Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: | Search |
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Perfumer and Flavorist: | Search |
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US Patents: | Search |
EU Patents: | Search |
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PubMed: | Search |
NCBI: | Search |
JECFA Food Flavoring: | 1857 2,6,6-trimethylcyclohex-2-ene-1,4-dione |
DG SANTE Food Flavourings: | 07.109 2,6,6-trimethylcyclohex-2-ene-1,4-dione |
FEMA Number: | 3421 2,6,6-trimethylcyclohex-2-ene-1,4-dione |
FDA: | No longer provide for the use of these seven synthetic flavoring substances |
FDA Mainterm (SATF): | 1125-21-9 ; 2,6,6-TRIMETHYLCYCLOHEX-2-ENE-1,4-DIONE |
Physical Properties:
Appearance: | white to yellowish tan green solid or liquid (est) |
Assay: | 98.00 to 100.00 %
|
Food Chemicals Codex Listed: | No |
Specific Gravity: | 0.91800 @ 25.00 °C.
|
Refractive Index: | 1.49100 @ 20.00 °C.
|
Melting Point: | 23.00 to 28.00 °C. @ 760.00 mm Hg
|
Boiling Point: | 92.00 to 94.00 °C. @ 11.00 mm Hg
|
Boiling Point: | 222.00 °C. @ 760.00 mm Hg
|
Vapor Pressure: | 0.158000 mmHg @ 25.00 °C. (est) |
Flash Point: | 205.00 °F. TCC ( 96.11 °C. )
|
logP (o/w): | 0.994 (est) |
Soluble in: |
| alcohol | | water, slightly | | water, 1839 mg/L @ 25 °C (est) |
Organoleptic Properties:
|
Odor Type: musty |
|
| musty woody sweet tea tobacco leafy |
Odor Description: at 1.00 % in dipropylene glycol. | musty woody sweet tea tobacco leaf |
|
| musty woody sweet tea citrus lemon brown |
Odor Description:
| Musty, woody, sweet, tea, citrus lemon with sI. brown nuances Mosciano, Gerard P&F 15, No. 4, 59, (1990) |
|
|
Flavor Type: citrus |
|
| citrus floral musty tea green sweet fruity |
Taste Description: at 40.00 ppm. | Citrus, floral, musty, tea like with green sweet fruity nuances Mosciano, Gerard P&F 15, No. 4, 59, (1990) |
|
Odor and/or flavor descriptions from others (if found). |
|
Sigma-Aldrich |
4-Oxoisophorone, ≥98%, FG |
Odor Description: | musty; woody; sweet |
Taste Description: | citrus floral musty tea green sweet fruity |
|
Pell Wall Perfumes |
4-Oxoisophorone |
Odor Description: | Sweet, floral, honey, tea, woody, musty Unusual and rarely offered ingredient that gives the core odour character to the scent of Buddliea flowers. Deceptively strong. This material was featured at the World Perfumery Congress in 2016. |
|
|
Cosmetic Information:
Suppliers:
Apple Flavor & Fragrance |
Oxoisophorone
|
Augustus Oils |
4 Oxoisophorone
|
Services |
Beijing Lys Chemicals |
4-OxoisoPhorone
|
Berjé |
ketoisophorone
|
Media |
BOC Sciences |
For experimental / research use only. |
4-oxoisoPhorone
|
DeLong Chemicals America |
2,6,6-Trimethylcyclohex-2-ene-1,4-dione
|
EMD Millipore |
For experimental / research use only. |
2,6,6-Trimethyl-2-cyclohexene-1,4-dione
|
M&U International |
4-oxoisoPhorone, Kosher
|
Pell Wall Perfumes |
4-Oxoisophorone 10%
Odor: Sweet, floral, honey, tea, woody, musty Use: Unusual and rarely offered ingredient that gives the core odour character to the scent of Buddliea flowers. Deceptively strong, and here offered at 10% dilution in ethanol to make it more affordable. |
Pell Wall Perfumes |
4-Oxoisophorone
Odor: Sweet, floral, honey, tea, woody, musty Use: Unusual and rarely offered ingredient that gives the core odour character to the scent of Buddliea flowers. Deceptively strong. This material was featured at the World Perfumery Congress in 2016. |
Penta International |
2,6,6-TRIMETHYLCYCLOHEX-2-ENE-1,4-DIONE
|
