Category: flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | colorless to yellow clear liquid (est) |
Assay: | 97.00 to 100.00 %
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Food Chemicals Codex Listed: | No |
Specific Gravity: | 1.05500 to 1.08500 @ 25.00 °C.
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Pounds per Gallon - (est).: | 8.779 to 9.028
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Specific Gravity: | 1.06700 to 1.07200 @ 25.00 °C.
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Pounds per Gallon - est.: | 8.879 to 8.920
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Refractive Index: | 1.51000 to 1.53000 @ 20.00 °C.
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Refractive Index: | 1.51600 to 1.52400 @ 20.00 °C.
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Melting Point: | 83.00 to 84.00 °C. @ 760.00 mm Hg
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Boiling Point: | 157.00 to 159.00 °C. @ 760.00 mm Hg
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Boiling Point: | 158.00 °C. @ 742.00 mm Hg
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Vapor Pressure: | 3.456000 mmHg @ 25.00 °C. (est) |
Vapor Density: | 3.8 ( Air = 1 ) |
Flash Point: | 125.00 °F. TCC ( 51.67 °C. )
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logP (o/w): | 1.184 (est) |
Soluble in: |
| alcohol | | ether | | water, 1750 mg/L @ 25 °C (est) |
Insoluble in: |
| water |
Organoleptic Properties:
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Odor Type: fishy |
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| roasted nutty fishy green shellfish |
Odor Description: at 0.10 % in dipropylene glycol. | roasted nutty fishy green boiled shrimp |
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| fishy ammoniacal seafood savory |
Odor Description:
| Fishy, amine and pyridine-like with shrimp and savory nuances Mosciano, Gerard P&F 22, No. 3, 47, (1997) |
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Flavor Type: fishy |
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| fishy earthy molasses savory |
Taste Description: at 5.00 ppm. | Fishy, pyidine-like with molasses and savory nuances Mosciano, Gerard P&F 22, No. 3, 47, (1997) |
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Odor and/or flavor descriptions from others (if found). |
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R C Treatt & Co Ltd |
4,5-Dimethylthiazole Halal, Kosher |
Odor Description: | Nutty, green, roasted, meaty, boiled poultry |
Taste Description: | nutty Used in condiments, soups and sauces at 20ppm, in bakery and confectionery at 10ppm. |
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Taytonn ASCC |
4,5-Dimethylthiazole |
Odor Description: | Roast, Nutty, Green, Fish |
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Cosmetic Information:
Suppliers:
Advanced Biotech |
4,5 DIMETHYL THIAZOLE
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Ambles Nature et Chimie |
4.5-DIMETHYL THIAZOLE
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Anhui Haibei |
4,5-Dimethyl Thiazole
Odor: Roasted nutty fishy green boiled shrimp |
Anhui Suzhou Jinli Aromatic Chemicals |
4,5-Dimethyl Thiazole
Odor: faint scent , baked nut |
Beijing Lys Chemicals |
4,5-Dimethylthiazole
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BOC Sciences |
For experimental / research use only. |
4,5-Dimethylthiazole
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Charkit Chemical |
DIMETHYLTHIAZOLE, 4,5- D1150 FEMA 3274
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DeLong Chemicals America |
4,5-Dimethylthiazole, Kosher
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Endeavour Specialty Chemicals |
4,5-Dimethylthiazole 98% F&F
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Speciality Chemical Product Groups |
Fleurchem |
4,5-dimethyl thiazole
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Frutarom |
4-5-DIMETHYLTHIAZOLE
KOSHER Flavor: Fishy, Green, Nutty, Roasted |
CBD Offering |
IFF |
4-5-DIMETHYLTHIAZOLE
KOSHER Flavor: Fishy, Green, Nutty, Roasted |
Jiangyin Healthway |
4,5-Dimethyl Thiazole
|
New functional food ingredients |
Jinan Enlighten Chemical Technology(Wutong Aroma ) |
4,5-Dimethyl thiazole, Kosherk
|
Lluch Essence |
4,5-DIMETHYL THIAZOLE
|
