Articles:
2-isopropyl-5-methylphenol
Notes:
a phenol obtained from thyme oil or other volatile oils. it is used as a stabilizer in pharmaceutic preparations. it has been used for its antiseptic, antibacterial, and antifungal actions, and was formerly used as a vermifuge. (dorland, 28th ed) Found in many essential oils. Esp. found in the Labiatae. Rich sources are thyme oil, seed oil of Ptychotis ajowan and oils of horsemint (Monarda punctata) and Ocimum spp. Flavouring ingredient
A phenol obtained from thyme oil or other volatile oils. It is used as a stabilizer in pharmaceutic preparations. It has been used for its antiseptic, antibacterial, and antifungal actions, and was formerly used as a vermifuge. (Dorland, 28th ed) -- Pubchem; In a 1994 report released by five top cigarette companies, thymol is one of the 599 additives to cigarettes. Its use or purpose, however, is unknown, like most cigarette additives. -- Wikipedia; In a 1994 report released by five top cigarette companies, thymol was listed as one of 599 additives to cigarettes. It is said to be added to improve the flavor of cigarettes, but as mentioned above, it relaxes the trachea.; Thymol (also known as 2-isopropyl-5-methylphenol), (IPMP) is a monoterpene phenol derivative of cymene, C10H14O, isomeric with carvacrol, found in oil of thyme, and extracted as a white crystalline substance of a pleasant aromatic odor and strong antiseptic properties. Thymol is only slightly soluble in water, but it is extremely soluble in alcohols and other organic solvents. It is also called "Isopropyl-m-cresol" and "hydroxy cymene".; Thymol is a monoterpene phenol derivative of cymene, C10H13OH, isomeric with carvacrol, found in oil of thyme, and extracted as a white crystalline substance of a pleasant aromatic odor and strong antiseptic properties. It is also called "hydroxy cymene". (from Webster's 1913 dictionary) -- Wikipedia
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Augustus Oils Ltd The Premier Supplier Augustus Oils Ltd, in harmony with nature - to present it at its best... A wealth of experience, expertise and knowledge has allowed Augustus to bridge the gulf in expectation and trust between growers and users of natural ingredients. The Company works in partnership with customers on the one hand, and growers, farmers and distillers on the other. Both users and producers can then focus on exactly what they do best, while skilled Augustus technicians closely monitor and control the delivered product. This ensures users can have the confidence that they will receive the best raw materials suited to their requirements. Email: Enquiries Email: Sales Email: web site enquiries Voice: +44 (0)1420 590555 Fax: +44 (0)1420 592420 Services Product(s): Thymol Crystals Thymol Natural
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Berje Inc. Where the world comes to its senses Where the world comes to its senses - Berjé is a global distributor of Essential Oils and Aromatic Chemicals. Berjé is a family-owned business that has been in operation for six decades. The company's origins and strength lie in a profound understanding of the supply and the quality of the diverse raw materials consumed by the flavor and fragrance industries. This base was expanded upon more than two decades ago to include fragrance production. The company's unparalleled raw material expertise is focused on the supply of essential oils and aromatic chemicals. This is supported by our long-standing relationships with a worldwide fabric of producers ensuring the greatest prospects for uninterrupted supply in markets that are often volatile and unpredictable. Email: For Information Email: For Sales Voice: 973-748-8980 Fax: 973-680-9618 Flavor Ingredients Fragrance Ingredients Functional Ingredients Happening at Berje Products List: View Product(s): Thymol Crystals Thymol Crystals Natural
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ECSA Chemicals International trading and distribution ECSA Group offers its customers in these business segments a complete 'one-stop shopping' solution. A hundred years on from its establishment, the Emanuele Centonze Holding SA has developed a solid presence in Switzerland and in Europe. The Group currently includes: ECSA Chemicals AG/ECSA Italia SRL Società con Unico Socio – ECSA Maintenance AG – ECSA Energy SA – Porta Ticino Easy Stop SA. Email: Info Email: Sales Email: Trading Email: Maintenance Email: Energy Voice: +41 91 695 88 00 Fax: +41 91 695 88 01 Linkedin Youtube RSS Feed ECSA Trade Company Profile Products List: View Product(s): Thymol, Natural Thymol
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Excellentia International Ingredients by Nature Exceptional quality and excellence in meeting our customers requirements. Excellentia International was founded in 2010 through the merger of Excellentia Flavors LLC and Polarome International. Collectively, these companies account for more than one hundred years of industry experience, and are recognized for exceptional quality and excellence in meeting our customers’ requirements. Email: Info Email: Sales Email: Regulatory Voice: 732.749.9840 Our Services Product(s): Thymol Natural Thymol FCC/NF
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Fleurchem, Inc. Have A Flavorful Day A leading global manufacturer and supplier of ingredients for Flavors, Fragrances, AromaTherapy, Foods, Beverages, Personal Care Products, and other uses. Operating out of the 200,000 sq. ft., former Hercules/PFW facility in Middletown, NY; Fleurchem produces a full range of natural isolates, synthetic chemicals & specialities, essential oils and flavors. Additionally, the company performs toll manufacturing, as well as custom chemical synthesis for a wide range of clients. Email: Information US Voice: 845-341-2100 US Fax: 845-341-2121 Product(s): thymol thymol natural
