Category: cosmetic ingredient for skin and hair care
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | colorless clear liquid (est) |
Assay: | 98.00 to 100.00 %
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Food Chemicals Codex Listed: | No |
Specific Gravity: | 0.92400 @ 25.00 °C.
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Melting Point: | -40.00 °C. @ 760.00 mm Hg
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Boiling Point: | 197.00 to 199.00 °C. @ 760.00 mm Hg
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Vapor Pressure: | 0.096000 mmHg @ 25.00 °C. (est) |
Vapor Density: | 4.1 ( Air = 1 ) |
Flash Point: | > 200.00 °F. TCC ( > 93.33 °C. )
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logP (o/w): | 0.004 (est) |
Soluble in: |
| alcohol | | water, 3.256e+004 mg/L @ 25 °C (est) | | water, 1.00E+06 mg/L @ 25 °C (exp) |
Organoleptic Properties:
Odor Strength: | none |
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Substantivity: | 400 Hour(s) |
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Odor Description: at 100.00 %. | odorless very mild green Luebke, William tgsc, (1985) |
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Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Arkema |
Hexylene Glycol
Odor: characteristic Use: It is mainly used as a solvent or coupling agent. It is a potential substitute for glycol ethers. It is also an effective shrinkage reduction admixture or SRA for concrete and mortar. Hexylene glycol can also be used as a building block in chemical synthesis. |
BOC Sciences |
For experimental / research use only. |
2-Methyl-2,4-pentanediol >98%
Odor: characteristic Use: 2-Methyl-2,4-pentanediol, an analog of hexylene glycol, is a small molecular surfactant which could be useful as an environmentally friendly industrial coating solvent.
2-Methyl-2,4-pentanediol, an analog of hexylene glycol, is a small molecular surfactant which could be useful as an |
Charkit Chemical |
HEXYLENE GLYCOL
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ECSA Chemicals |
HEXYLENE GLYCOL
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ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY |
Indukern F&F |
HEXYLENE GLYCOL
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Inoue Perfumery |
HEXYLENE GLYCOL
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Lluch Essence |
HEXYLENE GLYCOL
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Moellhausen |
HEXYLEN GLYCOL
Odor: virtually odourless, mild oily, ethereal Flavor: mild, soft, slightly ethereal |
Penta International |
HEXYLENE GLYCOL NF
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Penta International |
HEXYLENE GLYCOL
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Sigma-Aldrich: Aldrich |
For experimental / research use only. |
hexylene glycol 99%
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Silver Fern Chemical |
Hexylene Glycol (HG)
Odor: characteristic Use: Hexylene glycol has many uses including hydraulic brake fluids, printing inks, a coupling agent for textiles, fuels and lubricants, emulsifying agent, cosmetics, and cleaners. |
Wedor Corporation |
HEXYLENE GLYCOL
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Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | Xi - Irritant |
R 36/38 - Irritating to skin and eyes. S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 - Wear suitable gloves and eye/face protection.
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
oral-rat LD50 3700 mg/kg Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 68, 1974.
oral-rabbit LD50 3200 mg/kg BEHAVIORAL: GENERAL ANESTHETIC
LIVER: OTHER CHANGES
BEHAVIORAL: MUSCLE WEAKNESS Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 4, Pg. 142, 1945.
oral-mouse LD50 3097 mg/kg Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 45, Pg. 669, 1956.
intraperitoneal-mouse LD50 1299 mg/kg Shell Chemical Company. Unpublished Report. Vol. -, Pg. 5, 1961.
oral-guinea pig LD50 2800 mg/kg BEHAVIORAL: GENERAL ANESTHETIC
BEHAVIORAL: MUSCLE WEAKNESS
LIVER: OTHER CHANGES Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 4, Pg. 142, 1945.
intraperitoneal-rat LDLo 1500 mg/kg BEHAVIORAL: GENERAL ANESTHETIC
GASTROINTESTINAL: OTHER CHANGES
KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED Journal of Pharmacy and Pharmacology. Vol. 11, Pg. 150, 1959.
