asarone
1,2,4-trimethoxy-5-propenylbenzene
 
Notes:
None found
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CAS Number: 494-40-6Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 207-788-7
XlogP3: 3.00 (est)
Molecular Weight: 208.25712000
Formula: C12 H16 O3
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 92.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 62.00 to  63.00 °C. @ 760.00 mm Hg
Boiling Point: 167.00 to  168.00 °C. @ 12.00 mm Hg
Boiling Point: 265.00 to  267.00 °C. @ 760.00 mm Hg
Vapor Pressure: 0.003000 mmHg @ 25.00 °C. (est)
Flash Point: 226.00 °F. TCC ( 107.78 °C. )
logP (o/w): 3.406 (est)
Soluble in:
 alcohol
 water, slightly
 water, 101.8 mg/L @ 25 °C (est)
Insoluble in:
 water
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Organoleptic Properties:
Odor Description:
odorless
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
 None found
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: natural substances and extractives
IFRA Critical Effect: Carcinogenicity
IFRA fragrance material specification:
 

cis- and trans-Asarone as such should not be used as fragrance ingredients; essential oils containing cis- or trans-asarone (e.g. calamus oils) should not be used at a level such that the total concentration of cis- and trans-asarone exceeds 0.01% in consumer products.

IFRA: View Standard
View IFRA Standards Library for complete information.
Please review Amendment 49 IFRA documentation for complete information.
IFRA RESTRICTION LIMITS IN THE FINISHED PRODUCT (%):
Category 1: Products applied to the lips
See notebox %
Category 2: Products applied to the axillae
See notebox %
Category 3: Products applied to the face/body using fingertips
See notebox %
Category 4: Products related to fine fragrance
See notebox %
 Category 5: Products applied to the face and body using the hands (palms), primarily leave-on
Category 5A: Body lotion products applied to the body using the hands (palms), primarily leave-on
See notebox %
Category 5B: Face moisturizer products applied to the face using the hands (palms), primarily leave-on
See notebox %
Category 5C: Hand cream products applied to the hands using the hands (palms), primarily leave-on
See notebox %
Category 5D: Baby Creams, baby Oils and baby talc
See notebox %
Category 6: Products with oral and lip exposure
See notebox %
 Category 7: Products applied to the hair with some hand contact
Category 7A: Rinse-off products applied to the hair with some hand contact
See notebox %
Category 7B: Leave-on products applied to the hair with some hand contact
See notebox %
Category 8: Products with significant anogenital exposure
See notebox %
Category 9: Products with body and hand exposure, primarily rinse off
See notebox %
 Category 10: Household care products with mostly hand contact
Category 10A: Household care excluding aerosol products (excluding aerosol/spray products)
See notebox %
Category 10B: Household aerosol/spray products
See notebox %
 Category 11: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate
Category 11A: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
See notebox %
Category 11B: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
See notebox %
Category 12: Products not intended for direct skin contact, minimal or insignificant transfer to skin
See notebox
 Notes:
IFRA FLAVOR REQUIREMENTS:

Due to the possible ingestion of small amounts of fragrance ingredients from their use in products in Categories 1 and 6, materials must not only comply with IFRA Standards but must also be recognized as safe as a flavoring ingredient as defined by the IOFI Code of Practice (www.iofi.org). For more details see chapter 1 of the Guidance for the use of IFRA Standards.

Fragrance ingredient restriction - Note box
On the basis of established maximum concentration levels of this substance in commercially available natural sources (like essential oils, extracts and absolutes), exposure to this substance from the use of these oils and extracts (e.g. Calamus oils) is regarded acceptable as long as the level of cis- and trans-Asarone in the finished consumer product does not exceed 100ppm (0.01 %).
 
Recommendation for asarone flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 17903
National Institute of Allergy and Infectious Diseases: Data
 1,2,4-trimethoxy-5-prop-1-enylbenzene
Chemidplus: 0000494406
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References:
 1,2,4-trimethoxy-5-prop-1-enylbenzene
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 17903
Pubchem (sid): 135056886
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
HMDB (The Human Metabolome Database): Search
Typical G.C.
