diacetyl
2,3-butanedione
 
Notes:
Delute with two parts diacetyl to 1000 parts linalool carrier of aroma of butter, vinegar, coffee, and other foods. Constit. of butter; formed during fermentation. A common constit. of plant oils, prod. of breakdown of carbohydrates. Flavouring additive used in food industry. Also present in apple, orange, plum, okra, walnut, Bourbon vanilla, clary sage, soybean, coffee, honey, rose wine, port wine, cocoa and scallop Beer sometimes undergoes a diacetyl rest, in which its temperature is raised slightly for two or three days after fermentation is complete, to allow the yeast to absorb the diacetyl it produced earlier in the fermentation cycle. The makers of some wines, such as chardonnay, deliberately promote the production of diacetyl because of the feel and flavor it imparts. It is present in many California chardonnays known as "Butter Bombs," although there is a growing trend back toward the more traditional French styles.[citation needed]; Diacetyl (IUPAC systematic name: butanedione or 2,3-butanedione) is a natural byproduct of fermentation. It is a vicinal diketone (two C=O groups, side-by-side) with the molecular formula C4H6O2. Diacetyl occurs naturally in alcoholic beverages and is added to some foods to impart a buttery flavor.; Diacetyl is a natural by-product of secondary or malolactic fermentation. It is a vicinal diketone (two C=O groups, side-by-side) with the molecular formula C4H6O2.; Carrier of aroma of butter, vinegar, coffee, and other foods.; Beer sometimes undergoes a diacetyl rest, which entails waiting two or three days after fermentation is complete, to allow the yeast to absorb the diacetyl it produced earlier in the fermentation cycle. The makers of some wines, such as chardonnay, deliberately promote the production of diacetyl because of the feel and flavors it imparts.
  • Augustus Oils
    • Augustus Oils Ltd
      The Premier Supplier
      Augustus Oils Ltd, in harmony with nature - to present it at its best...
      A wealth of experience, expertise and knowledge has allowed Augustus to bridge the gulf in expectation and trust between growers and users of natural ingredients. The Company works in partnership with customers on the one hand, and growers, farmers and distillers on the other. Both users and producers can then focus on exactly what they do best, while skilled Augustus technicians closely monitor and control the delivered product. This ensures users can have the confidence that they will receive the best raw materials suited to their requirements.
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      Diacetyl
      Diacetyl Natural
       
  • Axxence Aromatic
    • Axxence Aromatic GmbH
      We bring nature to your flavour
      Dedicated to provide the best possible quality and supply service of natural aroma ingredients.
      Axxence Aromatic is entirely dedicated to provide the best possible quality and supply service of natural aroma ingredients to the Flavour & Fragrance Industry worldwide.
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      Product(s):
      237000 DIACETYL Natural Kosher
       
  • Beijing Lys Chemicals
    • Beijing Lys Chemicals Co, LTD.
      From Grams to Tons
      Fine chemical high-tech company which contains R&D, production, and sales.
      BEIJING LYS CHEMICALS CO, LTD, established in 2004, is a fine chemical high-tech company which contains R&D, production, and sales. We mainly engaged in export and technology development of flavor and fragrance materials and pharmaceutical intermediates. We have nearly 500 kinds of products, from grams to tons, exported to USA, Europe, South Asia and etc. And we custom manufacture new products according to customers’ needs, and serve good quality products and service. Our goal is to become a fine chemical enterprise which could provide special products and services.
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      10034 2,3-Butanedione
      20051 Diacetyl (natural)
       
  • Charkit Chemical
    • Charkit Chemical Corporation
      The Specialty Chemical Specialists
      Explore this website to discover the products and services that Charkit provides for your industry and please contact us directly to find out how we can be of service to you.
      about: Since 1982, Charkit has been committed to expanding the markets we serve as our roster of products and services continues to grow with us. Our substantial portfolio of personal care ingredients now include a wide array of luxury and exotic components to compliment the key products we have always offered. We have expanded our offerings to the nutraceutical, industrial, and resin markets with a growing roster of versatile and unique ingredients. We continue to lead the way in our traditional markets such as Metal and Water Treatment, Imaging, Flavor & Fragrance, Aroma and Food. Our Pharmaceutical offerings continue to expand, still anchored by the Boronic Derivatives that meet the demands of Suzuki coupling reactions. Please contact us to learn how we can help you reach your goals.
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      DIACETYL DO150
       
  • CJ Latta & Associates
    • CJ Latta & Associates, LLC
      Extensive Line
      Aromatic Chemicals and Organic Acids.
      CJ Latta & Associates is a distributor of specialty aromatics and organic acids used in the formulation of flavors and fragrance manufactured worldwide. We pride ourselves on our reputation for, fair pricing, quality and reliability. We’ve built our business on successfully sourcing and developing many challenging specialty chemicals and fine ingredients for our clients.
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      Product(s):
      DIACETYL
       
