Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | amber to amber brown liquid to solid (est) |
Assay: | 98.00 to 100.00 %
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Food Chemicals Codex Listed: | No |
Specific Gravity: | 1.13100 to 1.13500 @ 20.00 °C.
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Pounds per Gallon - (est).: | 9.422 to 9.455
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Refractive Index: | 1.61900 to 1.62200 @ 20.00 °C.
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Melting Point: | 20.00 to 21.00 °C. @ 760.00 mm Hg
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Boiling Point: | 120.00 °C. @ 15.00 mm Hg
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Vapor Pressure: | 0.046000 mmHg @ 25.00 °C. (est) |
Flash Point: | > 230.00 °F. TCC ( > 110.00 °C. )
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logP (o/w): | 2.040 |
Soluble in: |
| alcohol | | water, 1456 mg/L @ 25 °C (est) |
Insoluble in: |
| water |
Organoleptic Properties:
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Odor Type: nutty |
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| toasted roasted corn nutty coffee burnt |
Odor Description: at 0.10 % in dipropylene glycol. | toasted roasted corn nutty coffee burnt |
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| nutty musty roasted corn chip coffee hazelnut potato |
Odor Description:
| Nut shell, musty, roasted and pyrazine-like with coffee, hazelnut and potato nuances Mosciano, Gerard P&F 19, No. 6, 53, (1994) |
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Flavor Type: nutty |
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| nutty peanut roasted peanut yeasty corn chip |
Taste Description: at 2.00 ppm. | Nutty, roasted, peanut and pyrazine-like with a yeasty corn chip nuance Mosciano, Gerard P&F 19, No. 6, 53, (1994) |
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Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Anhui Haibei |
5-Methyl Quinoxaline
Odor: Toasted roasted corn nutty coffee burnt |
Anhui Suzhou Jinli Aromatic Chemicals |
5-Methyl Quinoxaline
Odor: nut, hazel nut, nutlet, coffee, chocolate, cocoa, baked maize |
Augustus Oils |
5 Methyl Quinoxaline
|
Services |
Beijing Lys Chemicals |
5-Methylquinoxaline
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BOC Sciences |
For experimental / research use only. |
5-Methylquinoxaline
|
Charkit Chemical |
METHYLQUINOXALINE, 5- FEMA 3203
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Endeavour Specialty Chemicals |
5-Methylquinoxaline
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Speciality Chemical Product Groups |
Jinan Enlighten Chemical Technology(Wutong Aroma ) |
5-Methyl quinoxaline, Kosherk
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Lluch Essence |
5-METHYL QUINOXALINE
|
M&U International |
5-METHYLQUINOXALINE, Kosher
|
Matrix Scientific |
For experimental / research use only. |
5-Methylquinoxaline, 95+%
|
Moellhausen |
MENOXALINE
|
Penta International |
5-METHYL QUINOXALINE
|
R C Treatt & Co Ltd |
5-Methylquinoxaline
Halal, Kosher Flavor: burnt, roasted hazelnut-like at 10 ppm. and toasted at 2.7 ppm in coffee Used in coffee and roast nut flavours. Normal use levels in finished consumer product: 0.1-10 ppm. Council of Europe limits: Foods (10 ppm); Beverages (10 ppm). |
Reincke & Fichtner |
5-Methylquinoxaline
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Robinson Brothers |
5-Methylquinoxaline
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https://www.robinsonbrothers.uk/chemistry-competences |
Shijiazhuang Donglian Nankai Aroma Chemicals |
5-Methylquinoxaline
Odor: Burnt coffee, chocolate and roasted |
Sigma-Aldrich |
5-Methylquinoxaline, ≥99%, FG
Odor: nutty; coffee |
Certified Food Grade Products |
Sunaux International |
5-Methylquinoxaline
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Synerzine |
5-Methylquinoxaline
|
TCI AMERICA |
For experimental / research use only. |
5-Methylquinoxaline >98.0%(GC)
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Tengzhou Xiang Yuan Aroma Chemicals |
5-Methylquinoxaline
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Tianjin Danjun International |
5-Methylquinoxaline
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United International |
5-Methyl Quinoxaline
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WholeChem |
5-Methyl Quinoxaline
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Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | Xi - Irritant |
R 36/37/38 - Irritating to eyes, respiratory system, and skin. S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 - Wear suitable gloves and eye/face protection.