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 asarum arifolium
Search Trop  Picture
 calamus root oil
Search Trop  Picture
 clove bud oil @ 1.08%
Data  GC  Search Trop  Picture
 clove leaf oil @ 0.45%
Data  GC  Search Trop  Picture
 clove stem oil india @ 0.50%
Data  GC  Search Trop  Picture
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Synonyms:
 azaron
 benzene, 1,2,4-trimethoxy-5-(1-propen-1-yl)-
 benzene, 1,2,4-trimethoxy-5-(1-propenyl)-
 benzene, 1,2,4-trimethoxy-5-propenyl-
2,4,5-trimethoxy-1-propenylbenzene
1,2,5-trimethoxy-4-propenyl benzene
1,2,4-trimethoxy-5-(prop-1-en-1-yl)benzene
1,2,4-trimethoxy-5-prop-1-enylbenzene
1,2,4-trimethoxy-5-propenyl benzene
1,2,4-trimethoxy-5-propenylbenzene
Synonyms   Articles   Notes   Search   Top
Articles:
PubMed: Proteomic analysis of β-asarone induced cytotoxicity in human glioblastoma U251 cells.
PubMed: α-Asarone attenuates microglia-mediated neuroinflammation by inhibiting NF kappa B activation and mitigates MPTP-induced behavioral deficits in a mouse model of Parkinson's disease.
PubMed: β-asarone and levodopa co-administration protects against 6-hydroxydopamine-induced damage in parkinsonian rat mesencephalon by regulating autophagy: down-expression Beclin-1 and light chain 3B and up-expression P62.
PubMed: β-asarone inhibits gastric cancer cell proliferation.
PubMed: Effect of α-asarone on angiogenesis and matrix metalloproteinase.
PubMed: [Pharmacokinetic study on dry powder inhalation administration of α-asarone in rats].
PubMed: β-Asarone Mitigates Amyloidosis and Downregulates RAGE in a Transgenic Mouse Model of Alzheimer's Disease.
PubMed: Coadministration of β-asarone and levodopa increases dopamine in rat brain by accelerating transformation of levodopa: a different mechanism from Madopar.
PubMed: Beta-asarone attenuates amyloid beta-induced autophagy via Akt/mTOR pathway in PC12 cells.
PubMed: β-Asarone (cis-2,4,5-trimethoxy-1-allyl phenyl), attenuates pro-inflammatory mediators by inhibiting NF-κB signaling and the JNK pathway in LPS activated BV-2 microglia cells.
PubMed: Distribution of α-asarone in brain following three different routes of administration in rats.
PubMed: Neuroprotective Effects of β-Asarone Against 6-Hydroxy Dopamine-Induced Parkinsonism via JNK/Bcl-2/Beclin-1 Pathway.
PubMed: β-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in asenescence-accelerated prone 8 mice.
PubMed: Reversing P-glycoprotein-mediated multidrug resistance in vitro by α-asarone and β-asarone, bioactive cis-trans isomers from Acorus tatarinowii.
PubMed: β-asarone reverses chronic unpredictable mild stress-induced depression-like behavior and promotes hippocampal neurogenesis in rats.
PubMed: The involvement of neuronal nitric oxide synthase in antiepileptic action of alpha-asarone on pentylenetetrazol molding rats.
PubMed: α-Asarone Ameliorates Memory Deficit in Lipopolysaccharide-Treated Mice via Suppression of Pro-Inflammatory Cytokines and Microglial Activation.
PubMed: Identification of both GABAA receptors and voltage-activated Na(+) channels as molecular targets of anticonvulsant α-asarone.
PubMed: Beta-asarone, a major component of Acorus tatarinowii Schott, attenuates focal cerebral ischemia induced by middle cerebral artery occlusion in rats.
PubMed: Alpha-Asarone Protects Endothelial Cells from Injury by Angiotensin II.
PubMed: Development of intravenous lipid emulsion of α-asarone with significantly improved safety and enhanced efficacy.
PubMed: Effect of Beta-Asarone on Impairment of Spatial Working Memory and Apoptosis in the Hippocampus of Rats Exposed to Chronic Corticosterone Administration.
PubMed: β-Asarone induces senescence in colorectal cancer cells by inducing lamin B1 expression.
PubMed: α-asarone from Acorus gramineus alleviates epilepsy by modulating A-type GABA receptors.
PubMed: Purple perilla extracts with α-asarone enhance cholesterol efflux from oxidized LDL-exposed macrophages.
PubMed: Antidepressant-like effects of essential oil and asarone, a major essential oil component from the rhizome of Acorus tatarinowii.
PubMed: β-Asarone, an active principle of Acorus calamus rhizome, inhibits morphogenesis, biofilm formation and ergosterol biosynthesis in Candida albicans.
PubMed: Anticonvulsant activity of acute and chronic treatment with a-asarone from Acorus gramineus in seizure models.
PubMed: [Quality evaluation and stability investigation of asarone submicro emulsion injection].
PubMed: Systemic delivery of alpha-asarone with Kolliphor HS 15 improves its safety and therapeutic effect on asthma.
PubMed: Hepatic Metabolism of Carcinogenic β-Asarone.