  • ECSA Chemicals
    • ECSA Chemicals
      Human Chemistry
      ECSA Chemicals has been active since 1913 in the trading and international commerce of raw materials. With an organisation divided into industrial segments managed by specialists, it has become one of the largest distributors worldwide.
      ECSA Chemicals is the largest Swiss-owned company in terms of warehouses for the distribution of chemical products. We have been distributing chemical products for over 100 years and we have a special interest in protecting the environment and in the safety of our facilities and collaborators.
      Established in 1913 as a small grocery store, in its over 100 years of activity ECSA Chemicals has become one of the most important Swiss-owned distributors of chemical products. The company, which is active in international distribution and trading, is organised into industrial segments that are managed by teams of specialists and experts. They guarantee professional and customised consultancy and services. With our experience, we can rapidly and safely connect you with the best suppliers on the market, providing you with a complete search, consulting and assistance service. The focus of our approach and operations is you, our customers. We strive every day to find the best products that satisfy your needs as quickly as possible. Your satisfaction is our greatest success. WHY CHOOSE ECSA? EXPERIENCE We have been working for 100 years. QUALITY We have obtained many certifications (ISO, SQAS, GDP, Responsible Care, Bio-Inspecta, RSPO, etc.). We guarantee full compliance with the current laws and continuous training for our staff. SAFETY We constantly carry out risk analyses for each infrastructure, defining safety levels and implementing corrective measures promptly wherever they are needed. WIDESPREAD DISTRIBUTION We have warehouses in strategic locations to supply goods to Switzerland and to the rest of the world. STORAGE CAPACITY The 3 ECSA-owned warehouses guarantee considerable storage area and capacity in each warehouse, with full availability of products (base chemicals and speciality chemicals). SPEED Presence all over the country, staff dedicated to sourcing raw materials and considerable storage capacity guarantee that goods are rapidly obtained and supplied. CONSULTANCY Our specialists - in-depth knowledge of the market and products allows us to provide full consulting services, from the purchase to the supply of raw materials.
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      Product(s):
      MP-001521 DIACETYL
      MP-027498 DIACETYL FLAVOUR USE
       
  • Elan Inc.
    • Elan Inc.
      Legacy of Innovation
      Highest quality natural and synthetic products.
      Elan Inc. is a privately held business that has been in operation for over 30 years. Our offices and production facility are located in Newark, NJ. We are dedicated to producing the highest quality natural and synthetic products available in the flavor and fragrance industry.
      US Email: Mr. David Pimentel
      US Email: Ms. Isabel Couto
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      Custom Solutions
      Product(s):
      DIACETYL Kosher
      SDS
       
  • Excellentia International
    • Excellentia International
      Ingredients by Nature
      Exceptional quality and excellence in meeting our customers requirements.
      Excellentia International was founded in 2010 through the merger of Excellentia Flavors LLC and Polarome International. Collectively, these companies account for more than one hundred years of industry experience, and are recognized for exceptional quality and excellence in meeting our customers’ requirements.
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      Product(s):
      Diacetyl Natural
       
  • FCI SAS
    • FCI SAS
      Inspired by Nature
      At FCI customer service is not a department it’s an attitude.
      Our team is composed of motivated professionals with great experience in the flavours and fragrances market. Our company has been serving this industry for more than 40 years and is ISO 9001 certified since 2009 . Whatever your question on flavour and fragrance ingredients: commercial, technical or regulatory – we will answer it very quickly.
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      Voice: +33 (0)1 34 25 58 10
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      About Us
      Product(s):
      50014 DIACETYL
      30016 DIACETYL NATURAL EU
       
  • Fleurchem
    • Fleurchem, Inc.
      Have A Flavorful Day
      A leading global manufacturer and supplier of ingredients for Flavors, Fragrances, AromaTherapy, Foods, Beverages, Personal Care Products, and other uses.
      Operating out of the 200,000 sq. ft., former Hercules/PFW facility in Middletown, NY; Fleurchem produces a full range of natural isolates, synthetic chemicals & specialities, essential oils and flavors. Additionally, the company performs toll manufacturing, as well as custom chemical synthesis for a wide range of clients.
      Email: Information
      US Voice: 845-341-2100
      US Fax: 845-341-2121
      Product(s):
      diacetyl natural
      diacetyl
       
  • Indukern F&F
  • Lluch Essence
    • Lluch Essence S.L.
      A family company dedicated to sales and distribution
      Flexibility, availability, price and quality.
      Flexibility, availability, price and quality make LLUCH ESSENCE S.L. one of Europe’s references when it comes to essential oils and aroma chemicals, and it is now well known all around the world.
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      Product(s):
      DIACETYL NATURAL (NO EU)
      DIACETYL NATURAL
      DIACETYL SYNTH.
       
