 @  20.00 °C.
Melting Point: -60.00 °C. @ 760.00 mm Hg
Boiling Point: 95.00 to  97.00 °C. @ 760.00 mm Hg
Vapor Pressure: 51.112999 mmHg @ 25.00 °C. (est)
Vapor Density: 3 ( Air = 1 )
Flash Point: 62.00 °F. TCC ( 16.67 °C. )
logP (o/w): 1.410 (est)
Soluble in:
 alcohol
 propylene glycol
 water
 glycerin
 water, 1.097e+005 mg/L @ 25 °C (est)
Similar Items: note
amyl amine
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Organoleptic Properties:
 
Odor Type: ammoniacal
 
 ammoniacal  
Odor Description:
at 0.10 % in propylene glycol. 
unpleasent ammonia
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
Augustus Oils
Iso Amyl Amine
Services
Penta International
ISOPENTYLAMINE
R C Treatt & Co Ltd
Isopentylamine
Kosher
Santa Cruz Biotechnology
For experimental / research use only.
isopentylamine
Sigma-Aldrich
Isopentylamine, ≥98%
Certified Food Grade Products
Synerzine
isoAmyl Amine
TCI AMERICA
For experimental / research use only.
isoamylamine >98.0%(GC)(T)
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Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
C - Corrosive.
R 11 - Highly flammable.
R 22 - Harmful if swallowed.
R 34 - Causes burns.
S 02 - Keep out of the reach of children.
S 16 - Keep away from sources of ignition - No Smoking.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
S 45 - In case of accident or if you feel unwell seek medical advice immediately.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: flavoring agents
Recommendation for isoamyl amine usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 24.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.07 (μg/capita/day)
Threshold of Concern:1800 (μg/person/day)
Structure Class: I
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 4
Click here to view publication 4
 average usual ppmaverage maximum ppm
baked goods: -0.10000
beverages(nonalcoholic): -0.10000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -0.10000
fruit ices: -0.10000
gelatins / puddings: -0.10000
granulated sugar: --
gravies: --
hard candy: -0.10000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
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Safety References:
European Food Safety Athority(EFSA): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Flavouring Group Evaluation 86, (FGE.86)[1] - Consideration of aliphatic and aromatic amines and amides evaluated by JECFA (65th meeting) - Scientific Opinion of the Panel on Food Additives - Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 86, Revision 1 (FGE.86Rev1): Consideration of aliphatic and aromatic amines and amides evaluated by JECFA (65th meeting)
View page or View pdf
Scientific Opinion on the safety and efficacy of aliphatic and aromatic amines (chemical group 33) when used as flavourings for all animal species
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 86, Revision 2 (FGE.86Rev2): Consideration of aliphatic and arylalkyl amines and amides evaluated by JECFA (65th meeting)
View page or View pdf
EPI System: View
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 107-85-7
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 7894
National Institute of Allergy and Infectious Diseases: Data
WISER: UN 1106
WGK Germany: 1
 3-methylbutan-1-amine
Chemidplus: 0000107857
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References:
 3-methylbutan-1-amine
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 107-85-7
Pubchem (cid): 7894
Pubchem (sid): 134972735
Pherobase: View
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS): View
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C02640
HMDB (The Human Metabolome Database): HMDB31659
FooDB: FDB008319
Export Tariff Code: 2921.19.5000
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 chocolateFR
 seafoodFL
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Occurrence (nature, food, other): note
 apple fruit
Search  PMC Picture
 arum dioscoridis
Search Trop  Picture
 arum italicum
Search Trop  Picture
 banana fruit
Search Trop  Picture
 beef boiled beef
Search  PMC Picture
 beer
Search  PMC Picture
 bread wheat bread
Search  PMC Picture
 caviar
Search  PMC Picture
 cheese bleu cheese
Search  PMC Picture
 cheese cheddar cheese
Search  PMC Picture
 cheese swiss cheese
Search  PMC Picture
 cocoa
Search Trop  Picture
 coffee
Search  PMC Picture
 corn sprout