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Foreverest Resources Ltd. Leading pine based chemicals supplier Supplying turpentine based and natural/extracted flavor & fragrance ingredients. FOREVERESTA® F&F RAW MATERIALS is a range of natural extracts and synthetic aroma chemicals based on the rich material resources and great supply network from China, which was applied for specialty chemicals industry. The markets cover application areas on food, beverage, custom fragrance, fine perfume, personal care, cosmetics, etc. Foreverest Resources Ltd. is a materials supplier, exporting gum turpentine based, terpene derivertives and natural/extracted monomers and intermediates from China since 1988. We offers high quality raw materials for flavors and fragrances synthetic manufacturing in the world. Email: Info Email: Sales Voice: +86 (0)592 5105533 Fax: +86 (0)592 5151667 foreverest 
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Global Essence Inc. Preferred Partner Accommodate each customers unique needs. Global Essence was founded in 1993 as a two person operation servicing regional customers in the New York/ New Jersey area. In the twenty years since, it has grown into a multinational operation with offices in the US, UK, and Singapore. These offices allow Global to provide regional support to its customers worldwide. As the world continues become more connected, this approach positions Global to continue to offer the highest quality products and experience to all of its customers. Email: Info US Email: Info Voice: +44 (0) 1279 876666 Fax: +44 (0)1279 876646 US Voice: 001 732 677 1100 US Fax: 001 732 677 1107 Blog Press Release News Product(s): Thymol
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Indukern, S.A. F&F Ingredients Division Commitment to quality Idukern F&F Ingredients is your partner for the fragrance and flavor ingredients. Indukern F&F focuses in particular on the service it offers its clients in terms of quality, speed and direct consultancy with more than 1600 different products in stock ready for prompt shipment: Aromachemicals, Essential Oils and Natural Isolates. Email: Info Email: Luciana Soares (Brazil) Email: Gabriela Garcia (Mexico) Email: Jorge Eduardo Clavijo (Colombia) Voice: +34 93 506 91 00 Fax: +34 93 506 91 95 Services Quality Facilities Products List: View Product(s): THYMOL THYMOL EXTRA THYMOL NATURAL
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Jiangyin Healthway International Trade Co., Ltd Independent Ingredients Supplier We provide custom synthesis and contract manufacturing from milligrams to metric tonnes. Jiangyin Healthway International Trade Co., Ltd is a professional company, main engaged in manufacturing and exporting aroma chemicals ,food additives , cosmetic ingredient ,pharmaceutical intermediates & other fine chemicals; especially on aroma chemicals , as the major manufacturer of heterocyclic and sulphur aroma compounds , we are the leading independent ingredients supplier to the flavour and fragrance industries in China, can offer hundreds of different high quality aroma chemicals. Email: Info Email: Sales Voice: 86-510-86023169 Fax: 86-510-86023170 Mobile 0086-13093133011 Services Biochemical Natural Food Colour New functional food ingredients Product(s): HLW-FC006 Thymol
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Lluch Essence S.L. A family company dedicated to sales and distribution Flexibility, availability, price and quality. Flexibility, availability, price and quality make LLUCH ESSENCE S.L. one of Europe’s references when it comes to essential oils and aroma chemicals, and it is now well known all around the world. Email: Info Voice: 34 93 379 38 49 Fax: 34 93 370 65 04 Linkedin Product(s): THYMOL THYMOL NATURAL EX-AJOWAN
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M&U International LLC Steady supply & demand Meeting customers increasing demands at home as well as abroad. M&U dedicates itself to the development and production of new products as well as continuously promoting those new products. We’ve maintained a steady supply&demand relationship with a large number of manufacturers at home and abroad. We’ve developed an extensive network and because of our relationships with these manufacturers, we’re able to provide a stable supply of great quality materials. We’re located in China’s largest communications hub, Shanghai and in the U.S. near one of the largest sea ports on the East Coast. The strategic locations of our facilities ensure convenient, prompt and secure delivery of our products to our customers. Email: Sales US Email: Sales Voice: +86-21-32515501 60762991 60762992 Fax: +86-21-32515502 64204960 US Voice: 908-359-9000 US Fax: 908-359-9002 News Product(s): A0500 THYMOL CRYSTAL
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Moellhausen S.P.A. THE CHEMISTRY OF EMOTIONS Innovation and commitment in the name of excellence. After 50 years in business, Moellhausen stands out as one of the world’s leading family-run companies in the industry of flavors and fragrances, raw materials, and specialties. Voice: +39 039.685.6262 Fax: +39 039.685.6263 Facebook Twitter Linkedin Youtube A network of knowledge to grow together Sustainability is at the foundation of a Pervasive technology and total control Product(s): 136900 THYMOL 1000634 THYMOL IN. 1000635 THYMOL DIST.