  • M&U International
    • M&U International LLC
      Steady supply & demand
      Meeting customers increasing demands at home as well as abroad.
      M&U dedicates itself to the development and production of new products as well as continuously promoting those new products. We’ve maintained a steady supply&demand relationship with a large number of manufacturers at home and abroad. We’ve developed an extensive network and because of our relationships with these manufacturers, we’re able to provide a stable supply of great quality materials. We’re located in China’s largest communications hub, Shanghai and in the U.S. near one of the largest sea ports on the East Coast. The strategic locations of our facilities ensure convenient, prompt and secure delivery of our products to our customers.
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      Product(s):
      A0036 Diacetyl, Kosher
      N0035 Nat. Diacetyl, Kosher
       
  • Moellhausen
  • O'Laughlin Industries
    • O'Laughlin Industries Inc.
      Manufacturer of chemicals and ingredients used in flavors, fragrances, food, beverages and cosmetics
      Leading the Flavor and Fragrance Industry since 1980.
      O'Laughlin was established in 1980 by its owner and chief executive Michael O'Laughlin, when he moved to Beijing, China and established a small office. Since then it has grown to be a world class producer of chemicals, with significant production facilities in China, and distribution and sales in all major world markets.
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      US Email: John Gick
      Voice: (852) 2527-1031
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      Product(s):
      772-2005 DIACETYL FCC
       
  • PerfumersWorld
    • PerfumersWorld Ltd.
      feeeel... the smell!
      The one-stop resource for the creative perfumer.
      No minimum orders. Aroma chemicals, essential oils, isolates, pheremones, absolutes, resinoids, FleuressenceTM key bases, PWx FactorTM, solubilizers, kits, creation systems, workshops, training, distance learning, The PerfumersWorld Perfumer's Studio, The Perfumer’s Formulation Bulletin, perfumery software, bespoke creation, analysis, consultancy, project counselling, trouble-shooting, unperfumed product bases, bottles, smelling strips, scales, distillation, equipment and inspiration!
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      Product(s):
      9DV00144 Diacetyl
      Blends-well-with - Artificial Essential Oils
       
      5DV07644 Diacetyl 1 one % in DPG
       
  • Prodasynth
    • Prodasynth
      PRODUCTEUR PAR ESSENCE
      Chemical specialist in manufacturing, distributing and sourcing of tailor-made ingredients for the Flavour & Fragrance industry.
      Today we are also proud to say, we have created an important range of Natural Molecules which can be found in our Raw Material Compendium. The versatility of our small but efficient structure is one of our main strengths when trying to fulfill our clients' requirements.
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      DIACETYL (> 97%)
       
  • Robertet
  • SRS Aromatics
    • SRS Aromatics Ltd
      For over 25 years
      Bringing flavour and fragrance into your world.
      As suppliers / distributors of ingredients to the fragrance and flavour industries, our goal is to provide high quality materials at competitive prices with an exceptional level of service. Established in 1984, SRS Aromatics Ltd is an independent family owned business which has become very well-respected within the fragrance and flavour industry as a reliable and trustworthy partner. Over the years this has allowed the company to develop strong relationships with many global manufacturers; several of whom we represent in the UK. A core aim of our business is to work extremely closely with both our suppliers and customers to maximise service levels with minimum disruption to supply.
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      DIACETYL FCC
       
  • Sunaux International
    • Sunaux International
      Buy With Confidence
      We have industry leading processes and procedures to ensure nothing but the most reliable product.
      Sunaux International was founded in 2012 by the owner Mr.John Felton after spending 18 years involved in developing global business in the aromatic chemicals, fragrance and flavour compounds business.
      Email: John Felton
      Email: Stephen Zhou (Sales)
      Voice: 0512-57995626
      Fax: 0512-57570299
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      Product(s):
      A0038 Diacetyl
      N0036 nat.Diacetyl
       
  • TCI AMERICA
    • TCI AMERICA
      Moving Your Chemistry Forward
      We continuously strive to advance our technology.
      With East & West Coast distribution centers, count on TCI to deliver products quickly and reliably. Over 30,000 Reagents available today in benchtop to bulk quantities. We also offer custom synthesis solutions. Sign up for a TCI account today for fast and free shipping!
      Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 70 years of synthesis experience and multi-purpose plants enable TCI to offer more than 30,000 products as well as custom synthesis.
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      Product(s):
      B0682 Diacetyl >98.0%(GC)
       
  • United International
    • Qingdao Free Trade Zone United International Co Ltd
      Quality Products
      A partner in your supply chain solution.
      Qingdao Free Trade Zone United International Trade Co., Ltd.was founded in 1996, specializing in the production and import and export of food additives,flavor raw materials and pharmaceutical and chemical raw materials. The company has experienced R&D and business personnel,product quality, low price, efficient service and fast insight and grasp the latest market information.
      Email: Info
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      Product(s):
      8009 2,3-Butanedione
      8009N 2,3-Butanedione Nat.
       
