Name: | humulus lupulus l. extract |
CAS Number: | 8060-28-4 |
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ECHA EC Number: | 232-504-3 |
Category: cosmetic, flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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PubMed: | Search |
NCBI: | Search |
FEMA Number: | 2578 hop extract |
FDA: | No longer provide for the use of these seven synthetic flavoring substances |
FDA Mainterm (SATF): | 8060-28-4 ; HOPS, EXTRACT (HUMULUS LUPULUS L.) |
FDA Regulation: | FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION Subpart C--Solvents, Lubricants, Release Agents and Related Substances Sec. 173.240 Isopropyl alcohol.
FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION Subpart C--Solvents, Lubricants, Release Agents and Related Substances Sec. 173.250 Methyl alcohol residues.
FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION Subpart C--Solvents, Lubricants, Release Agents and Related Substances Sec. 173.255 Methylene chloride.
FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION Subpart C--Solvents, Lubricants, Release Agents and Related Substances Sec. 173.270 Hexane.
FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE Subpart A--General Provisions Sec. 182.20 Essential oils, oleoresins (solvent-free), and natural extractives (including distillates).
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Physical Properties:
Appearance: | pale brown to dark brown liquid (est) |
Food Chemicals Codex Listed: | No |
Specific Gravity: | 0.97180 to 1.04180 @ 25.00 °C.
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Pounds per Gallon - (est).: | 8.086 to 8.669
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Refractive Index: | 1.35540 to 1.37140 @ 20.00 °C.
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Shelf Life: | 6.00 month(s) or longer if stored properly. |
Storage: | store in cool, dry place in tightly sealed containers, protected from heat and light. |
Organoleptic Properties:
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Odor Type: woody |
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| woody green citrus malty tagette |
Odor Description:
| woody green citrus malt tagette |
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Flavor Type: woody |
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| hops |
Taste Description:
| hops |
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Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
Not determined
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | cosmetic, flavor and fragrance agents |
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
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Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
publication number: 3 |
Click here to view publication 3 |
| average usual ppm | average maximum ppm |
baked goods: | - | - |
beverages(nonalcoholic): | - | 160.00000 |
beverages(alcoholic): | - | - |
breakfast cereal: | - | - |
cheese: | - | - |
chewing gum: | - | - |
condiments / relishes: | - | - |
confectionery froastings: | - | - |
egg products: | - | - |
fats / oils: | - | - |
fish products: | - | - |
frozen dairy: | - | - |
fruit ices: | - | - |
gelatins / puddings: | - | - |
granulated sugar: | - | - |
gravies: | - | - |
hard candy: | - | - |
imitation dairy: | - | - |
instant coffee / tea: | - | - |
jams / jellies: | - | - |
meat products: | - | - |
milk products: | - | - |
nut products: | - | - |
other grains: | - | - |
poultry: | - | - |
processed fruits: | - | - |
processed vegetables: | - | - |
reconstituted vegetables: | - | - |
seasonings / flavors: | - | - |
snack foods: | - | - |
soft candy: | - | - |
soups: | - | - |
sugar substitutes: | - | - |
sweet sauces: | - | - |
Safety References:
References:
| humulus lupulus l. extract |
Pubchem (sid): | 135325910 |
Other Information:
FDA Substances Added to Food (formerly EAFUS): | View |
Export Tariff Code: | 1302.13.0000 |
Wikipedia: | View |
Potential Blenders and core components note
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For Odor |
No odor group found for these |
(-)-gamma- | elemene | |
| humulus lupulus distillates | FL/FR |
aldehydic |
| dodecanal (aldehyde C-12 lauric) | FL/FR |
| green hexanal | FL/FR |
| undecanal | FL/FR |
