Category: fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | white crystalline powder (est) |
Assay: | 98.00 to 100.00 %
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Food Chemicals Codex Listed: | No |
Melting Point: | 67.00 to 69.00 °C. @ 760.00 mm Hg
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Boiling Point: | 297.00 to 298.00 °C. @ 760.00 mm Hg
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Vapor Pressure: | 0.000027 mmHg @ 20.00 °C. |
Flash Point: | 285.00 °F. TCC ( 140.80 °C. ) (est)
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logP (o/w): | 2.670 |
Soluble in: |
| alcohol | | water, 520 mg/L @ 25 °C (exp) |
Insoluble in: |
| water |
Organoleptic Properties:
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Odor Type: green |
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Substantivity: | 400 Hour(s) |
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| weedy green rose |
Odor Description: at 100.00 %. | weedy green rose |
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Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | Xi - Irritant |
R 36/37/38 - Irritating to eyes, respiratory system, and skin. S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36 - Wear suitable protective clothing.
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
oral-rat LD50 5000 mg/kg Food and Cosmetics Toxicology. Vol. 17, Pg. 713, 1979.
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Dermal Toxicity: |
skin-rabbit LD50 > 5000 mg/kg Food and Cosmetics Toxicology. Vol. 17, Pg. 713, 1979.
subcutaneous-guinea pig LDLo 2000 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 24, Pg. 405, 1925.
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| benzenemethanol, a-phenyl- | | benzhydryl alcohol | | diphenyl carbinol | | diphenylmethanol | alpha- | phenyl benzene methanol | alpha- | phenyl benzyl alcohol | a- | phenylbenzenemethanol | a- | phenylbenzyl alcohol |
Articles:
PubMed: | Structure-activity relationships of benzhydrol derivatives based on 1'-acetoxychavicol acetate (ACA) and their inhibitory activities on multiple myeloma cell growth via inactivation of the NF-κB pathway. |
PubMed: | Enantioselective synthesis of (thiolan-2-yl)diphenylmethanol and its application in asymmetric, catalytic sulfur ylide-mediated epoxidation. |
PubMed: | Racemic (1,4-dioxan-2-yl)diphenylmethanol. |
PubMed: | Synthesis and biological evaluation of (±)-benzhydrol derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors. |
PubMed: | Hydrogen-bonded adducts of ferrocene-1,1'-diylbis(diphenylmethanol): monomeric and polymeric adducts with 1,2-bis(4-pyridyl)ethene and 1,6-diaminohexane. |
PubMed: | Hydrogen-bonded adducts of ferrocene-1,1'-diylbis(diphenylmethanol): monomeric and dimeric 1:1 adducts with 1,2-bis(4-pyridyl)ethane and 1,2-diaminoethane. |
PubMed: | Analysis of cataract and keratotic damage induced by 4-diethylaminoethoxy-alpha-ethyl-benzhydrol (RGH-6201) in rats. |
PubMed: | Hydrogen-bonded adducts of ferrocene-1,1'-diylbis(diphenylmethanol): a finite cyclic 1:1 adduct with 2,2'-dipyridylamine. |
PubMed: | Identification of benzhydrol as a urinary metabolite of diphenylmethane in the rat. |
PubMed: | Alkylation by secondary alcohols III: Fusion of medicinal sulfanilamides with benzhydrol. |
PubMed: | Visible-Light Actinometry and Intermittent Illumination as Convenient Tools to Study Ru(bpy)3Cl2 Mediated Photoredox Transformations. |
PubMed: | Glycosylated derivatives of benzophenone, benzhydrol, and benzhydril as potential venous antithrombotic agents. |
PubMed: | Structural development of benzhydrol-type 1'-acetoxychavicol acetate (ACA) analogs as human leukemia cell-growth inhibitors based on quantitative structure-activity relationship (QSAR) analysis. |
PubMed: | Structure-activity studies on benzhydrol-containing nipecotic acid and guvacine derivatives as potent, orally-active inhibitors of GABA uptake. |
PubMed: | [Enzyme inductive effect of zixoryn (3-trifluoromethyl-alpha-ethyl-benzhydrol) in neonatal jaundice]. |
PubMed: | [Analysis of the microsomal enzyme-induction of 3-trifluoromethyl-alpha-ethyl-benzhydrol(RGH 3332)]. |
PubMed: | Clinical trials with alpha (2-piperidyl) benzhydrol hydrochloride (meratran) and methylphenidylate (ritalin) in chronic apathetic schizophrenics. |
PubMed: | Studies in detoxication. 74. The metabolism of benzhydrol, benzophenone and p-hydroxybenzophenone. |
PubMed: | A clinical study of Frenquel (alpha (4-piperidyl) benzhydrol hydrochloride) in chronic schizophrenia. |
PubMed: | Clinical studies on alpha-(2-piperidyl) benzhydrol hydrochloride, a new antidepressant drug. |
