caffeine
3,7-dihydro-1,3,7-trimethyl-1H-purine
 
Notes:
a methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. it also relaxes smooth muscle, stimulates cardiac muscle, stimulates diuresis, and appears to be useful in the treatment of some types of headache. several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. among the most important are inhibition of cyclic nucleotide phosphodiesterases, antagonism of adenosine receptors, and modulation of intracellular calcium handling. Component of coffee beans (Coffea arabica), many other Coffea spp., chocolate (Theobroma cacao), tea (Camellia thea), kolanut (Cola acuminata) and several other Cola spp. and several other plants. Used in many cola-type beverages as a flavour enhancer
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      CAFFUP Caffeine
       
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      Product(s):
      58-08-2 Caffeine min. 99%. (TLC)
       
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      CAFFEINE ANHYDROUS USP SYNTHETIC 100 MESH NLG 85%
      CAFFEINE ANHYDROUS USP
      CAFFEINE, ANHYDROUS, USP SYNTHETIC
       
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    • ECSA Chemicals
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      MP-020099 CAFFEINE ANHYDROUS BP/USP
       
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      A0244 Caffeine, Kosher
       
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      Natural Caffeine
       
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      Product(s):
      C2042 Caffeine >98.0%(LC)(T)
       
Synonyms   Articles   Notes   Search
CAS Number: 58-08-2Picture of molecule3D/inchi
Other(deleted CASRN): 71701-02-5
ECHA EINECS - REACH Pre-Reg: 200-362-1
FDA UNII: 3G6A5W338E
Nikkaji Web: J2.330B
Beilstein Number: 0017705
MDL: MFCD00005758
CoE Number: 11741
XlogP3: -0.10 (est)
Molecular Weight: 194.19410000
Formula: C8 H10 N4 O2
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome, Edge or firefox)
Category: cosmetic and flavor agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
 FDA/DG SANTE Petitions, Reviews, Notices:
182.1180 Caffeine View - review
GRN 347 7 Caffeine View - notice PDF
DG SANTE Food Flavourings: 16.016  caffeine
FEMA Number: 2224 caffeine
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):58-08-2 ; CAFFEINE
FDA Regulation:
FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE
Subpart B--Multiple Purpose GRAS Food Substances
Sec. 182.1180 Caffeine.
Synonyms   Articles   Notes   Search   Top
Physical Properties:
Appearance: white crystalline prisms (est)
Assay: 98.00 to 100.00 % 
Food Chemicals Codex Listed: Yes
Melting Point: 235.00 to  237.50 °C. @ 760.00 mm Hg
Boiling Point: 416.79 °C. @ 760.00 mm Hg (est)
PH Number: 6.50
Vapor Pressure: 15.000000 mmHg @ 89.00 °C.
Flash Point: > 350.00 °F. TCC ( > 176.67 °C. )
logP (o/w): -0.070
Shelf Life: 24.00 month(s) or longer if stored properly.
Storage: store in cool, dry place in tightly sealed containers, protected from heat and light.
Storage: refrigerate in tightly sealed containers.
Soluble in:
 acetone, 1 gram in 50 ml acetone
 alcohol, 1 gram in 22 ml alcohol of 60%
 water, 1 gram in 46 ml water
 water, 45.5 grams in 100 ml water @ 65C
 water, 2.16E+04 mg/L @ 25 °C (exp)
Synonyms   Articles   Notes   Search   Top
Organoleptic Properties:
 
Odor Type: odorless
 
Odor Strength: none
 
Odor Description:
at 100.00 %. 
odorless
 
 
Flavor Type: astringent
 
 astringent  
Taste Description:
astringent
 
Odor and/or flavor descriptions from others (if found).
 