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Penta International Corporation Chemistry innovation At Penta, our products and services help businesses do business better. For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes. US Email: Technical Services US Email: Sales US Voice: (973) 740-2300 US Fax: (973) 740-1839 Product(s): 20-51500 THYMOL CRYSTALS 20-51505 THYMOL CRYSTALS NF 20-51525 THYMOL NF FINE POWDER 60 MESH 20-51501 THYMOL CRYSTALS NATURAL 20-51503 THYMOL CRYSTALS FCC
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PerfumersWorld Ltd. feeeel... the smell! The one-stop resource for the creative perfumer. No minimum orders. Aroma chemicals, essential oils, isolates, pheremones, absolutes, resinoids, FleuressenceTM key bases, PWx FactorTM, solubilizers, kits, creation systems, workshops, training, distance learning, The PerfumersWorld Perfumer's Studio, The Perfumer’s Formulation Bulletin, perfumery software, bespoke creation, analysis, consultancy, project counselling, trouble-shooting, unperfumed product bases, bottles, smelling strips, scales, distillation, equipment and inspiration! Email: Enquiries Email: Sales Voice: +66(0)2-99-800-80 Fax: +66(0)2-99-800-80 PerfumersWorld
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Prodasynth PRODUCTEUR PAR ESSENCE Chemical specialist in manufacturing, distributing and sourcing of tailor-made ingredients for the Flavour & Fragrance industry. Today we are also proud to say, we have created an important range of Natural Molecules which can be found in our Raw Material Compendium. The versatility of our small but efficient structure is one of our main strengths when trying to fulfill our clients' requirements. Email: Info: Email: Karine Cohen Voice: (33) 4 93 09 00 11 Fax: (33) 4 22 13 07 38 New Catalog Products List: View Product(s): THYMOL (> 98,5%)
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Sigma-Aldrich Complete Supply Chain The perfect blend of products and services that bring your creativity to life. Sigma-Aldrich is a leading Life Science and High Technology company dedicated to providing high-quality, safe and certified flavor ingredients with transparent and easily accessible documentation to customers around the globe. Sigma-Aldrich also provides a suite of analytical tools that allow food analysts to simplify sample preparation, cleanup and analysis steps, while increasing sensitivity to trace ingredients and harmful substances to meet regulations and quality standards. Email: Information US Email: Sales US Voice: 800-244-1173 US Fax: 800-368-4661 Facebook Twitter Instagram Linkedin Flavors and Fragrances Analysis FandF Newsletter Subscription Flavors and Fragrances Learning Center Certified Food Grade Products Product(s): W306606 Thymol, ≥99%, FCC, FG SDS
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Useful in: mint, savory spices, fruity citrus.600349 Thymol cryst. PH 131138 Thymol dist.