Shanghai Vigen Fine Chemical |
4-Oxoisophorone
|
Sigma-Aldrich |
4-Oxoisophorone, ≥98%, FG
Odor: musty; woody; sweet |
Certified Food Grade Products |
Sunaux International |
4-oxoisoPhorone
|
Synerzine |
2,6,6-Trimethyl Cyclohex-2-ene-1,4-dione
|
Synerzine |
4-OXOISOPHORONE
|
TCI AMERICA |
For experimental / research use only. |
4-Ketoisophorone >98.0%(GC)
|
Tengzhou Xiang Yuan Aroma Chemicals |
2,6,6-Trimethyl-2-cyclohexene-1,4-dione
|
Tianjin Danjun International |
4-Oxoisophorone
|
United International |
2,6,6-Trimethyl-2-cyclohexene-1,4-dione
|
Vigon International |
Ketoisophorone Pure (Oxophorone-4)
Odor: FOOD-LIKE, FRUITY |
WEN International |
4-OXOISOPHORONE
Synthetic |
WholeChem |
4-Oxoisophorone
|
Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | Xn - Harmful. |
R 22 - Harmful if swallowed. R 38 - Irritating to skin. R 43 - May cause sensitisation by skin contact. S 02 - Keep out of the reach of children. S 20/21 - When using do not eat, drink or smoke. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 - Wear suitable gloves and eye/face protection.
|
|
Hazards identification |
|
Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
|
Pictogram | |
|
Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
Not determined
|
Dermal Toxicity: |
Not determined
|
Inhalation Toxicity: |
Not determined
|
Safety in Use Information:
Category: | flavor and fragrance agents |
RIFM Fragrance Material Safety Assessment: Search |
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
Recommendation for ketoisophorone usage levels up to: | | 2.0000 % in the fragrance concentrate.
|
|
Maximised Survey-derived Daily Intakes (MSDI-EU): | 50.00 (μg/capita/day) |
Modified Theoretical Added Maximum Daily Intake (mTAMDI): | 1900 (μg/person/day) |
Threshold of Concern: | 540 (μg/person/day) |
Structure Class: | II |
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
publication number: 7 |
Click here to view publication 7 |
| average usual ppm | average maximum ppm |
baked goods: | - | - |
beverages(nonalcoholic): | - | 1.00000 |
beverages(alcoholic): | - | - |
breakfast cereal: | - | - |
cheese: | - | - |
chewing gum: | - | - |
condiments / relishes: | - | - |
confectionery froastings: | - | - |
egg products: | - | - |
fats / oils: | - | - |
fish products: | - | - |
frozen dairy: | - | - |
fruit ices: | - | - |
gelatins / puddings: | - | - |
granulated sugar: | - | - |
gravies: | - | - |
hard candy: | - | 5.00000 |
imitation dairy: | - | - |
instant coffee / tea: | - | - |
jams / jellies: | - | - |
meat products: | - | - |
milk products: | - | - |
nut products: | - | - |
other grains: | - | - |
poultry: | - | - |
processed fruits: | - | - |
processed vegetables: | - | - |
reconstituted vegetables: | - | - |
seasonings / flavors: | - | - |
snack foods: | - | - |
soft candy: | - | - |
soups: | - | - |
sugar substitutes: | - | - |
sweet sauces: | - | - |
|
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i). |
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm. |
| average usage mg/kg | maximum usage mg/kg |
Dairy products, excluding products of category 02.0 (01.0): | 7.00000 | 35.00000 |
Fats and oils, and fat emulsions (type water-in-oil) (02.0): | 2.00000 | 10.00000 |
Edible ices, including sherbet and sorbet (03.0): | 3.00000 | 15.00000 |
Processed fruit (04.1): | 2.00000 | 10.00000 |
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): | - | - |
Confectionery (05.0): | 4.00000 | 20.00000 |
Chewing gum (05.0): | - | - |
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): | - | - |