Search Trop  Picture
 dragonwort
Search Trop  Picture
 elder black elder flower
Search Trop  Picture
 elder black elder plant
Search Trop  Picture
 grape
Search Trop  Picture
 grape fruit juice
Search Trop  Picture
 hydrosme rivieri
Search Trop  Picture
 kale
Search  PMC Picture
 mushroom porcini mushroom
Search  PMC Picture
 pork fried pork
Search  PMC Picture
 rhubarb
Search  PMC Picture
 rutabaga
Search Trop  Picture
 sauromatum guttatum
Search Trop  Picture
 spinach leaf
Search Trop  Picture
 tomato
Search Trop  Picture
 truffle
Search  Picture
 wine red wine
Search  Picture
 wine white wine
Search  Picture
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Synonyms:
1-amino-3-methyl butane
1-amino-3-methylbutane
1-aminoisopentane
isoamylamine
monoisoamylamine
1-butanamine, 3-methyl-
isobutyl carbyl amine
isobutyl carbylamine
 butylamine, 3-methyl-
3,3-dimethyl propyl amine
3,3-dimethylpropylamine
 leucamine
3-methyl butyl amine
3-methyl-1-butanamine
3-methyl-butan-1-amine
3-methylbutan-1-amine
3-methylbutanamine
3-methylbutyl amine
3-methylbutylamine
isopentyl amine
isopentylamine
monoisopentylamine
 propylamine, 3,3-dimethyl-
isovaleryl amine
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Articles:
Info: aliphatic and aromatic amines and amides
PubMed: Credneramides A and B: neuromodulatory phenethylamine and isopentylamine derivatives of a vinyl chloride-containing fatty acid from cf. Trichodesmium sp. nov.
PubMed: Synthesis of methylisoamylnitrosamine from isoamylamine by fungi (Fusarium moniliforme).
PubMed: Synthesis of nitrosomethylisoamylamine from isoamylamine and sodium nitrite by fungi.
PubMed: Nitrogen fertilisation increases biogenic amines and amino acid concentrations in Vitis vinifera var. Riesling musts and wines.
PubMed: [Studies on the synthesis of two new nitrosamines (NMAMBA and NMAMPA) from isoamylamine and sodium nitrite by fungi].
PubMed: The deamination of isoamylamine by monamine oxidase in mitochondrial preparations from rat liver and heart: a comparison with phenylethylamine.
PubMed: Impact of Gram-negative bacteria in interaction with a complex microbial consortium on biogenic amine content and sensory characteristics of an uncooked pressed cheese.
PubMed: Levels of histamine and other biogenic amines in high-quality red wines.
PubMed: Agonists for 13 trace amine-associated receptors provide insight into the molecular basis of odor selectivity.
PubMed: Validation of a method for the analysis of biogenic amines: histamine instability during wine sample storage.
PubMed: Study of the naphthalene-2,3-dicarboxaldehyde pre-column derivatization of biogenic mono- and diamines in mixture and fluorescence-HPLC determination.
PubMed: E-64c-hydrazide: a lead structure for the development of irreversible cathepsin C inhibitors.
PubMed: Diversity and assessment of potential risk factors of Gram-negative isolates associated with French cheeses.
PubMed: Metabolic profiling of the protozoan parasite Entamoeba invadens revealed activation of unpredicted pathway during encystation.
PubMed: Identification of puberty-accelerating pheromones in male mouse urine.
PubMed: Gas chromatography-mass spectrometry assessment of amines in Port wine and grape juice after fast chloroformate extraction/derivatization.
PubMed: Nakijiquinones J--R, sesquiterpenoid quinones with an amine residue from okinawan marine sponges.
PubMed: Autophagy in tobacco BY-2 cells cultured under sucrose starvation conditions: isolation of the autolysosome and its characterization.
PubMed: Analysis of puberty-accelerating pheromones.
PubMed: Trace amine-associated receptors are olfactory receptors in vertebrates.
PubMed: High-precision position-specific isotope analysis of 13C/12C in leucine and methionine analogues.
PubMed: Seasonal changes in plasma concentrations of cecum-derived amines in clinically normal ponies and ponies predisposed to laminitis.
PubMed: Gas chromatographic analysis of bacterial amines as their free bases.
PubMed: Suppression of calcium-induced removal of the Z-line by a thiol-protease inhibitor, E-64-c.
PubMed: Production of amines in equine cecal contents in an in vitro model of carbohydrate overload.
PubMed: Semicarbazide-sensitive amine oxidase (SSAO) of the rat aorta. Interactions with some naturally occurring amines and their structural analogues.