  • Ernesto Ventós
  • WholeChem
    • WholeChem, LLC
      Connecting Innovators To the Building Blocks Of the Universe
      Custom manufacturer and distributor of specialty ingredients. We make global local.
      SQF-Certified Supplier
      We owe our success to our integrity, our dedication to the industry, and our commitment to our clients. We invite your inquiries regarding our current product list and any other products you may be having trouble sourcing.
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      Product(s):
      2,3-Butanedione
      Diacetyl, Natural
       
Synonyms   Articles   Notes   Search
Fragrance Demo Formulas    Flavor Demo Formulas
CAS Number: 431-03-8Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 207-069-8
FDA UNII: K324J5K4HM
Nikkaji Web: J2.586K
Beilstein Number: 0605398
MDL: MFCD00008756
CoE Number: 752
XlogP3: -1.30 (est)
Molecular Weight: 86.09022000
Formula: C4 H6 O2
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome, Edge or firefox)
Category: flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
 FDA/DG SANTE Petitions, Reviews, Notices:
184.1278 Diacetyl View - review
JECFA Food Flavoring: 408  diacetyl
DG SANTE Food Flavourings: 07.052  diacetyl
FEMA Number: 2370 diacetyl
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):431-03-8 ; DIACETYL
FDA Regulation:
FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE
Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1278 Diacetyl.
Synonyms   Articles   Notes   Search   Top
Physical Properties:
Appearance: yellow to yellow green clear liquid (est)
Assay: 98.00 to 100.00 % 
Food Chemicals Codex Listed: Yes
Specific Gravity: 0.97900 to 0.98500 @  25.00 °C.
Pounds per Gallon - (est).: 8.146 to  8.196
Refractive Index: 1.39300 to 1.39700 @  20.00 °C.
Melting Point: -2.40 °C. @ 760.00 mm Hg
Boiling Point: 87.00 to  88.00 °C. @ 760.00 mm Hg
PH Number: 3.20
Vapor Pressure: 56.800000 mmHg @ 25.00 °C.
Vapor Density: 2.9 ( Air = 1 )
Flash Point: 45.00 °F. TCC ( 7.22 °C. )
logP (o/w): -1.340
Soluble in:
 alcohol
 fixed oils
 glycerin
 propylene glycol
 water, 200000 mg/L @ 15 °C (exp)
Insoluble in:
 paraffin oil
Synonyms   Articles   Notes   Search   Top
Organoleptic Properties:
 
Odor Type: buttery
 
Odor Strength: high ,
recommend smelling in a 1.00 % solution or less
 
Substantivity: 44 hour(s) at 10.00 % in dipropylene glycol
 
 buttery  sweet  creamy  pungent  caramellic  
Odor Description:
at 1.00 % in propylene glycol. 
strong butter sweet creamy pungent caramel
 
 sweet  creamy  buttery  pungent  pungent  caramellic  
Odor Description:
Sweet, creamy, buttery, pungent, with a pungent caramellic nuance
Mosciano, Gerard P&F 16, No. 6, 43, (1991)
 
 
Flavor Type: buttery
 
 sweet  buttery  creamy  milky  
Taste Description:
at 50.00 ppm.  
Sweet, buttery, creamy, milky
Mosciano, Gerard P&F 16, No. 6, 43, (1991)
 
Odor and/or flavor descriptions from others (if found).
 
Moellhausen
DIACETYL
Odor Description: creamy, fat, vanilla
Taste Description: strong, butter in dilution
 
