Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | colorless clear viscous liquid (est) |
Assay: | 97.00 to 100.00 %
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Food Chemicals Codex Listed: | No |
Specific Gravity: | 0.92110 @ 25.00 °C.
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Refractive Index: | 1.49630 @ 20.00 °C.
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Boiling Point: | 305.00 to 307.00 °C. @ 760.00 mm Hg
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Flash Point: | 267.00 °F. TCC ( 130.56 °C. )
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logP (o/w): | 4.639 (est) |
Soluble in: |
| alcohol | | water, 1.688 mg/L @ 25 °C (est) |
Insoluble in: |
| water |
Organoleptic Properties:
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Odor Type: citrus |
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Odor Strength: | medium |
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| citrus floral tart lemon fresh sweet herbal |
Odor Description: at 100.00 %. | citrus floral tangy lemon fresh sweet herbal |
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Flavor Type: citrus |
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| citrus lemon grapefruit |
Taste Description:
| citrus lemon grapefruit |
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Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
BOC Sciences |
For experimental / research use only. |
beta-Bisabolol > 95%
Odor: characteristic Use: beta-Bisabolol is a natural monocyclic sesquiterpene alcohol. It has a weak sweet floral aroma and is used in various fragrances. It has also been used for hundreds of years in cosmetics because of its perceived skin healing properties. |
Safety Information:
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
Not determined
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Safety References:
References:
Other Information:
Potential Blenders and core components note
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For Odor |
No odor group found for these |
| lemon leaf flavor | |
aldehydic |
| decanal (aldehyde C-10) | FL/FR |
| mandarine undecenal | FL/FR |
| TMH aldehyde | FR |
aromatic |
| aromatic woody citrus floral fragrance | FR |
balsamic |
iso | bornyl acetate | FL/FR |
iso | bornyl phenyl acetate | FL/FR |
| fenchyl acetate | FL/FR |
citronella |
4,8- | dimethyl-7-nonen-2-ol | FR |
citrus |
| acetaldehyde citronellyl methyl acetal | FR |
| agrestic specialty | FR |
| bergamot fragrance | FR |
| bergamot oil | FL/FR |
| bergamot oil bergaptene reduced italy | FL/FR |
| bergamot oil replacer | FR |
| bergamot oil turkey | FL/FR |
| bergamot specialty | FR |
| bergamot vanilla specialty | FR |
| citral diethyl acetal | FL/FR |
| citral dimethyl acetal | FL/FR |
| citronella fragrance | FR |
| citronella oil ceylon | FL/FR |
| citrus floral green fragrance | FR |
| citrus ocimenol | FR |
| citrus specialty | FR |
| dihydromyrcenol | FL/FR |
2,4- | dimethyl-3-cyclohexene-1-methanyl acetate | FR |
2- | dodecanone | FL/FR |
2- | ethyl-1-hexanol | FL/FR |
citrus | floral fragrance | FR |
| grapefruit oil terpenes | FL/FR |
2- | heptanol | FL/FR |
| lemon oil terpenes | FL/FR |
| lemongrass oil | FL/FR |
| lemongrass oil terpenes | FL/FR |
| lime fragrance | FR |
| lime octadienal | FR |
| lime oil distilled mexico | FL/FR |
| lime oil replacer | FR |
| lime oil terpenes | FL/FR |
| lime specialty | FR |
| mandarin fragrance | FR |
| mandarin oil | FL/FR |
| mandarin oil (citrus reticulata nova var. mandarin) uruguay | FL/FR |
| mandarin oil italy | FL/FR |
| mandarin oil replacer | FR |
| mandarin specialty | FR |
| melissa oil slovak republic | |
3- | methyl-4-(2-methyl butyl oxy) butyraldehyde | FR |
| nonanal dimethyl acetal | FL/FR |
(+)- | nootkatone | FL/FR |
| petitgrain bergamot oil | FL/FR |
| petitgrain combava oil | FR |
(±)-2,4,8- | trimethyl-7-nonen-2-ol | FL/FR |
10- | undecen-1-ol | FL/FR |
| verbena absolute france | FL/FR |
| verbena fragrance | FR |
| verbena oil terpeneless | FL/FR |