 
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: fragrance
skin conditioning
Synonyms   Articles   Notes   Search   Top
Suppliers:
AIDP
Caffeine (Natural) 98.5% min
AIDP
Caffeine 98.5%-101.5%
Allan Chemical
Caffeine
American International Chemical, LLC.
Caffeine
Atlantic Chemicals
Caffeine Anhydrous
AuNutra® Industries
Caffeine Anhydrous
Balchem
Caffeine
VitaShure®
Flavor: characteristic
Vitashure is an extensive line of microencapsulated vitamins, minerals, amino acids, and bioactive substances, specifically designed for the supplementation and fortification industries.
BASF
Caffeine Powder
Bell Flavors & Fragrances
Caffeine (USP Fine)
BOC Sciences
For experimental / research use only.
Caffeine min. 99%. (TLC)
Changsha Organic Herb
Guarana Seed Extract
Charkit Chemical
CAFFEINE ANHYDROUS USP SYNTHETIC 100 MESH NLG 85%
Charkit Chemical
CAFFEINE ANHYDROUS USP
Charkit Chemical
CAFFEINE, ANHYDROUS, USP SYNTHETIC
Coompo
For experimental / research use only.
Caffeine from Plants ≥95%
Odor: characteristic
Use: Caffeine has many effects on the body's metabolism, including stimulating the central nervous system. This can make you more alert and give you a boost of energy. For most people, the amount of caffeine in two to four cups of coffee a day is not harmful. However, too much caffeine can make you restless, anxious, and irritable. It may also keep you from sleeping well and cause headaches, abnormal heart rhythms, or other problems. If you stop using caffeine, you could get withdrawal symptoms. Inside the body caffeine acts through several mechanisms, but its most important effect is to counteract a substance called adenosine that naturally circulates at high levels throughout the body, and especially in the nervous system. In the brain, adenosine plays a generally protective role, part of which is to reduce neural activity levels – for example, there is some evidence that adenosine helps to induce torpor in animals that seasonally hibernate. Caffeine is toxic at sufficiently high doses. Ordinary consumption can have low health risks, even when carried on for years – there may be a modest protective effect against some diseases, including certain types of cancer. Caffeine can have both positive and negative effects on anxiety disorders. Some people experience sleep disruption if they consume caffeine, especially during the evening hours, but others show little disturbance and the effect of caffeine on sleep is highly variable. Evidence of a risk to pregnancy is equivocal, but some authorities have concluded that prudent advice is for pregnant women to limit consumption to the equivalent of two cups of coffee per day or less.
ECSA Chemicals
CAFFEINE ANHYDROUS BP/USP
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
Ernesto Ventós
NATURAL CAFFEINE ANHYDROUS
Foodchem International
Caffeine Anhydrous
George Uhe Company
Caffeine
Glentham Life Sciences
Caffeine
Graham Chemical
Caffeine
Kraft Chemical
Caffeine
M&U International
Caffeine, Kosher
Maypro Industries
Caffeine Anhydrous USP
Noble Molecular Research
For experimental / research use only.
Caffeine
Northwestern Extract
Caffeine Artificial or Natural
OQEMA
Natural Caffeine
Penta International
CAFFEINE POWDER ANHYDROUS FCC
Penta International
CAFFEINE POWDER ANHYDROUS USP FCC (SYNTHETIC)
Penta International
CAFFEINE POWDER NATURAL
Prinova
Caffeine
Sigma-Aldrich
Caffeine, anhydrous, FCC, 99%
Certified Food Grade Products
Silver Fern Chemical
Caffeine Anhydrous
Synthite Industries
Caffeine
E-books and Brochures
TCI AMERICA
For experimental / research use only.
Caffeine >98.0%(LC)(T)
Tianjin Talent Chemical
Caffeine
Vigon International
CAFFEINE NATURAL
WEN International
CAFFEINE Natural
Synonyms   Articles   Notes   Search   Top
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 22 - Harmful if swallowed.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  192 mg/kg
KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS BEHAVIORAL: WITHDRAWAL BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES
Journal of New Drugs. Vol. 5, Pg. 252, 1965.

intravenous-rat LD50  105 mg/kg
KIDNEY, URETER, AND BLADDER: STRUCTURAL OR FUNCTIONAL CHANGES IN URETER LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Journal of Pharmacology and Experimental Therapeutics. Vol. 82, Pg. 89, 1944.

intraperitoneal-rat LD50  240 mg/kg
Zeitschrift fuer Ernaehrungswissenschaft. Vol. 15, Pg. 64, 1976.

oral-rabbit LD50  224 mg/kg
Zeitschrift fuer Ernaehrungswissenschaft. Vol. 15, Pg. 64, 1976.

intravenous-rabbit LD50  58 mg/kg
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 791, 1979.

oral-mouse LD50  127 mg/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Toxicology and Applied Pharmacology. Vol. 44, Pg. 1, 1978.

intravenous-mouse LD50  62 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology Letters. Vol. 29, Pg. 25, 1985.