 
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: perfuming agents
Synonyms   Articles   Notes   Search   Top
Suppliers:
Ambles Nature et Chimie
DIACETYL NAT
Anhui Haibei
Diacetyl natural
Odor: Strong butter sweet creamy pungent caramel
Apple Flavor & Fragrance
Diacetyl Natural
Apple Flavor & Fragrance
Diacetyl
80%
Apple Flavor & Fragrance
Diacetyl
98%
Augustus Oils
Diacetyl Natural
Services
Augustus Oils
Diacetyl
Axxence Aromatic
DIACETYL Natural
Kosher
Sustainability
Beijing Lys Chemicals
2,3-Butanedione
Beijing Lys Chemicals
Diacetyl (natural)
BeYonde
Diacetyl
Charkit Chemical
DIACETYL DO150
CJ Latta & Associates
DIACETYL
De Monchy Aromatics
diacetyl natural
Odor: sweet, creamy, strong, butter, pungent, caramel
De Monchy Aromatics
Diacetyl
Diffusions Aromatiques
DIACETYL NATUREL
Diffusions Aromatiques
DIACETYL
ECSA Chemicals
DIACETYL FLAVOUR USE
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
ECSA Chemicals
DIACETYL
Elan Inc.
DIACETYL
Kosher
Ernesto Ventós
DIACETYL NATURAL
Ernesto Ventós
DIACETYL
Excellentia International
Diacetyl Natural
FCI SAS
DIACETYL NATURAL EU
Flavor: Cream, butter
FCI SAS
DIACETYL
Flavor: Cream, butter
Fleurchem
diacetyl natural
Fleurchem
diacetyl
Frey + Lau
Diacetyl
Odor: Buttery, creamy
Indukern F&F
DIACETYL NATURAL
Odor: BUTTER, POWERFUL, FATTY
Indukern F&F
DIACETYL
Odor: BUTTER, POWERFUL, FATTY
Inoue Perfumery
DIACETYL
Jinan Enlighten Chemical Technology(Wutong Aroma )
Diacetyl, Kosherk
K.L. Koh Enterprise
DIACETYL
Kingchem Laboratories
DIACETYL (2, 3 Butanedione)
Odor: Milk, cheese. Butter upon dilution
Kingchem Laboratories
DIACETYL, 98%+
Kingchem Laboratories
DIACETYL, NATURAL, 99%+
Kingchem Laboratories
DIACETYL, NATURAL
Lluch Essence
DIACETYL NATURAL (NO EU)
Lluch Essence
DIACETYL NATURAL
Lluch Essence
DIACETYL SYNTH.
M&U International
Diacetyl, Kosher
M&U International
Nat. Diacetyl, Kosher
Moellhausen
DIACETYL Natural
Odor: creamy, fat, vanilla;
Flavor: strong, butter in dilution
Moellhausen
DIACETYL
Odor: creamy, fat, vanilla
Flavor: strong, butter in dilution
Nagar Haveli Perfumes & Aromatics
Diacetyl
Odor: Strong butter sweet creamy pungent caramel
Nagar Haveli Perfumes & Aromatics
Diacetyl
Natural
Odor: Strong butter sweet creamy pungent caramel
O'Laughlin Industries
DIACETYL FCC
PerfumersWorld
Diacetyl 1 one % in DPG
PerfumersWorld
Diacetyl
Odor: strong butter sweet creamy pungent caramel buttery fatty-oily vanilla cream
Use: Blends-well-with - Artificial Essential Oils
Phoenix Aromas & Essential Oils
Diacetyl Natural
Phoenix Aromas & Essential Oils
Diacetyl
Prodasynth
DIACETYL
(> 97%)
Odor: SWEET, PUNGENT, BUTTERY, POWERFUL
Reincke & Fichtner
Diacetyl natural
Reincke & Fichtner
Diacetyl
Robertet
Diacethyl naturel
Seasons and Harvest / Crop calendar
Sigma-Aldrich: Aldrich
For experimental / research use only.
2,3-Butanedione 97%
SRS Aromatics
DIACETYL FCC
Sunaux International
Diacetyl
Sunaux International
nat.Diacetyl
SysKem Chemie
2,3-butane dione
TCI AMERICA
For experimental / research use only.
Diacetyl >98.0%(GC)
Tengzhou Jitian Aroma Chemiclal
2.3-Butanedione
United International
2,3-Butanedione Nat.
United International
2,3-Butanedione
WholeChem
2,3-Butanedione
WholeChem
Diacetyl, Natural
Synonyms   Articles   Notes   Search   Top
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 11 - Highly flammable.
R 20/22 - Harmful by inhalation and if swallowed.
R 38 - Irritating to skin.
R 41 - Risk of serious damage to eyes.
S 02 - Keep out of the reach of children.
S 16 - Keep away from sources of ignition - No Smoking.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 39 - Wear eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Human Experience:
2 % solution: no irritation or sensitization.
Oral/Parenteral Toxicity:
gavage-rat LD50  [sex: M,F] M:3400, F:3000 mg/kg
(Colley et al., 1969)

gavage-rat LD50  1580 mg/kg
(Jenner et al., 1964)

gavage-guinea pig LD50  990 mg/kg
(Jenner et al., 1964)

oral-guinea pig LD50  990 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: COMA BEHAVIORAL: ATAXIA
Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964.

intraperitoneal-rat LD50  400 mg/kg
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION
Food and Cosmetics Toxicology. Vol. 7, Pg. 571, 1969.

oral-rat LD50  1580 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964.

Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 17, Pg. 765, 1979.