PubMed: β-Asarone inhibits neuronal apoptosis via the CaMKII/CREB/Bcl-2 signaling pathway in an in vitro model and AβPP/PS1 mice.
PubMed: β-asarone from Acorus gramineus alleviates depression by modulating MKP-1.
PubMed: Assessment of the genotoxic activity of alpha-asarone and its derivatives in the comet assay.
PubMed: Synthesis and antifeedant activity of novel alpha-asarone derivatives against stored-product pests.
PubMed: Analysis of transformation and excretion of β-asarone in rabbits with GC-MS.
PubMed: Loading amorphous Asarone in mesoporous silica SBA-15 through supercritical carbon dioxide technology to enhance dissolution and bioavailability.
PubMed: Anxiolytic-like effect of α-asarone in mice.
PubMed: Role of Acorus calamus and alpha-asarone on hippocampal dependent memory in noise stress exposed rats.
PubMed: Cerebrovascular protection of β-asarone in Alzheimer's disease rats: a behavioral, cerebral blood flow, biochemical and genic study.
PubMed: Alpha-Asarone, a Major Component of Acorus gramineus, Attenuates Corticosterone-Induced Anxiety-Like Behaviours via Modulating TrkB Signaling Process.
PubMed: Synthesis and highly potent hypolipidemic activity of alpha-asarone- and fibrate-based 2-acyl and 2-alkyl phenols as HMG-CoA reductase inhibitors.
PubMed: Beta-asarone attenuates ischemia-reperfusion-induced autophagy in rat brains via modulating JNK, p-JNK, Bcl-2 and Beclin 1.
PubMed: Discrimination of fennel chemotypes applying IR and Raman spectroscopy: discovery of a new γ-asarone chemotype.
PubMed: Nitro Derivatives of Naturally Occurring β -Asarone and Their Anticancer Activity.
PubMed: Comparative study of the cytotoxicity and genotoxicity of alpha- and Beta-asarone.
PubMed: Pharmacokinetics of beta-asarone in rabbit blood, hippocampus, cortex, brain stem, thalamus and cerebellum.
PubMed: Fate of β-asarone in Ayurvedic Sodhana process of Vacha.
PubMed: Synthesis, antifeedant activity against Coleoptera and 3D QSAR study of alpha-asarone derivatives.
PubMed: Alpha- and beta-asarone in herbal medicinal products. A case study.
PubMed: Cognitive enhancing effects of alpha asarone in amnesic mice by influencing cholinergic and antioxidant defense mechanisms.
PubMed: β-Asarone protects PC12 cells against OGD/R-induced injury via attenuating Beclin-1-dependent autophagy.
PubMed: Beta-asarone induces LoVo colon cancer cell apoptosis by up-regulation of caspases through a mitochondrial pathway in vitro and in vivo.
PubMed: An efficient combination of supercritical fluid extraction and high-speed counter-current chromatography to extract and purify (E)- and (Z)-diastereomers of α-asarone and β-asarone from Acorus tatarinowii Schott.
PubMed: Simultaneous determination of α-, β- and γ-asarone in Acorus tatarinowii by microemulsion electrokinetic chromatography with [BMIM]PF6 as oil phase.
PubMed: Development and evaluation of α-asarone transdermal patches based on hot-melt pressure-sensitive adhesives.
PubMed: A rapid HPLC-ESI-MS/MS method for determination of β-asarone, a potential anti-epileptic agent, in plasma after oral administration of Acorus calamus extract to rats.
PubMed: Beta-asarone attenuates beta-amyloid-induced apoptosis through the inhibition of the activation of apoptosis signal-regulating kinase 1 in SH-SY5Y cells.
PubMed: Radioprotection by α-asarone: prevention of genotoxicity and hematopoietic injury in mammalian organism.
PubMed: Activities of α-asarone in various animal seizure models and in biochemical assays might be essentially accounted for by antioxidant properties.
PubMed: Beta-asarone inhibits synaptic inputs to airway preganglionic parasympathetic motoneurons.
PubMed: GC-MS method for determination and pharmacokinetic study of four phenylpropanoids in rat plasma after oral administration of the essential oil of Acorus tatarinowii Schott rhizomes.
PubMed: Protective effects of components of the Chinese herb grassleaf sweetflag rhizome on PC12 cells incubated with amyloid-beta42.
PubMed: Alpha-Asarone incorporated in mixed micelles suitable for intravenous administration: formulation, in-vivo distribution and anaphylaxis study.
PubMed: Separation of cis- and trans-Asarone from Acorus tatarinowii by Preparative Gas Chromatography.
