Category: indirect food additives: adhesives and components of coatings
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | colorless clear oily liquid (est) |
Assay: | 99.00 to 100.00 %
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Food Chemicals Codex Listed: | No |
Specific Gravity: | 1.04900 to 1.05300 @ 15.50 °C.
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Pounds per Gallon - (est).: | 8.729 to 8.762
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Melting Point: | -35.00 °C. @ 760.00 mm Hg
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Boiling Point: | 337.00 to 340.00 °C. @ 760.00 mm Hg
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Vapor Pressure: | 1.000000 mmHg @ 147.00 °C. |
Vapor Density: | 9.6 ( Air = 1 ) |
Flash Point: | 340.00 °F. TCC ( 171.11 °C. )
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logP (o/w): | 4.500 |
Soluble in: |
| alcohol | | solvents | | water, 2.351 mg/L @ 25 °C (est) | | water, 11.2 mg/L @ 25 °C (exp) |
Insoluble in: |
| water |
Organoleptic Properties:
Odor Strength: | low |
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Odor Description: at 100.00 %. | faint odor |
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Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | T N - Toxic, Dangerous for the environment. |
R 50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R 61 - May cause harm to the unborn child. R 62 - Possible risk of impaired fertility. S 02 - Keep out of the reach of children. S 20/21 - When using do not eat, drink or smoke. S 23 - Do not breath vapour. S 24/25 - Avoid contact with skin and eyes. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection. S 45 - In case of accident or if you feel unwell seek medical advice immediately. S 53 - Avoid exposure - obtain special instructions before use. S 61 - Avoid release to the environment. Refer to special instructions/safety data sheet.
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
oral-rat LD50 7499 mg/kg Weisheng Dulixue Zazhi. Journal of Health Toxicology. Vol. 5, Pg. 264, 1991.
intramuscular-rat LD50 > 8000 mg/kg "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New York, John Wiley & Sons, Inc., 1958-63Vol. 2, Pg. 1904, 1963.
oral-mouse LD50 3474 mg/kg Weisheng Dulixue Zazhi. Journal of Health Toxicology. Vol. 5, Pg. 264, 1991.
intravenous-mouse LD50 720 mg/kg Kanagawa-ken Eisei Kenkyusho Kenkyu Hokoku. Bulletin of Kanagawa Prefectural Public Health Laboratories. Vol. (3), Pg. 19, 1973.
intraperitoneal-mouse LD50 3570 mg/kg Journal of the Society of Cosmetic Chemists. Vol. 28, Pg. 667, 1977.
oral-guinea pig LD50 10000 mg/kg BEHAVIORAL: WITHDRAWAL
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 24(3), Pg. 25, 1980.
oral-human TDLo 140 mg/kg BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
GASTROINTESTINAL: NAUSEA OR VOMITING
KIDNEY, URETER, AND BLADDER: OTHER CHANGES Schweizerische Medizinische Wochenschrift. Vol. 84, Pg. 1243, 1954.
oral-mammal (species unspecified) LD50 5000 mg/kg Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 39(4), Pg. 86, 1974.
unreported-mouse LD50 8140 mg/kg LUNGS, THORAX, OR RESPIRATION: DYSPNEA
BEHAVIORAL: GENERAL ANESTHETIC
BEHAVIORAL: ATAXIA Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 55(6), Pg. 86, 1990.
intraperitoneal-rat LD50 3050 uL/kg Journal of Pharmaceutical Sciences. Vol. 61, Pg. 51, 1972.
unreported-rat LD50 9410 mg/kg BEHAVIORAL: ATAXIA
BEHAVIORAL: GENERAL ANESTHETIC
LUNGS, THORAX, OR RESPIRATION: DYSPNEA Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 55(6), Pg. 86, 1990.
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Dermal Toxicity: |
skin-rabbit LD50 > 20 ml/kg Union Carbide Data Sheet. Vol. 12/29/1971
skin-rat LDLo 6000 mg/kg "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 44, 1982.
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Inhalation Toxicity: |
inhalation-rat LC50 4250 mg/m3 Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 17(8), Pg. 26, 1973.
inhalation-mouse LC50 25000 mg/m3/2H "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 44, 1982.
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Safety in Use Information:
Category: | indirect food additives: adhesives and components of coatings |
Recommendation for dibutyl phthalate usage levels up to: | | not for fragrance use.