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The Good Scents Company Fragrance Creators For your fragrance creations. US Email: Sales US Voice: 414-764-2659 Product(s): thymol
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R C Treatt and Co Ltd Innovative ingredient solutions World-leading innovative ingredient solutions provider for the flavour, fragrance and FMCG industries. We offer innovative and trend-setting product concepts for our customers, collaborating with them to create true value for their products. Email: Enquiries US Email: Enquiries Voice: +44 (0) 1284 702500 Fax: +44 (0) 1284 703809 US Voice: +1 863 668 9500 US Fax: +1 863 668 3388 Twitter Linkedin Youtube News Product(s): Thymol Crystals Thymol Natural
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Ernesto Ventós S.A. Continued Customer Satisfaction We employ our five senses to do our job well. Ventós has specialized in the distribution of raw materials for the flavour and fragrance industry. With more than 1700 references permanently available from stock, we offer a just-in-time response to our customer needs, being able to deliver from 1kg to several tonnes all over the world. Email: Information Email: Gemma Parramon (Europe) US Email: Jordi Sort (Northern Europe and US) Email: Olivia Gautier (Asia, Africa and Oceania ) Email: Ramon Rubau (Latin America) Voice: +34 934706210 Fax: +34 934733010 Press Ads Videos Product(s): THYMOL THYMOL INDIA THYMOL NATURAL (EX-AJOWAN OIL)
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Vigon International, Inc. Passion for Simplicity Manufacturer and supplier of high quality flavor and fragrance ingredients. The growth and success of Vigon is due in large part to a unique corporate concept that Vigon has developed and established within the industry: Creative Partnerships. This partnership concept has been and continues to be the foundation and guiding principle for all of Vigon's activities. US Email: Sales US Voice: 570-476-6300 US Fax: 570-476-1110 Facebook Twitter Linkedin Newsletter Blog Products List: View Product(s): 501119 Thymol Crystals
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| Fragrance Demo Formulas | ||
| CAS Number: | 89-83-8 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 201-944-8 | |
| FDA UNII: | 3J50XA376E | |
| Nikkaji Web: | J10.606B | |
| Beilstein Number: | 1907135 | |
| MDL: | MFCD00002309 | |
| CoE Number: | 174 | |
| XlogP3: | 3.30 (est) | |
| Molecular Weight: | 150.22078000 | |
| Formula: | C10 H14 O | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| JECFA Food Flavoring: | 709 thymol |
| DG SANTE Food Flavourings: | 04.006 thymol |
| FEMA Number: | 3066 thymol |
| FDA: | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF): | 89-83-8 ; THYMOL |
| FDA Regulation: | |
| FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION Subpart F--Flavoring Agents and Related Substances Sec. 172.515 Synthetic flavoring substances and adjuvants. FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS Subpart B--Substances for Use Only as Components of Adhesives Sec. 175.105 Adhesives. | |
Physical Properties:
| Appearance: | white crystalline solid (est) |
| Assay: | 98.00 to 100.00 % |
| Food Chemicals Codex Listed: | Yes |
| Melting Point: | 49.00 to 51.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 231.00 to 232.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 143.00 to 144.00 °C. @ 50.00 mm Hg |
| Congealing Point: | 49.30 °C. |
| Vapor Pressure: | 0.038000 mmHg @ 25.00 °C. |
| Flash Point: | 216.00 °F. TCC ( 102.22 °C. ) |
| logP (o/w): | 3.300 |
| Shelf Life: | 36.00 month(s) or longer if stored properly. |
| Storage: | store in cool, dry place in tightly sealed containers, protected from heat and light. |
| Soluble in: | |
| alcohol | |
| paraffin oil | |
| water, 900 mg/L @ 25 °C (exp) | |
| Insoluble in: | |
| water | |
| Stability: | |
| non-discoloring in most media | |
Organoleptic Properties:
| Odor Type: herbal | |
| Odor Strength: | high , recommend smelling in a 1.00 % solution or less |
| Substantivity: | 176 hour(s) at 20.00 % in dipropylene glycol |
| herbal thyme phenolic medicinal camphoreous | |
| Odor Description: at 1.00 % in dipropylene glycol. | herbal thyme phenolic medicinal camphor Luebke, William tgsc, (1983) |
| spicy phenolic thyme chemical medicinal camphoreous | |
| Odor Description: | Spicy, phenolic and thymol with a chemical, medicinal, camphoreous nuance Mosciano, Gerard P&F 21, No. 3, 51, (1996) |
| Flavor Type: phenolic | |
| phenolic medicinal woody spicy | |
| Taste Description: | Phenolic, medicinal, woody and spicy Mosciano, Gerard P&F 21, No. 3, 51, (1996) |