Inhalation Toxicity:
Not determined
Synonyms   Articles   Notes   Search   Top
Safety in Use Information:
Category: flavoring agents
Recommendation for diacetyl usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 2200.00 (μg/capita/day)
Structure Class: II
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
 average usual ppmaverage maximum ppm
baked goods: -44.00000
beverages(nonalcoholic): -2.50000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: -35.00000
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: -11.00000
fish products: --
frozen dairy: -5.90000
fruit ices: -5.90000
gelatins / puddings: -19.00000
granulated sugar: --
gravies: --
hard candy: -21.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
Synonyms   Articles   Notes   Search   Top
Safety References:
European Food Safety Athority(EFSA): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 11 (FGE.11): Aliphatic dialcohols, diketones, and hydroxyketones from chemical group 10 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf
Flavouring Group Evaluation 11, Revision 1 (FGE.11Rev1) - Aliphatic dialcohols, diketones, and hydroxyketones from chemical group 10 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 11, Revision 2 (FGE.11Rev2): Aliphatic dialcohols, diketones, and hydroxyketones from chemical groups 8 and 10
View page or View pdf
Evaluation of a scientific publication associating diacetyl with enhancement of ß-amyloid-induced neurotoxicity
View page or View pdf
Safety and efficacy of secondary aliphatic saturated or unsaturated alcohols, ketones, ketals and esters with a second secondary or tertiary oxygenated functional group belonging to chemical group 10 when used as flavourings for all animal species
View page or View pdf
EPI System: View
NIOSH International Chemical Safety Cards: search
Chemical Carcinogenesis Research Information System: Search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 431-03-8
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 650
National Institute of Allergy and Infectious Diseases: Data
WISER: UN 2346
WGK Germany: 2
 butane-2,3-dione
Chemidplus: 0000431038
EPA/NOAA CAMEO: hazardous materials
RTECS: 431-03-8
Synonyms   Articles   Notes   Search   Top
References:
 butane-2,3-dione
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 431-03-8
Pubchem (cid): 650
Pubchem (sid): 134974156
Flavornet: 431-03-8
Pherobase: View
Synonyms   Articles   Notes   Search   Top
Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS): View
CHEBI: View
CHEMBL: View
Golm Metabolome Database: Search
KEGG (GenomeNet): C00741
HMDB (The Human Metabolome Database): HMDB03407
FooDB: FDB011930
YMDB (Yeast Metabolome Database): YMDB00367
Export Tariff Code: 2914.19.0000
Typical G.C.
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
Formulations/Preparations:
•grades: technical; flavor grade; fcc
Synonyms   Articles   Notes   Search   Top
Potential Blenders and core components note
 
For Odor
acidic
acidic
isobutyric acidFL/FR
aldehydic
 acetyl nonyrylFL/FR
balsamic
 cinnamyl benzoateFL/FR
bready
 coffee furanoneFL/FR
buttery
 acetoinFL/FR
 acetoin dimerFL/FR
 acetyl butyrylFL/FR
 acetyl isobutyrylFL/FR
 acetyl propionylFL/FR
 butyl butyryl lactateFL/FR
 butyl octanoateFL/FR
2,3-heptane dioneFL/FR
3,4-hexane dioneFL/FR
caramellic
2-oxobutyric acidFL/FR
alpha,alpha-dimethyl anisyl acetoneFL/FR
 levulinic acidFL/FR
 strawberry furanone acetateFL/FR
cheesy
 butyric acidFL/FR
2-methyl valeric acidFL/FR
coconut
 coconut decanone methylFR
delta-decalactoneFL/FR
delta-2-dodecenolactoneFL/FR
delta-nonalactoneFL/FR
gamma-nonalactone (aldehyde C-18 (so-called))FL/FR
gamma-octalactoneFL/FR
delta-undecalactoneFL/FR
coumarinic
epsilon-decalactoneFL/FR
creamy
gamma-butyrolactoneFL/FR
 creamy lactoneFL/FR
 cyclotene propionateFL/FR
3-heptyl dihydro-5-methyl-2(3H)-furanoneFL/FR
para-vanillic acidFL/FR
para-vanillyl alcoholFL/FR
 waxy lactoneFL/FR
earthy
1-nonen-3-olFL/FR
fatty
 butter estersFL/FR
 butyl undecylenateFL/FR
(Z)-dairy lactoneFL/FR
 ethyl undecylenateFL/FR
4-methyl octanoic acidFL/FR
fermented
 butyl laevo-lactateFL/FR
floral
 benzyl lactateFL/FR
 jasmin pyranoneFL/FR
 linalyl butyrateFL/FR
fruity
 acetoin acetateFL/FR
gamma-decalactoneFL/FR
 ethyl lactateFL/FR
 farnesyl acetoneFL/FR
 methyl (Z)-5-octenoateFL/FR
 octyl butyrateFL/FR
 prenyl isobutyrateFL/FR
gamma-undecalactone (aldehyde C-14 (so-called))FL/FR
 vanilla carboxylateFL/FR
green
isobutyl benzyl carbinolFL/FR
 butyl lactateFL/FR
(Z)-4-hepten-1-olFL/FR
(Z)-4-heptenalFL/FR
(Z)-4-heptenal diethyl acetalFL/FR
(Z)-3-hexen-1-yl butyrateFL/FR
 ivy dioxolaneFR
mushroom
3-octen-2-olFL/FR
1-octen-3-yl butyrateFL/FR
nutty
2-ethyl pyrazineFL/FR
soapy
 ethyl undecanoateFL/FR
sweet
 vanilla oleoresin baliFL/FR
tonka
6-amyl-alpha-pyroneFL/FR
 mint lactoneFL/FR
tropical
delta-dodecalactoneFL/FR
 glyceryl 5-hydroxydecanoateFL/FR
 glyceryl 5-hydroxydodecanoateFL/FR
vanilla
ortho-dimethyl hydroquinoneFL/FR
 ethyl vanillinFL/FR
 ethyl vanillin isobutyrateFL/FR
 ethyl vanillin propylene glycol acetalFL/FR
 vanillinFL/FR
 vanillyl acetateFL/FR
 vanillyl isobutyrateFL/FR
 vanillylidene acetoneFL/FR
vegetable
 methionalFL/FR
waxy
 allyl nonanoateFL/FR
 ethyl palmitateFL/FR
2-methyl heptanoic acidFL/FR
 methyl laurateFL/FR
2-nonanolFL/FR
 octyl isobutyrateFL/FR
delta-tetradecalactoneFL/FR
2-tridecanoneFL/FR
 undecanoic acidFL/FR
 
