Articles:
methoxybenzene
Notes:
Flavouring agent
Anisole is a precursor to perfumes, insect pheromones, and pharmaceuticals. For example, synthetic anethole is prepared from anisole.; Anisole undergoes electrophilic aromatic substitution reaction more quickly than does benzene, which in turn reacts more quickly than nitrobenzene. The methoxy group is an ortho/para directing group, which means that electrophilic substitution preferentially occurs at these three sites. The enhanced nucleophilicity of anisole vs benzene reflects the influence of the methoxy group, which renders the ring more electron-rich. The methoxy group strongly affects the pi cloud of the ring, moreso than the inductive effect of the electronegative oxygen.
-
Beijing Lys Chemicals Co, LTD. From Grams to Tons Fine chemical high-tech company which contains R&D, production, and sales. BEIJING LYS CHEMICALS CO, LTD, established in 2004, is a fine chemical high-tech company which contains R&D, production, and sales. We mainly engaged in export and technology development of flavor and fragrance materials and pharmaceutical intermediates. We have nearly 500 kinds of products, from grams to tons, exported to USA, Europe, South Asia and etc. And we custom manufacture new products according to customers’ needs, and serve good quality products and service. Our goal is to become a fine chemical enterprise which could provide special products and services. Email: Mr. Jia Email: Mr. Guo Voice: 86-10-68418738 Fax: 86-10-68418739 Mr. Guo 86-10-68483445 Mr. Guo 86-10-68418739 News Product(s): 10368 Methoxy benzene
-
-
Charkit Chemical Corporation The Specialty Chemical Specialists Explore this website to discover the products and services that Charkit provides for your industry and please contact us directly to find out how we can be of service to you. about: Since 1982, Charkit has been committed to expanding the markets we serve as our roster of products and services continues to grow with us. Our substantial portfolio of personal care ingredients now include a wide array of luxury and exotic components to compliment the key products we have always offered. We have expanded our offerings to the nutraceutical, industrial, and resin markets with a growing roster of versatile and unique ingredients. We continue to lead the way in our traditional markets such as Metal and Water Treatment, Imaging, Flavor & Fragrance, Aroma and Food. Our Pharmaceutical offerings continue to expand, still anchored by the Boronic Derivatives that meet the demands of Suzuki coupling reactions. Please contact us to learn how we can help you reach your goals. Email: Sales Voice: 203-299-3220 Fax: 203-299-1355 Facebook Twitter Linkedin Latest News Events Blog Products List: View Product(s): ANISOLE
-
-
Glentham Life Sciences Ltd The Chemical, Biochemical & Research Essentials Supplier Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK. With a Glentham Life Sciences account you can view more product details, request quotes and order products online. Email: Info Email: Sales Email: Tech Support Voice: +44 (0) 1225 667798 Fax: +44 (0) 2033 978909 Facebook Twitter Linkedin Google+ News Distribution Products List: View Product(s): GX1132 Anisole
-
-
M&U International LLC Steady supply & demand Meeting customers increasing demands at home as well as abroad. M&U dedicates itself to the development and production of new products as well as continuously promoting those new products. We’ve maintained a steady supply&demand relationship with a large number of manufacturers at home and abroad. We’ve developed an extensive network and because of our relationships with these manufacturers, we’re able to provide a stable supply of great quality materials. We’re located in China’s largest communications hub, Shanghai and in the U.S. near one of the largest sea ports on the East Coast. The strategic locations of our facilities ensure convenient, prompt and secure delivery of our products to our customers. Email: Sales US Email: Sales Voice: +86-21-32515501 60762991 60762992 Fax: +86-21-32515502 64204960 US Voice: 908-359-9000 US Fax: 908-359-9002 News Product(s): N0006 NAT.ANISOLE, Kosher A0533 Anisole
-
-
Penta International Corporation Chemistry innovation At Penta, our products and services help businesses do business better. For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes. US Email: Technical Services US Email: Sales US Voice: (973) 740-2300 US Fax: (973) 740-1839 Product(s): 01-37300 ANISOLE