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Dermal Toxicity: |
skin-rabbit LD50 8560 ul/kg "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 731, 1969.
subcutaneous-rabbit LD50 13000 mg/kg SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Food and Cosmetics Toxicology. Vol. 16, Pg. 777, 1978.
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Inhalation Toxicity: |
inhalation-rat LC50 > 310 mg/m3/1H BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 12-4/1970
inhalation-human TCLo 50 ppm/15M LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 312, 1969.
inhalation-mammal (species unspecified) TCLo 50 ppm SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Journal of Industrial Hygiene and Toxicology. Vol. 28, Pg. 262, 1946.
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Safety in Use Information:
Category: | cosmetic ingredient for skin and hair care |
Recommendation for hexylene glycol usage levels up to: | | not for fragrance use.
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Recommendation for hexylene glycol flavor usage levels up to: |
| not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
| blender | |
| emulsifying agents | |
| skin conditioning | |
| solvents | |
| surfactants | |
Occurrence (nature, food, other): note
Synonyms:
2,4- | dihydroxy-2-methyl pentane | 2,4- | dihydroxy-2-methylpentane | 1,3- | dimethyl-3-hydroxybutanol | | diolane | | hexylen glycol | (±)- | hexylene glycol | | isol | 2- | methyl pentane-2,4-diol | 2- | methyl-2,4-pentandiol | 4- | methyl-2,4-pentane diol | 2- | methyl-2,4-pentanediol | 2- | methylpentane-2,4-diol | 2,4- | pentanediol, 2-methyl- | | pinakon | 1,1,3- | trimethyl trimethylene diol | alpha,alpha,alpha'- | trimethyl trimethylene glycol | 1,1,3- | trimethyl-1,3-propanediol | 1,3,3- | trimethyl-1,3-propanediol | 1,1,3- | trimethyltrimethylenediol |
Articles:
PubMed: | Refolding of SDS-denatured proteins using amphipathic cosolvents and osmolytes. |
PubMed: | Crystallization and preliminary X-ray analysis of peptidyl-tRNA hydrolase from Thermus thermophilus HB8. |
PubMed: | Crystal structure of silkworm Bombyx mori JHBP in complex with 2-methyl-2,4-pentanediol: plasticity of JH-binding pocket and ligand-induced conformational change of the second cavity in JHBP. |
PubMed: | Nanolitre-scale crystallization using acoustic liquid-transfer technology. |
PubMed: | Sequence-dependent effects of cryoprotectants on the active sites of the human ABO(H) blood group A and B glycosyltransferases. |
PubMed: | Structure-property relationship in new photo-cured dimethacrylate-based dental resins. |
PubMed: | A strategy for purifying glutathione S-transferase in the presence of sodium dodecyl sulfate. |
PubMed: | Atomic force microscopy imaging of human metaphase chromosomes in liquid. |
PubMed: | The structure of human ubiquitin in 2-methyl-2,4-pentanediol: a new conformational switch. |
PubMed: | 2-Methyl-2,4-pentanediol induces spontaneous assembly of staphylococcal α-hemolysin into heptameric pore structure. |
PubMed: | Diffusion in ternary aqueous systems containing human serum albumin and precipitants of different classes. |
PubMed: | Properties of a new mouthrinse for patients receiving radiation therapy. |
PubMed: | PagP crystallized from SDS/cosolvent reveals the route for phospholipid access to the hydrocarbon ruler. |
PubMed: | Formulation of creams with betamethasone dipropionate: evaluation of chemical stability. |
PubMed: | Contact urticaria with systemic symptoms due to hexylene glycol in a topical corticosteroid: case report and review of hypersensitivity to glycols. |
PubMed: | Tryptophan as a three-way switch in regulating the function of the secretory signalling glycoprotein (SPS-40) from mammary glands: structure of SPS-40 complexed with 2-methylpentane-2,4-diol at 1.6 A resolution. |
PubMed: | Protecting role of cosolvents in protein denaturation by SDS: a structural study. |
PubMed: | Efficient low-power heteronuclear decoupling in 13C high-resolution solid-state NMR under fast magic angle spinning. |