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Recommendation for dibutyl phthalate flavor usage levels up to: |
| not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s): |
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to di-Butylphthalate (DBP) for use in food contact materials View page or View pdf |
Technical report of the public consultation on the ‘Draft update of the risk assessment of di-butylphthalate (DBP), butyl-benzyl-phthalate (BBP), bis(2-ethylhexyl)phthalate (DEHP), di-isononylphthalate (DINP) and di-isodecylphthalate (DIDP) for use in food contact materials’ View page or View pdf |
Update of the risk assessment of di-butylphthalate (DBP), butyl-benzyl-phthalate (BBP), bis(2-ethylhexyl)phthalate (DEHP), di-isononylphthalate (DINP) and di-isodecylphthalate (DIDP) for use in food contact materials View page or View pdf |
EPI System: | View |
EPA-Iris: | IRIS |
Daily Med: | search |
NIOSH International Chemical Safety Cards: | search |
NIOSH Pocket Guide: | search |
Chemical Carcinogenesis Research Information System: | Search |
AIDS Citations: | Search |
Cancer Citations: | Search |
Toxicology Citations: | Search |
EPA GENetic TOXicology: | Search |
EPA Substance Registry Services (TSCA): | 84-74-2 |
EPA ACToR: | Toxicology Data |
EPA Substance Registry Services (SRS): | Registry |
Laboratory Chemical Safety Summary : | 3026 |
National Institute of Allergy and Infectious Diseases: | Data |
SCCNFP: | opinion |
WISER: | UN 3082 |
WGK Germany: | 3 |
| dibutyl benzene-1,2-dicarboxylate |
Chemidplus: | 0000084742 |
EPA/NOAA CAMEO: | hazardous materials |
RTECS: | 84-74-2 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
o- | benzene dicarboxylic acid dibutyl ester | ortho- | benzene dicarboxylic acid dibutyl ester | | benzene-o-dicarboxylic acid di-n-butyl ester | | benzene-o-dicarboxylic acid, di-n-butyl ester | | benzenedicarboxylic acid dibutyl ester | 1,2- | benzenedicarboxylic acid dibutyl ester | o- | benzenedicarboxylic acid dibutyl ester | 1,2- | benzenedicarboxylic acid, 1,2-dibutyl ester | 1,2- | benzenedicarboxylic acid, dibutyl ester | | butyl 2-(butoxycarbonyl)benzoate | N- | butylphthalate | | celluflex DPB | | DBP | | di-butylphthalate | | di-n-butyl phthalate | | di-n-butylorthophthalate | | dibutyl 1,2-benzene dicarboxylate | | dibutyl 1,2-benzenedicarboxylate | | dibutyl benzene-1,2-dicarboxylate | | dibutyl o-phthalate | | dibutyl phthalate NF | | dibutyl-1,2-benzenedicarboxylate | | dibutyl-o-phthalate | | dibutylphthatlate | | elaol | | ergoplast FDB | | ergoplast FOB | | ersoplast FDA | | genoplast B | | hatcol DBP | | hexaplas m/b | | kodaflex DBP | | monocizer DBP | | palatinol C | | phthalic acid, dibutyl ester | | polycizer DBP | | px 104 | | staflex DBP | | unimoll DB | | vestinol C | | witcizer 300 |
Articles:
PubMed: | Development of magnetic micro-solid phase extraction for analysis of phthalate esters in packaged food. |
PubMed: | Chemical composition analysis of rose water samples from Iran. |
PubMed: | Intake estimates of phthalate esters for South Delhi population based on exposure media assessment. |
PubMed: | Cumulative risk assessment for plasticizer-contaminated food using the hazard index approach. |
PubMed: | Di-n-butyl phthalate causes estrogenic effects in adult male Murray rainbowfish (Melanotaenia fluviatilis). |
PubMed: | [Preparation of a hydrophilic-lipophilic composite solid phase extraction material and application in food safety inspection]. |
PubMed: | Dermal toxicity elicited by phthalates: evaluation of skin absorption, immunohistology, and functional proteomics. |
PubMed: | Phthalate intake by infants calculated from biomonitoring data. |
PubMed: | Childhood exposure to DEHP, DBP and BBP under existing chemical management systems: a comparative study of sources of childhood exposure in Korea and in Denmark. |
PubMed: | Phthalates in German daycare centers: occurrence in air and dust and the excretion of their metabolites by children (LUPE 3). |
PubMed: | Plasticizer contamination in edible vegetable oil in a U.S. retail market. |
PubMed: | Preliminary toxicological assessment of phthalate esters from drinking water consumed in Portugal. |
PubMed: | Phthalate metabolites in obese individuals undergoing weight loss: Urinary levels and estimation of the phthalates daily intake. |
PubMed: | Pentadecyl ferulate, a potent antioxidant and antiproliferative agent from the halophyte Salicornia herbacea. |
PubMed: | Development of an enzyme-linked immunosorbent assay for dibutyl phthalate in liquor. |
PubMed: | A screen for disruptors of the retinol (vitamin A) signaling pathway. |