| Odor and/or flavor descriptions from others (if found). | |
| Symrise | |
| Thymol cryst. | |
| Odor Description: | warm, thyme-like, medicinal |
| Taste Description: | strong spicy, thyme-like, phenolic, herbal Useful in: mint, savory spices, fruity citrus. |
| Moellhausen | |
| THYMOL | |
| Odor Description: | phenolic, camphoraceous, thyme |
| Taste Description: | aromatic, medicinal |
Cosmetic Information:
| CosIng: | cosmetic data |
| Cosmetic Uses: |
denaturants hair dyeing agents masking agents |
Suppliers:
Safety Information:
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| C N - Corrosive, Dangerous for the environment. | |
|
R 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R 34 - Causes burns. R 51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. S 01/02 - Keep locked up and out of the reach of children. S 20/21 - When using do not eat, drink or smoke. S 22 - Do not breath dust. S 23 - Do not breath vapour. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 28 - After contact with skin, wash immediately with plenty of water. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection. S 38 - In case of insufficient ventlation, wear suitable respiratory equipment. S 45 - In case of accident or if you feel unwell seek medical advice immediately. S 61 - Avoid release to the environment. Refer to special instructions/safety data sheet. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| Acute toxicity, Oral (Category 4), H302 Serious eye damage (Category 1), H318 Acute aquatic toxicity (Category 2), H401 Chronic aquatic toxicity (Category 2), H411 | |
| GHS Label elements, including precautionary statements | |
| Pictogram |    |
| Signal word | Danger |
| Hazard statement(s) | |
| H302 - Harmful if swallowed H314 - Causes severe skin burns and eye damage H318 - Causes serious eye damage H401 - Toxic to aquatic life H411 - Toxic to aquatic life with long lasting effects | |
| Precautionary statement(s) | |
| P260 - Do not breathe dust/fume/gas/mist/vapours/spray. P264 - Wash skin thouroughly after handling. P270 - Do not eat, drink or smoke when using this product. P273 - Avoid release to the environment. P280 - Wear protective gloves/protective clothing/eye protection/face protection. P301 + P312 - IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P301 + P330 + P331 - IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303 + P361 + P353 - IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P304 + P340 - IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310 - Immediately call a POISON CENTER or doctor/physician. P363 - Wash contaminated clothing before reuse. P391 - Collect spillage. Hazardous to the aquatic environment P405 - Store locked up. P501 - Dispose of contents/ container to an approved waste disposal plant. | |
| Oral/Parenteral Toxicity: | |
|
oral-rat LD50 980 mg/kg BEHAVIORAL: COMA BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964. oral-mouse LD50 640 mg/kg PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION Osaka Shiritsu Daigaku Igaku Zasshi. Journal of the Osaka City Medical Center. Vol. 5, Pg. 111, 19 intravenous-mouse LD50 100 mg/kg BEHAVIORAL: SLEEP Journal of Medicinal Chemistry. Vol. 23, Pg. 1350, 1980. intraperitoneal-mouse LD50 110 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA Quarterly Journal of Crude Drug Research. Vol. 19, Pg. 1, 1981. oral-guinea pig LD50 880 mg/kg BEHAVIORAL: COMA GASTROINTESTINAL: GASTRITIS BEHAVIORAL: TREMOR Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964. oral-cat LDLo 250 mg/kg "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 172, 1959. intravenous-dog LDLo 150 mg/kg LUNGS, THORAX, OR RESPIRATION: DYSPNEA Therapie. Vol. 3, Pg. 109, 1948. intraperitoneal-guinea pig LDLo 300 mg/kg "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 172, 1959. intravenous-rabbit LDLo 60 mg/kg "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 172, 1959. oral-rabbit LDLo 750 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 17, Pg. 261, 1921. | |
| Dermal Toxicity: | |
|
subcutaneous-mouse LD50 243 mg/kg SKIN AND APPENDAGES (SKIN): HAIR: OTHER BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Osaka Shiritsu Daigaku Igaku Zasshi. Journal of the Osaka City Medical Center. Vol. 5, Pg. 111, 1956. subcutaneous-frog LDLo 150 mg/kg "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 172, 1959. subcutaneous-guinea pig LDLo 1100 mg/kg "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 172, 1959. subcutaneous-rat LDLo 1600 mg/kg "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 172, 1959. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | flavor and fragrance agents | ||
