Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | colorless to pale yellow clear liquid (est) |
Assay: | 95.00 to 100.00 % sum of isomers
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Food Chemicals Codex Listed: | Yes |
Specific Gravity: | 1.04700 to 1.05500 @ 25.00 °C.
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Pounds per Gallon - (est).: | 8.712 to 8.779
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Specific Gravity: | 1.04800 to 1.05600 @ 20.00 °C.
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Pounds per Gallon - est.: | 8.731 to 8.797
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Refractive Index: | 1.56600 to 1.56900 @ 20.00 °C.
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Melting Point: | 16.00 to 17.00 °C. @ 760.00 mm Hg
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Boiling Point: | 262.00 to 264.00 °C. @ 760.00 mm Hg
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Vapor Pressure: | 0.011000 mmHg @ 25.00 °C. (est) |
Flash Point: | > 220.00 °F. TCC ( > 104.44 °C. )
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logP (o/w): | 3.049 (est) |
Shelf Life: | 24.00 month(s) or longer if stored properly. |
Storage: | store in cool, dry place in tightly sealed containers, protected from heat and light. |
Soluble in: |
| fixed oils | | paraffin oil | | water, 169.1 mg/L @ 25 °C (est) |
Insoluble in: |
| glycerin | | propylene glycol |
Stability: |
| non-discoloring in most media |
Organoleptic Properties:
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Odor Type: spicy |
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Odor Strength: | medium |
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Substantivity: | 240 hour(s) at 100.00 % |
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| spicy clove floral carnation woody |
Odor Description: at 100.00 %. | spicy clove blossom carnation woody Luebke, William tgsc, (1988) |
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Flavor Type: spicy |
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| spicy clove resinous galanga smoky woody powdery |
Taste Description:
| spicy warm clove resinous galanga smoky woody powdery Luebke, William tgsc, (1988) |
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Odor and/or flavor descriptions from others (if found). |
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Symrise |
Isoeugenol methyl ether |
Odor Description: | mildly spicy, like clove blossom oil |
Taste Description: | spicy, woody, smoky, tar-like Useful in: brown others, vanilla, savory spices, fruity red, fruity yellow, fruity tropical, sweet others, alcoholics. |
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Moellhausen |
isoEUGENYL METHYL ETHER |
Odor Description: | sweet aromatic, spicy, woody, smoky, fatty |
Taste Description: | spicy, woody, smoky, fatty |
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Pell Wall Perfumes |
Methyl Isoeugenol |
Odor Description: | Sweet-warm, spicy-clove, woody, floral, tea Arctander says that: “Of the common derivatives of Eugenol, it is one of the most Carnation-like. This phenolether is used in perfume compositions as part of Carnation bases, as a fixative in spicy fragrances, as a mildly spicy note in Rose, Ylang and other florals. It is commonly used in variations of ‘L’Origan’ type fragrances, Oriental perfumes, etc. and it blends well with Labdanum or other Ambre-like materials, with woody notes, Ionones, etc. Interesting combinations are obtained with Opopanax or Linalool or derivatives of Linalool.” |
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Prodasynth |
METHYL ISOEUGENOL (SUM OF ISOMERS > 99%) |
Odor Description: | SPICY, LIKE CLOVE BLOSSOM |
Taste Description: | spicy woody smoky resinous fatty |
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Robertet |
Methyl iso eugenol Natural identical, Kosher |
Odor Description: | Spicy, woody, floral, carnation |
Taste Description: | spicy woody smoky resinous fatty |
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Cosmetic Information:
Suppliers:
Advanced Biotech |
METHYL ISOEUGENOL NAT.
