Category: flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | white crystals (est) |
Assay: | 98.00 to 100.00 %
|
Food Chemicals Codex Listed: | No |
Melting Point: | 183.00 to 186.00 °C. @ 760.00 mm Hg
|
Boiling Point: | 275.00 to 280.00 °C. @ 760.00 mm Hg
|
Vapor Pressure: | 0.002000 mmHg @ 25.00 °C. (est) |
Flash Point: | 365.00 °F. TCC ( 185.00 °C. )
|
logP (o/w): | 1.960 |
Shelf Life: | 36.00 month(s) or longer if stored properly. |
Storage: | store in cool, dry place in tightly sealed containers, protected from heat and light. |
Soluble in: |
| alcohol | | ether | | water, 530 mg/L @ 37 °C (exp) |
Insoluble in: |
| water, hot |
Similar Items: note |
meta-anisic acid |
ortho-anisic acid |
Organoleptic Properties:
|
Odor Type: animal |
|
| fecal animal phenolic medicinal |
Odor Description: at 10.00 % in dipropylene glycol. | faint putrid sweet cadaverous |
|
Odor and/or flavor descriptions from others (if found). |
|
|
Cosmetic Information:
Suppliers:
Advanced Biotech |
ANISIC ACID NATURAL
98% min. |
Anhui Haibei |
Anisic Acid natural
Odor: Faint putrid sweet cadaverous |
Beijing Lys Chemicals |
Draconic acid
|
BOC Sciences |
For experimental / research use only. |
4-Methoxybenzoic acid
|
Charkit Chemical |
ANISIC ACID, P- (SNOW WHITE GRADE)
|
Charkit Chemical |
ANISIC ACID, P-
|
Demand And Supply Chem |
For experimental / research use only. |
4-Methoxy benzoic acid (p-Anisic acid)
|
Foreverest Resources |
p-Anisic Acid 99%
Odor: sweet flower Use: p-Anisic acid, also called 4-methoxybenzoic acid or draconic acid, is one of the isomers of anisic acid. It appears white to slight yellowish powder. |
Lluch Essence |
ANISIC ACID NATURAL
|
Natural Advantage |
Anisic Acid Nat
Flavor: spicy, sweet |
Riverside Aromatics LTD.is the exclusive distributor for Europe in UK for any non-US based inquiries |
Penta International |
P-ANISIC ACID NATURAL
|
Penta International |
P-ANISIC ACID
|
Santa Cruz Biotechnology |
For experimental / research use only. |
p-Anisic Acid
|
Sigma-Aldrich |
p-Anisic acid, ≥99%, FG
|
Certified Food Grade Products |
Sigma-Aldrich |
p-Anisic acid, natural, 99%, FG
Odor: animal |
TCI AMERICA |
For experimental / research use only. |
p-Anisic Acid >99.0%(GC)(T)
|
WEN International |
P-ANISIC ACID Natural
|
WholeChem |
Draconic acid
|
Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | Xi - Irritant |
R 36/37/38 - Irritating to eyes, respiratory system, and skin. S 02 - Keep out of the reach of children. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36 - Wear suitable protective clothing.
|
|
Hazards identification |
|
Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
|
Pictogram | |
|
Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
Not determined
|
Dermal Toxicity: |
subcutaneous-mouse LD50 400 mg/kg Cesko-Slovenska Farmacie. Vol. 31, Pg. 236, 1982.
|
Inhalation Toxicity: |
Not determined
|
Safety in Use Information:
Category: | flavoring agents |
Recommendation for para-anisic acid usage levels up to: | | not for fragrance use.