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice | |||
| Recommendation for thymol usage levels up to: | |||
| 0.1000 % in the fragrance concentrate. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 51.00 (μg/capita/day) | ||
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 160.00 (μg/capita/day) | ||
| Structure Class: | I | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 3 | |||
| Click here to view publication 3 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | 5.00000 | 6.50000 | |
| beverages(nonalcoholic): | 2.50000 | 11.00000 | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | - | 100.00000 | |
| condiments / relishes: | - | - | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | - | 44.00000 | |
| fruit ices: | - | 44.00000 | |
| gelatins / puddings: | - | - | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | - | 9.40000 | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | - | - | |
| milk products: | - | - | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | - | - | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
Safety References:
| European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): | |
| Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 22 (FGE.22): Ring-substituted phenolic substances from chemical groups 21 and 25 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) View page or View pdf | |
| Flavouring Group Evaluation 58 (FGE.58) Consideration of phenol derivatives evaluated by JECFA (55th meeting) structurally related to ring substituted phenolic substances evaluated by EFSA in FGE.22 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf | |
| Flavouring Group Evaluation 60 (FGE.60): Consideration of eugenol and related hydroxyallylbenzene derivatives evaluated by JECFA (65th meeting) structurally related to ring- substituted phenolic substances evaluated by EFSA in FGE.22 (2006) View page or View pdf | |
| Scientific Opinion on Flavouring Group Evaluation 22, Revision 1 (FGE.22Rev1): Ring-substituted phenolic substances from chemical groups 21 and 25 View page or View pdf | |
| Scientific Opinion on the safety and efficacy of phenol derivatives containing ring-alkyl, ring-alkoxy and side-chains with an oxygenated functional group (chemical group 25) when used as flavourings for all species View page or View pdf | |
| Conclusion on the peer review of the pesticide risk assessment of the active substance thymol View page or View pdf | |
| Review of substances/agents that have direct beneficial effect on the environment: mode of action and assessment of efficacy View page or View pdf | |
| Outcome of the consultation with Member States, the applicant and EFSA on the pesticide risk assessment for thymol in light of confirmatory data View page or View pdf | |
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA GENetic TOXicology: | Search |
| EPA Substance Registry Services (TSCA): | 89-83-8 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 6989 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WISER: | UN 3261 |
| WGK Germany: | 2 |
| 5-methyl-2-propan-2-ylphenol | |
| Chemidplus: | 0000089838 |
| RTECS: | PX2275000 for cas# 89-83-8 |
References:
| 5-methyl-2-propan-2-ylphenol | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 89-83-8 |
| Pubchem (cid): | 6989 |
| Pubchem (sid): | 134970607 |
| Pherobase: | View |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C09908 |
| HMDB (The Human Metabolome Database): | HMDB01878 |
| FooDB: | FDB014795 |
| YMDB (Yeast Metabolome Database): | YMDB01647 |
| Export Tariff Code: | 2907.19.4000 |
| Typical G.C. | |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
| Formulations/Preparations: •present in listerine antiseptic •present in bensulfoid lotion •technical, nf, reagent | |
Potential Blenders and core components note
Potential Uses:
| ajowan | FL/FR | |
| alpine bouquet | FR | |
| bouquet | FR | |
| florida soap | FR | |
| herbal | FR | |
| mint | FR | |
| oregano | FR | |
| peppermint | FR | |
| pizza | FR | |
| spice | FR | |
| thyme oil white replacer | FR | |
| windsor soap | FR | |
| wintergreen | FR | |
| yew | FR |
Occurrence (nature, food, other): note
| ajowan seed oil turkey @ 61.31% Data GC Search Trop Picture | |
| anise oil Search Trop Picture | |
| armoise oil morocco @ trace% Data GC Search Trop Picture | |
| artemisia variabilis flower oil italy @ 0.80% Data GC Search Trop Picture | |
| basil leaf Search Trop Picture | |
| basil oil Search Trop Picture | |
| basil shoot oil Search Trop Picture | |
| bay laurel leaf oil Search Trop Picture | |
| bergamot plant wild Search Trop Picture | |
