Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | white crystals (est) |
Assay: | 98.00 to 100.00 %
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Food Chemicals Codex Listed: | No |
Melting Point: | 77.00 to 79.00 °C. @ 760.00 mm Hg
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Boiling Point: | 287.00 to 288.00 °C. @ 760.00 mm Hg
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Acid Value: | 1.00 max. KOH/g
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Vapor Pressure: | 0.002000 mmHg @ 25.00 °C. (est) |
Flash Point: | 256.00 °F. TCC ( 124.44 °C. )
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logP (o/w): | 1.576 (est) |
Soluble in: |
| alcohol | | ethyl ether | | water, slightly | | water, 3057 mg/L @ 25 °C (est) |
Organoleptic Properties:
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Odor Type: vanilla |
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| sweet creamy vanilla powdery heliotrope |
Odor Description: at 100.00 %. | sweet creamy vanilla powdery heliotropin |
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| sweet creamy vanilla powdery heliotrope |
Odor Description:
| Sweet, creamy, vanilla-like with a powdery heliotropine nuance Mosciano, Gerard P&F 19, No. 2, 55, (1994) |
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Flavor Type: vanilla |
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| sweet vanilla creamy powdery balsamic beany |
Taste Description: at 40.00 ppm. | Sweet, vanilla, creamy, powdery with a balsamic beany nuance Mosciano, Gerard P&F 19, No. 2, 55, (1994) |
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Odor and/or flavor descriptions from others (if found). |
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Alfrebro |
VANILLIN ACETATE |
Odor Description: | Vanilla, Floral, Balsamic |
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Indukern F&F |
VANILLIN ACETATE |
Odor Description: | SWEET, CREAMY, POWDERY, VANILLA |
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Cosmetic Information:
Suppliers:
Advanced Biotech |
VANILLIN ACETATE NATURAL
Odor: Milky, Vanilla |
Alfrebro |
VANILLIN ACETATE NATURAL
Odor: Floral, Vanilla, Sweet |
Alfrebro |
VANILLIN ACETATE
Odor: Vanilla, Floral, Balsamic |
Anhui Haibei |
Vanillin acetate
Odor: Sweet creamy vanilla powdery heliotropin |
Apple Flavor & Fragrance |
Vanillin acetate
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Aromiens International |
Vanillin Acetate, Natural
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Beijing Lys Chemicals |
Vanillin acetate
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BOC Sciences |
For experimental / research use only. |
acetyl vanillin 98%
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Indukern F&F |
VANILLIN ACETATE
Odor: SWEET, CREAMY, POWDERY, VANILLA |
Inoue Perfumery |
ACETYL VANILLIN
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Jiangyin Healthway |
Vanillin acetate
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New functional food ingredients |
Kingchem Laboratories |
O-ACETYLVANILLIN
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Lluch Essence |
VANILLIN ACETATE NATURAL
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M&U International |
VANILLYL ACETATE
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Matrix Scientific |
For experimental / research use only. |
4-Formyl-2-methoxyphenyl acetate
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Penta International |
VANILLIN ACETATE NATURAL
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Penta International |
VANILLIN ACETATE
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Santa Cruz Biotechnology |
For experimental / research use only. |
Vanillyl Acetate
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Shanghai Vigen Fine Chemical |
Vanillin Acetate
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Shijiazhuang Donglian Nankai Aroma Chemicals |
Vanillin Acetate
Odor: Milk and vanillia |
Sigma-Aldrich |
Vanillin acetate, ≥98%, FG
Odor: balsam; floral |
Certified Food Grade Products |
Synerzine |
Vanillin Acetate
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TCI AMERICA |
For experimental / research use only. |
Vanillin Acetate >98.0%(GC)
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Tianjin Danjun International |
Vanillin acetate
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United International |
Vanillin acetate
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WholeChem |
Vanillin acetate
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Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | Xi - Irritant |
R 36/38 - Irritating to skin and eyes. S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36 - Wear suitable protective clothing.
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
Not determined
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | flavor and fragrance agents |
RIFM Fragrance Material Safety Assessment: Search |
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
Recommendation for vanillyl acetate usage levels up to: | | 5.0000 % in the fragrance concentrate.
