Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | white to yellow crystalline powder (est) |
Assay: | 97.00 to 100.00 %
|
Food Chemicals Codex Listed: | No |
Melting Point: | 128.00 to 130.00 °C. @ 760.00 mm Hg
|
Boiling Point: | 498.00 to 499.00 °C. @ 760.00 mm Hg
|
Flash Point: | 491.00 °F. TCC ( 255.00 °C. )
|
logP (o/w): | 2.656 (est) |
Soluble in: |
| alcohol | | water, 40 mg/L @ 18C (exp) |
Insoluble in: |
| water |
Organoleptic Properties:
|
Odor Type: spicy |
|
| peppery animal |
Odor Description: at 1.00 % in propylene glycol. | pepper animal |
|
|
Flavor Type: spicy |
|
| spicy peppery |
Taste Description:
| spicy peppery |
|
Odor and/or flavor descriptions from others (if found). |
|
Sigma-Aldrich |
Piperine, ≥97%, FG |
Odor Description: | pepper; animal |
|
|
Cosmetic Information:
Suppliers:
Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | Xn - Harmful. |
R 22 - Harmful if swallowed. S 02 - Keep out of the reach of children. S 20/21 - When using do not eat, drink or smoke. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 - Wear suitable gloves and eye/face protection.
|
|
Hazards identification |
|
Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
|
Pictogram | |
|
Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
oral-rat LD50 514 mg/kg BEHAVIORAL: EXCITEMENT
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Toxicology Letters. Vol. 16, Pg. 351, 1983.
intravenous-mouse LD50 15.1 mg/kg Toxicology Letters. Vol. 16, Pg. 351, 1983.
intraperitoneal-hamster LD50 105 mg/kg BEHAVIORAL: EXCITEMENT
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Toxicology Letters. Vol. 16, Pg. 351, 1983.
intramuscular-mouse LD50 400 ug/kg LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Toxicology Letters. Vol. 16, Pg. 351, 1983.
intraperitoneal-mouse LD50 43 mg/kg BEHAVIORAL: EXCITEMENT
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Toxicology Letters. Vol. 16, Pg. 351, 1983.
intravenous-mouse LD50 15100 ug/kg LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Toxicology Letters. Vol. 16, Pg. 351, 1983.
oral-mouse LD50 330 mg/kg LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Toxicology Letters. Vol. 16, Pg. 351, 1983.
intraperitoneal-rat LD50 34 mg/kg BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
BEHAVIORAL: EXCITEMENT
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Toxicology Letters. Vol. 16, Pg. 351, 1983.
|
Dermal Toxicity: |
subcutaneous-mouse LD50 200 mg/kg LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Toxicology Letters. Vol. 16, Pg. 351, 1983.
|
Inhalation Toxicity: |
Not determined
|
Safety in Use Information:
Category: | flavor and fragrance agents |
RIFM Fragrance Material Safety Assessment: Search |
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
Recommendation for (E,E)-piperine usage levels up to: | | 0.0100 % in the fragrance concentrate.
|
|
Maximised Survey-derived Daily Intakes (MSDI-EU): | 20.00 (μg/capita/day) |
Maximised Survey-derived Daily Intakes (MSDI-USA): | 0.07 (μg/capita/day) |
Threshold of Concern: | 90 (μg/person/day) |
Structure Class: | III |
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
publication number: 3. Update in publication number(s): 29 |
Click here to view publication 3 |
| average usual ppm | average maximum ppm |
baked goods: | 1.30000 | 2.10000 |
beverages(nonalcoholic): | 0.60000 | 0.70000 |
beverages(alcoholic): | 0.90000 | 1.00000 |
breakfast cereal: | - | - |
cheese: | - | - |
chewing gum: | - | - |
condiments / relishes: | 1.50000 | 2.25000 |
confectionery froastings: | - | - |
egg products: | - | - |
fats / oils: | - | - |
fish products: | 1.50000 | 2.25000 |
frozen dairy: | 1.00000 | 1.00000 |
fruit ices: | - | - |
gelatins / puddings: | 1.00000 | 1.00000 |
granulated sugar: | - | - |
gravies: | 1.50000 | 2.25000 |
hard candy: | - | - |
imitation dairy: | - | - |
instant coffee / tea: | - | - |
jams / jellies: | - | - |
meat products: | 2.00000 | 3.00000 |
milk products: | - | - |
nut products: | 0.80000 | 1.20000 |
other grains: | 2.04000 | 3.10000 |
poultry: | 1.50000 | 2.25000 |
processed fruits: | - | - |
processed vegetables: | 1.50000 | 2.25000 |
reconstituted vegetables: | 0.80000 | 1.20000 |
seasonings / flavors: | 2.04000 | 3.10000 |
snack foods: | 1.50000 | 2.25000 |
soft candy: | 1.00000 | 1.00000 |
soups: | 1.50000 | 2.25000 |
sugar substitutes: | - | - |
sweet sauces: | - | - |
Safety References:
European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
European Food Safety Authority (EFSA) reference(s): |
Flavouring Group Evaluation 86, (FGE.86)[1] - Consideration of aliphatic and aromatic amines and amides evaluated by JECFA (65th meeting) - Scientific Opinion of the Panel on Food Additives - Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 86, Revision 1 (FGE.86Rev1): Consideration of aliphatic and aromatic amines and amides evaluated by JECFA (65th meeting) View page or View pdf |
Statement on List of Representative Substances for Testing.