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
Not determined
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | flavor and fragrance agents |
RIFM Fragrance Material Safety Assessment: Search |
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
Recommendation for 5-methyl quinoxaline usage levels up to: | | 0.1000 % in the fragrance concentrate.
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Maximised Survey-derived Daily Intakes (MSDI-EU): | 22.00 (μg/capita/day) |
Maximised Survey-derived Daily Intakes (MSDI-USA): | 1.00 (μg/capita/day) |
Structure Class: | III |
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
publication number: 4 |
Click here to view publication 4 |
| average usual ppm | average maximum ppm |
baked goods: | - | - |
beverages(nonalcoholic): | - | 10.00000 |
beverages(alcoholic): | - | - |
breakfast cereal: | - | - |
cheese: | - | - |
chewing gum: | - | - |
condiments / relishes: | - | - |
confectionery froastings: | - | - |
egg products: | - | - |
fats / oils: | - | - |
fish products: | - | - |
frozen dairy: | - | 10.00000 |
fruit ices: | - | 10.00000 |
gelatins / puddings: | - | 10.00000 |
granulated sugar: | - | - |
gravies: | - | - |
hard candy: | - | 10.00000 |
imitation dairy: | - | - |
instant coffee / tea: | - | - |
jams / jellies: | - | - |
meat products: | - | - |
milk products: | - | - |
nut products: | - | - |
other grains: | - | - |
poultry: | - | - |
processed fruits: | - | - |
processed vegetables: | - | - |
reconstituted vegetables: | - | - |
seasonings / flavors: | - | - |
snack foods: | - | - |
soft candy: | - | - |
soups: | - | - |
sugar substitutes: | - | - |
sweet sauces: | - | - |
Safety References:
Flavor & Extract Manufacturers Association (FEMA) reference(s): |
The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients. View pdf |
European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
European Food Safety Authority (EFSA) reference(s): |
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) View page or View pdf |
Flavouring Group Evaluation 50 (FGE.50): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) [1] View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010) View page or View pdf |
Safety and efficacy of pyrazine derivatives including saturated ones belonging to chemical group 24 when used as flavourings for all animal species View page or View pdf |
EPI System: | View |
AIDS Citations: | Search |
Cancer Citations: | Search |
Toxicology Citations: | Search |
EPA Substance Registry Services (TSCA): | 13708-12-8 |
EPA ACToR: | Toxicology Data |
EPA Substance Registry Services (SRS): | Registry |
Laboratory Chemical Safety Summary : | 61670 |
National Institute of Allergy and Infectious Diseases: | Data |
WGK Germany: | 3 |
| 5-methylquinoxaline |
Chemidplus: | 0013708128 |
References:
Other Information:
Potential Blenders and core components note