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Maximised Survey-derived Daily Intakes (MSDI-EU): | 1.80 (μg/capita/day) |
Maximised Survey-derived Daily Intakes (MSDI-USA): | 1.00 (μg/capita/day) |
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
publication number: 3 |
Click here to view publication 3 |
| average usual ppm | average maximum ppm |
baked goods: | - | 28.00000 |
beverages(nonalcoholic): | - | 11.00000 |
beverages(alcoholic): | - | - |
breakfast cereal: | - | - |
cheese: | - | - |
chewing gum: | - | - |
condiments / relishes: | - | - |
confectionery froastings: | - | - |
egg products: | - | - |
fats / oils: | - | - |
fish products: | - | - |
frozen dairy: | - | 11.00000 |
fruit ices: | - | 11.00000 |
gelatins / puddings: | - | - |
granulated sugar: | - | - |
gravies: | - | - |
hard candy: | - | 28.00000 |
imitation dairy: | - | - |
instant coffee / tea: | - | - |
jams / jellies: | - | - |
meat products: | - | - |
milk products: | - | - |
nut products: | - | - |
other grains: | - | - |
poultry: | - | - |
processed fruits: | - | - |
processed vegetables: | - | - |
reconstituted vegetables: | - | - |
seasonings / flavors: | - | - |
snack foods: | - | - |
soft candy: | - | - |
soups: | - | - |
sugar substitutes: | - | - |
sweet sauces: | - | - |
Safety References:
Flavor & Extract Manufacturers Association (FEMA) reference(s): |
The FEMA GRAS assessment of hydroxyl- and alkoxy-substituted benzyl derivatives used as flavor ingredients. View pdf |
European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
European Food Safety Authority (EFSA) reference(s): |
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 20 (FGE.20): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical group 23 View page or View pdf |
Flavouring Group Evaluation 52 (FGE.52): Consideration of hydroxy- and alkoxy-substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
Flavouring Group Evaluation 20, Revision 1 (FGE.20Rev1): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters from chemical group 23 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 20, Revision 2 (FGE.20Rev2): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf |
EPI System: | View |
AIDS Citations: | Search |
Cancer Citations: | Search |
Toxicology Citations: | Search |
EPA Substance Registry Services (TSCA): | 881-68-5 |
EPA ACToR: | Toxicology Data |
EPA Substance Registry Services (SRS): | Registry |
Laboratory Chemical Safety Summary : | 61229 |
National Institute of Allergy and Infectious Diseases: | Data |
WGK Germany: | 3 |
| (4-formyl-2-methoxyphenyl) acetate |
Chemidplus: | 0000881685 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| acethyl vanillin | | acetovanillin | 4- | acetoxy-3-methoxybenzaldehyde | 4-( | acetyl oxy)-3-methoxybenzaldehyde | | acetyl vanillin | 4-( | acetyloxy)-3-methoxybenzaldehyde | | acetylvanillin | 4-O- | acetylvanillin | O- | acetylvanillin | | benzaldehyde, 4-(acetyloxy)-3-methoxy- | 4- | formyl-2-methoxyphenol acetate | 4- | formyl-2-methoxyphenyl acetate | (4- | formyl-2-methoxyphenyl) acetate | 3- | methoxy-4-acetoxybenzaldehyde | 3- | methoxy-4-acetoxybenzaldehyde natural | | vanillin acetate | | vanillin acetate natural | | vanillin, acetate |
Articles:
PubMed: | [Chemical constituents from tubers of Cremastra appendiculata]. |
PubMed: | Synthesis, crystal structure, fluorescence and electrochemical studies of a new tridentate Schiff base ligand and its nickel(II) and palladium(II) complexes. |
PubMed: | Identifying inhibitory compounds in lignocellulosic biomass hydrolysates using an exometabolomics approach. |
PubMed: | [Chemical constituents of Cudrania cochinchinensis]. |
PubMed: | Inhibition of arachidonic acid metabolism by the Andean crude drug Parastrephia lucida (Meyen) Cabrera. |
PubMed: | Sensitive and selective determination of phenolic compounds from aromatic plants using an electrochemical detection coupled with HPLC method. |
PubMed: | Inhibitory activity of carbonyl compounds on alcoholic fermentation by Saccharomyces cerevisiae. |
PubMed: | A new taraxerol derivative from the roots of Microcos tomentosa. |
PubMed: | A study on anticancer activity of Caulis Spatholobi extract on human osteosarcoma Saos-2 cells. |