M&U International |
4,5-DIMETHYL THIAZOLE, Kosher
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Matrix Scientific |
For experimental / research use only. |
4,5-Dimethylthiazole, 97%
|
Penta International |
4,5-DIMETHYLTHIAZOLE
|
R C Treatt & Co Ltd |
4,5-Dimethylthiazole
Halal, Kosher Odor: Nutty, green, roasted, meaty, boiled poultry Flavor: nutty Used in condiments, soups and sauces at 20ppm, in bakery and confectionery at 10ppm. |
Reincke & Fichtner |
4,5-Dimethylthiazole
|
Robinson Brothers |
4,5-Dimethylthiazole F&F
|
https://www.robinsonbrothers.uk/chemistry-competences |
Sigma-Aldrich |
4,5-Dimethylthiazole, ≥97%, FG
Odor: meaty; nutty |
Certified Food Grade Products |
Sunaux International |
4,5-Dimethyl Thiazole
|
Synerzine |
4,5-Dimethylthiazole
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Taytonn ASCC |
4,5-Dimethylthiazole
Odor: Roast, Nutty, Green, Fish |
TCI AMERICA |
For experimental / research use only. |
4,5-Dimethylthiazole >98.0%(GC)
|
Tengzhou Jitian Aroma Chemiclal |
4,5-Dimethyl Thiazole
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Tengzhou Xiang Yuan Aroma Chemicals |
4,5-Dimethyl Thiazole
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Tianjin Danjun International |
4,5-Dimethylthiazole
|
United International |
4,5-Dimethyl Thiazole
|
Vigon International |
Dimethyl-4,5 Thiazole
|
WholeChem |
4,5-Dimethylthiazole
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Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | Xn - Harmful. |
R 10 - Flammable. R 22 - Harmful if swallowed. R 37/38 - Irritating to respiratory system and skin. R 41 - Risk of serious damage to eyes. S 02 - Keep out of the reach of children. S 16 - Keep away from sources of ignition - No Smoking. S 20/21 - When using do not eat, drink or smoke. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
gavage-rat LD50 [sex: M,F] 964.90 mg/kg (Piccirillo et al., 1982a)
oral-rat LD50 960 mg/kg SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE
LUNGS, THORAX, OR RESPIRATION: DYSPNEA Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 95, 1990.
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | flavoring agents |
Recommendation for 4,5-dimethyl thiazole usage levels up to: | | not for fragrance use.
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Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.18 (μg/capita/day) |
Maximised Survey-derived Daily Intakes (MSDI-USA): | 0.40 (μg/capita/day) |
Structure Class: | II |
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
publication number: 5 |
Click here to view publication 5 |
| average usual ppm | average maximum ppm |
baked goods: | - | 10.00000 |
beverages(nonalcoholic): | - | - |
beverages(alcoholic): | - | - |
breakfast cereal: | - | - |
cheese: | - | - |
chewing gum: | - | - |
condiments / relishes: | - | 20.00000 |
confectionery froastings: | - | - |
egg products: | - | - |
fats / oils: | - | - |
fish products: | - | - |
frozen dairy: | - | 10.00000 |
fruit ices: | - | 10.00000 |
gelatins / puddings: | - | 6.00000 |
granulated sugar: | - | - |
gravies: | - | 20.00000 |
hard candy: | - | 10.00000 |
imitation dairy: | - | - |
instant coffee / tea: | - | - |
jams / jellies: | - | - |
meat products: | - | 20.00000 |
milk products: | - | - |
nut products: | - | - |
other grains: | - | - |
poultry: | - | - |
processed fruits: | - | - |
processed vegetables: | - | - |
reconstituted vegetables: | - | - |
seasonings / flavors: | - | - |
snack foods: | - | - |
soft candy: | - | - |
soups: | - | 20.00000 |
sugar substitutes: | - | - |
sweet sauces: | - | - |
Safety References:
European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
European Food Safety Authority (EFSA) reference(s): |
Flavouring Group Evaluation 21: Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29. Miscellaneous substances from chemical group 30. (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
Flavouring Group Evaluation 76, (FGE.76)[1] - Consideration of sulphur-containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29, miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf |
Flavouring Group Evaluation 21, Revision 1 (FGE.21Rev1): Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 Miscellaneous substances from chemical group 30 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 76, Revision 1 (FGE.76Rev1): Consideration of sulphur-containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 and miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21Rev3 View page or View pdf |
EPI System: | View |
AIDS Citations: | Search |
Cancer Citations: | Search |
Toxicology Citations: | Search |
EPA Substance Registry Services (TSCA): | 3581-91-7 |
EPA ACToR: | Toxicology Data |
EPA Substance Registry Services (SRS): | Registry |
Laboratory Chemical Safety Summary : | 62510 |
National Institute of Allergy and Infectious Diseases: | Data |
WISER: | UN 1992 |
WGK Germany: | 3 |
| 4,5-dimethyl-1,3-thiazole |
Chemidplus: | 0003581917 |
RTECS: | XJ4380000 for cas# 3581-91-7 |
References:
Other Information:
Potential Blenders and core components note
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For Odor |
No odor group found for these |
| sulfuryl octanoate | FL/FR |
| sulfuryl butyrate | FL/FR |
| sulfuryl decanoate | FL/FR |
| sulfuryl hexanoate | FL/FR |
| sulfuryl isobutyrate | FL/FR |
| sulfuryl propionate | FL/FR |
caramellic |
iso | propenyl pyrazine | FL/FR |
chocolate |
2,5- | dimethyl pyrazine | FL/FR |
green |
2-sec- | butyl-3-methoxypyrazine | FL/FR |
2- | heptyl furan | FL/FR |
2- | acetyl-3-methyl pyrazine | FL/FR |
2- | acetyl-3,5-dimethyl pyrazine | FL/FR |
2- | acetyl-3,5(or 6)-dimethyl pyrazine | FL/FR |
3,6- | cocoa pyrazine | FL/FR |
3,5- | cocoa pyrazine | FL/FR |
| filbert heptenone | FL/FR |
| filbert heptenone B | FL/FR |
| methoxymethyl pyrazine | FL/FR |
| nutty quinoxaline | FL/FR |
| sesame absolute | FL/FR |
roasted |
2- | acetyl-2-pyrroline | |
sulfurous |
| fish thiol | FL/FR |
| furfuryl thioacetate | FL/FR |
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For Flavor |
|
No flavor group found for these |
2- | acetyl-1-pyrroline | FL |
2- | acetyl-2-pyrroline | |
| amyl amine | FL |
(±)-sec- | butyl amine | FL |
| butyl amine | FL |
iso | butyl amine | FL |
6,7- | dihydro-2,3-dimethyl-5H-cyclopentapyrazine | FL |
6,7- | dimethyl dihydrocyclopentapyrazine | FL |
| dimethyl dihydrocyclopentapyrazine | FL |
2,5- | dimethyl pyrazine and 2,6-dimethyl pyrazine mixture | FL |
2,5- | dimethyl thiazole | FL |
| ethyl amine | FL |
| hexyl amine | FL |
| methyl 2-(methyl thio) acetate | FL |
2- | methyl butyl amine | FL |
iso | pentylidene isopentyl amine | FL |
| phenethyl amine | FL |
| propionyl pyrroline 1% in vegatable oil triglyceride | FL |
iso | propyl amine | FL |
| pyrazines mixture | FL |
| sulfuryl butyrate | FL/FR |
| sulfuryl decanoate | FL/FR |
| sulfuryl hexanoate | FL/FR |
| sulfuryl isobutyrate | FL/FR |
| thiazole | FL |
(R)-N,N,alpha- | trimethyl benzyl amine | FL |
| tripropyl amine | FL |
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5- | acetyl-2,3-dihydro-1,4-thiazine | FL |
| sulfuryl formate | FL |
| sulfuryl octanoate | FL/FR |
| sulfuryl propionate | FL/FR |
ammoniacal |
2- | methyl piperidine | FL |
burnt |
iso | propenyl pyrazine | FL/FR |
fatty |
2- | heptyl furan | FL/FR |
fishy |
3- | penten-2-one | FL |
| trimethyl amine | FL |
fruity |
2- | ethyl-2,5-dihydro-4-methyl thiazole | FL |
musty |
2,5- | dimethyl pyrazine | FL/FR |
2- | ethoxythiazole | FL |
nutty |
3- | acetyl-2,5-dimethyl thiophene | FL |
2- | acetyl-3-methyl pyrazine | FL/FR |
2- | acetyl-3,5-dimethyl pyrazine | FL/FR |
2- | acetyl-3,5(or 6)-dimethyl pyrazine | FL/FR |
| arachis hypogaea fruit extract | FL |
3,5- | cocoa pyrazine | FL/FR |
3,6- | cocoa pyrazine | FL/FR |
1- | ethyl-2-acetyl pyrrole | FL |
| filbert heptenone | FL/FR |
| filbert heptenone B | FL/FR |
| methoxymethyl pyrazine | FL/FR |
| nutty quinoxaline | FL/FR |
| sesame absolute | FL/FR |
popcorn |
2- | propionyl-2-thiazoline | FL |
roasted |
3,5- | diisobutyl-1,2,4-trithiolane | FL |
| furfuryl thioacetate | FL/FR |
rooty |
| guarana flavor | FL |
sulfurous |
| fish thiol | FL/FR |
vegetable |
2-sec- | butyl-3-methoxypyrazine | FL/FR |
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Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
4,5- | dimethyl thiazole, kosher | 4,5- | dimethyl-1,3-thiazole | | dimethyl-4,5 thiazole | 4,5- | dimethylthiazole | 4,5- | dimethythiazole | | shrimp thiazole | | thiazole, 4,5-dimethyl- |
Articles:
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