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Anhui Haibei |
Methyl Isoeugenol
Odor: Spicy pepper carnation woody |
Augustus Oils |
Methyl Iso Eugenol
|
Services |
Beijing Lys Chemicals |
Isoeugenyl methyl ether
|
Berjé |
Methyl Iso Eugenol natural
|
Media |
Berjé |
Methyl iso Eugenol
|
BOC Sciences |
For experimental / research use only. |
Methyl Isoeugenol 95%
|
Charabot |
Methyl iso eugenol
Natural identical, Kosher Odor: Spicy, woody, floral, carnation |
ECSA Chemicals |
METHYL ISOEUGENOL FLAVOUR USE
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ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY |
ECSA Chemicals |
METHYL ISOEUGENOL
|
Elan Inc. |
METHYL ISO EUGENOL
FCC, Kosher |
Ernesto Ventós |
METHYL ISOEUGENOL
|
Foreverest Resources |
Methyl Isoeugenol 98%
Odor: Eugenol aroma Use: Methyl isoeugenol (isomethyleugenol) is a phenylpropanoid, the methyl ether of isoeugenol. It is one of the main components found in the essential oil extracted from Acorus calamus, bark of Croton malambo and rhizomes of Zingiber zerumbet, Hedychium coronarium and Etlingera cevuga. It appears slight thick sticky liquid. Methyl isoeugenol is used in the formulation of flavor and fragrance. |
Fuzhou Farwell |
Methyl Isoeugenol 98%
|
Global Essence |
Methyl Isoeugenol
|
Indenta Group |
Methyl Iso Eugenol
|
Indukern F&F |
METHYL ISOEUGENOL
Odor: CLOVE, CARNATION |
Jiangyin Healthway |
Isoeugenenyl Methyl Ether
|
New functional food ingredients |
Jiangyin Healthway |
Methyl Isoeugenol
|
Lluch Essence |
METHYL ISOEUGENOL
|
M&U International |
METHYL ISOEUGENOL, Kosher
|
Miltitz Aromatics |
METHYL ISOEUGENOL
min. 98 % Odor: Sweet-warm, spicy, woody, mildly floral tea-like Use: METHYLISOEUGENOL is a base note and a fixative in spicy and floral perfumery compositions for all purposes. Flavor: Spicy, smoky, woody In flavors it is used for spicy blends. |
Moellhausen |
isoEUGENYL METHYL ETHER
Odor: sweet aromatic, spicy, woody, smoky, fatty Flavor: spicy, woody, smoky, fatty |
Natura Aromatik |
Methyl Isoeugenol
|
OQEMA |
Methyl Isoeugenol HT
|
OQEMA |
Methyl Isoeugenol
|
Pell Wall Perfumes |
Methyl Isoeugenol
Odor: Sweet-warm, spicy-clove, woody, floral, tea Use: Arctander says that: “Of the common derivatives of Eugenol, it is one of the most Carnation-like. This phenolether is used in perfume compositions as part of Carnation bases, as a fixative in spicy fragrances, as a mildly spicy note in Rose, Ylang and other florals. It is commonly used in variations of ‘L’Origan’ type fragrances, Oriental perfumes, etc. and it blends well with Labdanum or other Ambre-like materials, with woody notes, Ionones, etc. Interesting combinations are obtained with Opopanax or Linalool or derivatives of Linalool.” |
Penta International |
METHYL ISOEUGENOL FCC
|
Penta International |
METHYL ISOEUGENOL
|
PerfumersWorld |
Methyl Isoeugenol
|
Phoenix Aromas & Essential Oils |
Methyl Iso Eugenol
|
Prodasynth |
METHYL ISOEUGENOL
(SUM OF ISOMERS > 99%) Odor: SPICY, LIKE CLOVE BLOSSOM |
R C Treatt & Co Ltd |
Methyl Isoeugenol
|
Reincke & Fichtner |
isoEugenyl Methyl Ether natural
|
Reincke & Fichtner |
isoEugenyl Methyl Ether
|
Robertet |
Methyl iso eugenol
Natural identical, Kosher Odor: Spicy, woody, floral, carnation |
Seasons and Harvest / Crop calendar |
Santa Cruz Biotechnology |
For experimental / research use only. |
1,2-Dimethoxy-4-propenylbenzene
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Sigma-Aldrich |
Methyl isoeugenol, ≥98%, FG
Odor: spicy |
Certified Food Grade Products |
SRS Aromatics |
METHYL ISO EUGENOL
|
Taytonn ASCC |
Methyl Isoeugenol
Odor: Clove Blossom, Spicy |
TCI AMERICA |
For experimental / research use only. |
4-(1-Propenyl)-1,2-dimethoxybenzene >98.0%(GC)
|
The Good Scents Company |
methyl isoeugenol
Odor: spicy clove blossom carnation woody |
Ungerer & Company |
Methyl Iso Eugenol
|
Van Aroma |
METHYL ISO EUGENOL
Odor: mild, spicy, like clove blossom oil |
maps.vanaroma.com |
Vigon International |
Methyl Isoeugenol
Odor: Mildly spicy, like clove blossom oil |
WholeChem |
Isoeugenyl methyl ether
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Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | None - None found. |
S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes.