PubMed: | Refolding SDS-denatured proteins by the addition of amphipathic cosolvents. |
PubMed: | High-resolution solid-state MAS NMR of proteins-Crh as an example. |
PubMed: | The structures of transcription factor CGL2947 from Corynebacterium glutamicum in two crystal forms: a novel homodimer assembling and the implication for effector-binding mode. |
PubMed: | Aqueous self-assembly of phytantriol in ternary systems: effect of monoolein, distearoylphosphatidylglycerol and three water-miscible solvents. |
PubMed: | Isolation of Arabidopsis nuclei and measurement of gene transcription rates using nuclear run-on assays. |
PubMed: | A family of nanoporous materials based on an amino acid backbone. |
PubMed: | Andersen's syndrome mutation effects on the structure and assembly of the cytoplasmic domains of Kir2.1. |
PubMed: | Preferential hydration of DNA: the magnitude and distance dependence of alcohol and polyol interactions. |
PubMed: | Effect of organic cosolvents on the free solution mobility of curved and normal DNA molecules. |
PubMed: | Atomic force microscopy of native human metaphase chromosomes in a liquid. |
PubMed: | Effect of the solvent on the conformation of a depsipeptide: NMR-derived solution structure of hormaomycin in DMSO from residual dipolar couplings in a novel DMSO-compatible alignment medium. |
PubMed: | Pentane-1,5-diol as a percutaneous absorption enhancer. |
PubMed: | Polar body formation in Spisula oocytes: function of the peripheral aster. |
PubMed: | Induction of cytokinesis is independent of precisely regulated microtubule dynamics. |
PubMed: | A new arrangement of (beta/alpha)8 barrels in the synthase subunit of PLP synthase. |
PubMed: | Roles of polymerization dynamics, opposed motors, and a tensile element in governing the length of Xenopus extract meiotic spindles. |
PubMed: | Crystalization and preliminary X-ray crystallographic analysis of the laminarinase endo-beta-1,3-glucanase from Pyrococcus furiosus. |
PubMed: | A redetermination of the structure of the triple mutant (K53,56,120M) of phospholipase A2 at 1.6 A resolution using sulfur-SAS at 1.54 A wavelength. |
PubMed: | Exclusion of alcohols from spermidine-DNA assemblies: probing the physical basis of preferential hydration. |
PubMed: | Characteristics of migration patterns of DNA oligomers in gels and the relationship to the question of intrinsic DNA bending. |
PubMed: | Microtubule plus-end dynamics in Xenopus egg extract spindles. |
PubMed: | The OH-initiated oxidation of hexylene glycol and diacetone alcohol. |
PubMed: | Increased temperature and 2-methyl-2,4-pentanediol change the DNA structure of both curved and uncurved adenine/thymine-rich sequences. |
PubMed: | Development of indomethacin Carbopol ETD 2001 gels and the influence of storage time and temperature on their stability. |
PubMed: | The crystal structure and stereospecificity of levodione reductase from Corynebacterium aquaticum M-13. |
PubMed: | Observation of additional calcium ion in the crystal structure of the triple mutant K56,120,121M of bovine pancreatic phospholipase A2. |
PubMed: | Influence of storage time and temperature on the stability of indomethacin Pluronic F-127 gels. |
PubMed: | An overview on 2-methyl-2,4-pentanediol in crystallization and in crystals of biological macromolecules. |
PubMed: | Determination of glycols in biological specimens by gas chromatography-mass spectrometry. |
PubMed: | Pluronic F-127 gels as a vehicle for topical formulations of indomethacin and rheological behaviour of these formulations. |
PubMed: | KNI-272, a highly selective and potent peptidic HIV protease inhibitor. |
PubMed: | The 1.19 A X-ray structure of 2'-O-Me(CGCGCG)(2) duplex shows dehydrated RNA with 2-methyl-2,4-pentanediol in the minor groove. |
PubMed: | An open study of efficacy and safety of long-term treatment with mometasone furoate fatty cream in the treatment of adult patients with atopic dermatitis. |