earthy |
(Z)-4- | octen-1-ol | FL/FR |
floral |
iso | amyl salicylate | FL/FR |
| bergamot blossom fragrance | FR |
| bois de rose oil brazil | FL/FR |
| butyl tiglate | FR |
| citronellal | FL/FR |
2,4- | dimethyl-3-cyclohexene-1-methanol | FR |
| ethyl linalool | FR |
| ethyl linalyl acetal | FR |
| gardenia acetal | FR |
| herbal pyran | FR |
| karo karounde absolute | FR |
| lavandula angustifolia flower oil | FL/FR |
| lavender oil | FL/FR |
| lavender oil france | FL/FR |
| lavender oil greece | FL/FR |
| linalool | FL/FR |
para- | methyl benzyl acetate | FL/FR |
| methyl benzyl acetate (mixed ortho-,meta-,para-) | FL/FR |
(Z)- | methyl epi-jasmonate | FL/FR |
| muguet nitrile | FR |
| muguet octadienol | FR |
| nerol | FL/FR |
| neroli oil tunisia | FL/FR |
| nerolidyl acetate | FL/FR |
(R)- | ocean propanal | |
(Z)-beta- | ocimene | FL/FR |
| palmarosa oil | FL/FR |
| palmarosa oil replacer | FR |
| peony acetonitrile | FR |
| petitgrain concrete | FR |
| petitgrain grapefruit oil | FL/FR |
| petitgrain lemon oil | FL/FR |
| petitgrain oil morocco | FL/FR |
| petitgrain oil terpeneless | FL/FR |
iso | phytol | FL/FR |
| prenyl salicylate | FL/FR |
| rose undecene | FR |
| terpinyl isobutyrate | FL/FR |
| tetrahydrolinalyl acetate | FR |
(S)-2,5,6- | trimethyl-2-heptanol | |
| undecanal dimethyl acetal | FR |
fresh |
| fresh & clean fragrance | FR |
fruity |
| ethyl 3-hydroxyhexanoate | FL/FR |
| eucalyptus staigeriana oil | FR |
sesqui | phellandrene | |
fungal |
| hydroxymethyl hexyl ethyl ketone | FL/FR |
green |
iso | butyl benzyl carbinol | FL/FR |
| cucumber fragrance | FR |
| heptyl formate | FL/FR |
herbal |
| arnica flower oil | FR |
| carrot seed oil (daucus carota ssp. gummifer hook. fil.) spain | FR |
| chamomile isobutyrate | FR |
| chrysanthemum ketone | FR |
| freesia heptanol | FL/FR |
abrialis | lavandin oil | FL/FR |
| lavender absolute bulgaria | FL/FR |
| lavender absolute france | FL/FR |
| lavender concrete | FL/FR |
| lavender oil terpeneless | FL/FR |
| lavender oil terpenes | |
| lavender stem oil lithuania | FR |
| matricaria chamomilla flower oil | FL/FR |
| myrtle oil | FL/FR |
| tea leaf absolute | FL/FR |
alpha- | terpinyl acetate | FL/FR |
pine |
| dihydroterpineol | FR |
| caraway seed oleoresin | FL/FR |
| gingergrass oil | FR |
sulfurous |
4- | tropical oxathiane | FL/FR |
terpenic |
(E,E)-2,6-allo | ocimene | FL/FR |
alpha- | terpineol | FL/FR |
tobacco |
2,6,6- | trimethyl-2-hydroxycyclohexanone | FL/FR |
waxy |
| decanal dimethyl acetal | FL/FR |
1,8- | octane dinitrile | |
1- | undecanol | FL/FR |
woody |
cis-3-tert- | butyl cyclohexyl acetate | |
2- | decalinyl acetate | FR |
alpha- | terpinene | FL/FR |
| zdravetz oil | FL/FR |
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For Flavor |
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No flavor group found for these |
iso | bornyl phenyl acetate | FL/FR |
cis-3-tert- | butyl cyclohexyl acetate | |
| capsicum oleoresin CO2 extract | FL |
| decanal dimethyl acetal | FL/FR |
8,9- | dehydrotheaspirone | FL |
| hydroxymethyl hexyl ethyl ketone | FL/FR |
| lavender oil terpenes | |
| mandarine undecenal | FL/FR |
| melissa oil slovak republic | |
| methyl benzyl acetate (mixed ortho-,meta-,para-) | FL/FR |
| nerolidyl acetate | FL/FR |
(R)- | ocean propanal | |
(E,E)-2,6-allo | ocimene | FL/FR |
1,8- | octane dinitrile | |
(Z)-4- | octen-1-ol | FL/FR |
sesqui | phellandrene | |
| terpinyl isobutyrate | FL/FR |
(S)-2,5,6- | trimethyl-2-heptanol | |
2,6,6- | trimethyl-2-hydroxycyclohexanone | FL/FR |
10- | undecen-1-ol | FL/FR |
| zdravetz oil | FL/FR |
acidic |
(E)-2- | hexenoic acid | FL |
aldehydic |
1- | undecanol | FL/FR |
amber |
iso | butyl benzyl carbinol | FL/FR |
berry |
| berry lemon flavor | FL |
buttery |
| butter lemon flavor | FL |
citrus |
| bergamot oil | FL/FR |
| bergamot oil bergaptene reduced italy | FL/FR |
| bergamot oil turkey | FL/FR |
| citral diethyl acetal | FL/FR |
| citral dimethyl acetal | FL/FR |
| citron flavor | FL |