PubMed: | Pharmacologic studies on a new central stimulant, alpha-(2-piperidyl) benzhydrol hydrochloride (MRD-108). |
PubMed: | [Determination of dimedrol and benzhydrol in the urine by high efficient liquid chromatographic method]. |
PubMed: | Alkylation of alcohols for gas chromatographic analysis by a phase transfer catalysis technique. Evaluation of benzhydrol benzylation in a one-phase system. |
PubMed: | [Several new basic derivatives of benzhydrol]. |
PubMed: | The pharmacologic activity of alpha-(4-piperidyl)-benzhydrol hydrochloride (azacyclonol hydrochloride); an ataractive agent. |
PubMed: | [Stimulant action of (alpha-(2-piperidyl)-benzhydrol]. |
PubMed: | The effects of alpha-(2-piperidyl) benzhydrol hydrochloride (meratran) on psychomotor performance in a group of aged males. |
PubMed: | Selection of patients for treatment with alpha-4-piperidyl benzhydrol hydrochloride. |
PubMed: | Alpha-(2-piperidyl) benzhydrol hydrochloride (pipradrol) as an adjunct in the dietary management of obesity. |
PubMed: | The clinical effects of alpha-(2-piperidyl)-benzhydrol hydrochloride (meratran) in states of inactivity in elderly psychiatric patients. |
PubMed: | Alpha-(2-piperidyl) benzhydrol hydrochloride, a new central stimulant, in the treatment of blepharospasm, spasmodic torticollis and narcolepsy; preliminary report. |
PubMed: | Photochemical generation and kinetic studies of a putative porphyrin-ruthenium(V)-oxo species. |
PubMed: | Synthesis of a "super bulky" guanidinate possessing an expandable coordination pocket. |
PubMed: | Donor-activated alkali metal dipyridylamides: co-complexation reactions with zinc alkyls and reactivity studies with benzophenone. |
PubMed: | Synthesis and psychobiological evaluation of modafinil analogs in mice. |
PubMed: | Discovery of novel tricyclic compounds as squalene synthase inhibitors. |
PubMed: | 3d early transition metal complexes supported by a new sterically demanding aryloxide ligand. |
PubMed: | Biotransformation of the UV-filter sulisobenzone: challenges for the identification of transformation products. |
PubMed: | Intensely luminescent homoleptic alkynyl decanuclear gold(I) clusters and their cationic octanuclear phosphine derivatives. |
PubMed: | Water-assisted self-photoredox of 3-(hydroxymethyl)benzophenone: an unusual photochemistry reaction in aqueous solution. |
PubMed: | Determination of ultraviolet filters in water samples by vortex-assisted dispersive liquid-liquid microextraction followed by gas chromatography-mass spectrometry. |
PubMed: | Changes in thyroid peroxidase activity in response to various chemicals. |
PubMed: | Metabolism and toxicity of benzophenone in isolated rat hepatocytes and estrogenic activity of its metabolites in MCF-7 cells. |
PubMed: | Changing the substrate specificity of P450cam towards diphenylmethane by semi-rational enzyme engineering. |
PubMed: | Discovery of atrop fixed alkoxy-aminobenzhydrol derivatives: novel, highly potent and orally efficacious squalene synthase inhibitors. |
PubMed: | Photoreduction of Azoalkanes by Direct Hydrogen Abstraction from 1,4-Cyclohexadiene, Alcohols, Stannanes, and Silanes. |
PubMed: | Covalent sidewall functionalization of single-walled carbon nanotubes: a photoreduction approach. |
PubMed: | Bioremediation of Bisphenol A and Benzophenone by Glycosylation with Immobilized Marine Microalga Pavlova sp. |
PubMed: | Development and validation of HPLC method for determination of clotrimazole and its two degradation products in spray formulation. |
PubMed: | Benzophenone-induced estrogenic potency in ovariectomized rats. |
PubMed: | Analytical methods based on transformations with hydrochloric acid. |
PubMed: | Semi-quantitative profile of regioisomeric monohydroxydiphenylmethane metabolites in rat urine, faeces and bile. |
PubMed: | Influence of ionising irradiation on clotrimazole in the solid state. |
PubMed: | Genotoxic activation of benzophenone and its two metabolites by human cytochrome P450s in SOS/umu assay. |
PubMed: | Estrogenic potency of benzophenone and its metabolites in juvenile female rats. |
PubMed: | Products Formed from Analogues of 1,1,1-Trichloro-2,2-Bis(p-Chlorophenyl) Ethane (DDT) Metabolites by Pseudomonas putida. |
PubMed: | The first occurrence in nature of two compounds from hops. |
PubMed: | Degradation of DDT and its analogs by Pseudomonas aeruginosa 640x. |
PubMed: | Reduction of benzophenone by SmI2: the role of proton donors in determining product distribution. |
PubMed: | Time-resolved fluorescence monitoring of aromatic radicals in photoinitiated processes. |
PubMed: | Bacterial and fungal cometabolism of 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) and its breakdown products. |