PubMed: | Crystallization, structure solution and refinement of hen egg-white lysozyme at pH 8.0 in the presence of MPD. |
PubMed: | Bivariate flow cytometry DNA/BrdUrd analysis of plant cell cycle. |
PubMed: | Crystallographic studies on a family B DNA polymerase from hyperthermophilic archaeon Pyrococcus kodakaraensis strain KOD1. |
PubMed: | Effects of commonly used cryoprotectants on glycogen phosphorylase activity and structure. |
PubMed: | Non-flammable preparative reversed-phase liquid chromatography of recombinant human insulin-like growth factor-I. |
PubMed: | Division of polar bodies induced by their enlargement in the starfish Asterina pectinifera. |
PubMed: | Effects of neutral salts on RNA chain elongation and pausing by Escherichia coli RNA polymerase. |
PubMed: | Effect of the crystallizing agent 2-methyl-2,4-pentanediol on the structure of adenine tract DNA in solution. |
PubMed: | Comparison of the solution and crystal conformations of (G + C)-rich fragments of DNA. |
PubMed: | The organic crystallizing agent 2-methyl-2,4-pentanediol reduces DNA curvature by means of structural changes in A-tracts. |
PubMed: | Cosolvent-induced adsorption and desorption of serum proteins on an amphiphilic mercaptomethylene pyridine-derivatized agarose gel. |
PubMed: | MPD and DNA bending in crystals and in solution. |
PubMed: | What is the basis of sequence-directed curvature in DNAs containing A tracts? |
PubMed: | Dehydrating agents sharply reduce curvature in DNAs containing A tracts. |
PubMed: | Contribution of the surface free energy perturbation to protein-solvent interactions. |
PubMed: | High resolution structures of the 4-4-20 Fab-fluorescein complex in two solvent systems: effects of solvent on structure and antigen-binding affinity. |
PubMed: | High resolution detection of uncoated metaphase chromosomes by means of field emission scanning electron microscopy. |
PubMed: | Effect of hexylene glycol-altered microtubule distributions on cytokinesis and polar lobe formation in fertilized eggs of Ilyanassa obsoleta. |
PubMed: | Cosolvent modulation of the tubulin-colchicine GTPase-activating conformational change: strength of the enzymatic activity. |
PubMed: | Further evaluation of a new penetration enhancer, HPE-101. |
PubMed: | The alpha-helical content of calmodulin is increased by solution conditions favouring protein crystallisation. |
PubMed: | A high-yield procedure for isolation of metaphase chromosomes from root tips of Vicia faba L. |
PubMed: | Conditions for assembly of tubulin-based structures in unfertilized sea urchin eggs. Spirals, monasters and cytasters. |
PubMed: | The ultrastructure of Pityrosporum pachydermatis. |
PubMed: | Preparation and flow cytometric analysis of metaphase chromosomes of tomato. |
PubMed: | Change in the heterogeneous distribution of tubulin isotypes in mitotic microtubules of the sea urchin egg by treatment with microtubule depolymerizing or stabilizing drugs. |
PubMed: | Antibacterial and antifungal properties of propylene glycol, hexylene glycol, and 1,3-butylene glycol in vitro. |
PubMed: | Crystal structure of thioredoxin from Escherichia coli at 1.68 A resolution. |
PubMed: | [Effect of hexylene glycol on microtubular structures in starfish oocytes and sea urchin eggs]. |
PubMed: | Skin reactions to hexylene glycol. |
PubMed: | Three-dimensional structure of a fluorescein-Fab complex crystallized in 2-methyl-2,4-pentanediol. |
PubMed: | The genetic toxicology of some hydrocarbon and oxygenated solvents. |
PubMed: | Differences in crystal properties and ligand affinities of an antifluorescyl Fab (4-4-20) in two solvent systems. |
PubMed: | Phase diagrams for DNA crystallization systems. |
PubMed: | [The use of phase diagrams in the crystallization of oligonucleotide duplexes. I. A model of crystallization of the (pGpT)n.(pApC)n + spermine system]. |
PubMed: | Single crystals of hydrogenase from Desulfovibrio vulgaris Miyazaki F. |
PubMed: | Cytoskeleton of the unfertilized sea urchin egg. |
