Category: flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | white crystals (est) |
Assay: | 99.00 to 100.00 %
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Food Chemicals Codex Listed: | Yes |
Melting Point: | 73.00 to 79.00 °C. @ 760.00 mm Hg
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Boiling Point: | 303.00 °C. @ 725.00 mm Hg
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Congealing Point: | 73.50 °C.
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Vapor Pressure: | 0.001000 mmHg @ 25.00 °C. (est) |
Flash Point: | > 230.00 °F. TCC ( > 110.00 °C. )
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logP (o/w): | 1.933 (est) |
Soluble in: |
| alcohol | | water, very slightly | | water, 1189 mg/L @ 25 °C (est) |
Insoluble in: |
| water |
Stability: |
| non-discoloring in most media |
Organoleptic Properties:
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Odor Type: coconut |
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Odor Strength: | medium , recommend smelling in a 1.00 % solution or less |
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Substantivity: | 347 hour(s) at 1.00 % in dipropylene glycol |
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| coconut creamy powdery coumarinic tonka cinnamyl vanilla floral earthy |
Odor Description: at 1.00 % in dipropylene glycol. | coconut creamy powdery coumarinic tonka cinnamyl vanilla floral earthy Luebke, William tgsc, (2021) |
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| sweet coconut vanilla creamy powdery floral |
Odor Description:
| Sweet coconut, vanilla, creamy with a powdery floral nuance Mosciano, Gerard P&F 16, No. 3, 79, (1991) |
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Flavor Type: coconut |
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| coconut vanilla creamy coumarinic tonka cake |
Taste Description:
| coconut vanilla creamy coumarinic tonka cake Luebke, William tgsc, (2021) |
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| sweet coconut vanilla creamy |
Taste Description: at 20.00 ppm. | Sweet coconut, vanilla like with a creamy cake-like nuance Mosciano, Gerard P&F 16, No. 3, 79, (1991) |
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Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
ACS International |
Methylcoumarin-6
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Operational Capabilities |
Advanced Biotech |
6 METHYL COUMARIN SYNTHETIC
99% min. Odor: Coconut, Herbaceous |
Alfa Biotechnology |
For experimental / research use only. |
6-Methylcoumarin 98%
|
Anhui Haibei |
6-Methyl Coumarin
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Aroma Aromatics & Flavours |
6-Methyl Coumarin
Flavor: Dry herbaceous coconut It is one of the most important constituent of coconut flavours. It is also used effectively in nut, caramel, butter, date, fig, root beer etc. Frequently used in various vanilla compositions. Its extra ordinary stability towards heat makes it excellent for flavour meant for baked goods. The concentration in finished products is usually less then 30 ppm. |
Augustus Oils |
6 Methyl Coumarin
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Services |
Berjé |
6-Methyl Coumarin
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Media |
BOC Sciences |
For experimental / research use only. |
6-Methylcoumarin
|
Charkit Chemical |
METHYL COUMARIN, 6- FEMA 2699
|
Diffusions Aromatiques |
6-METHYLCOUMARINE
|
Elan Inc. |
6-METHYLCOUMARIN
Kosher |
Ernesto Ventós |
6-METHYLCOUMARIN
Odor: CREAMY, COCONUT Flavor: ALMOST BITTER, SWEET AT LOWER LEVEL |
H. Interdonati, Inc. |
6-Methylcoumarin Kosher
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Featured Products |
Indukern F&F |
6-METHYL COUMARIN
Odor: SWEET, COCONUT, CREAMY |
Jiangyin Healthway |
6-Methyl Coumarin
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New functional food ingredients |
Jiangyin Healthway |
6-Methylcoumarin
|
K.L. Koh Enterprise |
6-METHYL COUMARIN
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Lluch Essence |
6-METHYL COUMARIN
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M&U International |
6-Methyl Coumarin, Kosher
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Moellhausen |
6-METHYL COUMARIN
Odor: sweet, aromatic Flavor: sweet, cocoa, vanilla |
Pearlchem Corporation |
6-Methyl Coumarin
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Penta International |
6-METHYLCOUMARIN CRYSTAL
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Penta International |
6-METHYLCOUMARIN POWDER
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PerfumersWorld |
6-Methyl Coumarin 10% in DPG
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PerfumersWorld |
6-Methyl Coumarin
Odor: vanilla coconut tonka-bean sweet aromatic |
Phoenix Aromas & Essential Oils |
Methyl-6 Coumarin
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R C Treatt & Co Ltd |
6-Methylcoumarin
|
Reincke & Fichtner |
6-Methylcoumarin
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Sigma-Aldrich |
6-Methylcoumarin, ≥99%, FCC, FG
Odor: anise; coconut; creamy; herbaceous; vanilla; balsamic |
Certified Food Grade Products |
SRS Aromatics |
6-METHYL COUMARIN
|
Sunaux International |
6-Methyl Coumarin
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TCI AMERICA |
For experimental / research use only. |
6-Methylcoumarin >99.0%(GC)
|
United International |
6-Methylcoumarin
|
Vigon International |
Methyl-6 Coumarin
Odor: COCONUT-LIKE |
WholeChem |
6-Methyl coumarin
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Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | Xn - Harmful. |
R 22 - Harmful if swallowed. R 42/43 - May cause sensitization by inhalation and skin contact. S 02 - Keep out of the reach of children. S 20/21 - When using do not eat, drink or smoke. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 - Wear suitable gloves and eye/face protection.