Bakery wares (07.0): | 5.00000 | 25.00000 |
Meat and meat products, including poultry and game (08.0): | 1.00000 | 5.00000 |
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): | 1.00000 | 5.00000 |
Eggs and egg products (10.0): | - | - |
Sweeteners, including honey (11.0): | - | - |
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): | 2.00000 | 10.00000 |
Foodstuffs intended for particular nutritional uses (13.0): | 3.00000 | 15.00000 |
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): | 2.00000 | 10.00000 |
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): | 4.00000 | 20.00000 |
Ready-to-eat savouries (15.0): | 5.00000 | 25.00000 |
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): | 2.00000 | 10.00000 |
Safety References:
European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
European Food Safety Authority (EFSA) reference(s): |
Flavouring Group Evaluation 213: alpha,beta-Unsaturated alicyclic ketones and precursors from chemical subgroup 2.7 of FGE.19 View page or View pdf |
List of apha, beta-Unsaturated Aldehydes and Ketones representative of FGE.19 substances for Genotoxicity Testing [1] - Statement of the Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF) View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 73, Revision 3 (FGE.73Rev3): Consideration of alicyclic alcohols, aldehydes, acids and related esters evaluated by JECFA (59th and 63rd meeting) structurally related to primary saturated or unsaturated alicyclic alcohols, aldehydes, acids and esters evaluated by EFSA in FGE.12Rev4 (2013) View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 9, Revision 5 (FGE.09Rev5): Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols from chemical group 8 and 30, and an ester of a phenol derivative from chemical group 25 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 87, Revision 2 (FGE.87Rev2): Consideration of bicyclic secondary alcohols, ketones and related esters evaluated by JECFA (63rd meeting) structurally related to bicyclic secondary alcohols, ketones and related esters evaluated by EFSA in FGE.47Rev1 (2008) View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 9, Revision 6 (FGE.09Rev6): Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols from chemical group 8 and 30, and an ester of a phenol derivative from chemical group 25 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 213, Revision 2 (FGE.213Rev2): Consideration of genotoxic potential for a,ß-unsaturated alicyclic ketones and precursors from chemical subgroup 2.7 of FGE.19 View page or View pdf |
Safety and efficacy of secondary aliphatic saturated or unsaturated alcohols, ketones, ketals and esters with a second secondary or tertiary oxygenated functional group belonging to chemical group 10 when used as flavourings for all animal species View page or View pdf |
EPI System: | View |
AIDS Citations: | Search |
Cancer Citations: | Search |
Toxicology Citations: | Search |
EPA Substance Registry Services (TSCA): | 1125-21-9 |
EPA ACToR: | Toxicology Data |
EPA Substance Registry Services (SRS): | Registry |
Laboratory Chemical Safety Summary : | 62374 |
National Institute of Allergy and Infectious Diseases: | Data |
WISER: | UN 2811 |
WGK Germany: | 3 |
| 2,6,6-trimethylcyclohex-2-ene-1,4-dione |
Chemidplus: | 0001125219 |
References:
Other Information:
Potential Blenders and core components note
|
For Odor |
alcoholic |
alcoholic |
iso | propyl alcohol | FL/FR |
aldehydic |
| decanal (aldehyde C-10) | FL/FR |
amber |
