Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | pale yellow to amber brown clear liquid (est) |
Assay: | 98.00 to 100.00 %
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Food Chemicals Codex Listed: | No |
Specific Gravity: | 1.06000 to 1.06600 @ 25.00 °C.
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Pounds per Gallon - (est).: | 8.820 to 8.870
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Specific Gravity: | 1.06300 to 1.07100 @ 20.00 °C.
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Pounds per Gallon - est.: | 8.856 to 8.922
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Refractive Index: | 1.61100 to 1.61700 @ 20.00 °C.
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Melting Point: | -22.00 °C. @ 760.00 mm Hg
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Boiling Point: | 259.00 to 261.00 °C. @ 760.00 mm Hg
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Vapor Pressure: | 0.022000 mmHg @ 25.00 °C. (est) |
Flash Point: | > 230.00 °F. TCC ( > 110.00 °C. )
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logP (o/w): | 2.570 |
Soluble in: |
| alcohol | | dipropylene glycol | | water, 631.1 mg/L @ 25 °C (est) |
Insoluble in: |
| water |
Organoleptic Properties:
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Odor Type: animal |
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Odor Strength: | high , recommend smelling in a 1.00 % solution or less |
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Substantivity: | 400 hour(s) at 10.00 % in dipropylene glycol |
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| leathery tonka castoreum tobacco civet fecal |
Odor Description: at 1.00 % in dipropylene glycol. | leather tonka castoreum tobacco civet fecal Luebke, William tgsc, (1990) |
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Flavor Type: animal |
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| animal tonka naphthyl tobacco anisic phenolic |
Taste Description:
| sweet animal tonka naphthyl tobacco anisic phenolic Luebke, William tgsc, (1990) |
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Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | Xn - Harmful. |
R 22 - Harmful if swallowed. R 36/37/38 - Irritating to eyes, respiratory system, and skin. R 40 - Limited evidence of a carcinogenic effect. S 02 - Keep out of the reach of children. S 20/21 - When using do not eat, drink or smoke. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Human Experience: |
2 % solution: no irritation or sensitization. |
Oral/Parenteral Toxicity: |
oral-rat LD50 800 mg/kg (Soviet Toxicologic Center, 1984)
oral-rat LD50 1260 mg/kg (Moreno, 1976y)
oral-rat LD50 800 mg/kg BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 28(12), Pg. 56, 1984.
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Dermal Toxicity: |
skin-rabbit LD50 5000 mg/kg Food and Cosmetics Toxicology. Vol. 17, Pg. 871, 1979.
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | flavor and fragrance agents |
RIFM Fragrance Material Safety Assessment: Search |
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
Recommendation for 6-methyl quinoline usage levels up to: | | 1.0000 % in the fragrance concentrate.
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Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.32 (μg/capita/day) |
Maximised Survey-derived Daily Intakes (MSDI-USA): | 0.01 (μg/capita/day) |
Structure Class: | III |
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
publication number: 3 |
Click here to view publication 3 |
| average usual ppm | average maximum ppm |
baked goods: | - | 1.80000 |
beverages(nonalcoholic): | - | 0.22000 |
beverages(alcoholic): | - | - |
breakfast cereal: | - | - |