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Human Experience: |
4 % solution: no irritation or sensitization. |
Oral/Parenteral Toxicity: |
oral-rat LD50 1680 mg/kg Food and Cosmetics Toxicology. Vol. 14, Pg. 605, 1976.
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Dermal Toxicity: |
subcutaneous-mouse LD50 253 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Yakugaku Zasshi. Journal of Pharmacy. Vol. 76, Pg. 186, 1956.
skin-rabbit LD50 > 5000 mg/kg Food and Cosmetics Toxicology. Vol. 14, Pg. 605, 1976.
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | flavoring agents |
IFRA Critical Effect: | Photosensitization |
IFRA: | View Standard |
Recommendation for 6-methyl coumarin usage levels up to: | | PROHIBITED: Should not be used as a fragrance ingredient.
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Maximised Survey-derived Daily Intakes (MSDI-EU): | 250.00 (μg/capita/day) |
Maximised Survey-derived Daily Intakes (MSDI-USA): | 96.00 (μg/capita/day) |
NOEL (No Observed Effect Level): | 150.00 (mg/kg bw per day) |
Structure Class: | III |
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
publication number: 3 |
Click here to view publication 3 |
| average usual ppm | average maximum ppm |
baked goods: | - | 24.00000 |
beverages(nonalcoholic): | - | 5.20000 |
beverages(alcoholic): | - | - |
breakfast cereal: | - | - |
cheese: | - | - |
chewing gum: | 0.80000 | 15.00000 |
condiments / relishes: | - | - |
confectionery froastings: | - | - |
egg products: | - | - |
fats / oils: | - | - |
fish products: | - | - |
frozen dairy: | - | 4.80000 |
fruit ices: | - | 4.80000 |
gelatins / puddings: | - | 39.00000 |
granulated sugar: | - | - |
gravies: | - | - |
hard candy: | - | 21.00000 |
imitation dairy: | - | - |
instant coffee / tea: | - | - |
jams / jellies: | - | - |
meat products: | - | - |
milk products: | - | - |
nut products: | - | - |
other grains: | - | - |
poultry: | - | - |
processed fruits: | - | - |
processed vegetables: | - | - |
reconstituted vegetables: | - | - |
seasonings / flavors: | - | - |
snack foods: | - | - |
soft candy: | - | - |
soups: | - | - |
sugar substitutes: | - | - |
sweet sauces: | - | - |
Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
2H-1- | benzopyran-2-one, 6-methyl- | | cocodescol | | coumarin, 6-methyl- | 6- | methyl benzopyrone | 6- | methyl coumarin synthetic | 6- | methyl coumarine | 6- | methyl-1,2-benzopyrone | 5- | methyl-2-hydroxyphenyl propenoic acid lactone | 5- | methyl-2-hydroxyphenylpropenoic acid lactone | 6- | methyl-2H-1-benzopyran-2-one | 6- | methyl-2H-chromen-2-one | | methyl-6 coumarin | 6- | methyl-cis-o-coumarinic lactone | 6- | methyl-cis-ortho-coumarinic lactone | 6- | methylbenzopyrone | 6- | methylchromen-2-one | 6- | methylcoumarin | 6- | methylcoumarin crystal | 6- | methylcoumarin powder | | pralina | | toncair | | toncarine |
Articles:
Info: | EVALUATION OF CERTAIN FOOD ADDITIVES AND CONTAMINANTS |
PubMed: | Aquatic toxicity assessment of the additive 6-methylcoumarine using four experimental systems. |
PubMed: | Comparison of the hepatic effects of coumarin, 3,4-dimethylcoumarin, dihydrocoumarin and 6-methylcoumarin in the rat. |
PubMed: | A predictive mouse ear-swelling model for investigating topical photoallergy. |
PubMed: | Use of the occlusive patch to evaluate the photosensitive properties of chemicals in guinea-pigs. |
PubMed: | Regulatory issues concerning AETT and 6-MC. |
PubMed: | Insight into the Functional and Structural Properties of 3-Arylcoumarin as an Interesting Scaffold in Monoamine Oxidase B Inhibition. |
PubMed: | Supramolecular photocatalysis: insights into cucurbit[8]uril catalyzed photodimerization of 6-methylcoumarin. |
PubMed: | Photomicronucleus assay of phototoxic and pseudophotoclastogenic chemicals in human keratinocyte NCTC2544 cells. |