balsamic |
| betula pubescens bud oil | FL/FR |
| fir balsam absolute | FR |
| fir balsam concrete | FR |
citrus |
| citral diethyl acetal | FL/FR |
| citral dimethyl acetal | FL/FR |
(R)- | citronellyl nitrile | FR |
iso | decyl acetate | FR |
| lime oil fractions | FR |
| limonene aldehyde | FR |
| litsea cubeba fruit oil | FL/FR |
| methyl heptenone | FL/FR |
1- | methyl-4-methyl ethenyl cyclohexene sulfurized | FL/FR |
alpha- | methylene citronellal | FR |
| neroli ketone | FR |
| tangerine acetate | FR |
fatty |
6- | methyl-5-hepten-2-one propylene glycol acetal | FL/FR |
floral |
| citronellol | FL/FR |
| dihydrocitronellyl ethyl ether | FR |
| glycoacetal | FR |
| karo karounde absolute | FR |
| linalool | FL/FR |
| melaleuca ericifolia leaf oil | FR |
(E)- | nerolidol | FL/FR |
| orange leaf absolute | FL/FR |
fruity |
iso | butyl 2-methyl butyrate | FL/FR |
| cyclohexyl crotonate | FR |
1,4- | dibutyl-6,8-dioxabicyclo(3.2.1)octane | FR |
1,4- | diisopropyl-6,8-dioxabicyclo(3.2.1)octane | FR |
1,2- | dimethyl propyl 2-butenoate | |
| grapefruit acetal | FR |
| methyl acetoacetate | FL/FR |
green |
| bergoxane | FR |
| bicyclogermacrene | |
| citral / diisotridecyl acetal | FR |
| citrus carbaldehyde / methyl anthranilate schiff's base | FR |
| fresh nitrile | FR |
| galbanum oleoresin | FL/FR |
| galbanum resinoid | FL/FR |
| green carboxylate | FR |
| hop oil CO2 extract | FL/FR |
dextro- | limonene oxide | FL/FR |
| octanal diethyl acetal | FL/FR |
| octanal dimethyl acetal | FL/FR |
(E)-2- | octen-1-ol | FL/FR |
| tricyclene-9-butenone | |
2,2,4- | trimethyl-1,3-oxathiane | |
herbal |
(+)-alpha- | campholenic aldehyde | FL/FR |
| canarium luzonicum oil | FL/FR |
iso | dihydrolavandulal | FL/FR |
2- | dodecenal | FL/FR |
| hop absolute | FL/FR |
| hop cone oil | FL/FR |
| hop fragrance | FR |
| hop oil | FL/FR |
| hop oleoresin | FL/FR |
| humulus lupulus cone extract | FL/FR |
| linalyl formate | FL/FR |
| nonisyl formate | FR |
| tricyclo(5.2.1.02,6)dec-3-enyl acetate | FR |
minty |
(-)-iso | pulegol | FL/FR |
iso | pulegol | FL/FR |
2,4,4,6- | tetramethyl cyclohexa-2,5-diene-1-one | FR |
pine |
| pine oil 85 | FR |
spicy |
2,5- | dimethyl bicyclo(3.2.1)-2-octen-3-yl acetate + 1,4-dimethyl bicyclo(3.2.1)-2-octen-3-yl acetate | FR |
2- | octanol | FL/FR |
black | pepper oil CO2 extract | FL/FR |
terpenic |
| juniper branch oil | FR |
alpha- | phellandrene | FL/FR |
waxy |
| decanal dimethyl acetal | FL/FR |
woody |
| bruyere root absolute | FR |
alpha- | farnesene | FL/FR |
alpha- | farnesene isomer | FL/FR |
| furfuryl thenyl ether | |
| humulus lupulus tincture | FL/FR |
| moss naphthaleneol | FR |
(±)- | tetrahydronootkatone | FL/FR |
alpha- | thujene | |
| xanthoxylum alatum roxb. oil | FR |
yeasty |
| beer CO2 extract | FL/FR |
| beer extract | CS |
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For Flavor |
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No flavor group found for these |
| betula pubescens bud oil | FL/FR |
| bicyclogermacrene | |
| decanal dimethyl acetal | FL/FR |
1,2- | dimethyl propyl 2-butenoate | |
(-)-gamma- | elemene | |
| furfuryl thenyl ether | |
| linalyl formate | FL/FR |
| methyl acetoacetate | FL/FR |
6- | methyl-5-hepten-2-one propylene glycol acetal | FL/FR |
(±)- | tetrahydronootkatone | FL/FR |
alpha- | thujene | |
| tricyclene-9-butenone | |
2,4,4- | trimethyl-1,3-oxathiane | FL |
2,2,4- | trimethyl-1,3-oxathiane | |
dextro- | limonene oxide | FL/FR |
citrus |
| citral diethyl acetal | FL/FR |
| citral dimethyl acetal | FL/FR |
| linalool | FL/FR |
| litsea cubeba fruit oil | FL/FR |
1- | methyl-4-methyl ethenyl cyclohexene sulfurized | FL/FR |
fatty |
2- | dodecenal | FL/FR |
(E)-2- | octen-1-ol | FL/FR |
floral |
| citronellol | FL/FR |
| orange leaf absolute | FL/FR |
fruity |
iso | butyl 2-methyl butyrate | FL/FR |
green |
(+)-alpha- | campholenic aldehyde | FL/FR |
| canarium luzonicum oil | FL/FR |
alpha- | farnesene | FL/FR |
alpha- | farnesene isomer | FL/FR |
| galbanum oleoresin | FL/FR |
| galbanum resinoid | FL/FR |
| methyl heptenone | FL/FR |
(E)- | nerolidol | FL/FR |
(E,E)-2,6- | nonadienal | FL |
2,4- | octadienal | FL |
| octanal diethyl acetal | FL/FR |
| octanal dimethyl acetal | FL/FR |
herbal |
| beer flavor | FL |