intraperitoneal-mouse LD50  168 mg/kg
KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED BEHAVIORAL: AGGRESSION BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Chemical and Pharmaceutical Bulletin. Vol. 22, Pg. 1459, 1974.

oral-hamster LD50  230 mg/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Toxicology and Applied Pharmacology. Vol. 44, Pg. 1, 1978.

oral-guinea pig LD50  230 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1335, 1935.

oral-bird - wild LD50  316 mg/kg
Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.

intraperitoneal-cat LDLo  180 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1335, 1935.

intravenous-cat LDLo  80 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1335, 1935.

oral-cat LDLo  100 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1335, 1935.

oral-child LDLo  320 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Forensic Science. Vol. 3, Pg. 275, 1974.

oral-child TDLo  140 mg/kg
BLOOD: HEMORRHAGE BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
Pediatric Emergency Care. Vol. 10, Pg. 349, 1994.

oral-dog LD50  140 mg/kg
Drugs in Japan Vol. 6, Pg. 174, 1982.

intravenous-dog LDLo  4 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1335, 1935.

parenteral-frog LDLo  120 mg/kg
BEHAVIORAL: STIFFNESS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: OTHER CHANGES
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 166, Pg. 437, 1932.

oral-guinea pig LD50  230 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Toxicology and Applied Pharmacology. Vol. 2, Pg. 23, 1960.

intraperitoneal-guinea pig LDLo  220 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1335, 1935.

oral-human LDLo  192 mg/kg
Journal of New Drugs. Vol. 5, Pg. 252, 1965.

intravenous-human TDLo  7 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Acta Pharmacologica et Toxicologica. Vol. 15, Pg. 331, 1959.

oral-man TDLo  13 mg/kg
BEHAVIORAL: TOXIC PSYCHOSIS
American Journal of Psychiatry. Vol. 143, Pg. 1320, 1986.

oral-man TDLo  51 mg/kg
MUSCULOSKELETAL: TUMORS KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" CARDIAC: CHANGE IN RATE
Annals of Emergency Medicine. Vol. 18, Pg. 94, 1989.

unreported-mouse LD50  251 mg/kg
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 53, Pg. 2S, 1957.

oral-rabbit LD50  224 mg/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Toxicology and Applied Pharmacology. Vol. 44, Pg. 1, 1978.

intramuscular-rabbit LDLo  200 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 1, Pg. 572, 1910.

intraperitoneal-rabbit LDLo  150 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1335, 1935.

Dermal Toxicity:
subcutaneous-rat LD50 170 mg/kg
Journal of Clinical Pharmacology and Journal of New Drugs. Vol. 7, Pg. 131, 1967.

subcutaneous-mouse LD50 242 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 6, Pg. 601, 1956.

subcutaneous-cat LDLo 150 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1335, 1935.

subcutaneous-dog LD50 100 mg/kg
Drugs in Japan Vol. 6, Pg. 174, 1982.

subcutaneous-frog LDLo 120 mg/kg
Acta Pharmacologica et Toxicologica. Vol. 15, Pg. 331, 1959.

subcutaneous-guinea pig LDLo 200 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1335, 1935.

subcutaneous-rabbit LDLo 275 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 1, Pg. 572, 1910.

