Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | bluish green clear liquid (est) |
Assay: | 97.00 to 100.00 %
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Food Chemicals Codex Listed: | No |
Specific Gravity: | 0.98810 @ 25.00 °C.
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Boiling Point: | 159.00 °C. @ 11.00 mm Hg
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Boiling Point: | 298.00 to 300.00 °C. @ 760.00 mm Hg
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Vapor Pressure: | 0.002000 mmHg @ 25.00 °C. (est) |
Flash Point: | 279.00 °F. TCC ( 137.22 °C. )
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logP (o/w): | 5.510 |
Soluble in: |
| alcohol | | water, 0.2979 mg/L @ 25 °C (est) |
Insoluble in: |
| water |
Organoleptic Properties:
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Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
intramuscular-mouse LD50 3000 mg/kg Rastitel'nye Resursy. Plant Resources. Vol. 3, Pg. 67, 1967.
intravenous-rabbit LDLo 600 mg/kg LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Rastitel'nye Resursy. Plant Resources. Vol. 3, Pg. 67, 1967.
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | natural substances and extractives |
Recommendation for chamazulene usage levels up to: | | not for fragrance use.
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Recommendation for chamazulene flavor usage levels up to: |
| not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| azulene, 7-ethyl-1,4-dimethyl- | | camazulene | | dimethulene | 1,4- | dimethyl-7-(1-methylethyl) azulene | 1,4- | dimethyl-7-ethyl azulene | 1,4- | dimethyl-7-ethylazulene | 7- | ethyl-1,4-dimethyl azulene | 7- | ethyl-1,4-dimethylazulene | | lindazulene |
Articles:
PubMed: | Antinociceptive and anti-edematous activities of the essential oils of two Balkan endemic Laserpitium species. |
PubMed: | Chemopreventive and antioxidant activity of the chamazulene-rich essential oil obtained from Artemisia arborescens L. growing on the Isle of La Maddalena, Sardinia, Italy. |
PubMed: | Chemical composition and antifungal activity of Matricaria recutita flower essential oil against medically important dermatophytes and soil-borne pathogens. |
PubMed: | Pelargonium graveolens L'Her. and Artemisia arborescens L. essential oils: chemical composition, antifungal activity against Rhizoctonia solani and insecticidal activity against Rhysopertha dominica. |
PubMed: | The organ-specific expression of terpene synthase genes contributes to the terpene hydrocarbon composition of chamomile essential oils. |
PubMed: | Fast quality assessment of German chamomile (Matricaria chamomilla L.) by headspace solid-phase microextraction: influence of flower development stage. |
PubMed: | Guaianolides and volatile compounds in chamomile tea. |
PubMed: | Activity of Matricaria chamomilla essential oil against anisakiasis. |
PubMed: | Anglo-Saxon pharmacopoeia revisited: a potential treasure in drug discovery. |
PubMed: | Chemical composition and antibacterial potential of Artemisia arborescens L. essential oil. |
PubMed: | Variability of the essential oil content and composition of chamomile (Matricaria recutita L.) affected by weather conditions. |
PubMed: | Effect of Matricaria chamomilla L. flower essential oil on the growth and ultrastructure of Aspergillus niger van Tieghem. |
PubMed: | Content and composition of the essential oil of Chamomilla recutita (L.) Rauschert from some European countries. |
PubMed: | Chemical composition, antioxidant and antibacterial properties of Achillea collina Becker ex Heimerl s.l. and A. pannonica Scheele essential oils. |
PubMed: | Genotoxicity of Achillea millefolium essential oil in diploid cells of Aspergillus nidulans. |
PubMed: | Induction of mitochondrial-dependent apoptosis by an essential oil from Tanacetum gracile. |
PubMed: | Chemical composition and antibacterial activity of essential oil from Artemisia feddei. |
PubMed: | Trypanosoma cruzi: activity of essential oils from Achillea millefolium L., Syzygium aromaticum L. and Ocimum basilicum L. on epimastigotes and trypomastigotes. |
PubMed: | Phytochemical analysis of the essential oil of Achillea millefolium L. from various European Countries. |
PubMed: | Determination of chamazulene carboxylic acid in serum by high-performance liquid chromatography. Development and validation. |
PubMed: | Qualitative and quantitative analysis of the active components of the essential oil from Brickellia veronicaefolia by nuclear magnetic resonance spectroscopy. |