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For Odor |
No odor group found for these |
1- | propanoyl pyrrole | |
| sulfuryl octanoate | FL/FR |
|
| sulfuryl butyrate | FL/FR |
| sulfuryl decanoate | FL/FR |
| sulfuryl hexanoate | FL/FR |
| sulfuryl isobutyrate | FL/FR |
| sulfuryl propionate | FL/FR |
alcoholic |
| propyl alcohol | FL/FR |
anisic |
para- | anisaldehyde | FL/FR |
balsamic |
2- | acetyl furan | FL/FR |
iso | butyl cinnamate | FL/FR |
| ethyl cinnamate | FL/FR |
| methyl cinnamate | FL/FR |
3- | phenyl propyl alcohol | FL/FR |
bready |
| coffee furanone | FL/FR |
3,4- | hexane dione | FL/FR |
camphoreous |
| butyrophenone | FL/FR |
| cyclotene | FL/FR |
| immortelle absolute | FL/FR |
| maltol | FL/FR |
| strawberry furanone | FL/FR |
chocolate |
iso | amyl phenyl acetate | FL/FR |
| chocolate pyrazine A | FL/FR |
| cocoa hexenal | FL/FR |
2,5- | dimethyl pyrazine | FL/FR |
2- | methoxy-3-methyl pyrazine | FL/FR |
2,4,5- | trimethyl thiazole | FL/FR |
cocoa |
2-iso | butyl-3,5-(and 3,6)-dimethyl pyrazine | FL/FR |
coconut |
| coconut naphthalenone | FL/FR |
gamma- | nonalactone (aldehyde C-18 (so-called)) | FL/FR |
gamma- | octalactone | FL/FR |
coffee |
| coffea arabica seed extract | FL/FR |
| furfuryl mercaptan | FL/FR |
2- | methyl-3-,5 or 6-(furfuryl thio) pyrazine | FL/FR |
| popcorn pyrimidine | FL/FR |
| nutty pyrazine | FL/FR |
floral |
| bois de rose oil brazil | FL/FR |
| ethyl phenyl acetate | FL/FR |
fruity |
| nonyl isovalerate | FL/FR |
2- | heptyl furan | FL/FR |
hay |
| beeswax absolute | FL/FR |
honey |
| phenyl acetic acid | FL/FR |
musty |
2- | acetyl pyrrole | FL/FR |
3- | acetyl-2,5-dimethyl furan | FL/FR |
| hazelnut pyrazine | FL/FR |
| menthofuran | FL/FR |
nutty |
3- | acetyl pyridine | FL/FR |
2- | acetyl-3-ethyl pyrazine | FL/FR |
2- | acetyl-3-methyl pyrazine | FL/FR |
2- | acetyl-3,5-dimethyl pyrazine | FL/FR |
2- | acetyl-3,5(or 6)-dimethyl pyrazine | FL/FR |
2- | acetyl-5-methyl furan | FL/FR |
3,5- | cocoa pyrazine | FL/FR |
3,6- | cocoa pyrazine | FL/FR |
2,3- | dimethyl pyrazine | FL/FR |
4,5- | dimethyl-2-ethyl-3-thiazoline | FL/FR |
2- | ethyl pyrazine | FL/FR |
| filbert heptenone | FL/FR |
| filbert pyrazine | FL/FR |
(E)- | filbertone | FL/FR |
2,6- | lutidine | FL/FR |
| methoxymethyl pyrazine | FL/FR |
2- | methyl pyrazine | FL/FR |
2- | methyl thio-3,5 or 6-methyl pyrazine | FL/FR |
2- | methyl-3-(methyl thio) pyrazine | FL/FR |
2- | methyl-3-ethoxypyrazine | FL/FR |
2- | methyl-3-pentenoic acid | FL/FR |
| nutty quinoxaline | FL/FR |
| peanut fragrance | FR |
| sesame absolute CO2 extract | FL/FR |
2,3,5,6- | tetramethyl pyrazine | FL/FR |
2,3,5- | trimethyl pyrazine | FL/FR |
| vinyl sulfurol | FL/FR |
popcorn |
2- | acetyl pyrazine | FL/FR |
2- | acetyl thiazole | FL/FR |
powdery |
para- | anisyl alcohol | FL/FR |
roasted |