Inhalation Toxicity:
Not determined
Synonyms   Articles   Notes   Search   Top
Safety in Use Information:
Category: cosmetic and flavor agents
Recommendation for caffeine usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 380.00 (μg/capita/day)
Structure Class: III
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3. Update in publication number(s): 29
Click here to view publication 3
 average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): 120.00000150.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 20.0000070.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): --
Edible ices, including sherbet and sorbet (03.0): 20.0000070.00000
Processed fruit (04.1): --
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 25.00000100.00000
Chewing gum (05.0): --
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): --
Bakery wares (07.0): --
Meat and meat products, including poultry and game (08.0): --
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): --
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): --
Foodstuffs intended for particular nutritional uses (13.0): --
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 100.00000175.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 25.00000100.00000
Ready-to-eat savouries (15.0): --
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): --
Synonyms   Articles   Notes   Search   Top
Safety References:
European Food Safety Athority(EFSA): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Flavouring Group Evaluation 29 (FGE29)[1] - Substance from the priority list: Vinylbenzene from chemical group 31 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC)
View page or View pdf
Flavouring Group Evaluation 49, (FGE.49)[1]: Xanthin alkaloids from the Priority list from chemical group 30
View page or View pdf
Gathering consumption data on specific consumer groups of energy drinks
View page or View pdf
Extensive literature search as preparatory work for the safety assessment for caffeine
View page or View pdf
Outcome of a public consultation on the draft Scientific Opinion of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) on the safety of caffeine
View page or View pdf
EFSA explains risk assessment: Caffeine
View page or View pdf
Scientific Opinion on the safety of caffeine
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Scientific Opinion on Flavouring Group Evaluation 49, Revision 1 (FGE.49Rev1): xanthine alkaloids from the priority list
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Outcome of the consultation with Member States and EFSA on the basic substance application for approval of caffeine to be used in plant protection as insecticide in cabbage, potatoes and buxus and as molluscicide in all edible and non-edible crops
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EPI System: View
ClinicalTrials.gov: search
Daily Med: search
NIOSH International Chemical Safety Cards: search
Chemical Carcinogenesis Research Information System: Search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
Carcinogenic Potency Database: Search
EPA GENetic TOXicology: Search
EPA Substance Registry Services (TSCA): 58-08-2
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 2519
National Institute of Allergy and Infectious Diseases: Data
WISER: UN 1544
WGK Germany: 1
 1,3,7-trimethylpurine-2,6-dione
Chemidplus: 0000058082
EPA/NOAA CAMEO: hazardous materials
RTECS: 58-08-2
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References:
 1,3,7-trimethylpurine-2,6-dione
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 58-08-2
Pubchem (cid): 2519
Pubchem (sid): 134971358
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS): View
CHEBI: View
CHEMBL: View
Golm Metabolome Database: Search
Metabolomics Database: Search
UM BBD: Search
KEGG (GenomeNet): C07481
HMDB (The Human Metabolome Database): HMDB01847
FooDB: FDB002100
Export Tariff Code: 2939.30.0000
FDA Listing of Food Additive Status: View
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
Formulations/Preparations:
•formulation names: caffedrine, vivarin, quick-pep •grades: technical; usp; fcc •nodoz keep alert tablets contain 100% caffeine in each tablet •vivarin contains 200 mg caffeine alkaloid and 150 mg dextrose in each tablet
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 skin conditioning 
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Occurrence (nature, food, other): note
 cacao bean
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 cacao petiole
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 cacao testa
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 cherimoya seed
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 clover yellow sweet clover
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 coffee
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 coffee arabica coffee
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 coffee bean
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 coffee canephora coffee
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 coffee green coffee
PbMd  Search Trop  Picture
 guarana
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 kola
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 lemon
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 lemon flower
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 orange bud
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 orange flower
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 orange leaf
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 petitgrain orange
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 pomelo
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 tea anther
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 tea flower
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 tea green tea
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 tea leaf
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 tea pericarp
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 tea plant