PubMed: | Migration of mineral oil, photoinitiators and plasticisers from recycled paperboard into dry foods: a study under controlled conditions. |
PubMed: | Approach to distribution and accumulation of dibutyl phthalate in rats by immunoassay. |
PubMed: | Combined subchronic toxicity of bisphenol A and dibutyl phthalate on male rats. |
PubMed: | Analysis of 16 phthalic acid esters in food simulants from plastic food contact materials by LC-ESI-MS/MS. |
PubMed: | Phthalate analysis by gas chromatography-mass spectrometry: blank problems related to the syringe needle. |
PubMed: | A microflow chemiluminescence sensor for indirect determination of dibutyl phthalate by hydrolyzing based on biological recognition materials. |
PubMed: | Phthalate and di-(2-ethylhexyl) adipate (DEHA) intake by German infants based on the results of a duplicate diet study and biomonitoring data (INES 2). |
PubMed: | Study on the influence of temperature, storage time and packaging type on di-n-butylphthalate and di(2-ethylhexyl)phthalate release into packed meals. |
PubMed: | How dirty are the dirty dozen ingredients in cosmetics? |
PubMed: | Transfer of eight phthalates through the milk chain--a case study. |
PubMed: | Di(2-ethylhexyl)phthalate (DEHP) and di-n-butylphthalate (DBP) exposure through diet in hospital patients. |
PubMed: | Effect of cooking at home on the levels of eight phthalates in foods. |
PubMed: | Determination of phthalic acid diesters in human milk at low ppb levels. |
PubMed: | Study on chemical composition, anti-inflammatory and anti-microbial activities of extracts from Chinese pear fruit (Pyrus bretschneideri Rehd.). |
PubMed: | Occurrence and profiles of phthalates in foodstuffs from China and their implications for human exposure. |
PubMed: | PVC flooring is related to human uptake of phthalates in infants. |
PubMed: | Socioeconomic factors and phthalate metabolite concentrations among United States women of reproductive age. |
PubMed: | Cumulative risk assessment of phthalate exposure of Danish children and adolescents using the hazard index approach. |
PubMed: | Environmental and food contamination with plasticisers in China. |
PubMed: | Children's exposure to Di(2-ethylhexyl)phthalate and dibutylphthalate plasticizers from school meals. |
PubMed: | Exposure to phthalates among premenstrual girls from rural and urban Gharbiah, Egypt: a pilot exposure assessment study. |
PubMed: | Phthalates and bisphenols migration in Mexican food cans and plastic food containers. |
PubMed: | Phthalate metabolites in urine from China, and implications for human exposures. |
PubMed: | Identification of LI-F type antibiotics and di-n-butyl phthalate produced by Paenibacillus polymyxa. |
PubMed: | Ginger suppresses phthalate ester-induced airway remodeling. |
PubMed: | A survey of phthalate esters in consumer cosmetic products. |
PubMed: | Determination of phthalate esters in soil by microemulsion electrokinetic chromatography coupled with accelerated solvent extraction. |
PubMed: | [Effect of diisobutyl phthalate on antioxidase activity and DNA damage in mice]. |
PubMed: | Effects of in utero exposure to DI(n-Butyl) phthalate on development of male reproductive tracts in Sprague-Dawley rats. |
PubMed: | Phthalates and food-contact materials: enforcing the 2008 European Union plastics legislation. |
PubMed: | Mutagenicity and genotoxicity of tannery effluents used for irrigation at Kanpur, India. |
PubMed: | Assessing exposure to phthalates - the human biomonitoring approach. |
PubMed: | Cumulative effects of in utero administration of mixtures of reproductive toxicants that disrupt common target tissues via diverse mechanisms of toxicity. |
PubMed: | Fast polymer fingerprinting using flowing afterglow atmospheric pressure glow discharge mass spectrometry. |
PubMed: | Development and application of a method for analysis of phthalates in ham sausages by solid-phase extraction and gas chromatography-mass spectrometry. |
PubMed: | Phthalate esters reveal skin-sensitizing activity of phenethyl isothiocyanate in mice. |
PubMed: | Development of a gas chromatographic/mass spectrometric method for determination of phthalates in oily foods. |
PubMed: | Reproductive and developmental toxicity of phthalates. |
PubMed: | Determination of phthalates in diet and bedding for experimental animals using gas chromatography-mass spectrometry. |
PubMed: | Spectroscopic detection of pharmaceutical compounds from an aflatoxigenic strain of Aspergillus parasiticus. |
PubMed: | Analysis and migration of phthalates in infant food packed in recycled paperboard. |