PubMed: Interaction of 11 cisplatin analogues with DNA: characteristic pattern of damage with monofunctional analogues.
PubMed: Nitrosatable amines and nitrosamide formation in natural stimulants: Cola acuminata, C. nitida and Garcinia cola.
PubMed: Analysis of amines and other bacterial products by head-space gas chromatography.
PubMed: Modification of ion-exchange membrane used for separation of protons and metallic cations and characterization of the membrane by current-voltage curves.
PubMed: Application of polymethacrylate resin as stationary phase in liquid chromatography with UV detection for C1-C7 aliphatic monocarboxylic acids and C1-C7 aliphatic monoamines.
PubMed: Uptake of 5-hydroxytryptamine by equine digital vein endothelial cells: inhibition by amines found in the equine caecum.
PubMed: Identification and quantification of amines in the equine caecum.
PubMed: Effects of enzyme inducers and inhibitor on the pharmacokinetics of intravenous 2-(allylthio)pyrazine, a new chemoprotective agent, in rats.
PubMed: [The occurence and distribution of volatile amines in marine algae].
PubMed: THE METABOLISM OF THE ISCHEMIC KIDNEY : I. THE RESPIRATION AND THE OXIDASE ACTIVITY OF THE ISCHEMIC KIDNEY.
PubMed: Ion-trap versus time-of-flight mass spectrometry coupled to capillary electrophoresis to analyze biogenic amines in wine.
PubMed: Separation and conductimetric detection of C1-C7 aliphatic monocarboxylic acids and C1-C7 aliphatic monoamines on unfunctionized polymethacrylate resin columns.
PubMed: Effects of monoamines formed in the cecum of horses on equine digital blood vessels and platelets.
PubMed: Attractants fromStaphylococcus aureus cultures for Mexican fruit fly,Anastrepha ludens.
PubMed: Gas liquid chromatography of amines produced by the Enterobacteriaceae.
PubMed: [Evidence of synthesizing secondary amines from primary amines by fungi--microbiological production of methylisoamylamine and piperidine].
PubMed: Environmental effects on charge densities of biologically active molecules: do molecule crystal environments indeed approximate protein surroundings?
PubMed: Michael acceptors as cysteine protease inhibitors.
PubMed: Effect of cysteine protease inhibitor Ep-475 on TNF-alpha-independent cyclophosphamide-induced apoptosis in mouse lymphosarcoma LS cells.
PubMed: Involvement of calpain in osteoclastic bone resorption.
PubMed: Crystal structures of calpain-E64 and -leupeptin inhibitor complexes reveal mobile loops gating the active site.
PubMed: Cysteine proteases are the major beta-secretase in the regulated secretory pathway that provides most of the beta-amyloid in Alzheimer's disease: role of BACE 1 in the constitutive secretory pathway.
PubMed: Primate neurons show different vulnerability to transient ischemia and response to cathepsin inhibition.
PubMed: Structural basis for development of cathepsin B-specific noncovalent-type inhibitor: crystal structure of cathepsin B-E64c complex.
PubMed: Calpain-calpastatin: a novel, complete calcium-dependent protease system in human spermatozoa.
PubMed: Postictal blockade of ischemic hippocampal neuronal death in primates using selective cathepsin inhibitors.
PubMed: Striated muscle calcium-stimulated cysteine protease (calpain-like) activity promotes myeloperoxidase activity with exercise.
PubMed: A calcium stimulated cysteine protease involved in isoproterenol induced cardiac hypertrophy.
PubMed: m-calpain in rat growth plate chondrocyte cultures: its involvement in the matrix mineralization process.
PubMed: Retraction of cultured endothelial cell monolayer by human breast cancer cells, MCF-7.
PubMed: Determination of a cysteine protease inhibitor and its ethyl ester in mouse serum and muscle by liquid chromatography-mass spectrometry.
PubMed: Protease inhibition causes some manifestations of aging and Alzheimer's disease in rodent and primate brain.
PubMed: Effects of selective inhibition of cathepsin B and general inhibition of cysteine proteinases on lysosomal proteolysis in rat liver in vivo and in vitro.
PubMed: Inhibition of interleukin 1-stimulated cartilage proteoglycan degradation by a lipophilic inactivator of cysteine endopeptidases.