cheese: | - | - |
chewing gum: | - | - |
condiments / relishes: | - | - |
confectionery froastings: | - | - |
egg products: | - | - |
fats / oils: | - | - |
fish products: | - | - |
frozen dairy: | - | 1.40000 |
fruit ices: | - | 1.40000 |
gelatins / puddings: | - | - |
granulated sugar: | - | - |
gravies: | - | - |
hard candy: | - | 1.80000 |
imitation dairy: | - | - |
instant coffee / tea: | - | - |
jams / jellies: | - | - |
meat products: | - | - |
milk products: | - | - |
nut products: | - | - |
other grains: | - | - |
poultry: | - | - |
processed fruits: | - | - |
processed vegetables: | - | - |
reconstituted vegetables: | - | - |
seasonings / flavors: | - | - |
snack foods: | - | - |
soft candy: | - | - |
soups: | - | - |
sugar substitutes: | - | - |
sweet sauces: | - | - |
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Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i). |
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm. |
| average usage mg/kg | maximum usage mg/kg |
Dairy products, excluding products of category 02.0 (01.0): | 0.02400 | 19.00000 |
Fats and oils, and fat emulsions (type water-in-oil) (02.0): | 2.90000 | - |
Edible ices, including sherbet and sorbet (03.0): | - | 9.70000 |
Processed fruit (04.1): | - | - |
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): | - | - |
Confectionery (05.0): | 2.90000 | 29.00000 |
Chewing gum (05.0): | - | - |
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): | 5.00000 | - |
Bakery wares (07.0): | 1.50000 | 13.00000 |
Meat and meat products, including poultry and game (08.0): | - | - |
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): | - | - |
Eggs and egg products (10.0): | - | - |
Sweeteners, including honey (11.0): | - | - |
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): | 1.20000 | - |
Foodstuffs intended for particular nutritional uses (13.0): | - | - |
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): | 0.00058 | - |
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): | - | - |
Ready-to-eat savouries (15.0): | - | - |
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): | - | - |
Safety References:
European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
European Food Safety Authority (EFSA) reference(s): |
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 24 (FGE.24): Pyridine, pyrrole, indole and quinoline derivatives from chemical group 28 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) View page or View pdf |
Pyridine, pyrrole, indole and quinoline derivatives from chemical group 28 Flavouring Group Evaluation 24, Revision 1 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
Flavouring Group Evaluation 77 (FGE77) [1] - Consideration of Pyridine, Pyrrole and Quinoline Derivatives evaluated by JECFA (63rd meeting) structurally related to Pyridine, Pyrrole, Indole and Quinoline Derivatives evaluated by EFSA in FGE.24Rev1 (2008) View page or View pdf |
Statement on List of Representative Substances for Testing.
The current Statement lays down a list of substances in sub-groups with representative substances for which additional data are required prior to their evaluation through the Procedure (Regulation (EC) No 1565/2000). View page or View pdf |
Scientific opinion on Flavouring Group Evaluation 24, Revision 2 (FGE.24Rev2): Pyridine, pyrrole, indole and quinoline derivatives from chemical group 28 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 77, Revision 2 (FGE.77Rev2): Consideration of Pyridine, Pyrrole and Quinoline Derivatives evaluated by JECFA (63rd meeting) structurally related to Pyridine, Pyrrole, Indole and Quinoline Derivatives evaluated by EFSA in FGE.24Rev2 (2013) View page or View pdf |