PubMed: | [Determination of trace phthalates in beer by gas chromatography coupled with solid-phase microextraction using a calix[6] arene fiber]. |
PubMed: | Derivation of Biomonitoring Equivalents for di-n-butyl phthalate (DBP), benzylbutyl phthalate (BzBP), and diethyl phthalate (DEP). |
PubMed: | In vivo and in vitro skin absorption of lipophilic compounds, dibutyl phthalate, farnesol and geraniol in the hairless guinea pig. |
PubMed: | Determination of 2,6-diisopropylnaphthalene (DIPN) and n-dibutylphthalate (DBP) in food and paper packaging materials from US marketplaces. |
PubMed: | Comparison of in vitro hormone activities of selected phthalates using reporter gene assays. |
PubMed: | Recent European Food Safety Authority toxicological evaluations of major phthalates used in food contact materials. |
PubMed: | Determination of total and free mono-n-butyl phthalate in human urine samples after medication of a di-n-butyl phthalate containing capsule. |
PubMed: | Development and application of an SPME/GC method for the determination of trace phthalates in beer using a calix[6]arene fiber. |
PubMed: | Phthalate exposure through food and consumers' risk perception of chemicals in food. |
PubMed: | Comparison of aromatic and alkyl micelles for the electrokinetic determination of phthalates in virgin olive oil. |
PubMed: | Cumulative effects of in utero administration of mixtures of "antiandrogens" on male rat reproductive development. |
PubMed: | Hazard to the developing male reproductive system from cumulative exposure to phthalate esters--dibutyl phthalate, diisobutyl phthalate, butylbenzyl phthalate, diethylhexyl phthalate, dipentyl phthalate, and diisononyl phthalate. |
PubMed: | Impact of diisobutyl phthalate and other PPAR agonists on steroidogenesis and plasma insulin and leptin levels in fetal rats. |
PubMed: | Assessing human exposure to phthalic acid and phthalate esters from mineral water stored in polyethylene terephthalate and glass bottles. |
PubMed: | Plastic components affect the activation of the aryl hydrocarbon and the androgen receptor. |
PubMed: | [Matrix solid-phase dispersion and gas chromatography/mass spectrometry for the determination of phthalic acid esters in vegetables]. |
PubMed: | Mixture effects of estrogenic compounds on proliferation and pS2 expression of MCF-7 human breast cancer cells. |
PubMed: | Toxicity of atractylon and atractylenolide III Identified in Atractylodes ovata rhizome to Dermatophagoides farinae and Dermatophagoides pteronyssinus. |
PubMed: | Effects of constructed wetland system on the removal of dibutyl phthalate (DBP). |
PubMed: | Blank problems in trace analysis of diethylhexyl and dibutyl phthalate: investigation of the sources, tips and tricks. |
PubMed: | Oestrogenicity of paper and cardboard extracts used as food containers. |
PubMed: | Comparison and analysis of different approaches for estimating the human exposure to phthalate esters. |
PubMed: | Safe Cosmetics Act aims to lessen cancer risk. |
PubMed: | Determination of phthalate esters from food-contacted materials by on-line microdialysis and liquid chromatography. |
PubMed: | [Analysis of phthalates in plastic food-packaging bags by thin layer chromatography]. |
PubMed: | Toxicity of bisabolangelone from Ostericum koreanum roots to Dermatophagoides farinae and Dermatophagoides pteronyssinus (Acari: Pyroglyphidae). |
PubMed: | Analysis of consumer cosmetic products for phthalate esters. |
PubMed: | Determination of phthalates in milk and milk products by liquid chromatography/tandem mass spectrometry. |
PubMed: | Human exposure to phthalates via consumer products. |
PubMed: | Diisobutyl phthalate has comparable anti-androgenic effects to di-n-butyl phthalate in fetal rat testis. |
PubMed: | Injector-internal thermal desorption from edible oils. Part 2: chromatographic optimization for the analysis of migrants from food packaging material. |
PubMed: | Functional barriers: properties and evaluation. |
PubMed: | Analysis of the nitrogen mustard mechlorethamine in topical pharmaceutical preparations by high-performance liquid chromatography. |
PubMed: | Determination of partition behavior of organic surrogates between paperboard packaging materials and air. |
PubMed: | Food protective effect of acaricidal components isolated from anise seeds against the stored food mite, Tyrophagus putrescentiae (Schrank). |
PubMed: | Phthalate levels in baby milk powders sold in several countries. |
PubMed: | Acaricidal activity of Paeonia suffruticosa root bark-derived compounds against Dermatophagoides farinae and Dermatophagoides pteronyssinus (Acari: Pyroglyphidae). |