| amber naphthofuran | FL/FR |
| ambrette seed absolute | FL/FR |
| cistus ladaniferus resin | FR |
animal |
| methyl (E)-2-octenoate | FL/FR |
6- | methyl quinoline | FL/FR |
balsamic |
| amyl phenyl acetate | FL/FR |
laevo- | borneol | FL/FR |
iso | bornyl formate | FL/FR |
| brachyleana hutchinsii wood oil | FR |
| guaiacyl phenyl acetate | FL/FR |
| guaiyl acetate | FL/FR |
| myrrh absolute | FL/FR |
| opoponax resinoid replacer | FR |
| valerian rhizome absolute | FL/FR |
cereal |
| bran absolute | FR |
citrus |
| bergamot oil | FL/FR |
| bergamot oil bergaptene reduced italy | FL/FR |
| bergamot oil turkey | FL/FR |
beta- | bisabolol | FL/FR |
2- | dodecanone | FL/FR |
2- | ethyl-1-hexanol | FL/FR |
| petitgrain bergamot oil | FL/FR |
(±)-2,4,8- | trimethyl-7-nonen-2-ol | FL/FR |
10- | undecen-1-ol | FL/FR |
| verbena absolute france | FL/FR |
coconut |
(S)-gamma- | hexalactone | |
creamy |
3- | heptyl dihydro-5-methyl-2(3H)-furanone | FL/FR |
earthy |
| geosmin | FL/FR |
| geosmin | FL/FR |
(Z)- | linalool oxide (furanoid) | FL/FR |
fatty |
(E)-2- | octenal | FL/FR |
floral |
| boronia butenal | FR |
| champaca absolute | FR |
delta- | damascone | FL/FR |
| dimethyl benzyl carbinyl propionate | FR |
| geranyl formate | FL/FR |
| geranyl isobutyrate | FL/FR |
(Z)-3- | hexen-1-yl salicylate | FL/FR |
beta- | ionone | FL/FR |
(Z)- | jasmone | FL/FR |
| methyl dihydrojasmonate | FL/FR |
alpha-iso | methyl ionone (90% min.) | FL/FR |
2- | methyl naphthalene | FL/FR |
| neroli oil bigarde | FL/FR |
| neryl isovalerate | FL/FR |
bitter | orangeflower concrete morocco | FR |
| petitgrain absolute morocco | FL/FR |
| petitgrain bigarade oil | FL/FR |
| petitgrain oil morocco | FL/FR |
| phenethyl isobutyrate | FL/FR |
| rose butanoate | FL/FR |
| tea acetate | FR |
| tetrahydrolinalool | FL/FR |
| tetrahydrolinalyl acetate | FR |
| tobacco flower absolute | FR |
fruity |
alpha- | amyl cinnamyl isovalerate | FL/FR |
iso | butyl 2-butenoate | FL/FR |
iso | butyl isovalerate | FL/FR |
| cyclohexanone diethyl acetal | FL/FR |
(E)-beta- | damascone | FL/FR |
beta- | damascone | FL/FR |
(Z)-beta- | damascone | FL/FR |
(R)-gamma- | dodecalactone | FL/FR |
| ethyl 3-hexenoate | FL/FR |
| ethyl 3-hydroxyhexanoate | FL/FR |
2- | ethyl butyl 2-butenoate | |
(E,E)- | ethyl sorbate | FL/FR |
| geranyl acetoacetate | FL/FR |
| heptyl butyrate | FL/FR |
| menthyl isovalerate | FL/FR |
| neryl isobutyrate | FL/FR |
| prenyl acetate | FL/FR |
fungal |
| methyl 2-furoate | FL/FR |
iso | green methanoindene | FR |
| hexyl isobutyrate | FL/FR |
| magnolia flower oil | FL/FR |
| methyl R-3-acetoxyhexanoate | |
| phenethyl tiglate | FL/FR |
| rose leaf absolute (rosa centifolia) | FL/FR |
hay |
| beeswax absolute | FL/FR |
| hay absolute | FR |
| tobacco leaf absolute | FL/FR |
| woodruff absolute | FR |
herbal |
6- | acetoxydihydrotheaspirane | FL/FR |
| anthemis nobilis flower oil roman | FL/FR |
| arnica flower oil | FR |
| clary sage absolute | FL/FR |
| clary sage oil america | FL/FR |
| clary sage oil france | FL/FR |
| clary sage oil russia | FL/FR |
delta- | elemene | FL/FR |
| herbal undecanone | FR |
| matricaria chamomilla flower oil | FL/FR |
| methyl nicotinate | FL/FR |
| saffron indenone | FL/FR |
| safranal | FL/FR |
| tea leaf absolute | FL/FR |
| theaspirane | FL/FR |
| yerba mate absolute | FL/FR |
honey |
| methyl phenyl acetate | FL/FR |
| phenyl acetic acid | FL/FR |
licorice |
sweet | basil oleoresin | FL/FR |
marine |
| ozone propanal | FR |
iso | pulegyl acetate | FL/FR |
musk |