The current Statement lays down a list of substances in sub-groups with representative substances for which additional data are required prior to their evaluation through the Procedure (Regulation (EC) No 1565/2000). View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 86, Revision 2 (FGE.86Rev2): Consideration of aliphatic and arylalkyl amines and amides evaluated by JECFA (65th meeting) View page or View pdf |
Safety and efficacy of pyridine and pyrrole derivatives belonging to chemical group 28 when used as flavourings for all animal species View page or View pdf |
EPI System: | View |
ClinicalTrials.gov: | search |
Daily Med: | search |
Chemical Carcinogenesis Research Information System: | Search |
AIDS Citations: | Search |
Cancer Citations: | Search |
Toxicology Citations: | Search |
EPA Substance Registry Services (TSCA): | 94-62-2 |
EPA ACToR: | Toxicology Data |
EPA Substance Registry Services (SRS): | Registry |
Laboratory Chemical Safety Summary : | 638024 |
National Institute of Allergy and Infectious Diseases: | Data |
WGK Germany: | 3 |
| (2E,4E)-5-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one |
Chemidplus: | 0000094622 |
RTECS: | TN2321500 for cas# 94-62-2 |
References:
| (2E,4E)-5-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one |
NIST Chemistry WebBook: | Search Inchi |
Canada Domestic Sub. List: | 94-62-2 |
Pubchem (cid): | 638024 |
Pubchem (sid): | 134971294 |
Other Information:
Potential Blenders and core components note
|
For Odor |
amber |
| angelica seed oil CO2 extract | FL/FR |
anisic |
bitter | fennel seed oil spain | FR |
balsamic |
| amyris wood oil | FL/FR |
| copaiba balsam oil | FL/FR |
| hemlock western oil (tsuga heterophylla) canada | FR |
| opoponax oil (commiphora erythraea var. glabrescens engle) | FL/FR |
| tolu balsam oil | FL/FR |
citrus |
(E)-2- | tetradecenal | FL/FR |
earthy |
| cabralea cangerana root bark oil | FR |
2- | ethyl-3-methoxypyrazine | FL/FR |
floral |
alpha- | bisabolol | FL/FR |
green |
2-iso | butyl-3-methoxypyrazine | FL/FR |
2-sec- | butyl-3-methoxypyrazine | FL/FR |
| cortex pyridine | FL/FR |
| galbanum decatriene | FL/FR |
| galbanum oleoresin | FL/FR |
| galbanum resinoid | FL/FR |
(E,Z)-3,6- | nonadien-1-ol | FL/FR |
herbal |
| canarium luzonicum gum | FL/FR |
| canarium luzonicum oil | FL/FR |
mentholic |
| cornmint oil terpeneless | FL/FR |
laevo- | menthol | FL/FR |
dextro,laevo- | menthol | FL/FR |
| peppermint cyclohexanone | FL/FR |
dextro- | piperitone | FL/FR |
iso | pulegyl acetate | FL/FR |
minty |
(-)- | menthone | FL/FR |
| pennyroyal oil | FL/FR |
| peppermint oil idaho | FL/FR |
| peppermint oil terpeneless | FL/FR |
5- and 6-iso | propyl-1,3,3-trimethyl bicyclo(2.2.2)-5,7-octadien-2-one | |
(R)-(+)- | pulegone | FR |
iso | pulegone | FL/FR |
nutty |
| shoyu pyrazine | FL/FR |
peppery |
| asarum europaeum oil | FR |
1,5- | dimethyl-3-n-propyl-2-oxabicyclo(2.2.2)octane | |
spicy |
| agarospirol | FR |
| atractylis root oil | FR |
4- | carvomenthenol | FL/FR |
| croton eluteria bark oil | FL/FR |
| cumin seed oil | FL/FR |
| ethyl vinyl ketone | FL/FR |
| eucalyptus numerosa type oil | |
| grains of paradise oil | FL/FR |
| myrcene | FR |
black | pepper absolute | FL/FR |
| pepper hexanone | FR |
black | pepper oil | FL/FR |
black | pepper oleoresin | FL/FR |
| pepper tree berry oil | FL/FR |
| zvoulimba leaf oil | FR |
terpenic |
| angelica seed oil | FL/FR |
| elemi resinoid | FL/FR |
| frankincense oil | FL/FR |
| juniperus communis fruit oil | FL/FR |
laevo- | limonene | FL/FR |
alpha- | phellandrene | FL/FR |
woody |
| caryophyllene formate | FL/FR |
alpha- | guaiene | FL/FR |
| methyl vetivate | FR |
| spikenard oil | FL/FR |
| sugi wood oil | FR |
| xanthoxylum alatum roxb. oil | FR |
|
For Flavor |
|
No flavor group found for these |