PubMed: | Distribution of withaferin A, an anticancer potential agent, in different parts of two varieties of Withania somnifera (L.) Dunal. grown in Sri Lanka. |
PubMed: | The volatile profiles of a rare apple (Malus domestica Borkh.) honey: shikimic acid-pathway derivatives, terpenes, and others. |
PubMed: | Orchid bee (Hymenoptera: Apidae) community from a gallery forest in the Brazilian Cerrado. |
PubMed: | Ferrocene-based compartmental ligand for the assembly of neutral Zn(II)/Ln(III) heterometallic complexes. |
PubMed: | Inhibition of growth of Zymomonas mobilis by model compounds found in lignocellulosic hydrolysates. |
PubMed: | [Study on chemical composition of ethylacetate fraction from Polygonum amplexicaule var. sinense]. |
PubMed: | Rapid and sensitive high performance liquid chromatographic determination of zonisamide in human serum application to a pharmacokinetic study. |
PubMed: | Biological activities and chemical composition of the stems and roots of Helichrysum oligocephalum DC grown in Iran. |
PubMed: | High performance thin layer chromatography-densitometry: a step further for quality control of cranberry extracts. |
PubMed: | Polynuclear lanthanide (Ln) complexes of a tri-functional hydrazone ligand--mononuclear (Dy), dinuclear (Yb, Tm), tetranuclear (Gd), and hexanuclear (Gd, Dy, Tb) examples. |
PubMed: | Anti-biofouling property of vanillin on Aeromonas hydrophila initial biofilm on various membrane surfaces. |
PubMed: | Identification of the key odorants in Tahitian cured vanilla beans (Vanilla tahitensis) by GC-MS and an aroma extract dilution analysis. |
PubMed: | Fungi benefit from two decades of increased nutrient availability in tundra heath soil. |
PubMed: | Diastereoselective synthesis of 5-hydroxy-8-methoxy-1-oxaspiro[5,5]undeca-7,10-diene-9-one. |
PubMed: | In vitro degradation of lysine by ruminal fluid-based fermentations and by Fusobacterium necrophorum. |
PubMed: | Synthesis, antioxidant and antimicrobial activity of novel vanillin derived piperidin-4-one oxime esters: preponderant role of the phenyl ester substituents on the piperidin-4-one oxime core. |
PubMed: | Estimation of inhibitory effects of hemicellulosic wood hydrolysate inhibitors on PHA production by Burkholderia cepacia ATCC 17759 using response surface methodology. |
PubMed: | Correlation between slow magnetic relaxation and the coordination structures of a family of linear trinuclear Zn(II)-Ln(III)-Zn(II) complexes (Ln = Tb, Dy, Ho, Er, Tm and Yb). |
PubMed: | Antitumor and antimicrobial activities of some hetero aromatic benzofurans derived from naturally occurring visnagin. |
PubMed: | Validated determination of primulasaponins in primula root by a high-performance-thin-layer-chromatography densitometric approach. |
PubMed: | Comparative study of organosolv lignin extracted from prairie cordgrass, switchgrass and corn stover. |
PubMed: | Global regulator engineering significantly improved Escherichia coli tolerances toward inhibitors of lignocellulosic hydrolysates. |
PubMed: | Simultaneous determination of five active compounds in chimonanthus nitens by double-development HPTLC and scanning densitometry. |
PubMed: | Purification of vetiver alcohols and esters for quantitative high-performance thin-layer chromatography determination in Haitian vetiver essential oils and vetiver acetates. |
PubMed: | [Liposoluble constituents from Iodes cirrhosa and their neuroprotective and potassium channel-blocking activity]. |
PubMed: | Bioproduction of vanillin using an organic solvent-tolerant Brevibacillus agri 13. |
PubMed: | [Study on chemical constituents from ethyl acetate extract of Myricaria bracteata]. |
PubMed: | Evaluation of dual flow counter-current chromatography and intermittent counter-current extraction. |
PubMed: | Enhanced repellency of binary mixtures of Zanthoxylum armatum seed oil, vanillin, and their aerosols to mosquitoes under laboratory and field conditions. |
PubMed: | The Zymomonas mobilis regulator hfq contributes to tolerance against multiple lignocellulosic pretreatment inhibitors. |
PubMed: | Spectral study on the inclusion complex of cryptophane-E and CHCl3. |