PubMed: Beta-asarone protection against beta-amyloid-induced neurotoxicity in PC12 cells via JNK signaling and modulation of Bcl-2 family proteins.
PubMed: Development of drug-in-adhesive transdermal patch for α-asarone and in vivo pharmacokinetics and efficacy evaluation.
PubMed: Beta-asarone attenuates neuronal apoptosis induced by Beta amyloid in rat hippocampus.
PubMed: Metabolism mediated interaction of α-asarone and Acorus calamus with CYP3A4 and CYP2D6.
PubMed: Asarone inhibits adipogenesis and stimulates lipolysis in 3T3-L1 adipocytes.
PubMed: Reduction of beta-asarone in acori rhizoma by decoction.
PubMed: Bioanalytical investigation of asarone in connection with Acorus calamus oil intoxications.
PubMed: Effects of alpha-asarone on the glutamate transporter EAAC1 in Xenopus oocytes.
PubMed: Reinvestigation of structure-activity relationship of methoxylated chalcones as antimalarials: synthesis and evaluation of 2,4,5-trimethoxy substituted patterns as lead candidates derived from abundantly available natural β-asarone.
PubMed: Beta-asarone improves cognitive function by suppressing neuronal apoptosis in the beta-amyloid hippocampus injection rats.
PubMed: Design, synthesis, and docking of highly hypolipidemic agents: Schizosaccharomyces pombe as a new model for evaluating alpha-asarone-based HMG-CoA reductase inhibitors.
PubMed: 2,4,5-trimethoxycinnamic acid: the major metabolite of alpha-asarone, retains most of the pharmacological properties of alpha-asarone.
PubMed: Metabolite profiling of tissues of Acorus calamus and Acorus tatarinowii rhizomes by using LMD, UHPLC-QTOF MS, and GC-MS.
PubMed: Neuroprotective effect of alpha-asarone on spatial memory and nitric oxide levels in rats injected with amyloid-beta((25-35)).
PubMed: Hepatotoxic potential of asarones: in vitro evaluation of hepatotoxicity and quantitative determination in herbal products.
PubMed: Larvicidal activity of the essential oil of Youngia japonica aerial parts and its constituents against Aedes albopictus.
PubMed: [Effects of beta-asarone on expression of FOS and GAD65 in cortex of epileptic rat induced by penicillin].
PubMed: [Comparison of kinetic behavior in both plasma and tissue after intravenous administration of alpha-asarone in lipid emulsion and aqueous solution in rats and mice].
PubMed: [Effects of beta-asarone on morphology and cell viability in PC12 cells and cultured rat cortical neurons].
PubMed: Preparation and characterization of solid lipid nanoparticles loaded with alpha-Asarone.
PubMed: Effect of alpha-asarone and a derivative on lipids, bile flow and Na+/K+-ATPase in ethinyl estradiol-induced cholestasis in the rat.
PubMed: Rapid assessment of beta-asarone content of Acorus calamus by micellar electrokinetic capillary chromatography.
PubMed: Alpha-asarone inhibits HMG-CoA reductase, lowers serum LDL-cholesterol levels and reduces biliary CSI in hypercholesterolemic rats.
PubMed: Protection of cultured rat cortical neurons from excitotoxicity by asarone, a major essential oil component in the rhizomes of Acorus gramineus.
PubMed: Antifungal activity of beta-asarone from rhizomes of Acorus gramineus.
PubMed: [Effects of beta-asarone on expression of c-fos in kindling epilepsy rat brain].
PubMed: Antioxidant property of alpha-asarone against noise-stress-induced changes in different regions of rat brain.
PubMed: [Pharmacology and toxicology of Guatteria gaumeri and alpha-asarone].
PubMed: A herbal medicine for Alzheimer's disease and its active constituents promote neural progenitor proliferation.
PubMed: Systematic study of beta-asarone-rich volatile oil from Acori graminei rhizoma by off-line supercritical CO2 extraction-gas chromatography-mass spectrometry.
PubMed: Identification of an EcoRI restriction site for a rapid and precise determination of beta-asarone-free Acorus calamus cytotypes.
PubMed: [Pharmacokinetics of beta-asarone in rats].
PubMed: [Protective effects of beta-asarone on cultured rat cortical neurons damage induced by glutamate].
PubMed: Dominant lethal study of alpha-asarone in male mice.
PubMed: alpha-Asarone toxicity in long-term cultures of adult rat hepatocytes.
PubMed: Compositional variations and anthelmentic activity of essential oils from rhizomes of different wild populations of Acorus calamus L. and its major component, beta-Asarone.
PubMed: Effects of asarone and beta-asarone on conditioned responses, fighting behaviour and convulsions.