|
|
Maximised Survey-derived Daily Intakes (MSDI-EU): | 1.70 (μg/capita/day) |
Maximised Survey-derived Daily Intakes (MSDI-USA): | 0.10 (μg/capita/day) |
Structure Class: | I |
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
publication number: 19 |
Click here to view publication 19 |
| average usual ppm | average maximum ppm |
baked goods: | 2.50000 | 5.00000 |
beverages(nonalcoholic): | 0.50000 | 1.00000 |
beverages(alcoholic): | - | - |
breakfast cereal: | - | - |
cheese: | - | - |
chewing gum: | - | - |
condiments / relishes: | - | - |
confectionery froastings: | - | - |
egg products: | - | - |
fats / oils: | - | - |
fish products: | - | - |
frozen dairy: | 1.00000 | 3.00000 |
fruit ices: | - | - |
gelatins / puddings: | 2.00000 | 4.00000 |
granulated sugar: | - | - |
gravies: | - | - |
hard candy: | - | - |
imitation dairy: | - | - |
instant coffee / tea: | - | - |
jams / jellies: | - | - |
meat products: | - | - |
milk products: | - | - |
nut products: | - | - |
other grains: | - | - |
poultry: | - | - |
processed fruits: | - | - |
processed vegetables: | - | - |
reconstituted vegetables: | - | - |
seasonings / flavors: | - | - |
snack foods: | - | - |
soft candy: | 3.00000 | 6.00000 |
soups: | - | - |
sugar substitutes: | - | - |
sweet sauces: | - | - |
Safety References:
Flavor & Extract Manufacturers Association (FEMA) reference(s): |
The FEMA GRAS assessment of hydroxyl- and alkoxy-substituted benzyl derivatives used as flavor ingredients. View pdf |
European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
European Food Safety Authority (EFSA) reference(s): |
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 20 (FGE.20): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical group 23 View page or View pdf |
Flavouring Group Evaluation 52 (FGE.52): Consideration of hydroxy- and alkoxy-substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
Flavouring Group Evaluation 20, Revision 1 (FGE.20Rev1): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters from chemical group 23 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 20, Revision 2 (FGE.20Rev2): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 96 (FGE.96): Consideration of 88 flavouring substances considered by EFSA for which EU production volumes / anticipated production volumes have been submitted on request by DG SANCO. Addendum to FGE. 51, 52, 53, 54, 56, 58, 61, 62, 63, 64, 68, 69, 70, 71, 73, 76, 77, 79, 80, 83, 84, 85 and 87. View page or View pdf |
EPI System: | View |
AIDS Citations: | Search |
Cancer Citations: | Search |
Toxicology Citations: | Search |
EPA Substance Registry Services (TSCA): | 100-09-4 |
EPA ACToR: | Toxicology Data |
EPA Substance Registry Services (SRS): | Registry |
Laboratory Chemical Safety Summary : | 7478 |
National Institute of Allergy and Infectious Diseases: | Data |
WGK Germany: | 1 |
| 4-methoxybenzoic acid |
Chemidplus: | 0000100094 |
RTECS: | BZ4395000 for cas# 100-09-4 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
4- | anisic acid | p- | anisic acid | p- | anisic acid natural | | benzoic acid, 4-methoxy- | | draconic acid | 4- | methoxy benzoic acid | 4- | methoxybenzoic acid | p- | methoxybenzoic acid | para- | methoxybenzoic acid |
Articles:
PubMed: | Effect of chlorocholine chlorid on phenolic acids accumulation and polyphenols formation of buckwheat plants. |
PubMed: | Production of natural fragrance aromatic acids by coexpression of trans-anethole oxygenase and p-anisaldehyde dehydrogenase genes of Pseudomonas putida JYR-1 in Escherichia coli. |
PubMed: | Screening of Burkholderia sp. WGB31 producing anisic acid from anethole and optimization of fermentation conditions. |
PubMed: | Development and validation of a liquid chromatographic method for the simultaneous determination of aniracetam and its related substances in the bulk drug and a tablet formulation. |
PubMed: | Chemistry of spices: bornyl 4-methoxybenzoate from Ferula ovina (Boiss.) Boiss. (Apiaceae) induces hyperalgesia in mice. |
PubMed: | [Synthesis and spectroscopic properties of rare earth and p-anisic acid with 1, 10-phenanthroline]. |
PubMed: | Intermolecular interaction of voriconazole analogues with model membrane by DSC and NMR, and their antifungal activity using NMR based metabolic profiling. |
PubMed: | Inhibition of toxic actions of phospholipase A2 isolated & characterized from the Indian Banded Krait (Bungarus fasciatus) venom by synthetic herbal compounds. |
PubMed: | The crystal structures of 4-methoxybenzoate bound CYP199A2 and CYP199A4: structural changes on substrate binding and the identification of an anion binding site. |
PubMed: | The preclinical toxicology of anisoylated plasminogen streptokinase activator complex. |
PubMed: | Identification and effects of interaction phytotoxic compounds from exudate of Cistus ladanifer leaves. |
