Articles:
7H-furo[3,2-g][1]benzopyran-7-one, 9-[(3-methyl-2-butenyl)oxy]-
Notes:
tumor necrosis factor antagonist; furanocoumarin from west african medicinal plant clausena anisata. Present in Aegle marmelos (bael fruit) and seeds of Pastinaca sativa (parsnip)
Imperatorin is a furocoumarin and a phytochemical that has been isolated from Urena lobata L. (Malvaceae). It is biosynthesized from umbelliferone, a coumarin derivative.
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BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 482-44-0 Imperatorin 0.985 Imperatorin isolated from the root of Angelica dahurica Benth. et Hook. It can suppress multidrug-resistant human liver cancer growth in vivo by inducing Mcl-1 degradation . anti-HIV; anticonvulsant; anti-inflammatory; antimicrobial;
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Glentham Life Sciences Ltd The Chemical, Biochemical & Research Essentials Supplier Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK. With a Glentham Life Sciences account you can view more product details, request quotes and order products online. Email: Info Email: Sales Email: Tech Support Voice: +44 (0) 1225 667798 Fax: +44 (0) 2033 978909 Facebook Twitter Linkedin Google+ News Distribution Products List: View Product(s): GL5875 Imperatorin
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| CAS Number: | 482-44-0 |  3D/inchi
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| Other(deleted CASRN): | 70102-00-0 | |
| ECHA EINECS - REACH Pre-Reg: | 207-581-1 | |
| FDA UNII: | K713N25C78 | |
| Nikkaji Web: | J25.135F | |
| MDL: | MFCD00016881 | |
| XlogP3: | 3.40 (est) | |
| Molecular Weight: | 270.28438000 | |
| Formula: | C16 H14 O4 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 102.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 448.00 to 449.00 °C. @ 760.00 mm Hg (est) |
| Flash Point: | 437.00 °F. TCC ( 224.90 °C. ) (est) |
| logP (o/w): | 2.983 (est) |
| Soluble in: | |
| alcohol | |
| water, 635.5 mg/L @ 25 °C (est) | |
| Insoluble in: | |
| water | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| Alfa Biotechnology |
| For experimental / research use only. |
| Imperatorin 98% |
| BOC Sciences |
| For experimental / research use only. |
| Imperatorin 0.985
Odor: characteristic Use: Imperatorin isolated from the root of Angelica dahurica Benth. et Hook. It can suppress multidrug-resistant human liver cancer growth in vivo by inducing Mcl-1 degradation .
anti-HIV; anticonvulsant; anti-inflammatory; antimicrobial; |
| Coompo |
| For experimental / research use only. |
| Imperatorin from Plants ≥96%
Odor: characteristic Use: Imperatorin inhibit T cell-receptor-mediated proliferation in human primary T cells in a concentration-dependent manner. Both compounds also induce apoptosis. While imperatorin induces DNA fragmentation at the G1/S phase of the cell cycle, heraclenin induces DNA fragmentation at the G2/M phases of the cell cycle, thus despite a close structural similarity they induce apoptosis in mechanistically different ways. Imperatorin inhibits HIV-1 replication as well as the expression of ICAM-1 in U937 foam cells. Imperatorin can function as a cancer suppressor by inducing apoptosis in HepG2 cells through both death-receptor- and mitochondria-mediated pathways. Furthermore, the in vivo antitumor activities of Imperatorin are significant with negligible weight loss and damage to the host.
Imperatorin can also cause apoptosis in human promyelocytic leukaemia, HL-60 via the cytochrome c/caspase-9 pathway.