PubMed: Genotoxicity of alpha-asarone analogues.
PubMed: Quantitative determination of beta-asarone in calamus by high-performance thin-layer chromatography.
PubMed: [Asarone and its biological properties].
PubMed: Molecular and chemical profiling of 'sweet flag' (Acorus calamus L.) germplasm from India.
PubMed: [1,2,4-TRIMETHOXY-5-PROPENYLBENZENE: A POSSIBLE SOURCE OF A FAMILY OF ANXIOLYTIC DRUGS].
PubMed: [Study on alpha-asarone reservoir-type patch].
PubMed: Comparison of GC-MS and TLC techniques for asarone isomers determination.
PubMed: Mobility inhibition and nematocidal activity of asarone and related phenylpropanoids on second-stage larvae of Toxocara canis.
PubMed: Disposition of asarone after intravenous administration to rabbits assessed using HPLC.
PubMed: [The effective parts of liangxue tongyu prescription on cooling-blood and activating-blood and analysis of chemical constituents by HPLC-MS and GC-MS].
PubMed: Consumer and farmer safety evaluation of application of botanical pesticides in black pepper crop protection.
PubMed: In vitro genotoxic evaluation of three alpha-asarone analogues.
PubMed: Pest-managing efficacy of trans-asarone isolated from Daucus carota L. seeds.
PubMed: A mild and convenient procedure for the conversion of toxic beta-asarone into rare phenylpropanoids: 2,4,5-trimethoxycinnamaldehyde and gamma-asarone.
PubMed: Synthesis and hypolipidemic and antiplatelet activities of alpha-asarone isomers in humans (in vitro), mice (in vivo), and rats (in vivo).
PubMed: Inhibition of lipid synthesis and secretion in long-term cultures of adult rat hepatocytes by alpha-asarone.
PubMed: Molecular docking of the highly hypolipidemic agent alpha-asarone with the catalytic portion of HMG-CoA reductase.
PubMed: New studies on trans-anethole oxide and trans-asarone oxide.
PubMed: Gas-liquid chromatographic determination of beta-asarone in wines and flavors.
PubMed: Dominant lethal study of alpha-asarone in male and female mice after sub-chronic treatment.
PubMed: Synthesis and hypolipidaemic evaluation of a series of alpha-asarone analogues related to clofibrate in mice.
PubMed: alpha-asarone congeners as hypolipidemic agents. Pseudoreceptor versus minireceptor modeling.
PubMed: Genotoxicity of the alkenylbenzenes alpha- and beta-asarone, myristicin and elimicin as determined by the UDS assay in cultured rat hepatocytes.
PubMed: An overview on traditional uses and pharmacological profile of Acorus calamus Linn. (Sweet flag) and other Acorus species.
PubMed: Identification of insecticidal constituents of the essential oil of Acorus calamus rhizomes against Liposcelis bostrychophila Badonnel.
PubMed: The Rhizomes of Acorus gramineus and the Constituents Inhibit Allergic Response In vitro and In vivo.
PubMed: A fraction of Acorus calamus L. extract devoid of beta-asarone enhances adipocyte differentiation in 3T3-L1 cells.
PubMed: Development of self-microemulsifying drug delivery systems for oral bioavailability enhancement of alpha-Asarone in beagle dogs.
PubMed: Ultrasound-assisted conversion of toxic beta-asarone into nontoxic bioactive phenylpropanoid: isoacoramone, a metabolite of Piper marginatum and Acorus tararinowii.
PubMed: One step conversion of toxic beta-asarone from Acorus calamus into 1-(2,4,5-trimethoxyphenyl)-1,2-dihydroxypropane and asaronaldehyde occurring in Piper clusii.
PubMed: Sister-chromatid exchange induction produced by in vivo and in vitro exposure to alpha-asarone.
PubMed: [A review of recent ten-year study on alpha-asarone].
PubMed: Hypolipidaemic and antiplatelet activity of phenoxyacetic acid derivatives related to alpha-asarone.
PubMed: Synthesis and hypolipidemic activity of modified side chain alpha-asarone homologues.
PubMed: [Teratogenic action of alpha-asarone in the mouse].
PubMed: Quantitative analysis of alpha, beta-thujone, pulegone, safrole, coumarin and beta-asarone in alcoholic beverages by selected-ion monitoring.
PubMed: Simultaneous Determination of Volatile Constituents from Acorus tatarinowii Schott in Rat Plasma by Gas Chromatography-Mass Spectrometry with Selective Ion Monitoring and Application in Pharmacokinetic Study.
PubMed: The efficacy of essential oils as natural preservatives in vegetable oil.