| citronella oil ceylon | FL/FR |
| freesia heptanol | FL/FR |
| grapefruit oil terpenes | FL/FR |
| lemon berry flavor | FL |
| lemon oil terpenes | FL/FR |
| lemon tarragon flavor | FL |
| lemongrass flavor | FL |
| lemongrass oil | FL/FR |
| lemongrass oil terpenes | FL/FR |
| lime oil distilled mexico | FL/FR |
| lime oil terpenes | FL/FR |
| linalool | FL/FR |
| mandarin oil | FL/FR |
| mandarin oil (citrus reticulata nova var. mandarin) uruguay | FL/FR |
| mandarin oil italy | FL/FR |
| nerol | FL/FR |
| neroli oil tunisia | FL/FR |
(+)- | nootkatone | FL/FR |
| petitgrain bergamot oil | FL/FR |
| petitgrain grapefruit oil | FL/FR |
| petitgrain lemon oil | FL/FR |
| petitgrain oil morocco | FL/FR |
| petitgrain oil terpeneless | FL/FR |
alpha- | terpineol | FL/FR |
(±)-2,4,8- | trimethyl-7-nonen-2-ol | FL/FR |
| verbena absolute france | FL/FR |
| verbena oil terpeneless | FL/FR |
fatty |
2- | dodecanone | FL/FR |
2- | ethyl-1-hexanol | FL/FR |
| heptyl formate | FL/FR |
floral |
| bois de rose oil brazil | FL/FR |
| citronellal | FL/FR |
pseudo | ionone | FL |
(Z)- | methyl epi-jasmonate | FL/FR |
fruity |
| blueberry lemon flavor | FL |
| ethyl 3-hydroxyhexanoate | FL/FR |
2- | heptanol | FL/FR |
para- | methyl benzyl acetate | FL/FR |
4- | tropical oxathiane | FL/FR |
grassy |
| palmarosa oil | FL/FR |
green |
iso | amyl salicylate | FL/FR |
| dihydromyrcenol | FL/FR |
(E,E)-2,4- | hexadienal | FL |
| lemon leaf flavor | |
| nonanal dimethyl acetal | FL/FR |
(Z)-beta- | ocimene | FL/FR |
herbal |
abrialis | lavandin oil | FL/FR |
| lavandula angustifolia flower oil | FL/FR |
| lavender absolute bulgaria | FL/FR |
| lavender absolute france | FL/FR |
| lavender concrete | FL/FR |
| lavender oil | FL/FR |
| lavender oil france | FL/FR |
| lavender oil greece | FL/FR |
| lavender oil terpeneless | FL/FR |
| matricaria chamomilla flower oil | FL/FR |
| prenyl salicylate | FL/FR |
oily |
iso | phytol | FL/FR |
spicy |
| caraway seed oleoresin | FL/FR |
| myrtle oil | FL/FR |
tea |
| tea leaf absolute | FL/FR |
terpenic |
alpha- | terpinene | FL/FR |
waxy |
| decanal (aldehyde C-10) | FL/FR |
woody |
iso | bornyl acetate | FL/FR |
| fenchyl acetate | FL/FR |
alpha- | terpinyl acetate | FL/FR |
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Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
.beta.- | bisabolol | 3- | cyclohexen-1-ol, 1-(1,5-dimethyl-4-hexenyl)-4-methyl- | (1S)-1-((1S)-1,5- | dimethyl-4-hexenyl)-4-methyl-3-cyclohexen-1-ol | (S-(R*,R*))-1-(1,5- | dimethyl-4-hexenyl)-4-methyl-3-cyclohexen-1-ol | 4- | methyl-1-(6-methylhept-5-en-2-yl)cyclohex-3-en-1-ol |
Articles:
PubMed: | Essential oils composition of croton species from the Amazon. |
PubMed: | Hepatoprotection of sesquiterpenoids: a quantitative structure-activity relationship (QSAR) approach. |
PubMed: | Hydroxylated bisabolol oxides: evidence for secondary oxidative metabolism in Matricaria chamomilla. |
PubMed: | Antihyperalgesic and antiedematous activities of bisabolol-oxides-rich matricaria oil in a rat model of inflammation. |
PubMed: | Chemotaxonomic importance of the essential-oil composition in two subspecies of Teucrium stocksianum Boiss. from Iran. |
PubMed: | Essential oil of flowers of Anaphalis contorta, an aromatic and medicinal plant from India. |
PubMed: | α-bisabolol is an effective proapoptotic agent against BCR-ABL(+) cells in synergism with Imatinib and Nilotinib. |
PubMed: | Fast quality assessment of German chamomile (Matricaria chamomilla L.) by headspace solid-phase microextraction: influence of flower development stage. |
PubMed: | STAT-3 inhibitory bisabolanes from Carthamus glaucus. |
PubMed: | Psychopharmacological profile of Chamomile (Matricaria recutita L.) essential oil in mice. |
PubMed: | Composition and antimicrobial activity of the essential oil of Heracleum thomsonii (Clarke) from the cold desert of the western Himalayas. |
PubMed: | Inhibitory effects of (-)-α-bisabolol on LPS-induced inflammatory response in RAW264.7 macrophages. |