| blackberry fruit Search PMC Picture | |
| blueberry fruit Search Trop Picture | |
| boldo leaf oil italy @ 0.07% Data GC Search Trop Picture | |
| boldus leaf oil chile @ 0.03% Data GC Search Trop Picture | |
| carrot seed oil spain @ trace-0.35% Data GC Search Trop Picture | |
| cascarilla bark oil @ trace% Data GC Search Trop Picture | |
| celery seed Search Trop Picture | |
| celery seed oil Search Trop Picture | |
| chenopodium ambrosioides oil @ 2.0% Data GC Search Trop Picture | |
| cistus oil @ 0.2% Data GC Search Trop Picture | |
| clary sage oil greece @ trace% Data GC Search Trop Picture | |
| coriander seed oil Search Trop Picture | |
| corn seed oil Search Trop Picture | |
| corn silk Search Trop Picture | |
| crithmum maritimum l. oil turkey @ <0.10% Data GC Search Trop Picture | |
| croton cajucara benth. leaf oil brazil @ 0.10% Data GC Search Trop Picture | |
| croton flavens l. (welensali) leaf oil curacao @ trace% Data GC Search Trop Picture | |
| cumin seed oil Search Trop Picture | |
| dill herb Search Trop Picture | |
| dill shoot oil Search Trop Picture | |
| dill weed oil cuba @ 0.16% Data GC Search Trop Picture | |
| dill weed oil reunion @ trace% Data GC Search Trop Picture | |
| eucalyptus camaldulensis dehn. leaf oil jerusalem @ 0.40% Data GC Search Trop Picture | |
| eucalyptus delegatensis r. baker leaf oil ethiopia @ 0.40% Data GC Search Trop Picture | |
| eucalyptus globulus bud oil @ 0.14% Data GC Search Trop Picture | |
| eucalyptus globulus fruit oil @ 0.28% Data GC Search Trop Picture | |
| eucalyptus globulus oil rwanda @ trace% Data GC Search Trop Picture | |
| featherfew leaf oil @ trace% Data GC Search Trop Picture | |
| fir needle oil canada @ 0.00-2.89% Data GC Search Trop Picture | |
| geranium rose-scented oil (pelargonium spp.) cuba @ 0.10% Data GC Search Trop Picture | |
| ginkgo biloba wood Search Trop Picture | |
| grapefruit Search Trop Picture | |
| guava leaf oil cuba @ 0.10% Data GC Search Trop Picture | |
| helichrysum arenarium (l.) moench oil hungary @ 0.60% Data GC Search Trop Picture | |
| horsemint shoot Search Trop Picture | |
| hyssop shoot Search Trop Picture | |
| laurel leaf oil turkey @ trace% Data GC Search Trop Picture | |
| lavender oil france @ trace% Data GC Search Trop Picture | |
| lemon balm shoot Search Trop Picture | |
| lemon leaf oil Search Trop Picture | |
| lemon pericarp oil Search Trop Picture | |
| lemon verbena oil morocco @ 0.3% Data GC Search Trop Picture | |
| licorice Search Trop Picture | |
| lime oil expressed florida @ trace% Data GC Search Trop Picture | |
| lippia aff. gracillis h.b.k. leaf oil brazil @ 8.00% Data GC Search Trop Picture | |
| mandarin fruit Search Trop Picture | |
| mandarin oil @ trace% Data GC Search Trop Picture | |
| mandarin oil avana @ 0.02% Data GC Search Trop Picture | |
| mandarin oil avana @ 0.11% Data GC Search Trop Picture | |
| mandarin oil italy @ 0.05% Data GC Search Trop Picture | |
| mandarin oil italy @ trace% Data GC Search Trop Picture | |
| mangrove bark red oil cuba @ 0.70% Data GC Search Trop Picture | |
| marjoram oil Search Trop Picture | |
| marjoram oil @ 0.51% Data GC Search Picture | |
| marjoram oil spain @ trace% Data GC Search Trop Picture | |
| marjoram oil sweet cuba @ 11.55% Data GC Search Trop Picture | |
| marjoram oil sweet cyprus @ 0.00-0.10% Data GC Search Trop Picture | |
| marjoram oil sweet morocco @ 0.56% Data GC Search Trop Picture | |
| marjoram oil sweet turkey @ 0.48-1.53% Data GC Search Trop Picture | |
| marjoram pot oil turkey @ 0.17-39.81% Data GC Search Trop Picture | |
| marjoram shoot oil Search Trop Picture | |
| mikan peel oil @ trace% Data GC Search Trop Picture | |
| nepeta betonicifolia c.a. meyer oil turkey @ 1.20% Data GC Search Trop Picture | |
| orange fruit Search Trop Picture | |
| orange peel oil bitter china @ 0.12% Data GC Search Trop Picture | |
| oregano flower oil Search Trop Picture | |
| oregano leaf Search Trop Picture | |
| oregano oil Search Trop Picture | |
| oregano oil mexico @ 46.30% Data GC Search Trop Picture | |
| oregano plant Search Trop Picture | |
| oregano plant Search Trop Picture | |
| oregano shoot Search Trop Picture | |
| oregano shoot Search Trop Picture | |
| oregano shoot oil Search Trop Picture | |
| origanum oil greece @ 0.25% Data GC Search Trop Picture | |
| osmanthus absolute @ 0.23% Data GC Search Trop Picture | |
| parsley leaf Search Trop Picture | |
| parsley leaf oil cuba @ 0.02% Data GC Search Trop Picture | |
| pennyroyal oil cuba @ 3.03% Data GC Search Trop Picture | |
| peppermint oil Search Trop Picture | |
| petitgrain lemon oil Search Trop Picture | |