2- | acetyl-2-pyrroline | |
| trigonella foenum-graecum seed oil CO2 extract | FL/FR |
spicy |
| cassia bark oil china | FL/FR |
| clove bud oil | FL/FR |
alpha- | methyl cinnamaldehyde | FL/FR |
| furfuryl thioacetate | FL/FR |
tonka |
| tonka bean absolute | FR |
| whiskey lactone | FL/FR |
vanilla |
| ethyl vanillin | FL/FR |
| vanilla bean absolute (vanilla planifolia) | FL/FR |
| vanillyl acetate | FL/FR |
waxy |
| butyl laurate | FL/FR |
woody |
| cedrenyl acetate | FR |
2- | methoxy-4-vinyl phenol | FL/FR |
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For Flavor |
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No flavor group found for these |
| acetyl acetaldehyde dimethyl acetal | FL |
2- | acetyl-2-pyrroline | |
(E)- | aconitic acid | FL |
2-iso | butyl-3,5-(and 3,6)-dimethyl pyrazine | FL/FR |
2(4)-iso | butyl-4(2),6-dimethyl dihydro-4H-1,3,5-dithiazine | FL |
| butyrophenone | FL/FR |
| chocolate pyrazine A | FL/FR |
| chocolate pyrazine B | FL |
| coconut naphthalenone | FL/FR |
| cyclohexyl methyl pyrazine | FL |
2,5- | diethyl thiazole | FL |
6,7- | dihydro-2,3-dimethyl-5H-cyclopentapyrazine | FL |
| dimethyl dihydrocyclopentapyrazine | FL |
2,5- | dimethyl thiazole | FL |
4,5- | dimethyl-2-ethyl thiazole | FL |
(E)- | filbertone | FL/FR |
2- | methoxy-6-methyl pyrazine | FL |
| methyl 2-(methyl thio) acetate | FL |
| methyl octyl sulfide | FL |
2- | methyl-3-,5 or 6-(furfuryl thio) pyrazine | FL/FR |
2- | methyl-3-(methyl thio) pyrazine | FL/FR |
2- | methyl-3-ethoxypyrazine | FL/FR |
2- | methyl-3-pentenoic acid | FL/FR |
| nonyl isovalerate | FL/FR |
| peanut dithiazine | FL |
| pyrazine | FL |
| pyrazines mixture | FL |
| sulfuryl butyrate | FL/FR |
| sulfuryl decanoate | FL/FR |
| sulfuryl hexanoate | FL/FR |
| sulfuryl isobutyrate | FL/FR |
|
| sulfuryl formate | FL |
| sulfuryl octanoate | FL/FR |
| sulfuryl propionate | FL/FR |
alcoholic |
| propyl alcohol | FL/FR |
astringent |
1- | propanoyl pyrrole | |
balsamic |
iso | butyl cinnamate | FL/FR |
| ethyl cinnamate | FL/FR |
brown |
| beeswax absolute | FL/FR |
burnt |
2- | methyl quinoxaline | FL |
buttery |
| diacetyl | FL |
3,4- | hexane dione | FL/FR |
caramellic |
| caramel furanone | FL |
| cyclotene | FL/FR |
| maltol | FL/FR |
| strawberry furanone | FL/FR |
cocoa |
| chocolate enhancers | FL |
| cocoa hexenal | FL/FR |
coconut |
gamma- | nonalactone (aldehyde C-18 (so-called)) | FL/FR |
coffee |
| coffea arabica seed extract | FL/FR |
| furfuryl mercaptan | FL/FR |
2- | thiophene thiol | FL |
corn chip |
2- | acetyl thiazole | FL/FR |
2- | acetyl-2-thiazoline | FL |
| popcorn pyrimidine | FL/FR |
creamy |
para- | anisaldehyde | FL/FR |
earthy |
(±)-2- | mercapto-5-methylheptan-4-one | FL |
fatty |
2- | heptyl furan | FL/FR |
fishy |
4,5- | dimethyl thiazole | FL |
floral |
iso | amyl phenyl acetate | FL/FR |
| bois de rose oil brazil | FL/FR |