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
Acute toxicity, Oral (Category 4), H302
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GHS Label elements, including precautionary statements |
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Pictogram | |
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Signal word | Warning |
Hazard statement(s) |
H302 - Harmful if swallowed
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Precautionary statement(s) |
P264 - Wash skin thouroughly after handling. P270 - Do not eat, drink or smoke when using this product. P301 + P312 - IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P330 - Rinse mouth. P501 - Dispose of contents/ container to an approved waste disposal plant.
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Human Experience: |
8 % solution: no irritation or sensitization. |
Oral/Parenteral Toxicity: |
oral-rat LD50 2500 mg/kg Food and Cosmetics Toxicology. Vol. 13, Pg. 865, 1975.
intravenous-mouse LD50 181 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) Archives Internationales de Pharmacodynamie et de Therapie. Vol. 199, Pg. 226, 1972.
intraperitoneal-mouse LD50 570 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) Archives Internationales de Pharmacodynamie et de Therapie. Vol. 199, Pg. 226, 1972.
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Dermal Toxicity: |
skin-rabbit LD50 > 5000 mg/kg Food and Cosmetics Toxicology. Vol. 13, Pg. 865, 1975.
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | flavor and fragrance agents |
RIFM Fragrance Material Safety Assessment: Search |
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
Recommendation for methyl isoeugenol usage levels up to: | | 8.0000 % in the fragrance concentrate.
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Maximised Survey-derived Daily Intakes (MSDI-EU): | 109.00 (μg/capita/day) |
Maximised Survey-derived Daily Intakes (MSDI-USA): | 129.00 (μg/capita/day) |
Structure Class: | III |
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
publication number: 3 |
Click here to view publication 3 |
| average usual ppm | average maximum ppm |
baked goods: | - | 18.00000 |
beverages(nonalcoholic): | - | 4.00000 |
beverages(alcoholic): | - | - |
breakfast cereal: | - | - |
cheese: | - | - |
chewing gum: | - | 110.00000 |
condiments / relishes: | - | - |
confectionery froastings: | - | - |
egg products: | - | - |
fats / oils: | - | - |
fish products: | - | - |
frozen dairy: | - | 7.70000 |
fruit ices: | - | 7.70000 |
gelatins / puddings: | - | 0.10000 |
granulated sugar: | - | - |
gravies: | - | - |
hard candy: | - | 13.00000 |
imitation dairy: | - | - |
instant coffee / tea: | - | - |
jams / jellies: | - | - |
meat products: | - | - |
milk products: | - | - |
nut products: | - | - |
other grains: | - | - |
poultry: | - | - |
processed fruits: | - | - |
processed vegetables: | - | - |
reconstituted vegetables: | - | - |
seasonings / flavors: | - | - |
snack foods: | - | - |
soft candy: | - | - |
soups: | - | - |
sugar substitutes: | - | - |
sweet sauces: | - | - |
Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| benzene, 1,2-dimethoxy-4-(1-propen-1-yl)- | 3,4- | dimethoxy-1,1-propen-1-yl benzene | 1,2- | dimethoxy-4-(1-propen-1-yl) benzene | 1,2- | dimethoxy-4-(1-propenyl) benzene | 1,2- | dimethoxy-4-(1-propenyl)-benzene | 1,2- | dimethoxy-4-(1-propenyl)benzene | 1,2- | dimethoxy-4-(prop-1-en-1-yl)benzene | 1,2- | dimethoxy-4-(prop-1-enyl)benzene | 1,2- | dimethoxy-4-prop-1-enylbenzene | 1,2- | dimethoxy-4-propen-1-yl benzene | 1-(3,4- | dimethoxyphenyl)-1-propene | 3-(3,4- | dimethoxyphenyl)-2-propene | 3,4- | dimethoxypropylbenzene | | ether, isoeugenyl methyl | iso | eugenol methyl | 1,3,4-iso | eugenol methyl ether | iso | eugenol methyl ether | iso- | eugenol methyl ether | iso | eugenyl methyl ether | | methyl iso eugenol | | methylisoeugenol | 4- | prop-1-enyl veratrole | 4- | prop-1-enylveratrole | 4- | propenyl veratrole | 4-(1- | propenyl)-1,2-dimethoxybenzene | 4- | propenylveratrole | 1- | veratryl-1-propene |