For Flavor
 
No flavor group found for these
 allyl methyl trisulfideFL
 benzyl lactateFL/FR
 butyl octanoateFL/FR
2-butyl thiopheneFL
 cinnamyl benzoateFL/FR
 cyclotene propionateFL/FR
6-decenoic acidFL
alpha,alpha-dimethyl anisyl acetoneFL/FR
ortho-dimethyl hydroquinoneFL/FR
delta-2-dodecenolactoneFL/FR
 farnesyl acetoneFL/FR
3-(methyl thio) hexanalFL
4,5-octane dioneFL
 prenyl isobutyrateFL/FR
 sodium 4-methyl-2-oxovalerateFL
acidic
isobutyric acidFL/FR
 levulinic acidFL/FR
aldehydic
 acetyl nonyrylFL/FR
alliaceous
3-tetrahydrothiophenoneFL
amber
isobutyl benzyl carbinolFL/FR
balsamic
 vanillylidene acetoneFL/FR
brown
2-oxobutyric acidFL/FR
buttery
 butter cream frosting flavorFL
 butyl laevo-lactateFL/FR
 butyroinFL
2,3-heptane dioneFL/FR
3,4-hexane dioneFL/FR
2-methyl valeric acidFL/FR
(E)-2-pentenoic acidFL
cabbage
 methyl 2-thiofuroateFL
caramellic
3-methyl butyl 2-furyl butyrateFL
 strawberry furanone acetateFL/FR
chocolate
 chocolate butter cream flavorFL
coconut
delta-decalactoneFL/FR
(R)-massoia lactoneFL
6-methyl coumarinFL
gamma-nonalactone (aldehyde C-18 (so-called))FL/FR
creamy
 acetoinFL/FR
 acetyl butyrylFL/FR
 acetyl ethyl carbinolFL
 acetyl isobutyrylFL/FR
6-amyl-alpha-pyroneFL/FR
 butter estersFL/FR
 butyl butyryl lactateFL/FR
 creamy lactoneFL/FR
5,5-dibutyl dihydrofuran-2(3H)-oneFL
 divanillinFL
delta-dodecalactoneFL/FR
 glyceryl 5-hydroxydecanoateFL/FR
 glyceryl 5-hydroxydodecanoateFL/FR
 jasmin pyranoneFL/FR
 mint lactoneFL/FR
delta-nonalactoneFL/FR
 octyl isobutyrateFL/FR
delta-undecalactoneFL/FR
gamma-undecalactone (aldehyde C-14 (so-called))FL/FR
para-vanillic acidFL/FR
para-vanillyl alcoholFL/FR
 waxy lactoneFL/FR
dairy
 acetoin dimerFL/FR
 methyl (Z)-5-octenoateFL/FR
earthy
1-nonen-3-olFL/FR
fatty
(Z)-dairy lactoneFL/FR
 diacetyl trimerFL
 ethyl undecylenateFL/FR
4-methyl octanoic acidFL/FR
2,4-octadien-1-olFL
2-tridecanoneFL/FR
(E,E)-2,4-undecadienalFL
floral
 linalyl butyrateFL/FR
fruity
 acetoin acetateFL/FR
 acetyl isovalerylFL
gamma-decalactoneFL/FR
 ethyl lactateFL/FR
3-heptyl dihydro-5-methyl-2(3H)-furanoneFL/FR
 vanilla carboxylateFL/FR
green
 butyl lactateFL/FR
 heptanal 2,3-butane diol acetalFL
(Z)-4-hepten-1-olFL/FR
(Z)-4-heptenalFL/FR
(Z)-4-heptenal diethyl acetalFL/FR
(Z)-3-hexen-1-yl butyrateFL/FR
lactonic
gamma-octalactoneFL/FR
milky
gamma-butyrolactoneFL/FR
dextro,laevo-3-(methyl thio) butanoneFL
mushroom
3-octen-2-olFL/FR
1-octen-3-yl butyrateFL/FR
nutty
 coffee furanoneFL/FR
2-ethyl pyrazineFL/FR
sour
 butyric acidFL/FR
spicy
 benzylidene acetoneFL
sweet
 vanilla oleoresin baliFL/FR
toasted
 acetyl propionylFL/FR
tomato
 methionalFL/FR
vanilla
 ethyl vanillinFL/FR
 ethyl vanillin isobutyrateFL/FR
 ethyl vanillin propylene glycol acetalFL/FR
 vanillinFL/FR
 vanillyl acetateFL/FR
 vanillyl isobutyrateFL/FR
waxy
 allyl nonanoateFL/FR
 butyl undecylenateFL/FR
epsilon-decalactoneFL/FR
 ethyl palmitateFL/FR
 ethyl undecanoateFL/FR
2-methyl heptanoic acidFL/FR
 methyl laurateFL/FR
2-nonanolFL/FR
 octyl 2-furoateFL
 octyl butyrateFL/FR
delta-tetradecalactoneFL/FR
 undecanoic acidFL/FR
 