-
-
SRS Aromatics Ltd For over 25 years Bringing flavour and fragrance into your world. As suppliers / distributors of ingredients to the fragrance and flavour industries, our goal is to provide high quality materials at competitive prices with an exceptional level of service. Established in 1984, SRS Aromatics Ltd is an independent family owned business which has become very well-respected within the fragrance and flavour industry as a reliable and trustworthy partner. Over the years this has allowed the company to develop strong relationships with many global manufacturers; several of whom we represent in the UK. A core aim of our business is to work extremely closely with both our suppliers and customers to maximise service levels with minimum disruption to supply. Email: Info Email: Sales Voice: +44 (0) 1284 704076 Fax: +44 (0) 1284 760819 Twitter Linkedin News Product(s): ANISOLE
-
-
Sunaux International Buy With Confidence We have industry leading processes and procedures to ensure nothing but the most reliable product. Sunaux International was founded in 2012 by the owner Mr.John Felton after spending 18 years involved in developing global business in the aromatic chemicals, fragrance and flavour compounds business. Email: John Felton Email: Stephen Zhou (Sales) Voice: 0512-57995626 Fax: 0512-57570299 Sales 0512-57995626 Sales 0512-57570299 News Product(s): N0006 nat.Anisole
-
-
Synerzine, Inc. Innovation. Customization. Aroma Ingredients. Synerzine is a leading supplier of flavor and fragrance ingredients. Synerzine expresses what we have grown to embody as an organization - the synergy and connection between raw ingredients, science, technology, and the final product. Our experienced team is passionate about bringing our customers high-quality innovative ingredients that they can trust. Building upon our 44 year history, the Synerzine team provides customers around the globe with convenient access to over 1200 high-quality aroma ingredients. We actively engage with customers to add a wide array of new products and services on a regular basis. Our aim is to delight every customer with our exceptional services, large product selection, customization and the highest quality and safety standards. We provide our customers with true value designed to help them bring their products to market faster. US Email: Customer Service US Email: Sales US Voice: (404) 524-6744 US Fax: (404) 577-1651 Inquiry Products List: View Product(s): W01353 Anisole
-
-
TCI AMERICA Moving Your Chemistry Forward We continuously strive to advance our technology. With East & West Coast distribution centers, count on TCI to deliver products quickly and reliably. Over 30,000 Reagents available today in benchtop to bulk quantities. We also offer custom synthesis solutions. Sign up for a TCI account today for fast and free shipping! Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 70 years of synthesis experience and multi-purpose plants enable TCI to offer more than 30,000 products as well as custom synthesis. US Email: Sales Email: Technical Support Voice: 1-800-423-8616 Fax: 1- 888-520-1075 Facebook Twitter Instagram Linkedin Product(s): A0492 Anisole >99.0%(GC)
-
-
WholeChem, LLC Connecting Innovators To the Building Blocks Of the Universe Custom manufacturer and distributor of specialty ingredients. We make global local. SQF-Certified Supplier We owe our success to our integrity, our dedication to the industry, and our commitment to our clients. We invite your inquiries regarding our current product list and any other products you may be having trouble sourcing. Email: Info Email: Orders Voice: +1 (262) 995.8668 Certification Our Services Products List: View Product(s): Methoxy benzene
-
| CAS Number: | 100-66-3 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 202-876-1 | |
| FDA UNII: | B3W693GAZH | |
| Nikkaji Web: | J4.012F | |
| Beilstein Number: | 0506892 | |
| MDL: | MFCD00008354 | |
| CoE Number: | 2056 | |
| XlogP3: | 2.10 (est) | |
| Molecular Weight: | 108.13996000 | |
| Formula: | C7 H8 O | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| JECFA Food Flavoring: | 1241 anisole |
| DG SANTE Food Flavourings: | 04.032 anisole |
| FEMA Number: | 2097 anisole |
| FDA: | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF): | 100-66-3 ; ANISOLE |
| FDA Regulation: | |
| FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION Subpart F--Flavoring Agents and Related Substances Sec. 172.515 Synthetic flavoring substances and adjuvants. | |
Physical Properties:
| Appearance: | colorless clear liquid (est) |
| Assay: | 99.00 to 100.00 % |
| Food Chemicals Codex Listed: | Yes |
| Specific Gravity: | 0.99500 to 1.00100 @ 20.00 °C. |
| Pounds per Gallon - (est).: | 8.289 to 8.339 |
| Refractive Index: | 1.51600 to 1.51900 @ 20.00 °C. |
| Melting Point: | -38.00 to -37.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 153.00 to 155.00 °C. @ 760.00 mm Hg |
| Vapor Pressure: | 3.540000 mmHg @ 25.00 °C. |
| Vapor Density: | 3.7 ( Air = 1 ) |
| Flash Point: | 125.00 °F. TCC ( 51.67 °C. ) |
| logP (o/w): | 2.110 |
| Soluble in: | |
| alcohol | |
| ether | |
| water, 1040 mg/L @ 25 °C (exp) | |
| Stability: | |
| non-discoloring in most media | |
Organoleptic Properties:
| Odor Type: phenolic | |
| Odor Strength: | high , recommend smelling in a 1.00 % solution or less |
| Substantivity: | 4 hour(s) at 100.00 % |
| phenolic gasoline ethereal anise | |
| Odor Description: at 1.00 % in dipropylene glycol. | phenolic gasoline ethereal anise Luebke, William tgsc, (1987) |
| Flavor Type: aromatic | |
| aromatic acrylate acetone plastic | |
| Taste Description: | aromatic acrylate acetone plastic Luebke, William tgsc, (1987) |
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| CosIng: | cosmetic data |
| Cosmetic Uses: |
perfuming agents |
Suppliers:
| Beijing Lys Chemicals |
| Methoxy benzene |
| Charkit Chemical |
| ANISOLE |
| EMD Millipore |
| For experimental / research use only. |
| Anisole |
| Glentham Life Sciences |
| Anisole |
| Indenta Group |
| Anisole |
| Inoue Perfumery |
| ANISOLE |
| M&U International |
| Anisole |
| M&U International |
| NAT.ANISOLE, Kosher |
| Penta International |
| ANISOLE |
| Reincke & Fichtner |
| Anisole |
| Sigma-Aldrich |
| For experimental / research use only. |
| Anisole analytical standard |
| SRS Aromatics |
| ANISOLE
Odor: Phenolic, Gasoline, Ethereal, Anise |
| Sunaux International |
| nat.Anisole |
| Synerzine |
| Anisole |
| TCI AMERICA |
| For experimental / research use only. |
| Anisole >99.0%(GC) |
| WholeChem |
| Methoxy benzene |
Safety Information:
| European information : | |
| Most important hazard(s): | |
| Xi - Irritant | |
|
R 10 - Flammable. R 38 - Irritating to skin. S 02 - Keep out of the reach of children. S 24 - Avoid contact with skin. S 36 - Wear suitable protective clothing. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
oral-rat LD50 [sex: M,F] 3700 mg/kg (Taylor et al., 1964) oral-rat LD50 [sex: M,F] 3700 mg/kg (Bär & Griepentrog, 1967) oral-rat LD50 [sex: M,F] 3700 mg/kg (Jenner et al., 1964) oral-mouse LD50 2800 mg/kg BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT Journal of Pharmacology and Experimental Therapeutics. Vol. 88, Pg. 400, 1946. oral-rat LD50 3700 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS KIDNEY, URETER, AND BLADDER: HEMATURIA Toxicology and Applied Pharmacology. Vol. 6, Pg. 378, 1964. intraperitoneal-rat LDLo 500 mg/kg Journal of Agricultural and Food Chemistry. Vol. 17, Pg. 497, 1969. | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
|
inhalation-rat LC50 > 5000 mg/m3 Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 28(6), Pg. 43, 1984. inhalation-mouse LC50 3021 mg/m3/2H Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 28(6), Pg. 43, 1984. | |
Safety in Use Information:
| Category: | flavor and fragrance agents | ||
| RIFM Fragrance Material Safety Assessment: Search | |||
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice | |||
| Recommendation for anisole usage levels up to: | |||
| 0.6000 % in the fragrance concentrate. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.024 (μg/capita/day) | ||
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 0.01 (μg/capita/day) | ||
| Structure Class: | I | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 3 | |||
| Click here to view publication 3 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | - | 34.00000 | |
| beverages(nonalcoholic): | - | 9.00000 | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | - | - | |
| condiments / relishes: | - | - | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | - | 16.00000 | |
| fruit ices: | - | 16.00000 | |
| gelatins / puddings: | - | - | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | - | 51.00000 | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | - | - | |
| milk products: | - | - | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | - | - | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
Safety References:
| European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): | |
| Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 23 (FGE.23): Aliphatic, alicyclic and aromatic ethers including anisole derivatives From chemical groups 15, 16 and 26 (Commission Regulation (EC) No 1565/2000 of 18 July 2000 View page or View pdf | |
| Flavouring Group Evaluation 59 (FGE.59): Consideration of aliphatic and aromatic ethers evaluated by JECFA (61st meeting) structurally related to aliphatic, alicyclic and aromatic ethers including anisole derivatives evaluated by EFSA in FGE.23 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf | |
| Flavouring Group Evaluation 23, Revision 1 (FGE.23Rev1): Aliphatic, alicyclic and aromatic ethers including anisole derivatives from chemical groups 15, 16, 26 and 30[1] - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf | |
| Scientific Opinion on Flavouring Group Evaluation 59, Revision 1 (FGE.59Rev1): Consideration of aliphatic and aromatic ethers evaluated by JECFA (61st meeting and 63rd meeting) structurally related to aliphatic, alicyclic and aromatic ethers including anisole derivatives evaluated by EFSA in FGE.23 Rev2 (2010) View page or View pdf | |
| EPI System: | View |
| NIOSH International Chemical Safety Cards: | search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 100-66-3 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 7519 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WISER: | UN 2222 |
| WGK Germany: | 2 |
| anisole | |
| Chemidplus: | 0000100663 |
| EPA/NOAA CAMEO: | hazardous materials |
| RTECS: | 100-66-3 |
References:
| anisole | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 100-66-3 |
| Pubchem (cid): | 7519 |
| Pubchem (sid): | 134972719 |
| Pherobase: | View |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| CHEBI: | View |
| CHEMBL: | View |
| Metabolomics Database: | Search |
| KEGG (GenomeNet): | C01403 |
| HMDB (The Human Metabolome Database): | HMDB33895 |
| FooDB: | FDB012090 |
| Export Tariff Code: | 2909.30.6000 |
| Typical G.C. | |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
Potential Blenders and core components note
| For Odor | ||
| No odor group found for these | ||
| 2,6- | diisopropyl phenol | FL/FR |
| camphoreous | ||
| cyclohexanol | FL/FR | |
| citrus | ||
| neroli ketone | FR | |
| phenolic | ||
| phenyl acetate | FL/FR | |
| 4- | propyl phenol | FL/FR |
| smoky | ||
| birch tar oil | FL/FR | |
| For Flavor | ||
| No flavor group found for these | ||
| birch tar oil | FL/FR | |
| cyclohexanol | FL/FR | |
| 2,4- | dihydroxybenzoic acid | FL |
| 2,6- | diisopropyl phenol | FL/FR |
| para- | guaiacol | FL |
| meta- | guaiacol | FL |
| 4- | propyl phenol | FL/FR |
| 4- | propyl syringol | FL |
| phenolic | ||
| phenyl acetate | FL/FR | |
Potential Uses:
| hawthorn | FR | |
| hay new mown hay | FR | |
| lilac | FR |
Occurrence (nature, food, other): note
| aerangis appendiculata Search Trop Picture | |
| aeranthes grandiflora Search Trop Picture | |
| artemisia dracumculus car. turkestanica Search Trop Picture | |
| asterogyne martiana Search Trop Picture | |
| bollea coelestis Search Trop Picture | |
| brassavola digbyana Search Trop Picture | |
| brassia verucosa Search Trop Picture | |
| cattleya lawrenceana Search Trop Picture | |
| dendrobium chrysotoxum Search Trop Picture | |
| dracula chestertonii Search Trop Picture | |
| encyclia fragrans Search Trop Picture | |
| epidendrum lacertinum Search Trop Picture | |
| geonoma brongniartii Search Trop Picture | |
| ginger lily white ginger lily Search Trop Picture | |
| liparis viridiflora Search Trop Picture | |
| magnolia kobus Search Trop Picture | |
| mangrove bark red oil cuba @ 0.10% Data GC Search Trop Picture | |
| masdevallia glandulosa Search Trop Picture | |
| mushroom giant puffball mushroom Search PMC Picture | |
| nigritella nigra Search Trop Picture | |
| raspberry red raspberry Search Trop Picture | |
| rosa chinensis Search Trop Picture | |
| sauromatum guttatum Search Trop Picture |
Synonyms:
| anisol | |
| nat. | anisole |
| anisole FCC | |
| benzene, methoxy- | |
| ether, methyl phenyl | |
| methoxy benzene | |
| methoxybenzene | |
| 4- | methoxybenzene |
| methyl phenyl ether | |
| phenol methyl ether | |
| phenoxymethane | |
| phenyl methyl ether |