Articles:
PubMed: | Chemical compositions, phytotoxicity, and biological activities of Acorus calamus essential oils from Nepal. |
PubMed: | Characterization of a self-sufficient trans-anethole oxygenase from Pseudomonas putida JYR-1. |
PubMed: | Utility of rat liver S9 fractions to study skin-sensitizing prohaptens in a modified KeratinoSens assay. |
PubMed: | Synthesis, spectroscopic characterization and DFT calculations of β-O-4 type lignin model compounds. |
PubMed: | Neural coding of binary mixtures in a structurally related odorant pair. |
PubMed: | Production of natural fragrance aromatic acids by coexpression of trans-anethole oxygenase and p-anisaldehyde dehydrogenase genes of Pseudomonas putida JYR-1 in Escherichia coli. |
PubMed: | Isolation of a gene responsible for the oxidation of trans-anethole to para-anisaldehyde by Pseudomonas putida JYR-1 and its expression in Escherichia coli. |
PubMed: | Involvement of 5-HT1A in the anxiolytic-like effect of dichloromethane fraction of Pimenta pseudocaryophyllus. |
PubMed: | A hexane fraction of guava Leaves (Psidium guajava L.) induces anticancer activity by suppressing AKT/mammalian target of rapamycin/ribosomal p70 S6 kinase in human prostate cancer cells. |
PubMed: | Chemical composition of the essential oil of aerial parts of Haussknechtia elymaitica Boiss. from Iran: a good natural source for trans-asaron. |
PubMed: | Chemical composition, antinociceptive and anti-inflammatory properties of essential oil from the roots of Illicium lanceolatum. |
PubMed: | Major constituents and antimicrobial activity of Korean herb Acorus calamus. |
PubMed: | Terpenoid composition and antifungal activity of three commercially important essential oils against Aspergillus flavus and Aspergillus niger. |
PubMed: | Phosphoinositide 3-kinase-dependent antagonism in mammalian olfactory receptor neurons. |
PubMed: | Chemical composition of the essential oil of Feronia elephantum Correa. |
PubMed: | Natural compounds endowed with cholinergic or anticholinergic activity. Enhancement of acetylcholine release by a quaternary derivative of L-hyoscyamine. |
PubMed: | [Studies on constituents of rootsanel leaves from Desmodium blandum and their cytotoxic activity against growth of several tumor cells]. |
PubMed: | Nematicidal Activity of Plant Essential Oils and Components From Ajowan (Trachyspermum ammi), Allspice (Pimenta dioica) and Litsea (Litsea cubeba) Essential Oils Against Pine Wood Nematode (Bursaphelenchus Xylophilus). |
PubMed: | threo-2-(2,6-dimethoxyphenoxy)-1-(4-hydroxy-3,5-dimethoxyphenyl)propane-1,3-diol: a conformational study. |
PubMed: | Evidence for positive selection on the floral scent gene isoeugenol-O-methyltransferase. |
PubMed: | NTP Toxicology and Carcinogenesis Studies of Methyleugenol (CAS NO. 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies). |
PubMed: | Inhibition of nicotinic acetylcholine receptors and calcium channels by clozapine in bovine adrenal chromaffin cells. |
PubMed: | Lignin peroxidase initiates O2-dependent self-propagating chemical reactions which accelerate the consumption of 1-(3',4'-dimethoxyphenyl)propene. |
PubMed: | Antiproliferative constituents in umbelliferae plants. IV. Constituents in the fruits of Anthriscus sylvestris Hoffm. |
PubMed: | Synthesis, structure and quantitative structure-activity relationships of sigma receptor ligands, 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl) piperazines. |
PubMed: | A 28-day feeding study with methyl isoeugenol in rats. |
PubMed: | Semiochemical attractants ofDiabrotica undecimpunctata howardi barber, southern corn rootworm, andDiabrotica virgifera virgifera leconte, the western corn rootworm (Coleoptera: Chrysomelidae). |
PubMed: | Influence of vehicles on penetration through human epidermis of benzyl alcohol, isoeugenol and methyl isoeugenol. |
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