PubMed: | Fast and green microwave-assisted conversion of essential oil allylbenzenes into the corresponding aldehydes via alkene isomerization and subsequent potassium permanganate promoted oxidative alkene group cleavage. |
PubMed: | Prediction of solubility of drugs and other compounds in organic solvents. |
PubMed: | Fate of key odorants in Sauternes wines through aging. |
PubMed: | [Olfactory functional magnetic resonance imaging with modified OEP-98C olfactometer and event-related design]. |
PubMed: | Effects of biomass hydrolysis by-products on oleaginous yeast Rhodosporidium toruloides. |
PubMed: | Scale-up of counter-current chromatography: demonstration of predictable isocratic and quasi-continuous operating modes from the test tube to pilot/process scale. |
PubMed: | Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols. |
PubMed: | New 18-l process-scale counter-current chromatography centrifuge. |
PubMed: | Synthesis and characterization of a novel cross-linking complex of beta-cyclodextrin-o-vanillin furfuralhydrazone and highly selective spectrofluorimetric determination of trace gallium. |
PubMed: | Chemical constituents of Antrodia camphorata submerged whole broth. |
PubMed: | Vanillin inhibits matrix metalloproteinase-9 expression through down-regulation of nuclear factor-kappaB signaling pathway in human hepatocellular carcinoma cells. |
PubMed: | Qualitative and quantitative analysis of four species of Curcuma rhizomes using twice development thin layer chromatography. |
PubMed: | [Composition and seasonality of Euglossina Species (Hymenoptera: Apidae) in forest and dune in the Environmental Protection Area of the Mamanguape River Bar, PB]. |
PubMed: | Spectral study on the interaction of cryptophane-A and neutral molecules CHnCl4-n (n=0, 1, 2). |
PubMed: | Chemical profile of rums as a function of their origin. The use of chemometric techniques for their identification. |
PubMed: | [Activity time of male Euglossina and preference for artificial fragrances in forest and dunes in the Environmental Protection Area of the Mamanguape River Bar, Rio Tinto, ParaĆba, Brazil]. |
PubMed: | Effects of phenolic monomers on the enzymes activities and volatile fatty acids production of Neocallimastix frontalis B9. |
PubMed: | [Chemical constituents from root barks of Periploca sepium]. |
PubMed: | Effects of Chamaecyparis formosensis Matasumura extractives on lipopolysaccharide-induced release of nitric oxide. |
PubMed: | Quantitative determination of phyllanthin and hypophyllanthin in Phyllanthus species by high-performance thin layer chromatography. |
PubMed: | Aroma extraction dilution analysis of Sauternes wines. Key role of polyfunctional thiols. |
PubMed: | Effect of essential oil active compounds on rumen microbial fermentation and nutrient flow in in vitro systems. |
PubMed: | Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis. |
PubMed: | Aroma composition of red wines by different extraction methods and Gas Chromatography-SIM/MASS spectrometry analysis. |
PubMed: | Cholesterol-dependent hemolytic activity of Passiflora quadrangularis leaves. |
PubMed: | HPLC determination of salinomycin and related compounds in fermentation media of Streptomyces albus and premixes. |
PubMed: | Cytotoxic chromenes from Myriactis humilis. |
PubMed: | Synthesis of a novel host molecule of cross-linking-polymeric-beta-cyclodextrin-o-vanillin furfuralhydrazone and spectrofluorimetric analysis of its identifying cadmium. |
PubMed: | Comparison between cachaƧa and rum using pattern recognition methods. |
PubMed: | Crystal structure and magnetic interactions in nickel(II) dibridged complexes formed by two azide groups or by both phenolate oxygen-azide, -thiocyanate, -carboxylate, or -cyanate groups. |
PubMed: | Gas chromatography-olfactometry and chemical quantitative study of the aroma of six premium quality spanish aged red wines. |
PubMed: | Characterization of odor-active compounds in Californian chardonnay wines using GC-olfactometry and GC-mass spectrometry. |
PubMed: | Synthesis and characterization of a novel cross-linking complex of beta-cyclodextrin-o-vanillin benzoylhydrazone and its selective spectrofluorimetric determination of trace amounts of zinc. |
PubMed: | Nitrite as an energy-conserving electron sink for the acetogenic bacterium Moorella thermoacetica. |