Scientific opinion on flavouring group evaluation 77, revision 3 (FGE.77Rev3): consideration of pyridine, pyrrole and quinoline derivatives evaluated by JECFA (63rd meeting) structurally related to pyridine, pyrrole, indole and quinoline derivatives evaluated by EFSA in FGE.24Rev2 View page or View pdf |
EPI System: | View |
Chemical Carcinogenesis Research Information System: | Search |
AIDS Citations: | Search |
Cancer Citations: | Search |
Toxicology Citations: | Search |
Carcinogenic Potency Database: | Search |
EPA GENetic TOXicology: | Search |
EPA Substance Registry Services (TSCA): | 91-62-3 |
EPA ACToR: | Toxicology Data |
EPA Substance Registry Services (SRS): | Registry |
Laboratory Chemical Safety Summary : | 7059 |
National Institute of Allergy and Infectious Diseases: | Data |
WGK Germany: | 3 |
| 6-methylquinoline |
Chemidplus: | 0000091623 |
EPA/NOAA CAMEO: | hazardous materials |
RTECS: | VC0550000 for cas# 91-62-3 |
References:
Other Information:
Potential Blenders and core components note
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For Odor |
No odor group found for these |
7- | methyl coumarin replacer | FR |
amber |
| ambrette seed absolute | FL/FR |
animal |
| animal fragrance | FR |
iso | butyl quinoline | FR |
2-iso | butyl quinoline | FR |
iso | butyl quinoline | FR |
6-tert- | butyl-meta-cresol | FL/FR |
para- | methyl tetrahydroquinoline | FL/FR |
| procavia capensis excrete absolute | FR |
| skatole | FL/FR |
1,2,3,4- | tetrahydroquinoline | FR |
balsamic |
| amyl phenyl acetate | FL/FR |
| pine needle absolute | FL/FR |
burnt |
| amber oil | FR |
caramellic |
| immortelle absolute | FL/FR |
cereal |
| bran absolute | FR |
chocolate |
iso | amyl phenyl acetate | FL/FR |
coconut |
| coconut decanone methyl | FR |
| coconut naphthalenone | FL/FR |
gamma- | heptalactone | FL/FR |
coumarinic |
| coumane | FL/FR |
| phthalide | FL/FR |
| tonka bean oleoresin | FR |
| tonka bean resinoid | FR |
| tonka furanone | FL/FR |
| tonka ketone | FR |
| tonkavert | FR |
creamy |
para- | vanillyl alcohol | FL/FR |
floral |
alpha- | amyl cinnamyl acetate | FL/FR |
| boronia butenal | FR |
| citronellol | FL/FR |
delta- | damascone | FL/FR |
| dimethyl octanol | FL/FR |
| floral methanol | FR |
| orris pyridine 25% IPM | FR |
| tobacco flower absolute | FR |
fruity |
alpha- | amyl cinnamyl isovalerate | FL/FR |
| cyclohexanone diethyl acetal | FL/FR |
(E)-beta- | damascone | FL/FR |
(Z)-beta- | damascone | FL/FR |
beta- | damascone | FL/FR |
| ethyl 3-hydroxyhexanoate | FL/FR |
| leather propionate | FR |
| osmanthus flower absolute | FL/FR |
fungal |
| methyl 2-furoate | FL/FR |
green |
| narcissus flower absolute | FR |
| oakmoss oil | FR |
| phenoxyacetaldehyde 50% in benzyl alcohol | FR |
| syringaldehyde | FL/FR |
hay |
| beeswax absolute | FL/FR |
| hay absolute | FR |
| tobacco leaf absolute | FL/FR |
| woodruff absolute | FR |
| matricaria chamomilla flower oil | FL/FR |
| methyl nicotinate | FL/FR |
| saffron indenone | FL/FR |
| safranal | FL/FR |
| theaspirane | FL/FR |
| thyme undecane | FR |
| yerba mate absolute | FL/FR |
honey |
| phenyl acetic acid | FL/FR |
leathery |
4-tert- | butyl phenol | CS |
| castoreum absolute | FL/FR |
| leather cyclohexanol | FR |
marine |
| marine pyridine | FR |
musk |
| musk amberol | FR |
musty |
ketoiso | phorone | FL/FR |
nutty |
2,3- | dimethyl pyrazine | FL/FR |
phenolic |
2'- | hydroxyacetophenone | FL/FR |
popcorn |
2- | acetyl pyridine | FL/FR |
powdery |
para- | anisyl acetate | FL/FR |
smoky |
alpha- | ethoxy-ortho-cresol | FL/FR |
| cuminyl alcohol | FL/FR |
N,N- | diethyl octanamide | FR |
4- | methyl guaiacol | FL/FR |
| myrtenal | FL/FR |
tobacco |
para- | cresyl isovalerate | FL/FR |