PubMed: | Chamazulene carboxylic acid and matricin: a natural profen and its natural prodrug, identified through similarity to synthetic drug substances. |
PubMed: | Comparative analysis of the oil and supercritical CO(2) extract of Artemisia arborescens L. and Helichrysum splendidum (Thunb.) Less. |
PubMed: | A review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.). |
PubMed: | Inhibitory effects of the essential oil of chamomile (Matricaria recutita L.) and its major constituents on human cytochrome P450 enzymes. |
PubMed: | Smooth muscle relaxant action of benzyl benzoates and salicylic acid derivatives from Brickellia veronicaefolia on isolated guinea-pig ileum. |
PubMed: | Screening of chemical composition and antifungal and antioxidant activities of the essential oils from three Turkish artemisia species. |
PubMed: | Effect of magnesium on essential oil formation of genetically transformed and non-transformed chamomile cultures. |
PubMed: | [Pharmacognostic research of some species of Achillea. Note 1. Volatile oils analysis]. |
PubMed: | New terpenoids in cultivated and wild chamomile (in vivo and in vitro). |
PubMed: | Inhibitory effect of chamomile essential oil on the sister chromatid exchanges induced by daunorubicin and methyl methanesulfonate in mouse bone marrow. |
PubMed: | Synthesis of new azulene derivatives and study of their effect on lipid peroxidation and lipoxygenase activity. |
PubMed: | Absolute stereochemistry of guaianolides, of matricin and its epimers, of yarrow proazulenes, and of chamazulene carboxylic acid. |
PubMed: | On the absolute configuration of matricin. |
PubMed: | Antifungal activity of the essential oil of flowerheads of garland chrysanthemum (Chrysanthemum coronarium) against agricultural pathogens. |
PubMed: | Production of yarrow (Achillea millefolium L.) in Norway: essential oil content and quality. |
PubMed: | In vitro study on the transfer of volatile oil components. |
PubMed: | A study of the production of essential oils in chamomile hairy root cultures. |
PubMed: | Incorporation of 1-[1-(13)C]Deoxy-D-xylulose in chamomile sesquiterpenes. |
PubMed: | Investigation of the effect of chamazulene on lipid peroxidation and free radical processes. |
PubMed: | Effects of some components of the essential oil of chamomile, Chamomilla recutita, on histamine release from rat mast cells. |
PubMed: | Chamazulene: an antioxidant-type inhibitor of leukotriene B4 formation. |
PubMed: | Management of oral mucositis during local radiation and systemic chemotherapy: a study of 98 patients. |
PubMed: | Studies on the Origin of (-)-alpha-Bisabolol and Chamazulene in Chamomile Preparations; Part I. Investigations by Isotope Ratio Mass Spectrometry (IRMS). |
PubMed: | [Observations and research on an extract of Inula viscosa Ait ]. |
PubMed: | [Pharmacologic studies on chamomile compounds. VI. Studies on the antiphlogistic effect of chamazulene and matricine]. |
PubMed: | Constituents of Essential Oil of Artemisia arborescens. |
PubMed: | [A chemical study of the essential oil from Artemisia arborescens]. |
PubMed: | [Determination of bisabolol, spiroether and chamazulene in Anthodium Chamomillae]. |
PubMed: | On the quantitative determination of chamazulene and prochamazulenes in essential oils and crude drugs from yarrow (Achillea sp.--Compositae). II.: A new colorimetric method of high sensitivity for determination of chamazulene in the essential oils. |
PubMed: | [A method for the determination of the chamazulene content of chamomile oil]. |
PubMed: | Quantitative determination of essential oil, total azulenes and chamazulene in German chamomile (Matricaria chamomilla) cultivated in Argentina. |
PubMed: | [Change in the content of essential oil and chamazulene in German camomile (Matricaria chamomilla L.) during vegetative period]. |
PubMed: | Chamazulene from Artemesia caruthii. |
PubMed: | [Comparative toxicity of S-guaiazulene, chamazulene and their 3-monosulfone derivatives in white rat]. |
PubMed: | [Studies on the effect of chamazulene on the human skin]. |
PubMed: | [Contribution to the presence and amount of chamazulene in solitary growing plants of the species Achillea millefolium L..]. |
PubMed: | [New possibilities of preparation of chamazulene]. |
PubMed: | Studies on seven-membered ring derivatives. III. Partial synthesis of 1,4-dimethyl-7-ethylazulene (lindazulene). |
PubMed: | [Antipyretic action of chamazulene]. |
PubMed: | [Further results with chamazulene in the treatment of asthmatic diseases in infancy and childhood]. |
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