Synonyms   Articles   Notes   Search   Top
Potential Uses:
 angelicaFL/FR
 azaleaFR
 bananaFL
 bayberryFR
 beerFL
 butterFL
 butterscotchFL
 caramelFL
 caraway seedFL/FR
 champacaFR
 cheese cheddar cheeseFL
 cheese swiss cheeseFL
 chicory rootFL
 citronellaFR
 clary sage oil replacerFR
 coffeeFL
 cranberryFL
 creamFL
 custardFL
 cypress oil replacerFR
 dairyFL
 gardeniaFR
 geraniumFR
 jasminFL
 lavandinFR
 lavenderFR
 lilacFR
 magnoliaFR
 narcissusFR
 nutmegFR
 orrisFR
 patchouli oil replacerFR
 sandalwoodFR
 savinFL/FR
 strawberryFL
 sugar brown sugarFL
 tomatoFL
 tulipFR
 vetiverFR
 vinegarFL
 ylang ylangFR
 yogurtFL
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 bilberry fruit
Search Trop  Picture
 blackberry fruit
Search  PMC Picture
 butter
Search  PMC Picture
 cabbage leaf
Search Trop  Picture
 cacao plant
Search Trop  Picture
 caraway seed
Search Trop  Picture
 celery leaf
Search Trop  Picture
 celery seed
Search Trop  Picture
 celery shoot
Search Trop  Picture
 cheese @ 605.00 ± 354 µg%
Data  GC  Search  PMC Picture
 cheese cheddar cheese
Search  PMC Picture
 chicory root
Search Trop  Picture
 citronella oil java
Search Trop  Picture
 coffee
Search  PMC Picture
 cranberry fruit
Search Trop  Picture
 currant fruit
Search  Picture
 geranium oil
Search Trop  Picture
 grape
Search Trop  Picture
 guava fruit
Search Trop  Picture
 honey buckwheat honey
PbMd  Search  PMC Picture
 kohlrabi stem
Search Trop  Picture
 lavandin oil
Search Trop  Picture
 lavender oil
Search Trop  Picture
 lavender oil spike spain @ 0.331%
Data  GC  Search Trop  Picture
 lemongrass plant
Search Trop  Picture
 milk
Search  PMC Picture
 papaya fruit
Search Trop  Picture
 pear fruit
Search Trop  Picture
 pineapple fruit
Search Trop  Picture
 raspberry red raspberry fruit
Search Trop  Picture
 sesame seed oil
Search Trop  Picture
 spearmint oil
Search Trop  Picture
 strawberry wild strawberry fruit
Search Trop  Picture
 tomato fruit
Search Trop  Picture
 vinegar
Search  PMC Picture
 yogurt
Search  PMC Picture
Synonyms   Articles   Notes   Search   Top
Synonyms:
 biacetyl
2,3-butadione
 butan-2,3-dione
2,3-butandione
2,3-butane dione
 butane-2,3-dione
2,3-butanedione
 diacethyl naturel
nat.diacetyl
 diacetyl (2, 3 butanedione)
 diacetyl (natural)
 diacetyl 99/100% FCC
 diacetyl FCC
 diacetyl natural
2,3-diketobutane
 dimethyl diketone
 dimethyl glyoxal
2,3-dioxobutane
Synonyms   Articles   Notes   Search   Top
Synonyms   Articles   Notes   Search   Top
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