PubMed: Bicycloillicinone asarone acetal: a novel prenylated C6-C3 compound increasing choline acetyltransferase (ChAT) activity from Illicium tashiroi.
PubMed: Hypolipidaemic activity of alpha-asarone in mice.
PubMed: The anticoagulant effect of beta-asarone in the mouse and the rat.
PubMed: Mutagenicity testing of beta-asarone and commercial calamus drugs with Salmonella typhimurium.
PubMed: [Teratogenic evaluation of alpha-asarone in the rat].
PubMed: Determination of beta-asarone, safrole, isosafrole and anethole in alcoholic drinks by high-performance liquid chromatography.
PubMed: [Research on the anticarcinogenic activation of Acorus calcamus. Anticarcinogenic activation of alpha-asarone on human carcinoma cells].
PubMed: Status epilepticus treated by alpha-asarone. Report of 18 cases.
PubMed: Studies on Acorus calamus. VI. Pharmacological actions of asarone and beta-asarone on cardiovascular system and smooth muscles.
PubMed: Pharmacodynamical effects of asarone and beta-asarone.
PubMed: Chemical compositions, phytotoxicity, and biological activities of Acorus calamus essential oils from Nepal.
PubMed: [Composition of the essential oil from beta-Asarone free calamus.].
PubMed: Gas-liquid chromatographic determination of beta-asarone in wine: collaborative study.
PubMed: Studies on Acorus calamus. V. Pharmacological actions of asarone and beta-asarone on central nervous system.
PubMed: Spectrofluorometric determination of beta-asarone in sweet and dry vermouths.
PubMed: [Thin-layer cromatographic and densitometric evaluation of beta-asarone in alcoholic flavored beverages (author's transl)].
PubMed: New compounds: structural analogs related to asarone and mescaline.
PubMed: Is asarone a tranquilliser?
PubMed: Is asarone a tranquilliser?
PubMed: The mechanism of the tranquillizing action of asarone from Acorus calamus Linn.
PubMed: Effect of asarone on experimentally induced conflict neurosis in rats.
PubMed: ACTIONS OF ASARONE ON BEHAVIOR, STRESS, AND HYPERPYREXIA, AND ITS INTERACTION WITH CENTRAL STIMULANTS.
PubMed: Spasmolytic activity of asarone and essential oil of Acorus calamus, Linn.
PubMed: Interaction of asarone with mescaline, amphetamine and tremorine.
PubMed: [ANALYSIS OF THE COMPONENTS OF ASARUM EUROPEUM L. VI. DETERMINATION OF THE VOLATILE OIL AND ASARONE-(1-PROPENYL-2,4,5,-TRIMETHOXY-BENZOL) CONTENT].
PubMed: [Chemical constituents from rhizomes of Acorus tatarinowii].
PubMed: Metabolism by grasshoppers of volatile chemical constituents from Mangifera indica and Solanum paniculatum leaves.
PubMed: The effects of Acorus tatarinowii Schott on 5-HT concentrations, TPH2 and 5-HT1B expression in the dorsal raphe of exercised rats.
PubMed: Terpenoid composition and antifungal activity of three commercially important essential oils against Aspergillus flavus and Aspergillus niger.
PubMed: Antioxidant and α -amylase inhibitory property of phyllanthus virgatus L.: an in vitro and molecular interaction study.
PubMed: Growth-Inhibiting and morphostructural effects of constituents identified in Asarum heterotropoides root on human intestinal bacteria.
PubMed: Chemical composition and insecticidal activities of essential oils against diamondback moth, Plutella xylostella (L.) (Lepidoptera: Yponomeutidae).
PubMed: Hypocholesterolemic and choleretic effects of three dimethoxycinnamic acids in relation to 2,4,5-trimethoxycinnamic acid in rats fed with a high-cholesterol/cholate diet.
PubMed: Śodhana: An Ayurvedic process for detoxification and modification of therapeutic activities of poisonous medicinal plants.
PubMed: Identification of sesquiterpene lactones in the Bryophyta (mosses) Takakia: Takakia species are closely related chemically to the Marchantiophyta (liverworts).
PubMed: [Chemical Constituents from Cynanchum paniculatum].
PubMed: Development and validation of a high-performance liquid chromatographic method for the simultaneous quantification of marker constituents in Cheonwangbosimdan.
PubMed: Chemical composition of the essential oil of aerial parts of Haussknechtia elymaitica Boiss. from Iran: a good natural source for trans-asaron.
PubMed: Fumigant toxicity of Oriental sweetgum (Liquidambar orientalis) and valerian (Valeriana wallichii) essential oils and their components, including their acetylcholinesterase inhibitory activity, against Japanese termites (Reticulitermes speratus).