iso | dihydrolavandulal | FL/FR |
| green hexanal | FL/FR |
| hop absolute | FL/FR |
| hop cone oil | FL/FR |
| hop flavor | FL |
| hop oil | FL/FR |
| hop oleoresin | FL/FR |
| humulus lupulus cone extract | FL/FR |
| humulus lupulus distillates | FL/FR |
| humulus lupulus extract modified | FL |
| humulus lupulus extract solid | FL |
| humulus lupulus tincture | FL/FR |
malty |
| yeast thiazoline | FL |
minty |
(-)-iso | pulegol | FL/FR |
iso | pulegol | FL/FR |
orris |
| costus root oil | FL |
soapy |
| dodecanal (aldehyde C-12 lauric) | FL/FR |
spicy |
| hop oil CO2 extract | FL/FR |
2- | octanol | FL/FR |
black | pepper oil CO2 extract | FL/FR |
terpenic |
alpha- | phellandrene | FL/FR |
waxy |
| undecanal | FL/FR |
yeasty |
| beer | FL |
| beer CO2 extract | FL/FR |
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Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| extract of the hops, humulus lupulus l., cannabidaceae | | hop CL (Symrise) | | hop extract | extrapone | hop GW (Symrise) | | hops extract | | hops extract HS 2367 G | | hops extract LS 3473 G | | hops extract natural | | hops P.E | | phytovital hops |
Articles:
PubMed: | Effects of Xanthohumol-Rich Hop Extract on the Differentiation of Preadipocytes. |
PubMed: | Comprehensive separation and structural analyses of polyphenols and related compounds from bracts of hops (Humulus lupulus L.). |
PubMed: | Effects of xanthohumol-rich extract from the hop on fatty acid metabolism in rats fed a high-fat diet. |
PubMed: | A preliminary investigation of anticholinesterase activity of some Iranian medicinal plants commonly used in traditional medicine. |
PubMed: | Inhibition of human cytochrome P450 enzymes by hops (Humulus lupulus) and hop prenylphenols. |
PubMed: | In vitro and in vivo antioxidant and antimutagenic activities of polyphenols extracted from hops (Humulus lupulus L.). |
PubMed: | Antiadherent and antibiofilm activity of Humulus lupulus L. derived products: new pharmacological properties. |
PubMed: | Comparative study of antioxidant properties and total phenolic content of the extracts of Humulus lupulus L. and quantification of bioactive components by LC-MS/MS and GC-MS. |
PubMed: | A semi-automatic microextraction in packed sorbent, using a digitally controlled syringe, combined with ultra-high pressure liquid chromatography as a new and ultra-fast approach for the determination of prenylflavonoids in beers. |
PubMed: | Differential regulation of detoxification enzymes in hepatic and mammary tissue by hops (Humulus lupulus) in vitro and in vivo. |
PubMed: | Effects of extracts of Humulus lupulus (hops) and Yucca schidigera applied alone or in combination with monensin on rumen fermentation and microbial populations in vitro. |
PubMed: | Evaluation of the effect of Humulus lupulus alcoholic extract on rifampin-sensitive and resistant isolates of Mycobacterium tuberculosis. |
PubMed: | Hop water extract inhibits double-stranded RNA-induced thymic stromal lymphopoietin release from human nasal epithelial cells. |
PubMed: | Optimized mixture of hops rho iso-alpha acids-rich extract and acacia proanthocyanidins-rich extract reduces insulin resistance in 3T3-L1 adipocytes and improves glucose and insulin control in db/db mice. |
PubMed: | META060 protects against diet-induced obesity and insulin resistance in a high-fat-diet fed mouse. |
PubMed: | The sedative effects of hops (Humulus lupulus), a component of beer, on the activity/rest rhythm. |
PubMed: | Hop bitter acids inhibit tumorigenicity of hepatocellular carcinoma cells in vitro. |
PubMed: | Hop (Humulus lupulus L.) extract inhibits obesity in mice fed a high-fat diet over the long term. |
PubMed: | Dose-response relationships for the antifeedant effects of Humulus lupulus extracts against larvae and adults of the Colorado potato beetle. |
PubMed: | Hop bitter acids exhibit anti-fibrogenic effects on hepatic stellate cells in vitro. |
PubMed: | Hops (Humulus lupulus) inhibits oxidative estrogen metabolism and estrogen-induced malignant transformation in human mammary epithelial cells (MCF-10A). |
PubMed: | [Effects of ethanol extracts of herbal medicines on dermatitis in an atopic dermatitis mouse model]. |
PubMed: | The extract from hop cones (Humulus lupulus) as a modulator of oxidative stress in blood platelets. |