| acetyl ethyl tetramethyl tetralin replacer | FR |
| musk decanolide | FR |
phenolic |
2'- | hydroxyacetophenone | FL/FR |
popcorn |
2- | acetyl pyridine | FL/FR |
spicy |
| cassia bark oleoresin | FL/FR |
(-)- | cubenol | FL/FR |
N,N- | diethyl octanamide | FR |
2,5- | dimethyl bicyclo(3.2.1)-2-octen-3-yl acetate + 1,4-dimethyl bicyclo(3.2.1)-2-octen-3-yl acetate | FR |
| ginger root absolute | FL/FR |
| grains of paradise oil | FL/FR |
| methyl heptadienone | FL/FR |
tea |
| camellia oleifera leaf extract | FL/FR |
tobacco |
para- | cresyl isovalerate | FL/FR |
3- | ethyl pyridine | FL/FR |
| methyl benzoxole | FL/FR |
| tobacco concrete | FR |
(E,E/E,Z)- | tobacco cyclohexenone | FL/FR |
| veltonal (Bedoukian) | FR |
tonka |
| deertongue absolute | FR |
gamma- | hexalactone | FL/FR |
| mint lactone | FL/FR |
| saffron resinoid | FL/FR |
| tonka undecanone | FR |
tropical |
| genet absolute | FL/FR |
vanilla |
| propenyl guaethol | FL/FR |
woody |
| agarwood oil (aetoxylon sympetalum) | FR |
| amber decatriene | FR |
| cabreuva wood oil | FR |
alpha- | cedrene epoxide | FR |
| cedrol methyl ether | FR |
| cyperus root oil (cyperus rotundus) | FR |
| guaiacwood oil 20% in gurjun balsam oil | FR |
(-)- | guaiol | FR |
| gurjun balsam oil | FR |
| homalomena rubescens root oil | FR |
iso | longifolene ketone | FR |
para- | menth-3-en-1-ol | FL/FR |
| patchouli hexanol | FR |
| sandalwood oil CO2 extract | FL/FR |
| spikenard oil CO2 extract | FL/FR |
| timber propanol | FR |
| tobacarol (IFF) | FR |
| tobacco nonene | FR |
| woody dioxolane | FR |
| woody ether | FR |
|
For Flavor |
|
No flavor group found for these |
6- | acetoxydihydrotheaspirane | FL/FR |
| amyl phenyl acetate | FL/FR |
| cyclohexanone diethyl acetal | FL/FR |
(R)-gamma- | dodecalactone | FL/FR |
delta- | elemene | FL/FR |
2- | ethyl butyl 2-butenoate | |
| fig leaf absolute | FL |
| geosmin | FL/FR |
| grains of paradise oil | FL/FR |
| guaiyl acetate | FL/FR |
(S)-gamma- | hexalactone | |
(Z)- | linalool oxide (furanoid) | FL/FR |
| magnolia flower oil | FL/FR |
para- | menth-3-en-1-ol | FL/FR |
| methyl nicotinate | FL/FR |
2- | propyl pyridine | FL |
| spikenard oil CO2 extract | FL/FR |
10- | undecen-1-ol | FL/FR |
|
beta- | damascone | FL/FR |
alcoholic |
iso | propyl alcohol | FL/FR |
amber |
| amber naphthofuran | FL/FR |
animal |
6- | methyl quinoline | FL/FR |
balsamic |
| myrrh absolute | FL/FR |
brown |
| beeswax absolute | FL/FR |
camphoreous |
laevo- | borneol | FL/FR |
caramellic |
3- | ethyl pyridine | FL/FR |
| methyl 2-furoate | FL/FR |
citrus |
| bergamot flavor | FL |
| bergamot oil | FL/FR |
| bergamot oil bergaptene reduced italy | FL/FR |
| bergamot oil turkey | FL/FR |
beta- | bisabolol | FL/FR |
| petitgrain bergamot oil | FL/FR |
| petitgrain bigarade oil | FL/FR |
| petitgrain oil morocco | FL/FR |
(±)-2,4,8- | trimethyl-7-nonen-2-ol | FL/FR |
| verbena absolute france | FL/FR |
coffee |
2,4- | dimethyl thiazole | FL |
cooling |
iso | menthol | FL |
| theaspirane | FL/FR |
corn |
2- | acetyl pyridine | FL/FR |
creamy |
gamma- | hexalactone | FL/FR |
| mint lactone | FL/FR |
earthy |
| geosmin | FL/FR |
fatty |
2- | dodecanone | FL/FR |
2- | ethyl-1-hexanol | FL/FR |
(E)-2- | octenal | FL/FR |
floral |
| geranyl isobutyrate | FL/FR |
| methyl dihydrojasmonate | FL/FR |
alpha-iso | methyl ionone (90% min.) | FL/FR |
| methyl phenyl acetate | FL/FR |
| neroli oil bigarde | FL/FR |
| petitgrain absolute morocco | FL/FR |
| phenyl acetic acid | FL/FR |
| tetrahydrolinalool | FL/FR |