PubMed: | The effects of phthalate esters on the tryptophan-niacin metabolism. |
PubMed: | New methodology for the determination of phthalate esters, bisphenol A, bisphenol A diglycidyl ether, and nonylphenol in commercial whole milk samples. |
PubMed: | Occurrence of phthalates and musk fragrances in indoor air and dust from apartments and kindergartens in Berlin (Germany). |
PubMed: | [Effects of environmental estrogens on apoptosis induced by estrogen depletion in T47D cells]. |
PubMed: | Estimated daily intake of plasticizers in 1-week duplicate diet samples following regulation of DEHP-containing PVC gloves in Japan. |
PubMed: | A simple and reproducible testing method for dialkyl phthalate migration from polyvinyl chloride products into saliva simulant. |
PubMed: | Aggregate exposures of nine preschool children to persistent organic pollutants at day care and at home. |
PubMed: | Generation of anticalins with specificity for a nonsymmetric phthalic acid ester. |
PubMed: | [Levels of phthalates and adipates in processed foods and migration of di-isononyl adipate from polyvinyl chloride film into foods]. |
PubMed: | Comparison of embryotoxicity of ESBO and phthalate esters using an in vitro battery system. |
PubMed: | Effects of dibutyl phthalate and monobutyl phthalate on cytotoxicity and differentiation in cultured rat embryonic limb bud cells; protection by antioxidants. |
PubMed: | [Residual chemicals in silicone rubber products for food contact use]. |
PubMed: | A biomarker approach to measuring human dietary exposure to certain phthalate diesters. |
PubMed: | [Residual chemicals in natural rubber products for food contact use]. |
PubMed: | [Contents of eleven phthalates and di(2-ethylhexyl) adipate in retail packed lunches after prohibition of DEHP-containing PVC gloves for cooking purposes]. |
PubMed: | Adverse effects on development of the reproductive system in male offspring of rats given monobutyl phthalate, a metabolite of dibutyl phthalate, during late pregnancy. |
PubMed: | Investigation of migration from paper and board into food--development of methods for rapid testing. |
PubMed: | Phthalates in paper and board packaging and their migration into Tenax and sugar. |
PubMed: | Effects of di-n-butyl phthalate (DBP) on male reproductive development in the rat: implications for human risk assessment. |
PubMed: | Study of diffusion through LDPE film of Di-n-butyl phthalate. |
PubMed: | Critical period for adverse effects on development of reproductive system in male offspring of rats given di-n-butyl phthalate during late pregnancy. |
PubMed: | Analysis of di-n-butylphthalate biotransformation in cattle by liquid chromatography/ion trap mass spectrometry/mass spectrometry. |
PubMed: | Hypertrophy of brown adipocytes in brown and white adipose tissues and reversal of diet-induced obesity in rats treated with a beta3-adrenoceptor agonist. |
PubMed: | UK panics over phthalates in babymilk formulae. |
PubMed: | A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic. |
PubMed: | NTP technical report on the toxicity studies of Dibutyl Phthalate (CAS No. 84-74-2) Administered in Feed to F344/N Rats and B6C3F1 Mice. |
PubMed: | Studies into the transfer and migration of phthalate esters from aluminium foil-paper laminates to butter and margarine. |
PubMed: | Migration of plasticizers from printing inks into foods. |
PubMed: | Non-aqueous size-exclusion chromatography coupled on-line to reversed-phase high-performance liquid chromatography. Interface development and applications to the analysis of low-molecular-weight contaminants and additives in foods. |
PubMed: | Migration from plasticized films into foods. 3. Migration of phthalate, sebacate, citrate and phosphate esters from films used for retail food packaging. |
PubMed: | Skin-tumour promoting activity of methyl ethyl ketone peroxide--a potent lipid-peroxidizing agent. |
PubMed: | The effect of intestinal esterase inhibition on the in vivo absorption and toxicity of Di-n-butyl phthalate. |
PubMed: | Teratogenicity of di(2-ethylhexyl) phthalate (DEHP) and di-n-butyl phthalate (DBP) in mice. |
PubMed: | Occurrence of dibutyl and di(2-ethylhexyl) phthalate in chicken eggs. |
PubMed: | Absorption and metabolism of three phthalate diesters by the rat small intestine. |
PubMed: | Recent progress in safety evaluation studies on plasticizers and plastics and their controlled use in Japan. |
PubMed: | The retention, distribution, excretion, and metabolism of dibutyl phthalate-7-14 C in the rat. |
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