Articles:
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hydroquinone methyl ether
Notes:
depigmenting agent. Mequinol is a drug used in combination with the drug tretinoin in the treatment of liver spots. Mequinol used alone and in higher doses is used as a topical drug for medical depigmentation. (Wikipedia)
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BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 150-76-5 Mequinol >98%
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Glentham Life Sciences Ltd The Chemical, Biochemical & Research Essentials Supplier Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK. With a Glentham Life Sciences account you can view more product details, request quotes and order products online. Email: Info Email: Sales Email: Tech Support Voice: +44 (0) 1225 667798 Fax: +44 (0) 2033 978909 Facebook Twitter Linkedin Google+ News Distribution Products List: View Product(s): GK5518 4-Methoxyphenol
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OQEMA With a focus on providing the highest level of service OQEMA has established itself at the forefront of the global chemical industry. The guiding principles of OQEMA have always been to establish long term relationships with customers and suppliers alike to build sustainable and profitable business for all parties. Through OQEMA’s business divisions the company tailors products and services to better support and service our customers requirements. This structure also allows the company to focus its marketing campaigns more effectively to certain industries. Over the last decade OQEMA has achieved strong growth as a result of the expansion of our business model. Going forward, the company will be expanding this business model into existing and new strategic territories. Email: Contact Us: US Email: Dean Matienzo Email: Sales US Email: Dean Matienzo - Sales Manager Voice: +44 1993 843081 Fax: +44 1993 841261 US Voice: +1 973 886 3778 US Fax: +1 973 346 1106 Linkedin Website Global Distribution Product(s): 4-Methoxyphenol
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Penta International Corporation Chemistry innovation At Penta, our products and services help businesses do business better. For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes. US Email: Technical Services US Email: Sales US Voice: (973) 740-2300 US Fax: (973) 740-1839 Product(s): 08-54000 HYDROQUINONE MONOMETHYL ETHER
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TCI AMERICA Moving Your Chemistry Forward We continuously strive to advance our technology. With East & West Coast distribution centers, count on TCI to deliver products quickly and reliably. Over 30,000 Reagents available today in benchtop to bulk quantities. We also offer custom synthesis solutions. Sign up for a TCI account today for fast and free shipping! Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 70 years of synthesis experience and multi-purpose plants enable TCI to offer more than 30,000 products as well as custom synthesis. US Email: Sales Email: Technical Support Voice: 1-800-423-8616 Fax: 1- 888-520-1075 Facebook Twitter Instagram Linkedin Product(s): M0123 4-Methoxyphenol >99.0%(GC)
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| CAS Number: | 150-76-5 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 205-769-8 | |
| FDA UNII: | 6HT8U7K3AM | |
| Nikkaji Web: | J2.031A | |
| Beilstein Number: | 0507924 | |
| MDL: | MFCD00002332 | |
| CoE Number: | 11241 | |
| XlogP3: | 1.30 (est) | |
| Molecular Weight: | 124.13916000 | |
| Formula: | C7 H8 O2 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| DG SANTE Food Flavourings: | 04.077 4-methoxyphenol |
| FDA Mainterm (IAUFC): | 150-76-5 ; 4-METHOXYPHENOL |
Physical Properties:
| Appearance: | white crystalline powder (est) |
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 53.00 to 57.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 243.00 to 245.00 °C. @ 760.00 mm Hg |
| Vapor Pressure: | 0.021000 mmHg @ 25.00 °C. (est) |
| Vapor Density: | 4.3 ( Air = 1 ) |
| Flash Point: | 249.00 °F. TCC ( 120.56 °C. ) |
| logP (o/w): | 1.580 |
| Soluble in: | |
| alcohol | |
| water, 1.648e+004 mg/L @ 25 °C (est) | |
| water, 4.00E+04 mg/L @ 25 °C (exp) | |
Organoleptic Properties:
| Odor Description: at 1.00 % in dipropylene glycol. | phenolic |
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| CosIng: | cosmetic data |
| Cosmetic Uses: |
antioxidants reducing agents |
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Mequinol >98% |
| Glentham Life Sciences |
| 4-Methoxyphenol |
| OQEMA |
| 4-Methoxyphenol |
| Penta International |
| HYDROQUINONE MONOMETHYL ETHER |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| 4-Methoxyphenol ≥99% |
| Sigma-Aldrich |
| For experimental / research use only. |
| 4-Methoxyphenol purum, =98.0% (HPLC) |
| TCI AMERICA |
| For experimental / research use only. |
| 4-Methoxyphenol >99.0%(GC) |
Safety Information:
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| Xn - Harmful. | |
|
R 22 - Harmful if swallowed. R 36 - Irritating to eyes. R 43 - May cause sensitisation by skin contact. S 02 - Keep out of the reach of children. S 20 - When using do not eat or drink. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 - Wear suitable gloves and eye/face protection. S 46 - If swallowed, seek medical advice immediately and show this container or label. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