PubMed: Spasmolytische wirkung des isoasaronfreien kalmus1.
PubMed: [To the classification of commercial Calamus drugs].
PubMed: [Study on relationship of properties and drug release rate of hot melt pressure sensitive adhesive].
PubMed: The effects of Zibu Piyin Recipe components on scopolamine-induced learning and memory impairment in the mouse.
PubMed: Phenolic constituents of Acorus gramineus.
PubMed: In vitro acetylcholinesterase inhibitory activity of the essential oil from Acorus calamus and its main constituents.
PubMed: Rhizoma acori graminei and its active principles protect PC-12 cells from the toxic effect of amyloid-beta peptide.
PubMed: Comparison of the volatile oil composition of three Atalantia species.
PubMed: Synthesis, anticancer and antioxidant activities of 2,4,5-trimethoxy chalcones and analogues from asaronaldehyde: structure-activity relationship.
PubMed: [Research on liposoluble ingredients of Quchiling].
PubMed: Development of gas chromatography/mass spectrometry following headspace solid-phase microextraction for fast determination of asarones in plasma.
PubMed: Gas chromatography-mass spectrometry analysis on compounds in volatile oils extracted from yuan zhi (radix polygalae) and shi chang pu (acorus tatarinowii) by supercritical CO2.
PubMed: Asarones fromAcorus calamus L. Oil : Their effect on feeding behavior and dietary utilization inPeridroma saucia.
PubMed: Enhanced toxicity of binary mixtures of larvicidal constituents from Asarum heterotropoides root to Culex pipiens pallens (Diptera: Culicidae).
PubMed: Chemical composition, antinociceptive and anti-inflammatory properties of essential oil from the roots of Illicium lanceolatum.
PubMed: Supercritical fluid CO₂ extraction of Acorus calamus L. (Arales: Araceae) and its contact toxicity to Sitophilus zeamais Motschusky (Coleoptera: Curculionidae).
PubMed: Chemical compositions and anti-influenza activities of essential oils from Mosla dianthera.
PubMed: Neuroprotective effect of honokiol and magnolol, compounds from Magnolia officinalis, on beta-amyloid-induced toxicity in PC12 cells.
PubMed: Larvicidal activity of Asarum heterotropoides root constituents against insecticide-susceptible and -resistant Culex pipiens pallens and Aedes aegypti and Ochlerotatus togoi.
PubMed: [Studies on chemical constituents of green algae Ulva pertusa].
PubMed: [Study on GC-MS fingerprint analysis in rhizome of volatile oil of Acorus tatarinowii].
PubMed: Chemical composition and biological activity of the volatile extracts of Achillea millefolium.
PubMed: Discovery of gemfibrozil analogues that activate PPARα and enhance the expression of gene CPT1A involved in fatty acids catabolism.
PubMed: Brazilian red propolis: unreported substances, antioxidant and antimicrobial activities.
PubMed: A solid-phase microextraction GC/MS/MS method for rapid quantitative analysis of food and beverages for the presence of legally restricted biologically active flavorings.
PubMed: Insecticidal effect and chemical composition of the volatile oil from Bergenia ligulata.
PubMed: Positive GABA(A) receptor modulators from Acorus calamus and structural analysis of (+)-dioxosarcoguaiacol by 1D and 2D NMR and molecular modeling.
PubMed: Supplemental ultraviolet-B induced changes in essential oil composition and total phenolics of Acorus calamus L. (sweet flag).
PubMed: Quality assessment of a formulated Chinese herbal decoction, Kaixinsan, by using rapid resolution liquid chromatography coupled with mass spectrometry: A chemical evaluation of different historical formulae.
PubMed: Structure-activity studies of the hepatocarcinogenicities of alkenylbenzene derivatives related to estragole and safrole on administration to preweanling male C57BL/6J x C3H/HeJ F1 mice.
PubMed: Identification of host plant attractants for the carrot fly,Psila rosae.
PubMed: Standardization and in vivo antioxidant activity of ethanol extracts of fruit and leaf of Piper sarmentosum.
PubMed: [GC-MS analysis of essential oil from nutmeg processed by different traditional methods].
PubMed: [Effects of annao tablet on S100B and NPY of cortex in chronic epilepsy rats].
PubMed: 3D QSAR study of hypolipidemic asarones by comparative molecular surface analysis.
PubMed: [Studies on the chemical constituents of Asarum longerhizomatosum C. F. Liang et C. S. Yang].
PubMed: Insecticidal activity against Aedes aegypti larvae of some medicinal South American plants.
PubMed: [Study on the chemical constituents of Humulus scandens].