PubMed: A comparison between the binding modes of a substrate and inhibitor to papain as observed in complex crystal structures.
PubMed: Suppressive effect of E-64c on ischemic degradation of cerebral proteins following occlusion of the middle cerebral artery in rats.
PubMed: Diabetic state-induced activation of calcium-activated neutral proteinase in mouse skeletal muscle.
PubMed: Differences in substrate specificities for cysteine proteinases used in blood group serology, and the use of bromelain in a two-phase inhibitor technique.
PubMed: Cathepsin L--a latent proteinase in guinea pig sperm.
PubMed: The role of increased proteolysis in the atrophy and arrest of proliferation in serum-deprived fibroblasts.
PubMed: Two-step mechanism of myofibrillar protein degradation in acute plasmocid-induced muscle necrosis.
PubMed: Limited benefit to genetically dystrophic chickens from a synthetic proteinase inhibitor: Ep475.
PubMed: A novel type of autophagy occurs together with vacuole genesis in miniprotoplasts prepared from tobacco culture cells.
PubMed: Effect of a cysteine protease inhibitor on Fasciola hepatica (liver fluke) fecundity, egg viability, parasite burden, and size in experimentally infected sheep.
PubMed: Involvement of calpain and synaptotagmin Ca2+ sensors in hormone secretion from excitable endocrine cells.
PubMed: Cathepsin L plays an important role in the lysosomal degradation of L-lactate dehydrogenase.
PubMed: Relative contribution of matrix metalloprotease and cysteine protease activities to cytokine-stimulated articular cartilage degradation.
PubMed: A homologue of cathepsin L identified in conditioned medium from Sf9 insect cells.
PubMed: Entamoeba histolytica: correlation of assessment methods to measure erythrocyte digestion, and effect of cysteine proteinases inhibitors in HM-1:IMSS and HK-9:NIH strains.
PubMed: Differential effects of calpain inhibitors on hypertrophy of cardiomyocytes.
PubMed: Participation of intracellular cysteine proteinases, in particular cathepsin B, in degradation of collagen in periosteal tissue explants.
PubMed: Both cathepsin B and cathepsin D are necessary for processing of ovalbumin as well as for degradation of class II MHC invariant chain.
PubMed: Effect of Ep475 on changes induced by calcium activated neutral protease on erythrocyte membrane.
PubMed: The inhibition of interleukin 1-stimulated cartilage proteoglycan degradation by cysteine endopeptidase inactivators.
PubMed: The ATP-independent pathway in red blood cells that degrades oxidant-damaged hemoglobin.
PubMed: Ester and amide derivatives of E64c as inhibitors of platelet calpains.
PubMed: Involvement of reactive oxygen species in post-ischaemic flap necrosis and its prevention by antioxidants.
PubMed: Effects of the calpain inhibitor E64-d on platelet activation responses.
PubMed: Isolation of rod outer segments on Percoll gradients: effect of specific protease inhibition.
PubMed: Mode of binding of E-64-c, a potent thiol protease inhibitor, to papain as determined by X-ray crystal analysis of the complex.
PubMed: Morphological, physiological and biochemical alterations in livers of rodents induced by protease inhibitors: a comparison with old livers.
PubMed: Autodegradation of lysosomal cysteine proteinases.
PubMed: Cleavage site of calcium-dependent protease in human platelet membrane glycoprotein Ib.
PubMed: Metabolic acidosis stimulates protein degradation in rat muscle by a glucocorticoid-dependent mechanism.
PubMed: Induction and inhibition of cathepsin B and hemoglobin-hydrolase activity in murine B16 melanoma by thiol protease inhibitors.
PubMed: Isolation of two forms of the high-molecular-mass serine protease, ingensin, from porcine skeletal muscle.
PubMed: Relation between in vivo effects and in vitro effects of serine and thiol proteinase inhibitors.
PubMed: The effect of an in vivo-injected thiol protease inhibitor, E-64-c, on the calcium-induced degeneration of myofilaments.
PubMed: Effects of cathepsin B, H, and D in pectoral muscle of dystrophic chickens (line 413) of in vivo administration of E-64-c (N-[N-(L-3-transcarboxyoxirane-2-carbonyl)-L-leucyl]-3-methyl-butylamine).
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