3- | ethyl pyridine | FL/FR |
| methyl benzoxole | FL/FR |
| tobacco concrete | FR |
(E,E/E,Z)- | tobacco cyclohexenone | FL/FR |
| veltonal (Bedoukian) | FR |
tonka |
6- | amyl-alpha-pyrone | FL/FR |
| coumarin | FR |
| deertongue absolute | FR |
| deertongue oleoresin | FR |
| flouve absolute | FR |
gamma- | hexalactone | FL/FR |
7- | methyl coumarin | CS |
| mint lactone | FL/FR |
| octahydrocoumarin | FL/FR |
| saffron resinoid | FL/FR |
| tonka bean absolute | FR |
| tonka undecanone | FR |
| whiskey lactone | FL/FR |
tropical |
| genet absolute | FL/FR |
vanilla |
| propenyl guaethol | FL/FR |
woody |
| amber decatriene | FR |
alpha- | cedrene epoxide | FR |
iso | longifolene ketone | FR |
| methyl cedryl ketone | FL/FR |
| tobacarol (IFF) | FR |
| tobacco nonene | FR |
| woody dioxolane | FR |
| woody ether | FR |
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For Flavor |
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No flavor group found for these |
| amyl phenyl acetate | FL/FR |
6-tert- | butyl-meta-cresol | FL/FR |
| capsicum oleoresin | FL |
| coconut naphthalenone | FL/FR |
| coumane | FL/FR |
| cyclohexanone diethyl acetal | FL/FR |
2,6- | dimethoxy-4-vinyl phenol | FL |
alpha- | ethoxy-ortho-cresol | FL/FR |
| fig leaf absolute | FL |
2- | furfurylidene butyraldehyde | FL |
7- | methoxycoumarin | FL |
| methyl nicotinate | FL/FR |
para- | methyl tetrahydroquinoline | FL/FR |
| pine needle absolute | FL/FR |
2- | propyl pyridine | FL |
| skatole | FL/FR |
(R)- | tonka furanone | FL |
| tonka furanone | FL/FR |
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beta- | damascone | FL/FR |
brown |
| beeswax absolute | FL/FR |
caramellic |
3- | ethyl pyridine | FL/FR |
| methyl 2-furoate | FL/FR |
citrus |
ketoiso | phorone | FL/FR |
cocoa |
| syringaldehyde | FL/FR |
coconut |
| octahydrocoumarin | FL/FR |
cooling |
| theaspirane | FL/FR |
corn |
2- | acetyl pyridine | FL/FR |
coumarinic |
| phthalide | FL/FR |
creamy |
6- | amyl-alpha-pyrone | FL/FR |
| dihydrocoumarin | FL |
gamma- | hexalactone | FL/FR |
| mint lactone | FL/FR |
para- | vanillyl alcohol | FL/FR |
earthy |
alpha- | amyl cinnamyl acetate | FL/FR |
fatty |
| dimethyl octanol | FL/FR |
floral |
iso | amyl phenyl acetate | FL/FR |
| citronellol | FL/FR |
| phenyl acetic acid | FL/FR |
fruity |
alpha- | amyl cinnamyl isovalerate | FL/FR |
para- | anisyl acetate | FL/FR |
(Z)-beta- | damascone | FL/FR |
(E)-beta- | damascone | FL/FR |
| ethyl 3-hydroxyhexanoate | FL/FR |
| osmanthus flower absolute | FL/FR |
grassy |
| tobacco leaf absolute | FL/FR |
green |
| immortelle absolute | FL/FR |
hay |
| genet absolute | FL/FR |
herbal |
| matricaria chamomilla flower oil | FL/FR |
| saffron indenone | FL/FR |
| yerba mate absolute | FL/FR |
lactonic |
gamma- | heptalactone | FL/FR |
leathery |
| castoreum absolute | FL/FR |
minty |
| myrtenal | FL/FR |
naphthyl |
2'- | hydroxyacetophenone | FL/FR |
nutty |
2,3- | dimethyl pyrazine | FL/FR |
| methyl benzoxole | FL/FR |
(E,E/E,Z)- | tobacco cyclohexenone | FL/FR |
phenolic |
para- | cresyl isovalerate | FL/FR |
spicy |
| cuminyl alcohol | FL/FR |
| levisticum officinale oleoresin | FL |
4- | methyl guaiacol | FL/FR |
| paprika oleoresin | FL |
sweet |
| saffron resinoid | FL/FR |
vanilla |
| propenyl guaethol | FL/FR |
woody |
| ambrette seed absolute | FL/FR |
delta- | damascone | FL/FR |
| methyl cedryl ketone | FL/FR |
| safranal | FL/FR |
| whiskey lactone | FL/FR |
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Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| khinaldin | 6- | methylchinolin | 6- | methylquinoline | | paramethylquinolene | | quinoline, 6-methyl- |
Articles:
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