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 tea seed
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 tea seed coat
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 tea shoot
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 tea stem
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 tea tissue culture
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Synonyms:
 biogenic caffeine-210
 caffeine anhydrous
 caffeine anhydrous USP
 caffeine natural
 caffeine USP FCC powder anhydrous
 coffeine
3,7-dihydro-1,3,7-trimethyl-1H-purine
 guaranine
 methyl theobromine
7-methyl theophylline
1-methyl-theobromine
1H-purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-
 theine
1,3,7-trimethyl xanthine
1,3,7-trimethyl-1,3,7-trihydropurine-2,6-dione
1,3,7-trimethyl-1H-purine-2,6(3H,7H)-dione
1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
1,3,7-trimethyl-2,6-dioxo-1,2,3,6-tetrahydropurine
1,3,7-trimethyl-2,6-dioxopurine
1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
1,3,7-trimethyl-3,7-dihydro-purine-2,6-dione
1,3,7-trimethylpurine-2,6-dione
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Articles:
PubMed: The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.
J-Stage: Coffee and Caffeine Improve Insulin Sensitivity and Glucose Tolerance in C57BL/6J Mice Fed a High-Fat Diet
PubMed: Design, formulation and evaluation of green tea chewing gum.
PubMed: The role of dissolved cations in coffee extraction.
PubMed: Simultaneous determination of caffeine and some selected polyphenols in Wuyi Rock tea by high-performance liquid chromatography.
PubMed: Cardiovascular and ride time-to-exhaustion effects of an energy drink.
PubMed: Chemical composition and sensory evaluation of fermented tea with medicinal mushrooms.
PubMed: Design, formulation and evaluation of caffeine chewing gum.
PubMed: Determination of the alkylpyrazine composition of coffee using stable isotope dilution-gas chromatography-mass spectrometry (SIDA-GC-MS).
PubMed: Identification of aroma active compounds of cereal coffee brew and its roasted ingredients.
PubMed: The effects of six weeks of supplementation with multi-ingredient performance supplements and resistance training on anabolic hormones, body composition, strength, and power in resistance-trained men.
PubMed: Identification of enterodiol as a masker for caffeine bitterness by using a pharmacophore model based on structural analogues of homoeriodictyol.
PubMed: Influence of caffeine on the liking of novel-flavored soda in adolescents.
PubMed: Effect of physicochemical parameters on enzymatic biodecaffeination during tea fermentation.
PubMed: Enhancement of fermentation process in Pu-erh tea by tea-leaf extract.
PubMed: [Neurophysiological effect of flavor and caffeine added to toothpaste].
PubMed: Identification of bisprenylated benzoic acid derivatives from yerba santa (Eriodictyon ssp.) using sensory-guided fractionation.
PubMed: Characterization of flavor modulating effects in complex mixtures via high temperature liquid chromatography.
PubMed: Taste disorders and oral evaluation in patients undergoing allogeneic hematopoietic SCT.
PubMed: Identification and quantification of free radical scavengers in Pu-erh tea by HPLC-DAD-MS coupled online with 2,2'-Azinobis(3-ethylbenzthiazolinesulfonic acid) diammonium salt assay.
PubMed: Preservation of kombucha tea-effect of temperature on tea components and free radical scavenging properties.
PubMed: Conditioned flavor avoidance as a measure of withdrawal in rats chronically exposed to a caffeine solution.
PubMed: Structural analogues of homoeriodictyol as flavor modifiers. Part III: short chain gingerdione derivatives.
PubMed: Fast and direct screening of solid materials for their potential liberation of hydrophobic organic compounds using hot cell membrane inlet mass spectrometry.
PubMed: Effect of supercritical carbon dioxide decaffeination on volatile components of green teas.
PubMed: Caffeine as a flavor additive in soft-drinks.
PubMed: New bitter-masking compounds: hydroxylated benzoic acid amides of aromatic amines as structural analogues of homoeriodictyol.
PubMed: Reinforcing and aversive effects of caffeine measured by flavor preference conditioning in caffeine-naive and caffeine-acclimated rats.
PubMed: Product-oriented flavor research: learnings from the past, visions for the future.
PubMed: Taste masking analysis in pharmaceutical formulation development using an electronic tongue.
PubMed: Chlorogenic acids and lactones in regular and water-decaffeinated arabica coffees.
PubMed: Does dietary learning occur outside awareness?
PubMed: Phenolic metabolites from honeybush tea (Cyclopia subternata).
PubMed: Age-associated increases in intensity discrimination for taste.
PubMed: Researching on new species of "Mate": Ilex brevicuspis: phytochemical and pharmacology study.
PubMed: Caffeine-reinforced conditioned flavor preferences in rats.
PubMed: The science and complexity of bitter taste.
PubMed: Is caffeine a flavoring agent in cola soft drinks?
PubMed: Genetic engineering of foods to reduce the risk of heart disease and cancer.
PubMed: Oral caffeine consumption by rats: the role of flavor history, concentration, concurrent food, and an adenosine agonist.
PubMed: Solventless determination of caffeine in beverages using solid-phase microextraction with fused-silica fibers.
PubMed: Use of flavor-amplified foods to improve nutritional status in elderly patients.
PubMed: Aversive conditioning properties of caffeine in rats.
PubMed: A confirmatory study of the up-and-down method for acute oral toxicity testing.
PubMed: Caffeine enhancement of saccharin but not cyclamate flavor avoidance.
PubMed: Use of taste repellants and emetics to prevent accidental poisoning of dogs.
PubMed: Caffeine: an update.
PubMed: The biochemistry and technology of tea manufacture.
PubMed: Evidence for withdrawal from caffeine by rats.
PubMed: Caffeine: preferential consumption by rats.
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