Imperatorin was mutagenic and induced transformation of mouse fibroblast cell lines, whereas it provided inhibiting effects on mutagenesis and carcinogenesis induced by various carcinogens. |
| ExtraSynthese |
| For experimental / research use only. |
| Imperatorin (HPLC) ≥99% |
| Glentham Life Sciences |
| Imperatorin |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Imperatorin |
| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| Imperatorin ≥98% (HPLC), powder |
| TCI AMERICA |
| For experimental / research use only. |
| Imperatorin >98.0%(HPLC) |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intraperitoneal-mouse LD50 330 mg/kg Quarterly Journal of Pharmacy & Pharmacology. Vol. 21, Pg. 499, 1948. parenteral-mouse LDLo 600 mg/kg "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 7, Pg. 689, 1955. | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | natural substances and extractives | ||
| Recommendation for imperatorin usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for imperatorin flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| Chemical Carcinogenesis Research Information System: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA GENetic TOXicology: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 10212 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| 9-(3-methylbut-2-enoxy)furo[3,2-g]chromen-7-one | |
| Chemidplus: | 0000482440 |
| RTECS: | LV1575000 for cas# 482-44-0 |
References:
| 9-(3-methylbut-2-enoxy)furo[3,2-g]chromen-7-one | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 10212 |
| Pubchem (sid): | 134974858 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C09269 |
| HMDB (The Human Metabolome Database): | HMDB34376 |
| FooDB: | FDB012752 |
| Export Tariff Code: | 2932.20.4500 |
| Typical G.C. | |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
| EFSA Update of results on the monitoring of furan levels in food: | Read Report |
| EFSA Previous report: Results on the monitoring of furan levels in food: | Read Report |
| EFSA Report of the CONTAM Panel on provisional findings on furan in food: | Read Report |
| Formulations/Preparations: decoction (5%), infusion (8%), distillate (in 55% ethanol), and tincture (20% in 60% ethanol). imperatoria | |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| angelica leaf Search Trop Picture | |
| angelica seed Search Trop Picture | |
| angelica seed oil Search Trop Picture | |
| anise leaf Search Trop Picture | |
| celery leaf Search Trop Picture | |
| celery root Search Trop Picture | |
| celery seed Search Trop Picture | |
| clausena anisata Search Trop Picture | |
| dill seed oil Search Trop Picture | |
| fennel seed Search Trop Picture | |
| goosefoot plant Search Trop Picture | |
| lemon fruit Search Trop Picture | |
| lemon fruit oil Search Trop Picture | |
| lemon oil Search Trop Picture | |
| lime fruit Search Trop Picture | |
| lovage fruit Search Trop Picture | |
| lovage root Search Trop Picture | |
| masterwort Search Trop Picture | |
| parsley fruit Search Trop Picture | |
| parsley leaf Search Trop Picture | |
| parsley leaf oil @ 0.04% Data GC Search Trop Picture | |
| parsnip leaf Search Trop Picture | |
| parsnip root Search Trop Picture | |
| parsnip seed Search Trop Picture |
Synonyms:
| ammidin | |
| 8-iso | amylenoxypsoralen |
| 5- | benzofuranacrylic acid, 6-hydroxy-7-((3-methyl-2-butenyl)oxy)-, d-lactone |
| 5- | benzofuranacrylic acid, 6-hydroxy-7-[(3-methyl-2-butenyl)oxy]-, d-lactone |
| 7H- | furo[3,2-g][1]benzopyran-7-one, 9-((3-methyl-2-butenyl)oxy)- |
| 7H- | furo[3,2-g][1]benzopyran-7-one, 9-[(3-methyl-2-buten-1-yl)oxy]- |
| 7H- | furo[3,2-g][1]benzopyran-7-one, 9-[(3-methyl-2-butenyl)oxy]- |
| 6- | hydroxy-7-(3-methyl-2-butenyloxy)-5-benzofuranacrylic acid d-lactone |
| 6- | hydroxy-7-(3-methyl-2-butenyloxy)-5-benzofuranacrylic acid omega-lactone |
| marmelide | |
| marmelosin | |
| 9-(3- | methyl but-2-enyl oxy)-7H-furo(3,2-g)chromen-7-one |
| 9-[(3- | methyl-2-buten-1-yl)oxy]-7H-furo[3,2-g]chromen-7-one |
| 9-((3- | methyl-2-butenyl)oxy)-7H-furo(3,2-g)(1)benzopyran-7-one |
| 9-[(3- | methyl-2-butenyl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one |
| 9-(3- | methyl-but-2-enyloxy)-furo[3,2-g]chromen-7-one |
| 9-((3- | methylbut-2-en-1-yl)oxy)-7H-furo[3,2-g]chromen-7-one |
| 9-[(3- | methylbut-2-en-1-yl)oxy]-2H-furo[3,2-g]chromen-2-one |
| 9-[(3- | methylbut-2-en-1-yl)oxy]-7H-furo[3,2-g]chromen-7-one |
| 9-(3- | methylbut-2-enoxy)furo[3,2-g]chromen-7-one |
| 9-(3- | methylbut-2-enyloxy)-7H-furo(3,2-g)chromen-7-one |
| 9-(3- | methylbut-2-enyloxy)-7H-furo[3,2-g]chromen-7-one |
| 9-(3- | methylbut-2-enyloxy)furano[3,2-g]chromen-2-one |
| 9-(3- | methylbut-2-enyloxy)furo(3,2-g)chromen-7-one |
| 9-(3- | methylbut-2-enyloxy)furo[3,2-g]chromen-7-one |
| 8-iso | pentenyloxypsoralene |
| pentosalen |