PubMed: | Phosphorylation of histone H2AX is a powerful tool for detecting chemical photogenotoxicity. |
PubMed: | Vibrational and ab initio studies of 3-acetyl-6-bromocoumarin and 3-acetyl-6-methylcoumarin. |
PubMed: | Supramolecular photocatalysis by confinement--photodimerization of coumarins within cucurbit[8]urils. |
PubMed: | Development of an in vitro photosensitization assay using human monocyte-derived cells. |
PubMed: | Complete reduction of 2H-pyran-2-one moiety of coumarin and 6-methyl coumarin by Colletotrichum capsici. |
PubMed: | Simultaneous determination of 6-methylcoumarin and 7-methoxycoumarin in cosmetics using three-dimensional excitation-emission matrix fluorescence coupled with second-order calibration methods. |
PubMed: | Aquatic toxicity assessment of the additive 6-methylcoumarine using four experimental systems. |
PubMed: | Infrared study of 6-methylcoumarin in binary solvent mixtures. |
PubMed: | In vitro phototoxicity test using artificial skin with melanocytes. |
PubMed: | Induction of keratinocyte apoptosis by photosensitizing chemicals plus UVA. |
PubMed: | Causal agents of photoallergic contact dermatitis diagnosed in the national institute of dermatology of Colombia. |
PubMed: | Fourier transform-infrared and Raman spectra, ab initio calculations and assignments for 6-methyl-4-bromomethylcoumarin. |
PubMed: | Photoallergic contact sensitization to 6-methylcoumarin in poikiloderma of Civatte. |
PubMed: | Selectivity in the photodimerization of 6-alkylcoumarins. |
PubMed: | Use of human reconstituted epidermis Episkin for assessment of weak phototoxic potential of chemical compounds. |
PubMed: | Development of a highly sensitive in vitro phototoxicity assay using the SkinEthic reconstructed human epidermis. |
PubMed: | Photochemical formation of singlet molecular oxygen ((1)O2) in illuminated 6-methylcoumarin solutions. |
PubMed: | Comparison of the hepatic effects of coumarin, 3,4-dimethylcoumarin, dihydrocoumarin and 6-methylcoumarin in the rat. |
PubMed: | Photoallergic contact dermatitis. Results of photopatch testing in New York, 1985 to 1990. |
PubMed: | The phototoxicity of 8-methoxythionepsoralen and 6-methylthionecoumarin. |
PubMed: | A predictive mouse ear-swelling model for investigating topical photoallergy. |
PubMed: | Use of UVB and UVA to induce and elicit contact photoallergy in the mouse. |
PubMed: | Use of the occlusive patch to evaluate the photosensitive properties of chemicals in guinea-pigs. |
PubMed: | Perfume dermatitis. |
PubMed: | Mechanisms of contact photosensitivity in mice. III. Predictive testing of chemicals with photoallergenic potential in mice. |
PubMed: | [New data on photoallergy]. |
PubMed: | Determination of coumarin and 6-methylcoumarin in cosmetics by high-performance liquid chromatography. |
PubMed: | Experimental photoallergic contact dermatitis: a mouse model. |
PubMed: | The guinea pig as a model for predicting photoallergic contact dermatitis. |
PubMed: | Perfume dermatitis. Part II. Photodermatitis to Musk Ambrette and 6-methylcoumarin. |
PubMed: | Evaluation of the photocontact allergenic potential of 6-methylcoumarin in the guinea pig. |
PubMed: | Photomaximization test for identifying photoallergic contact sensitizers. |
PubMed: | Regulatory issues concerning AETT and 6-MC. |
PubMed: | Contact photoallergy to 6-methylcoumarin in proprietary sunscreens. |
PubMed: | Photocontact allergy to 6-methylcoumarin. |
PubMed: | Caffeine, caffeine derivatives and chromosomal aberrations. II. Different responses of Allium root tips and Chinese hamster cells to treatments with caffeine, 8-ethoxycaffeine and 6-methylcoumarin. |
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