alpha- | bisabolol | FL/FR |
| caryophyllene formate | FL/FR |
2- | ethyl-3-methoxypyrazine | FL/FR |
| eucalyptus numerosa type oil | |
| grains of paradise oil | FL/FR |
| green pea pyrazine | FL |
alpha- | guaiene | FL/FR |
2- | methoxy-3-propyl pyrazine | FL |
5- and 6-iso | propyl-1,3,3-trimethyl bicyclo(2.2.2)-5,7-octadien-2-one | |
iso | pulegone | FL/FR |
| spikenard oil | FL/FR |
amber |
| angelica seed oil | FL/FR |
balsamic |
| copaiba balsam oil | FL/FR |
| opoponax oil (commiphora erythraea var. glabrescens engle) | FL/FR |
| tolu balsam oil | FL/FR |
cooling |
4- | carvomenthenol | FL/FR |
laevo- | menthol | FL/FR |
dextro,laevo- | menthol | FL/FR |
green |
2-iso | butyl-3-methoxypyrazine | FL/FR |
| canarium luzonicum gum | FL/FR |
| canarium luzonicum oil | FL/FR |
| cortex pyridine | FL/FR |
| elemi resinoid | FL/FR |
| galbanum decatriene | FL/FR |
| galbanum oleoresin | FL/FR |
| galbanum resinoid | FL/FR |
(E,Z)-3,6- | nonadien-1-ol | FL/FR |
herbal |
| angelica seed oil CO2 extract | FL/FR |
mentholic |
| cornmint oil terpeneless | FL/FR |
| peppermint cyclohexanone | FL/FR |
minty |
(-)- | menthone | FL/FR |
| pennyroyal oil | FL/FR |
| peppermint oil idaho | FL/FR |
| peppermint oil terpeneless | FL/FR |
dextro- | piperitone | FL/FR |
musty |
| shoyu pyrazine | FL/FR |
peppery |
1,5- | dimethyl-3-n-propyl-2-oxabicyclo(2.2.2)octane | |
spicy |
| croton eluteria bark oil | FL/FR |
| cubeb oleoresin | FL |
| cumin seed oil | FL/FR |
| ethyl vinyl ketone | FL/FR |
black | pepper absolute | FL/FR |
black | pepper oil | FL/FR |
white | pepper oleoresin | FL |
black | pepper oleoresin | FL/FR |
| pepper tree berry oil | FL/FR |
terpenic |
| juniperus communis fruit oil | FL/FR |
laevo- | limonene | FL/FR |
alpha- | phellandrene | FL/FR |
vegetable |
2-sec- | butyl-3-methoxypyrazine | FL/FR |
waxy |
(E)-2- | tetradecenal | FL/FR |
woody |
| amyris wood oil | FL/FR |
| frankincense oil | FL/FR |
iso | pulegyl acetate | FL/FR |
|
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
(2E,4E)-5- | benzo[1,3]dioxol-5-yl-1-piperidin-1-yl-penta-2,4-dien-1-one | (2E,4E)-5-(2H- | benzo[3,4-d]1,3-dioxolen-5-yl)-1-piperidylpenta-2,4-dien-1-one | (2E,4E)-5-( | benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one | (2E,4E)-5-(1,3- | benzodioxol-5-yl)-1-(1-piperidinyl)-2,4-pentadien-1-one | (2E,4E)-5-(1,3- | benzodioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one | 1-((E,E)-5-(1,3- | benzodioxol-5-yl)-1-oxo-2,4-pentadienyl) piperidine | (E,E)-1-(5-(1,3- | benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)piperidine | (E,E) 1-[5-(1,3- | benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]piperidine | (E,E)-1-[5-(1,3- | benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]piperidine | 1-[(2E,4E)-5-(1,3- | benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]piperidine | (2E,4E)-5-(1,3- | benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one | 1-[(2E,4E)-5-(1,3- | benzodioxol-5-yl)-2,4-pentadienoyl]piperidine | 1-[(2E,4E)-5-(1,3- | benzodioxol-5-yl)penta-2,4-dienoyl]piperidine | | bioperine | | piperidine, 1-((2E,4E)-5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)- | | piperidine, 1-(5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)-, (E,E)- | | piperidine, 1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]- | | piperidine, 1-[5- (1, 3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-, (E,E)- | | piperidine, 1-[5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-, (E,E)- | | piperidine, 1-piperoyl-, (E,E)- | | piperine natural | (E,E)- | piperoyl piperidine | (E,E)-1- | piperoyl piperidine | N-(E,E)- | piperoyl-piperidine | N-[(E,E)- | piperoyl]-piperidine | N-[(E,E)- | piperoyl]piperidine | (E,E)- | piperoylpiperidine | (E,E)-1- | piperoylpiperidine | 1- | piperoylpiperidine, (E,E)- |
Articles:
|