PubMed: | Composition and antifungal activity of the essential oil from the rhizome and roots of Ferula hermonis. |
PubMed: | Pro-apoptotic activity of α-bisabolol in preclinical models of primary human acute leukemia cells. |
PubMed: | Sandalwood fragrance biosynthesis involves sesquiterpene synthases of both the terpene synthase (TPS)-a and TPS-b subfamilies, including santalene synthases. |
PubMed: | Effect of topical heparin and levomenol on atopic dermatitis: a randomized four-arm, placebo-controlled, double-blind clinical study. |
PubMed: | Antiplasmodial volatile extracts from Cleistopholis patens Engler & Diels and Uvariastrum pierreanum Engl. (Engl. & Diels) (Annonaceae) growing in Cameroon. |
PubMed: | In vivo effect of alpha-bisabolol, a nontoxic sesquiterpene alcohol, on the induction of spontaneous mammary tumors in HER-2/neu transgenic mice. |
PubMed: | Variability of the essential oil content and composition of chamomile (Matricaria recutita L.) affected by weather conditions. |
PubMed: | alpha-Bisabolol induces dose- and time-dependent apoptosis in HepG2 cells via a Fas- and mitochondrial-related pathway, involves p53 and NFkappaB. |
PubMed: | Content and composition of the essential oil of Chamomilla recutita (L.) Rauschert from some European countries. |
PubMed: | Validation of a high-performance liquid chromatography method for the determination of (-)-alpha-bisabolol from particulate systems. |
PubMed: | Chemical composition and antifungal activity of Arnica longifolia, Aster hesperius, and Chrysothamnus nauseosus essential oils. |
PubMed: | Chemical composition and antimicrobial activity of volatile components from capitula and aerial parts of Rhaponticum acaule DC growing wild in Tunisia. |
PubMed: | Analysis of leaf volatiles of Zanthoxylum gillettii used in folk medicine of Cameroon. |
PubMed: | Phytochemical analysis of the essential oil of Achillea millefolium L. from various European Countries. |
PubMed: | Synthesis of beta-bisabolol by ring-closing olefin metathesis reaction. |
PubMed: | Evaluation of mutagenic and antimutagenic activities of alpha-bisabolol in the Salmonella/microsome assay. |
PubMed: | Effect of magnesium on essential oil formation of genetically transformed and non-transformed chamomile cultures. |
PubMed: | Determination of alpha-bisabolol in human blood by micro-HPLC-ion trap MS and head space-GC-MS methods. |
PubMed: | New terpenoids in cultivated and wild chamomile (in vivo and in vitro). |
PubMed: | Sensitization of Staphylococcus aureus and Escherichia coli to antibiotics by the sesquiterpenoids nerolidol, farnesol, bisabolol, and apritone. |
PubMed: | The ability of Bipolaris sorokiniana to modify geraniol and (-)-alpha-bisabolol as exogenous substrates. |
PubMed: | Phase solubility studies of pure (-)-alpha-bisabolol and camomile essential oil with beta-cyclodextrin. |
PubMed: | Anthocyanin, bisabolol and phenylammonialyase activity in cell cultures of Populus deltoides. |
PubMed: | [Study of tolerance and efficacy of cosmetic preparations with lenitive action in atopic dermatitis in children]. |
PubMed: | Antennal olfactory responsiveness ofMicroplitis croceipes (Hymenoptera: Braconidae) to cotton plant volatiles. |
PubMed: | Determination of alpha-bisabolol and d-panthenol in cosmetic products by gas chromatography. |
PubMed: | Orientation of boll weevil,Anthonomus grandis boh. (Coleoptera: Curculionidae), to pheromone and volatile host compound in the laboratory. |
PubMed: | Electroantennogram responses ofTrirhabda bacharides (weber) (Coleoptera: Chrysomelidae) to plant volatiles. |
PubMed: | Olfaction in the boll weevil,Anthonomus grandis Boh. (Coleoptera: Curculionidae): Electroantennogram studies. |
PubMed: | Isolation and identification of cotton synomones mediating searching behavior by parasitoidCampoletis sonorensis. |
PubMed: | Identification and quantitative analysis of the volatile substances emitted by maturing cotton in the field. |
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