| phenyl acetic acid | FL/FR |
fruity |
para- | anisyl alcohol | FL/FR |
2,4- | hexadien-1-ol | FL |
green |
| dihydroxyacetophenone (mixed isomers) | FL |
| immortelle absolute | FL/FR |
honey |
| ethyl phenyl acetate | FL/FR |
lactonic |
gamma- | octalactone | FL/FR |
meaty |
| propyl 2-mercaptopropionate | FL |
metallic |
2,5- | dihydroxy-1,4-dithiane | FL |
mustard |
| furfuryl methyl ether | FL |
musty |
2,5- | dimethyl pyrazine | FL/FR |
2- | ethoxythiazole | FL |
| hazelnut pyrazine | FL/FR |
| menthofuran | FL/FR |
2,3,5- | trimethyl pyrazine | FL/FR |
nutty |
2- | acetyl furan | FL/FR |
3- | acetyl pyridine | FL/FR |
2- | acetyl pyrrole | FL/FR |
3- | acetyl-2,5-dimethyl furan | FL/FR |
2- | acetyl-3-ethyl pyrazine | FL/FR |
2- | acetyl-3-methyl pyrazine | FL/FR |
2- | acetyl-3,5-dimethyl pyrazine | FL/FR |
2- | acetyl-3,5(or 6)-dimethyl pyrazine | FL/FR |
2- | acetyl-5-methyl furan | FL/FR |
| arachis hypogaea fruit extract | FL |
2- | butyl-2-butenal | FL |
roasted | chestnut flavor | FL |
3,6- | cocoa pyrazine | FL/FR |
3,5(6)- | cocoa pyrazine | FL |
3,5- | cocoa pyrazine | FL/FR |
| coffee furanone | FL/FR |
2,5- | diethyl-3-methyl pyrazine | FL |
2,3- | dimethyl pyrazine | FL/FR |
4,5- | dimethyl-2-ethyl-3-thiazoline | FL/FR |
2- | ethyl pyrazine | FL/FR |
| filbert heptenone | FL/FR |
| filbert pyrazine | FL/FR |
european | hazelnut oleoresin | FL |
2,6- | lutidine | FL/FR |
2- | methoxy-3-methyl pyrazine | FL/FR |
| methoxymethyl pyrazine | FL/FR |
2- | methyl pyrazine | FL/FR |
2- | methyl thio-3,5 or 6-methyl pyrazine | FL/FR |
| nutty pyrazine | FL/FR |
| nutty quinoxaline | FL/FR |
| nutty thiazole | FL |
| peanut brittle flavor | FL |
| peanut flavor | FL |
roasted | peanut flavor | FL |
| sesame absolute CO2 extract | FL/FR |
| sesame distillates | FL |
2,3,5,6- | tetramethyl pyrazine | FL/FR |
2,4,5- | trimethyl thiazole | FL/FR |
| vinyl sulfurol | FL/FR |
popcorn |
2- | propionyl-2-thiazoline | FL |
roasted |
2- | acetyl pyrazine | FL/FR |
| ethyl 3-(furfuryl thio) propionate | FL |
| furfuryl thioacetate | FL/FR |
| trigonella foenum-graecum seed oil CO2 extract | FL/FR |
smoky |
2- | methoxy-4-vinyl phenol | FL/FR |
spicy |
| cassia bark oil china | FL/FR |
| clove bud oil | FL/FR |
alpha- | methyl cinnamaldehyde | FL/FR |
| methyl cinnamate | FL/FR |
3- | phenyl propyl alcohol | FL/FR |
sulfurous |
2- | thienyl mercaptan | FL |
vanilla |
| ethyl vanillin | FL/FR |
| vanilla bean absolute (vanilla planifolia) | FL/FR |
| vanillyl acetate | FL/FR |
waxy |
| butyl laurate | FL/FR |
woody |
| whiskey lactone | FL/FR |
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Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
5- | methyl-1,4-benzodiazine | 5- | methylquinoxaline | | nutty oxaline | | quinoxaline, 5-methyl- |
Articles:
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