PubMed: | [Metabolism of fenofibrate and fenofibric acid in vivo and in cultures of liver epithelial cells (author's transl)]. |
PubMed: | [Not Available]. |
PubMed: | Comparative pharmacokinetics of diphenhydramine in camels and horses after intravenous administration. |
PubMed: | Synthesis of terfenadine. |
PubMed: | [Metabolic pathways of dipfluzine in rats]. |
PubMed: | Purification and characterization of an alcohol dehydrogenase from the Antarctic psychrophile Moraxella sp. TAE123. |
PubMed: | High performance liquid chromatographic determination of clotrimazole in pharmaceutical formulations. |
PubMed: | Miniaturized hollow fiber assisted liquid-phase microextraction and gas chromatography-mass spectrometry for determination of benzophenone and derivates in human urine sample. |
PubMed: | Asymmetric esterification of ketenes catalyzed by an N-heterocyclic carbene. |
PubMed: | Raman spectroscopic study of the solvation of decafluorobenzophenone ketyl radical and related compounds in 2-propanol at ambient to supercritical temperatures. |
PubMed: | The Mg-oppenauer oxidation as a mild method for the synthesis of aryl and metallocenyl ketones. |
PubMed: | Biotransformation of cyclizine in greyhounds. 2: N(1)-dealkylation and identification of some neutral and phenolic metabolites in canine urine by gas chromatography-mass spectrometry. |
PubMed: | Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents. |
PubMed: | Degradation mechanism of nefopam in solution under stressed storage conditions. |
PubMed: | The metabolism and disposition of 14C-fenofibrate in human volunteers. |
PubMed: | Metabolism of flumecinol in humans. |
PubMed: | Proton magnetic spectroscopic (PMR) determination of diphenhydramine hydrochloride in dosage forms. |
PubMed: | Determination of erythrocyte membrane-buffer partition coefficients by numerical analysis of multicomponent spectra. |
PubMed: | [Isolation and identification of some metabolites of clofedanol from human urine (author's transl]. |
PubMed: | Measurement of benzophenones in human urine samples by stir bar sorptive extraction and thermal desorption-gas chromatography-mass spectrometry. |
PubMed: | Toxicokinetics and metabolisms of benzophenone-type UV filters in rats. |
PubMed: | The FEMA GRAS assessment of aromatic substituted secondary alcohols, ketones, and related esters used as flavor ingredients. |
PubMed: | Simultaneous determination of benzophenone-type UV filters in water and soil by gas chromatography-mass spectrometry. |
PubMed: | N-8-Substituted benztropinamine analogs as selective dopamine transporter ligands. |
PubMed: | Enhancement of chain amplification in photoreactions of N-methoxypyridinium salts with alcohols. |
PubMed: | Chain amplification in photoreactions of N-alkoxypyridinium salts with alcohols: mechanism and kinetics. |
PubMed: | [Estrogenic activity of ultraviolet absorbers and the related compounds]. |
PubMed: | "Venetian blinds" mechanism of solvation/desolvation in palladium(II) wheel-and-axle organic-inorganic diols. |
PubMed: | Tuning copper-dioxygen reactivity and exogenous substrate oxidations via alterations in ligand electronics. |
PubMed: | Photoreduction of benzophenones by amines in room-temperature ionic liquids. |
PubMed: | Alkali and alkaline-earth metal ketyl complexes: isolation, structural diversity, and hydrogenation/protonation reactions |
PubMed: | Antineoplastic agents. 443. Synthesis of the cancer cell growth inhibitor hydroxyphenstatin and its sodium diphosphate prodrug. |
PubMed: | Estimation of impurity profiles of drugs and related materials. Part 9: HPLC investigation of flumecinol. |
PubMed: | Metabolism of 4,4'-methylene-bis-2-chloroaniline (MOCA) by rats in vivo and formation of N-hydroxy MOCA by rat and human liver microsomes. |
PubMed: | Effect of 3-trifluoromethyl-alpha-ethylbenzhydrol (flumecinol) on lipid peroxidation in early human placenta. |
PubMed: | Preclinical safety studies with Temofel, a new choleretic compound. |
PubMed: | New derivatization reactions in pharmaceutical analysis. |
PubMed: | The cell-wall phosphatase of cotton (Gossypium) is inhibited by kelthane. |
PubMed: | Metabolism of 14C-3-trifluoromethyl-alpha-ethylbenzhydrol in rats. |
PubMed: | Biological response of new activated acrylic bone cements with antiseptic properties. Histomorphometric analysis. |
PubMed: | Metabolism of a dicofol impurity alpha-chloro-DDT, but not dicofol or dechlorodicofol, to DDE in mice and a liver microsomal system. |
PubMed: | Allergic contact dermatitis from carbonless copy paper. |
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