fruity |
alpha- | amyl cinnamyl isovalerate | FL/FR |
fuji | apple flavor | FL |
(E)-beta- | damascone | FL/FR |
(Z)-beta- | damascone | FL/FR |
| ethyl 3-hexenoate | FL/FR |
| ethyl 3-hydroxyhexanoate | FL/FR |
| ethyl 3-oxohexanoate | FL |
(E,E)- | ethyl sorbate | FL/FR |
3- | heptyl dihydro-5-methyl-2(3H)-furanone | FL/FR |
| menthyl isovalerate | FL/FR |
| methyl (E)-2-octenoate | FL/FR |
| neryl isobutyrate | FL/FR |
| neryl isovalerate | FL/FR |
| prenyl acetate | FL/FR |
| rose butanoate | FL/FR |
| valerian rhizome absolute | FL/FR |
grassy |
| tobacco leaf absolute | FL/FR |
green |
iso | butyl 2-butenoate | FL/FR |
iso | butyl isovalerate | FL/FR |
| cucumber distillates | FL |
| cucumber flavor | FL |
| geranyl formate | FL/FR |
(E)-2- | heptenal | FL |
| heptyl butyrate | FL/FR |
(Z)-3- | hexen-1-yl salicylate | FL/FR |
| hexyl isobutyrate | FL/FR |
| methyl heptadienone | FL/FR |
| methyl R-3-acetoxyhexanoate | |
| phenethyl tiglate | FL/FR |
iso | phorone | FL |
| rose leaf absolute (rosa centifolia) | FL/FR |
hay |
| genet absolute | FL/FR |
herbal |
| anthemis nobilis flower oil roman | FL/FR |
| clary sage absolute | FL/FR |
| clary sage oil america | FL/FR |
| clary sage oil france | FL/FR |
| clary sage oil russia | FL/FR |
| matricaria chamomilla flower oil | FL/FR |
| saffron indenone | FL/FR |
| yerba mate absolute | FL/FR |
honey |
| phenethyl isobutyrate | FL/FR |
licorice |
sweet | basil oleoresin | FL/FR |
mushroom |
| methional diethyl acetal | FL |
musty |
| geranyl acetoacetate | FL/FR |
naphthyl |
2'- | hydroxyacetophenone | FL/FR |
nutty |
| methyl benzoxole | FL/FR |
(E,E/E,Z)- | tobacco cyclohexenone | FL/FR |
oily |
2- | methyl naphthalene | FL/FR |
phenolic |
para- | cresyl isovalerate | FL/FR |
| guaiacyl phenyl acetate | FL/FR |
smoky |
dextro- | xylose | FL |
spicy |
| cassia bark oleoresin | FL/FR |
(-)- | cubenol | FL/FR |
| ginger root absolute | FL/FR |
| paprika oleoresin | FL |
sweet |
| acetone alcohol | FL |
| saffron resinoid | FL/FR |
tea |
| camellia oleifera leaf extract | FL/FR |
| tea leaf absolute | FL/FR |
vanilla |
| propenyl guaethol | FL/FR |
waxy |
| decanal (aldehyde C-10) | FL/FR |
woody |
| ambrette seed absolute | FL/FR |
iso | bornyl formate | FL/FR |
delta- | damascone | FL/FR |
beta- | ionone | FL/FR |
(Z)- | jasmone | FL/FR |
iso | pulegyl acetate | FL/FR |
| safranal | FL/FR |
| sandalwood oil CO2 extract | FL/FR |
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Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| cetotabac | | cyclohex-2-ene-1,4-dione, 2,6,6-trimethyl- | 2- | cyclohexene-1,4-dione, 2,6,6-trimethyl- | oxo | pholone | 4-ketoiso | phorone | 4-oxo-alpha-iso | phorone | 4-oxoiso | phorone | 6-oxoiso | phorone | keto-iso | phorone | ketoiso | phorone | oxoiso | phorone | ketoiso | phorone pure | 2,6,6- | trimethyl cyclohex-2-ene-1,4-dione | 2,2,6- | trimethyl cyclohex-5-en-1,4-dione | 2,6,6- | trimethyl-2-cyclohexene-1,4-dione | 3,5,5- | trimethyl-2-cyclohexene-1,4-dione | 2,2,6- | trimethyl-5-cyclohexen-1,4-dione | 2,6,6- | trimethyl-cyclohex-2-ene-1,4-dione | 3,5,5- | trimethyl-cyclohex-2-ene-1,4-dione | 2,2,6- | trimethyl-cyclohex-5-en-1,4-dione | 2,6,6- | trimethylcyclohex-2-ene-1,4-dione | 2,2,6- | trimethylcyclohex-5-en-1,4-dione |
Articles:
US Patents: | 3,941,828 - Process for the preparation of oxophorones |
PubMed: | Attraction of the orange mint moth and false celery leaftier moth (Lepidoptera: Crambidae) to floral chemical lures. |