PubMed: | Increased sexual motivation in female rats treated with Humulus lupulus L. extract. |
PubMed: | A dietary supplement to improve the quality of sleep: a randomized placebo controlled trial. |
PubMed: | Effects of hops (Humulus lupulus L.) extract on volatile fatty acid production by rumen bacteria. |
PubMed: | Xanthohumol from hop (Humulus lupulus L.) is an efficient inhibitor of monocyte chemoattractant protein-1 and tumor necrosis factor-alpha release in LPS-stimulated RAW 264.7 mouse macrophages and U937 human monocytes. |
PubMed: | Experimental evidence of the anaphrodisiac activity of Humulus lupulus L. in naïve male rats. |
PubMed: | The antimicrobial effects of hops (Humulus lupulus L.) on ruminal hyper ammonia-producing bacteria. |
PubMed: | Oestrogenicity of prenylflavonoids from hops: activation of pro-oestrogens by intestinal bacteria. |
PubMed: | In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin. |
PubMed: | Development of a screening assay for ligands to the estrogen receptor based on magnetic microparticles and LC-MS. |
PubMed: | Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system. |
PubMed: | Antimutagenicity of hops (Humulus lupulus L.): bioassay-directed fractionation and isolation of xanthohumol. |
PubMed: | Effects of aqueous hop (Humulus Lupulus L.) extract on vascular reactivity in rats: mechanisms and influence of gender and hormonal status. |
PubMed: | Modulation of breast cancer cell survival by aromatase inhibiting hop (Humulus lupulus L.) flavonoids. |
PubMed: | NMR assignment of iso-alpha-acids from isomerised extracts of Humulus lupulus L. cones. |
PubMed: | Hypothermic effects of hops are antagonized with the competitive melatonin receptor antagonist luzindole in mice. |
PubMed: | Determination of xanthohumol in hops (Humulus lupulus L.) by nonaqueous CE. |
PubMed: | Flavonoid glycosides extracted from hop (Humulus lupulus L.) as inhibitors of chemical mediator release from human basophilic KU812 cells. |
PubMed: | Behavioural response of Colorado potato beetle (Leptinotarsa decemlineata) larvae to selected plant extracts. |
PubMed: | Open, non-controlled clinical studies to assess the efficacy and safety of a medical device in form of gel topically and intravaginally used in postmenopausal women with genital atrophy. |
PubMed: | Effects of hop extracts on nasal rubbing and sneezing in BALB/c mice. |
PubMed: | Effects of beer and hop on ionotropic gamma-aminobutyric acid receptors. |
PubMed: | Selective inhibition of COX-2 by a standardized CO2 extract of Humulus lupulus in vitro and its activity in a mouse model of zymosan-induced arthritis. |
PubMed: | A first prospective, randomized, double-blind, placebo-controlled study on the use of a standardized hop extract to alleviate menopausal discomforts. |
PubMed: | Anti-inflammatory acylphloroglucinol derivatives from Hops (Humulus lupulus). |
PubMed: | Screening method for the discovery of potential cancer chemoprevention agents based on mass spectrometric detection of alkylated Keap1. |
PubMed: | Xanthohumol isolated from Humulus lupulus Inhibits menadione-induced DNA damage through induction of quinone reductase. |
PubMed: | Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense). |
PubMed: | New insight in the neuropharmacological activity of Humulus lupulus L. |
PubMed: | Estrogens and congeners from spent hops (Humulus lupulus). |
PubMed: | The antimycobacterial components of hops (Humulus lupulus) and their dereplication. |
PubMed: | Direct characterization of bitter acids in a crude hop extract by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. |
PubMed: | Occupational airborne and hand dermatitis to hop (Humulus lupulus) with non-occupational relapses. |
PubMed: | Comparison of the most odor-active compounds in fresh and dried hop cones (Humulus lupulus L. variety spalter select) based on GC-olfactometry and odor dilution techniques. |
PubMed: | Molecular characterization and genome organization of 7SL RNA genes from hop (Humulus lupulus L.). |
PubMed: | Phlorisovalerophenone synthase, a novel polyketide synthase from hop (Humulus lupulus L.) cones. |
PubMed: | Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus. |
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