| peucedanum petiolare (dc) boiss oil iran @ 0.10% Data GC Search Trop Picture | |
| pimenta leaf oil @ 1.00% Data GC Search Trop Picture | |
| plectranthus glandulosus hook f. leaf oil cameroon @ 0.40% Data GC Search Trop Picture | |
| prangos uechtritzii boiss. et hausskn. fruit oil turkey @ 3.50% Data GC Search Trop Picture | |
| rosemary oil CO2 extract @ 0.69% Data GC Search Trop Picture | |
| rosemary oil france @ 0.00-0.18% Data GC Search Trop Picture | |
| rosemary oil turkey @ 0.90% Data GC Search Trop Picture | |
| rosemary plant Search Trop Picture | |
| rosemary shoot oil Search Trop Picture | |
| sage leaf Search Trop Picture | |
| sage oil Search Trop Picture | |
| sage oil dalmatian @ 0.20% Data GC Search Trop Picture | |
| sage oil england @ 0.20% Data GC Search Trop Picture | |
| salvia atropatana bunge oil iran @ 0.40% Data GC Search Trop Picture | |
| salvia officinalis seed oil tunisia @ 0.37% Data GC Search Trop Picture | |
| salvia sclarea seed oil tunisia @ 0.10% Data GC Search Trop Picture | |
| satureja khuzistanica jamzad oil iran @ trace% Data GC Search Trop Picture | |
| savory oil summer @ 0.12-0.14% Data GC Search Trop Picture | |
| savory oil winter @ 0.30% Data GC Search Trop Picture | |
| savory oleoresin winter @ 0.30% Data GC Search Trop Picture | |
| savory summer savory plant Search Trop Picture | |
| savory winter savory oil Search Trop Picture | |
| savory winter savory plant Search Trop Picture | |
| spearmint oil Search Trop Picture | |
| tanacetum annum l. oil marocco @ 0.80% Data GC Search Trop Picture | |
| tansy oil marocco @ 1.20% Data GC Search Trop Picture | |
| tea leaf Search Trop Picture | |
| thyme Search Picture | |
| thyme absolute @ 43.10% Data GC Search Trop Picture | |
| thyme oil Search Trop Picture | |
| thyme oil portuguese @ 0.2% Data GC Search Trop Picture | |
| thyme oil red CO2 extract @ 36.59% Data GC Search Trop Picture | |
| thyme oil red CO2 extract spain @ 13.2% Data GC Search Trop Picture | |
| thyme oil red india @ 60.1% Data GC Search Trop Picture | |
| thyme oil red spain @ 16.55-38.24% Data GC Search Trop Picture | |
| thyme oil spain @ 34.18% Data GC Search Trop Picture | |
| thyme oil spain @ 71.84% Data GC Search Trop Picture | |
| thyme oil wild or creeping canada @ 3.50% Data GC Search Trop Picture | |
| thyme oil wild or creeping pakistan @ 42.63% Data GC Search Trop Picture | |
| thyme plant Search Trop Picture | |
| thyme shoot Search Trop Picture | |
| thymus richardii pers. subsp. nitidus (guss.) jalas oil italy @ 1.30% Data GC Search Trop Picture | |
| valerian root oil @ 0.1% Data GC Search Trop Picture | |
| walnut black walnut oil Search Trop Picture | |
| wormseed oil america @ 0.02% Data GC Search Trop Picture | |
| wormseed oil spain @ 1.0% Data GC Search Trop Picture | |
| wormwood oil annus france @ 0.00-0.83% Data GC Search Trop Picture | |
| yarrow oil greece @ 0.10% Data GC Search Trop Picture | |
| yuzu peel oil c.p. @ 0.12-0.21% Data GC Search Trop Picture | |
| yuzu peel oil CO2 extract @ 0.24-1.10% Data GC Search Trop Picture |
Synonyms:
| apiguard | |
| p- | cymen-3-ol |
| para- | cymen-3-ol |
| 3-p- | cymenol |
| 3-para- | cymenol |
| a- | cymophenol |
| alpha- | cymophenol |
| 3- | hydroxy p-cymene |
| 2- | hydroxy-1-isopropyl-4-methylbenzene |
| 3- | hydroxy-1-methyl-4-isopropylbenzene |
| 1- | hydroxy-5-methyl-2-isopropylbenzene |
| 3- | hydroxy-p-cymene |
| 3- | hydroxy-para-cymene |
| 5- | methyl-2-(1-methyl ethyl) phenol |
| 5- | methyl-2-(1-methylethyl)-phenol |
| 5- | methyl-2-(1-methylethyl)phenol |
| 5- | methyl-2-(methylethyl)phenol |
| 5- | methyl-2-(propan-2-yl)phenol |
| 5- | methyl-2-isopropyl-1-phenol |
| 5- | methyl-2-isopropylphenol |
| 5- | methyl-2-propan-2-ylphenol |
| 5- | methyl-2,1-methyl ethyl phenol |
| 1- | methyl-3-hydroxy-4- isopropylbenzene |
| 1- | methyl-3-hydroxy-4-isopropylbenzene |
| 3- | methyl-6-isopropylphenol |
| phenol, 5-methyl-2-(1-methylethyl)- | |
| iso | propyl cresol |
| 6-iso | propyl-3-methyl phenol |
| 6-iso | propyl-3-methylphenol |
| 2-iso | propyl-5-methyl phenol |
| 2-iso | propyl-5-methyl-phenol |
| 2-iso | propyl-5-methylphenol |
| 6-iso | propyl-m-cresol |
| 6-iso | propyl-meta-cresol |
| 6-iso | propyl-p-cresol |
| 6-iso | propyl-para-cresol |
| thyme camphor | |
| thymic acid | |
| thymol cryst. | |
| thymol crystal natural | |
| thymol crystals | |
| thymol crystals (natural) | |
| thymol crystals N.F. | |
| thymol crystals natural | |
| thymol crystals NF | |
| thymol crystals U.S.P. | |
| thymol dist. | |
| thymol extra | |
| thymol natural | |
| thymol NF fine powder 60 mesh | |
| thymol USP natural |