PubMed: | Crystal structures of the free and anisic acid bound triple mutant of phospholipase A2. |
PubMed: | Aniracetam enhances cortical dopamine and serotonin release via cholinergic and glutamatergic mechanisms in SHRSP. |
PubMed: | Reduction of aryl acids by white-rot fungi for the biocatalytic production of aryl aldehydes and alcohols. |
PubMed: | Liquid-chromatographic assay of cefmenoxime in serum and urine. |
PubMed: | Pharmacokinetics of aniracetam and its metabolites in rats. |
PubMed: | Metabolism of p-anisic acid by the rat. |
PubMed: | Caffeic acid inhibits the formation of 7-carboxyheptyl radicals from oleic acid under flavin mononucleotide photosensitization by scavenging singlet oxygen and quenching the excited state of flavin mononucleotide. |
PubMed: | Differentiation of manuka honey from kanuka honey and from jelly bush honey using HS-SPME-GC/MS and UHPLC-PDA-MS/MS. |
PubMed: | Aryl-alcohol oxidase involved in lignin degradation: a mechanistic study based on steady and pre-steady state kinetics and primary and solvent isotope effects with two alcohol substrates. |
PubMed: | New alternatives to cosmetics preservation. |
PubMed: | Third calcium ion found in an inhibitor-bound phospholipase A2. |
PubMed: | Kinetics of thermal decomposition of 4-carboxyl-2,6-dinitrobenzenediazonium ion (CDNBD). |
PubMed: | Tyrosinase inhibition kinetics of anisic acid. |
PubMed: | New 4-methoxybenzoyl derivatives from the ascidian Polycarpa aurata. |
PubMed: | Substrate and solvent isotope effects on the fate of the active oxygen species in substrate-modulated reactions of putidamonooxin. |
PubMed: | Antihepatotoxic activity of p-methoxy benzoic acid from Capparis spinosa. |
PubMed: | Comparison of the properties of polymeric and C8 based materials for solid phase extraction. |
PubMed: | Selective effects of aniracetam across receptor types and forms of synaptic facilitation in hippocampus. |
PubMed: | The trans-anethole degradation pathway in an Arthrobacter sp. |
PubMed: | An improved method for the production of antibodies to lipophilic carboxylic hapten using small amount of hapten-carrier conjugate. |
PubMed: | Peptidyl inverse esters of p-methoxybenzoic acid: a novel class of potent inactivator of the serine proteases. |
PubMed: | Platinum(II) complexes of 4-methoxy- and 4-chlorobenzoic acid hydrazides. Synthesis, characterization, and cytotoxic effect. |
PubMed: | Effects of solute characteristics and concentration on a lyotropic liquid crystal: solute-induced phase change. |
PubMed: | Two independently regulated cytochromes P-450 in a Rhodococcus rhodochrous strain that degrades 2-ethoxyphenol and 4-methoxybenzoate. |
PubMed: | Utilization of methoxylated benzoates and formation of intermediates by Desulfotomaculum thermobenzoicum in the presence or absence of sulfate. |
PubMed: | Metabolism of the 18O-methoxy substituent of 3-methoxybenzoic acid and other unlabeled methoxybenzoic acids by anaerobic bacteria. |
PubMed: | The aniracetam metabolite 2-pyrrolidinone induces a long-term enhancement in AMPA receptor responses via a CaMKII pathway. |
PubMed: | Mono- and dimethylation of arsenic in rat liver cytosol in vitro. |
PubMed: | Enzyme production by Mycena galopus mycelium in artificial media and in Picea sitchensis F1 horizon needle litter. |
PubMed: | Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism. |
PubMed: | A very precise high-performance liquid chromatographic procedure for the determination of cefmenoxime, a new cephalosporin antibiotic, in plasma. |
PubMed: | First general, direct, and regioselective synthesis of substituted methoxybenzoic acids by ortho metalation. |
PubMed: | Identification of syn- and anti-anethole-2,3-epoxides in the metabolism of trans-anethole by the newly isolated bacterium Pseudomonas putida JYR-1. |
PubMed: | Pharmacokinetics of aniracetam and its metabolites in rat brain. |
PubMed: | Molecular mechanism of lung hemorrhage induction by VRV-PL-VIIIa from Russell's viper (Vipera russelli) venom. |
PubMed: | Group II metabotropic glutamate receptors are a common target of N-anisoyl-GABA and 1S,3R-ACPD in enhancing ACh release in the prefrontal cortex of freely moving SHRSP. |
PubMed: | Activation of the reticulothalamic cholinergic pathway by the major metabolites of aniracetam. |
PubMed: | Synthesis, characterisation and antifungal activity of some N-bridged heterocycles derived from 3-(3-bromo-4-methoxyphenyl)-4-amino-5-mercapto-1,2,4-triazole. |
PubMed: | Thiopurine methyltransferase activity in a French population: h.p.l.c. assay conditions and effects of drugs and inhibitors. |
PubMed: | Degradation of methoxylated benzoic acids by a Nocardia from a lignin-rich environment: significance to lignin degradation and effect of chloro substituents. |
|