gavage-rat LD50 [sex: M,F] > 5000 mg/kg (Blaszcak & Auletta, 1987) intraperitoneal-mouse LD50 250 mg/kg National Technical Information Service. Vol. AD691-490 oral-rat LD50 1600 mg/kg Kodak Company Reports. Vol. 21MAY1971 | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | flavoring agents | ||
| IFRA Critical Effect: | Depigmentation | ||
| IFRA: | View Standard | ||
| Recommendation for para-guaiacol usage levels up to: | |||
| PROHIBITED: Should not be used as a fragrance ingredient. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.12 (μg/capita/day) | ||
| Modified Theoretical Added Maximum Daily Intake (mTAMDI): | 420 (μg/person/day) | ||
| Threshold of Concern: | 1800 (μg/person/day) | ||
| Structure Class: | I | ||
| Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i). | |||
| Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm. | |||
| average usage mg/kg | maximum usage mg/kg | ||
| Dairy products, excluding products of category 02.0 (01.0): | 0.50000 | 2.50000 | |
| Fats and oils, and fat emulsions (type water-in-oil) (02.0): | 0.20000 | 1.00000 | |
| Edible ices, including sherbet and sorbet (03.0): | 0.50000 | 2.50000 | |
| Processed fruit (04.1): | 0.40000 | 2.00000 | |
| Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): | - | - | |
| Confectionery (05.0): | 1.00000 | 5.00000 | |
| Chewing gum (05.0): | - | - | |
| Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): | 0.20000 | 1.00000 | |
| Bakery wares (07.0): | 2.00000 | 10.00000 | |
| Meat and meat products, including poultry and game (08.0): | 0.20000 | 1.00000 | |
| Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): | 0.20000 | 1.00000 | |
| Eggs and egg products (10.0): | - | - | |
| Sweeteners, including honey (11.0): | - | - | |
| Salts, spices, soups, sauces, salads, protein products, etc. (12.0): | 0.30000 | 1.50000 | |
| Foodstuffs intended for particular nutritional uses (13.0): | 0.50000 | 2.50000 | |
| Non-alcoholic ("soft") beverages, excl. dairy products (14.1): | 0.20000 | 1.00000 | |
| Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): | 1.00000 | 5.00000 | |
| Ready-to-eat savouries (15.0): | 2.00000 | 10.00000 | |
| Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): | 0.40000 | 2.00000 | |
Safety References:
| European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): | |
| Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 22 (FGE.22): Ring-substituted phenolic substances from chemical groups 21 and 25 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) View page or View pdf | |
| Flavouring Group Evaluation 58 (FGE.58) Consideration of phenol derivatives evaluated by JECFA (55th meeting) structurally related to ring substituted phenolic substances evaluated by EFSA in FGE.22 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf | |
| Flavouring Group Evaluation 60 (FGE.60): Consideration of eugenol and related hydroxyallylbenzene derivatives evaluated by JECFA (65th meeting) structurally related to ring- substituted phenolic substances evaluated by EFSA in FGE.22 (2006) View page or View pdf | |
| Scientific Opinion on Flavouring Group Evaluation 22, Revision 1 (FGE.22Rev1): Ring-substituted phenolic substances from chemical groups 21 and 25 View page or View pdf | |
| EPI System: | View |
| NIOSH International Chemical Safety Cards: | search |
| NIOSH Pocket Guide: | search |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| Carcinogenic Potency Database: | Search |
| EPA GENetic TOXicology: | Search |
| EPA Substance Registry Services (TSCA): | 150-76-5 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 9015 |
| National Institute of Allergy and Infectious Diseases: | Data |
| SCCNFP: | opinion |
| WGK Germany: | 1 |
| 4-methoxyphenol | |
| Chemidplus: | 0000150765 |
| EPA/NOAA CAMEO: | hazardous materials |
| RTECS: | 150-76-5 |
References:
| 4-methoxyphenol | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 150-76-5 |
| Pubchem (cid): | 9015 |
| Pubchem (sid): | 134973235 |
| Pherobase: | View |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | D04926 |
| HMDB (The Human Metabolome Database): | HMDB29696 |
| FooDB: | FDB000886 |
| Export Tariff Code: | 2909.50.5000 |
| Typical G.C. | |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
| Formulations/Preparations: topical solution; 2% mequinol with tretinoin 0.01% (solage) (with alcohol 77.8% vv); (galderma) | |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| artificial nail systems |
Occurrence (nature, food, other): note
| anise seed Search Trop Picture | |
| anise star anise oil Search Trop Picture | |
| champaca concrete @ trace% Data GC Search Trop Picture | |
| galangal lesser galangal - less than 500 mg/kg Search Trop Picture | |
| marjoram shoot Search Trop Picture |
Synonyms:
| p- | guaiacol |
| para- | guaiacol |
| HQMME | |
| hydroquinone methyl ether | |
| hydroquinone monomethyl ether | |
| 1- | hydroxy-4-methoxybenzene |
| 4- | hydroxyanisole |
| p- | hydroxyanisole |
| para- | hydroxyanisole |
| p- | hydroxymethoxybenzene |
| para- | hydroxymethoxybenzene |
| leucobasal | |
| leucodine B | |
| mechinolum | |
| mequinol | |
| 4- | methoxy-phenol |
| 4- | methoxyphenol |
| p- | methoxyphenol |
| para- | methoxyphenol |
| mono | methyl ether hydroquinone |
| phenol, 4-methoxy- | |
| phenol, p-methoxy- | |
| solage |