J-Stage: | Old Yellow Enzyme from Candida macedoniensis Catalyzes the Stereospecific Reduction of the C=C Bond of Ketoisophorone |
US Patents: | 3,981,311 - Aromatic compositions |
PubMed: | Recombinant S. cerevisiae expressing Old Yellow Enzymes from non-conventional yeasts: an easy system for selective reduction of activated alkenes. |
US Patents: | 3,989,857 - Flavoring phenol or phenol derivative containing food or feed with cycloaliphatic derivatives |
PubMed: | An ene reductase from Clavispora lusitaniae for asymmetric reduction of activated alkenes. |
US Patents: | 4,014,350 - Aromatic compositions |
PubMed: | Improved biocatalysts from a synthetic circular permutation library of the flavin-dependent oxidoreductase old yellow enzyme. |
PubMed: | Comparative characterization of novel ene-reductases from cyanobacteria. |
PubMed: | Aerobic oxidation of β-isophorone catalyzed by N-hydroxyphthalimide: the key features and mechanism elucidated. |
PubMed: | Enoate reductases from non conventional yeasts: bioconversion, cloning, and functional expression in Saccharomyces cerevisiae. |
PubMed: | Bioreduction of α,β-unsaturated ketones and aldehydes by non-conventional yeast (NCY) whole-cells. |
PubMed: | Composition of sulla (Hedysarum coronarium L.) honey solvent extractives determined by GC/MS: norisoprenoids and other volatile organic compounds. |
PubMed: | Volatile composition screening of Salix spp. nectar honey: benzenecarboxylic acids, norisoprenoids, terpenes, and others. |
PubMed: | Rapid method for screening enoate reductase activity in yeasts. |
PubMed: | Asymmetric reduction of activated alkenes using an enoate reductase from Gluconobacter oxydans. |
PubMed: | Continuous two-phase flow miniaturised bioreactor for monitoring anaerobic biocatalysis by pentaerythritol tetranitrate reductase. |
PubMed: | Asymmetric Reduction of Activated Alkenes by Pentaerythritol Tetranitrate Reductase: Specificity and Control of Stereochemical Outcome by Reaction Optimisation. |
PubMed: | Metabolite and target transcript analyses during Crocus sativus stigma development. |
PubMed: | Emission of volatile chemicals from flowering dogwood (cornus Florida L.) flowers. |
PubMed: | Ketoisophorone transformation by Marchantia polymorpha and Nicotiana tabacum cultured cells. |
PubMed: | Quality and functionality of saffron: quality control, species assortment and affinity of extract and isolated saffron compounds to NMDA and sigma1 (sigma-1) receptors. |
PubMed: | A variety of volatile compounds as markers in unifloral honey from dalmatian sage (Salvia officinalis L.). |
PubMed: | In situ product recovery (ISPR) by crystallization: basic principles, design, and potential applications in whole-cell biocatalysis. |
PubMed: | Floral odor variation in two heterostylous species of Primula. |
PubMed: | Cloning and overexpression of the old yellow enzyme gene of Candida macedoniensis, and its application to the production of a chiral compound. |
PubMed: | Anthropogenic organic contaminants in sediments of the Lippe river, Germany. |
PubMed: | In situ product removal using a crystallization loop in asymmetric reduction of 4-oxoisophorone by Saccharomyces cerevisiae. |
PubMed: | Molecular markers of anthropogenic activity in sediments of the Havel and Spree Rivers (Germany). |
PubMed: | Old Yellow Enzyme from Candida macedoniensis catalyzes the stereospecific reduction of the C=C bond of ketoisophorone. |
US Patents: | Process for the preparation of a diketone derivative |
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