PubMed: [Chemical constituents from petroleum ether fraction of ethanol extract of Acorus tatarinowii].
PubMed: Larvicidal and structure-activity studies of natural phenylpropanoids and their semisynthetic derivatives against the tobacco armyworm Spodoptera litura (Fab.) (Lepidoptera: Noctuidae).
PubMed: Inhibitors of HMG-CoA Reductase: Current and Future Prospects.
PubMed: Fumigant antifungal activity of essential oil components from Acorus gramineus against three phytopathogenic fungi.
PubMed: Volatiles from leaves and rhizomes of Fragrant Acorus spp. (Acoraceae).
PubMed: Evaluation of analgesic and anti-inflammatory activities of Nectandra megapotamica (Lauraceae) in mice and rats.
PubMed: Rapid determination of volatile constituents in safflower by microwave distillation and simultaneous solid-phase microextraction coupled with gas chromatography-mass spectrometry.
PubMed: Rapid determination of essential oil in Acorus tatarinowii Schott. by pressurized hot water extraction followed by solid-phase microextraction and gas chromatography-mass spectrometry.
PubMed: Micronucleus formation in human lymphocytes and in the metabolically competent human hepatoma cell line Hep-G2: results with 15 naturally occurring substances.
PubMed: DNA profiling of Acorus calamus chemotypes differing in essential oil composition.
PubMed: Central inhibitory effects of water extract of Acori graminei rhizoma in mice.
PubMed: Structure-genotoxicity relationships of allylbenzenes and propenylbenzenes: a quantum chemical study.
PubMed: Potential allelochemicals fromPistia stratiotes L.
PubMed: Bioanalytical and clinical evaluation of 103 suspected cases of intoxications with psychoactive plant materials.
PubMed: Chemical composition, oviposition deterrent and larvicidal activities against Aedes aegypti of essential oils from Piper marginatum Jacq. (Piperaceae).
PubMed: A high performance liquid chromatography method for simultaneous determination of rosiglitazone and gemfibrozil in human plasma.
PubMed: Variability in essential-oil composition of Piper marginatum sensu lato.
PubMed: Suppression of MeIQ-induced SOS response by allylbenzenes from Asiasarum heterotropoides in the Salmonella typhimurium OY1001/1A2 umu test.
PubMed: Fungicidal property of active component derived from Acorus gramineus rhizome against phytopathogenic fungi.
PubMed: A simple and practical phase-separation approach to the recycling of a homogeneous metathesis catalyst.
PubMed: Antioxidative activity of volatile extracts isolated from Angelica tenuissimae roots, peppermint leaves, pine needles, and sweet flag leaves.
PubMed: A new amide from Asarum forbesii Maxim.
PubMed: [Effects of beta-asaron on gene expression in mouse brain].
PubMed: Inhibition of cyclooxygenase (COX) enzymes by compounds from Daucus carota L. Seeds.
PubMed: Antifungal and larvicidal compounds from the root bark of Cordia alliodora.
PubMed: Getting to the root (Acorus calamus) of the problem.
PubMed: Studies on anti-allergic components in the roots of Asiasarum sieboldi.
PubMed: Central nervous system studies on an ethanol extract of Acorus calamus rhizomes.
PubMed: [Antianaphylactic components of Asarum forbsii Maxin].
PubMed: [Chromosome-damaging effect of beta-asaron on human lymphocytes].
PubMed: [Spasmolytic actions of active principles of volatile oil of Acorus gramineus].
PubMed: [Extraction of thermolabile compounds with supercritical gases.].
PubMed: Nematicidal activity of plant essential oils and components from coriander (Coriandrum sativum), Oriental sweetgum (Liquidambar orientalis), and valerian (Valeriana wallichii) essential oils against pine wood nematode (Bursaphelenchus xylophilus).
PubMed: Chemical composition of the essential oil and supercritical CO2 extract of Commiphora myrrha (Nees) Engl. and of Acorus calamus L.
PubMed: Essential oils from two endemic species of Apiaceae from Iran.
PubMed: [New data on composition of esssential oil from inflorescence of everlasting (Helichrysum arenarium(L.) Moench.)].
PubMed: SOS induction of selected naturally occurring substances in Escherichia coli (SOS chromotest).
PubMed: [Variations of the essential oils in Acorua calamus L. and their major compositions].
PubMed: [Spasmolytic effect of isoasaron free calamus].
PubMed: [In vitro study of the expectorant effect of phenylpropane derivatives of hazelwort. 12. Active substances form Asarum europaeum. L].
PubMed: [Use of the mass spectrometer as a specific detector in the analysis of alcoholic beverages by gas-liquid chromatography].
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