PubMed: | Optimum methamphetamine profiling with sample preparation by solid-phase microextraction. |
PubMed: | New chemical constituents of Euphorbia quinquecostata and absolute configuration assignment by a convenient Mosher ester procedure carried out in NMR tubes. |
PubMed: | Amperometric biosensors for detection of phenol using chemically modified electrodes containing immobilized bacteria. |
PubMed: | [TLC analysis of harpagoside in devil claw extract and its tablets]. |
PubMed: | A novel strategy for the synthesis of benzofuran skeleton neolignans: application to ailanthoidol, XH-14, and obovaten. |
PubMed: | Identification of impurities and statistical classification of methamphetamine tablets (Ya-Ba) seized in Thailand. |
PubMed: | Purification and characterization of a microbial dehydrogenase: a vanillin:NAD(P)+ oxidoreductase. |
PubMed: | Volatile components of Loureira, Dona Branca, and Treixadura wines. |
PubMed: | Bioactive aromatic compounds from leaves and stems of Vanilla fragrans. |
PubMed: | Functional consequences following infection of the olfactory system by intranasal infusion of the olfactory bulb line variant (OBLV) of mouse hepatitis strain JHM. |
PubMed: | Measurement of urinary methoxyphenols and their use for biological monitoring of wood smoke exposure. |
PubMed: | Characterization of Volatiles in Rambutan Fruit (Nephelium lappaceum L.). |
PubMed: | Neurophysiological and behavioral responses to olfactory stimuli in the snail Helix pomatia L. |
PubMed: | Sensitivity of the olfactory sense declines with the aging in senescence-accelerated mouse (SAM-P1). |
PubMed: | Effects of the sniffing port air makeup in gas chromatography-olfactometry. |
PubMed: | Endothelial cell oxidant production: effect of NADPH oxidase inhibitors. |
PubMed: | [Color reactions for identification of nalidixic acid]. |
PubMed: | Similarities in the aroma chemistry of GewĆ¼rztraminer variety wines and lychee (Litchi chinesis sonn.) fruit. |
PubMed: | Veratryl alcohol-mediated oxidation of isoeugenyl acetate by lignin peroxidase. |
PubMed: | Trace-level determination of polar flavour compounds in butter by solid-phase extraction and gas chromatography-mass spectrometry. |
PubMed: | Odor response properties of rat olfactory receptor neurons. |
PubMed: | Antiosteoporotic activity of the stems of Sambucus sieboldiana. |
PubMed: | Hyposmia for butanol and vanillin in mutant staggerer male mice. |
PubMed: | Determination of ionophores in the tissues of food animals by liquid chromatography. |
PubMed: | [Substituted methoxyphenol with antioxidative activity: correlation between physicochemical and biological results]. |
PubMed: | Nitrate as a preferred electron sink for the acetogen Clostridium thermoaceticum. |
PubMed: | Generation of mutagenicity by ozonation of humic substances' components. |
PubMed: | The role of sucrose-sensitive neurons in ingestion of sweet stimuli by hamsters. |
PubMed: | Xylose uptake by the ruminal bacterium Selenomonas ruminantium. |
PubMed: | Isolation, characterization and biological activities of a toxin from Bacillus megaterium (B-23). |
PubMed: | High-speed liquid chromatographic determination of monensin, narasin, and salinomycin in feeds, using post-column derivatization. |
PubMed: | Reverse phase liquid chromatographic determination of some food additives. |
PubMed: | Effects of ammoniation of tall fescue on phenolic composition, feed intake, site and extent of nutrient digestion and ruminal dilution rates of steers. |
PubMed: | Mechanism of the desmutagenic effect of humic acid. |
PubMed: | Measurement of plasma vanillylmandelic acid by liquid chromatography with electrochemical detection. |
PubMed: | Iron Deficiency Decreases Suberization in Bean Roots through a Decrease in Suberin-Specific Peroxidase Activity. |
PubMed: | Evaluation of immunomodulatory chemicals: alteration of macrophage function in vitro. |
PubMed: | Neuroblastoma cell as model for olfactory cell: mechanism of depolarization in response to various odorants. |
PubMed: | Biosynthesis, deposition, and partial characterization of potato suberin phenolics. |
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