PubMed: | Oxygen consumption by tumor cells during membrane vesicle shedding. |
PubMed: | Dual effect of procaine in sea urchin eggs. Inducer and inhibitor of microtubule assembly. |
PubMed: | Effect of a nonsteroidal antiandrogen, flutamide, on androgen receptor dynamics and ornithine decarboxylase gene expression in mouse kidney. |
PubMed: | Nuclear androgen receptors in different stages of the seminiferous epithelial cycle and the interstitial tissue of rat testis. |
PubMed: | Nonaqueous fractionation of HeLa cells in glycols. |
PubMed: | Composition of the isolated mitotic apparatus: analysis by polyacrylamide gel electrophoresis. |
PubMed: | [Study of a lysis medium stabilizing microfilaments and microtubules in vitro and in vivo]. |
PubMed: | Structure of variant-3 scorpion neurotoxin from Centruroides sculpturatus Ewing, refined at 1.8 A resolution. |
PubMed: | Localization of estrogen receptor regulatory factor in the uterine nucleus. |
PubMed: | Selective crystallization of horse isoferritins. |
PubMed: | Chinese hamster metaphase chromosomes isolated under physiological conditions. A partial characterization of associated non-histone proteins and protein cores. |
PubMed: | Possible role of microtubules in tumor cell surface membrane shedding, permeability, and lympholysis. |
PubMed: | Preparation of calmodulin crystals. |
PubMed: | Stereo electron microscope studies of mitotic chromosomes from Chinese hamster ovary cells. |
PubMed: | Safety evaluation of some humectants and moisturizers used in cosmetic formulations. |
PubMed: | Parthenogenetic activation of sea urchin egg induces a cyclical variation of the cytoplasmic resistance to hexylene glycol-Triton X-100 treatment. |
PubMed: | Six polymorphic crystal forms of alpha-cobratoxin. |
PubMed: | A new method for the preparation of metaphase chromosomes for flow analysis. |
PubMed: | Packing DNA into chromosomes. |
PubMed: | Experimental determinations of tubulin in the in vivo mitotic apparatus of sea urchin zygotes. |
PubMed: | An analysis of spindle ultrastructure during prometaphase and metaphase of micronuclear division in Tetrahymena. |
PubMed: | Induction of cleavage in nucleated and enucleated frog eggs by injection of isolated sea-urchin mitotic apparatus. |
PubMed: | Studies on the de novo formation of centrioles: aster formation in the activated eggs of sea urchin. |
PubMed: | Cytochemical and ultrastructural studies on the synaptonemal complex of rat spermatocytes. |
PubMed: | Isolation of nuclei using hexylene glycol. |
PubMed: | Spindle birefringence of isolated mitotic apparatus: further evidence for two birefringent spindle components. |
PubMed: | The effect of vinblastine, colchicine and hexylene glycol on migration of human monocytes. |
PubMed: | Spindle birefringence of isolated mitotic apparatus analysed by pressure treatment. |
PubMed: | Studies on intracellular transport of secretory proteins in the rat exocrine pancreas. II. Inhibition of antimicrotubular agents. |
PubMed: | The avian erythrocyte: a study of fixation for electron microscopy. |
PubMed: | Colchicine-binding protein and the secretion of thyroid hormone. |
PubMed: | Electron probe analysis of freeze-substituted, epoxy resin embedded tissue for ion transport studies in plants. |
PubMed: | Purification of intact microtubules from brain. |
PubMed: | The mitotic apparatus. Physical chemical characterization of the 22S protein component and its subunits. |
PubMed: | The mitotic apparatus. Identification of the major soluble component of the glycol-isolated mitotic apparatus. |
PubMed: | The toxicity of 2-methylpentan-2, 4-diol (hexylene glycol) by chronic oral administration to rats and mice. |
PubMed: | The excretion of hexylene glycol (2-methyl-2,4-pentane diol) in man. |
PubMed: | Determination of 2-methyl-2,4-pentane diol (hexylene glycol) in the urine of man and rats. |
PubMed: | Local and systemic effects of 2-methyl 2,4 pentanediol (hexylene glycol). |
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